Abstract:
BACKGROUND:Despite high 1-dose vaccination coverage, breakthrough varicella infections still occur. Therefore, 2-dose vaccination is recommended to enhance the immune response to the virus. However, the reported incremental vaccine effectiveness (VE) of 2-dose vaccination varies widely among studies. METHODS:To determine the overall effectiveness, immunogenicity and safety of one vs. two-dose varicella vaccination, we searched five databases for articles published during 1995-2017. RESULTS:The incremental VE/efficacy of 2-dose vaccination was 79% (95% confidence interval [CI]: 56%-90%) in randomized controlled trials,63% (95% CI: 36%-79%) in cohort studies and 81% (95% CI: 65%-90%) in case-control studies. Regarding immunogenicity, the pooled standardized mean differences (SMD) of geometric mean titer (GMT) and the pooled relative risk (RR) of seroconversion for 2-dose vs. 1-dose vaccine were 562.44 (95% CI: 471.78-653.10) and 1.03 (95% CI: 1.02-1.04), respectively. Children who received second dose vaccination were at increased risk of grade 3 redness (RR: 4.93, 95% CI: 1.89 - 12.87) and swelling of any intensity (RR: 1.34, 95% CI: 1.08 - 1.66). CONCLUSIONS:Two-dose varicella vaccination resulted in higher levels of immunogenicity and provided superior protection than 1-dose vaccination. Safety profiles showed 2-dose vaccination was well tolerated but the incidence of grade 3 redness and of any intensity was significantly higher.
journal_name
Expert Rev Vaccinesjournal_title
Expert review of vaccinesauthors
Yin M,Xu X,Liang Y,Ni Jdoi
10.1080/14760584.2018.1433999subject
Has Abstractpub_date
2018-04-01 00:00:00pages
351-362issue
4eissn
1476-0584issn
1744-8395journal_volume
17pub_type
杂志文章,meta分析,评审abstract::A key challenge to HIV vaccine development is the integration of HIV proviral DNA into the host genome upon infection. Therefore, an optimal vaccine should block infection within hours of viral exposure, providing 'sterilizing immunity' at mucosal sites and in blood via potent, broadly reactive antibody to the HIV env...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.3.4.s105
更新日期:2004-08-01 00:00:00
abstract::Lipopolysaccharide (LPS), a dominant component of the Gram-negative bacterial outer membrane, is a strong activator of the innate immune system, and thereby an important determinant in the adaptive immune response following bacterial infection. This adjuvant activity can be harnessed following immunization with bacter...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2015.1026808
更新日期:2015-06-01 00:00:00
abstract::The USA is experiencing a pertussis resurgence that resulted in a 60-year high of 48,000 cases in 2012. Our ability to counteract this resurgence is hampered by the fact that pertussis pathogenesis and immunity to pertussis infection are not well studied. Studies in humans are difficult due to the low frequency of per...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2014.946016
更新日期:2014-10-01 00:00:00
abstract::With approximately 2.4 billion people at risk, Plasmodium falciparum malaria infection caused by an infectious bite of an Anopheles mosquito continues to be a major cause of mortality and morbidity, mainly in the tropics and subtropics. Measures to control the mosquito vector on a broad scale are expensive and need to...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.5.1.81
更新日期:2006-02-01 00:00:00
abstract::Plasmid DNA is a promising vaccine modality that is regularly examined in prime-boost immunization regimens. Recent advances in skin immunity increased our understanding of the sophisticated cutaneous immune network, which revived scientific interest in delivering vaccines to the skin. Intradermal administration of pl...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.11.66
更新日期:2011-08-01 00:00:00
abstract::Newborns and infants are highly susceptible to infectious diseases, resulting in high mortality and morbidity, particularly in resource-poor settings. Many vaccines require several booster doses, resulting in an extensive vaccine schedule, and yet there is still inadequate protection from some of these diseases. This ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.10.41
更新日期:2010-06-01 00:00:00
abstract::Antigenic changes in influenza virus occur gradually, owing to mutations (antigenic drift), and abruptly, owing to reassortment among subtypes (antigenic shift). Availability of strain-matched vaccines often lags behind these changes, resulting in a shortfall in public health. In animal models, cross-protection by vac...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2010-11-01 00:00:00
abstract::Complex antigen structures currently represent the most-studied approach for prophylactic as well as therapeutic vaccines. Different types of complex vaccines, including virus-like particles and virosomes, have been developed depending on the nature of the viral pathogen they are trying to replicate (enveloped vs nake...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2009-10-01 00:00:00
abstract::The bacillus Calmette-Guérin (BCG) vaccine, initially developed to provide protection against TB, also protects against leprosy; and the magnitude of this effect varies. Previous meta-analyses did not provide a summary estimate of the efficacy due to the heterogeneity of the results. We conducted a meta-analysis of pu...
journal_title:Expert review of vaccines
pub_type: 杂志文章,meta分析
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更新日期:2010-02-01 00:00:00
abstract::While vaccination continues to be the most successful interventionist health policy to date, infectious disease remains a significant cause of death worldwide. A primary reason that vaccination is not able to generate effective immunity is a lack of appropriate adjuvants capable of initiating the desired immune respon...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.6.4.559
更新日期:2007-08-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.7.7.1005
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:We evaluated memory responses and antibody persistence to diphtheria-toxoid, tetanus-toxoid, whole-cell-pertussis (DTwP), and Hepatitis-B vaccines in HIV-unexposed, HIV-exposed-uninfected and HIV-infected children previously randomized to initiate time-limited ART at 6-10 weeks (ART-Immed) or when clinically...
journal_title:Expert review of vaccines
pub_type: 杂志文章,随机对照试验
doi:10.1080/14760584.2019.1547195
更新日期:2019-01-01 00:00:00
abstract::The success of vaccine regimens against viral pathogens hinges on the elicitation of protective responses. Hypervariable pathogens such as HIV avoid neutralization by masking protective epitopes with more immunogenic decoys. The identification of protective, conserved epitopes is crucial for future vaccine candidate d...
journal_title:Expert review of vaccines
pub_type: 社论
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更新日期:2014-08-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2016.1124762
更新日期:2016-01-01 00:00:00
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journal_title:Expert review of vaccines
pub_type:
doi:10.1586/erv.09.122
更新日期:2009-12-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2013-05-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2016.1150182
更新日期:2016-07-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1080/14760584.2019.1607303
更新日期:2019-06-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.5.4.495
更新日期:2006-08-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章
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更新日期:2016-05-01 00:00:00
abstract::Serogroup B Neisseria meningitidis is the leading cause of meningococcal disease in developed countries. There is currently no vaccine offering wide-ranging protection. Development of a serogroup B polysaccharide-based vaccine has been hindered by potential risks of autoantibodies that cross-react with glycosylated ho...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2008-11-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2018-10-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2003-04-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.7.10.1547
更新日期:2008-12-01 00:00:00
abstract::In addition to the use of traditional vaccines in the National Immunization Program, the introduction: of additional vaccines in Indonesia appears to be important to further reduce rates of childhood mortality. However, it typically takes at least two decades for additional vaccines to be introduced into the National ...
journal_title:Expert review of vaccines
pub_type: 社论
doi:10.1586/14760584.2014.944165
更新日期:2014-12-01 00:00:00
abstract::Immunotherapy is a promising means to fight cancer, prompting a steady increase in clinical trials and correlative laboratory studies in this field. As antitumor T cells play central roles in immunity against malignant diseases, most immunotherapeutic protocols aim to induce and/or strengthen their function. Various t...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2013.843456
更新日期:2013-11-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2016.1158650
更新日期:2016-08-01 00:00:00
abstract::Dr Tamar Ben-Yedidia has more than 15 years of experience in the field of immunology, with specific expertise in the development of vaccines. She started her career with Biotechnology General Ltd (BTG; Rehovot, Israel), working on the development of a recombinant hepatitis B vaccine. She joined the Weizmann Institute ...
journal_title:Expert review of vaccines
pub_type: 面试
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更新日期:2010-03-01 00:00:00
abstract::Baculovirus and insect cell culture technologies have mostly been limited to research laboratories for the transient expression of target proteins for drug development purposes. With the renaissance of the vaccine field and the regulatory acceptance of recombinant DNA technology, the baculovirus expression system has ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.11.24
更新日期:2011-07-01 00:00:00