Outlining novel scenarios for improved therapeutic cancer vaccines: the PANVAC paradigm.

abstract：:A novel vaccine platform uses DNA immunization to launch live-attenuated virus vaccines in vivo. This technology has been applied for vaccine development against positive-strand RNA viruses with global public health impact including alphaviruses and flaviviruses. The DNA-launched vaccine represents the recombinant pla...

journal_title：Expert review of vaccines

authors： Pushko P,Lukashevich IS,Weaver SC,Tretyakova I

更新日期：2016-09-01 00:00:00

abstract：:While vaccination continues to be the most successful interventionist health policy to date, infectious disease remains a significant cause of death worldwide. A primary reason that vaccination is not able to generate effective immunity is a lack of appropriate adjuvants capable of initiating the desired immune respon...

journal_title：Expert review of vaccines

authors： Fraser CK,Diener KR,Brown MP,Hayball JD

更新日期：2007-08-01 00:00:00

abstract：INTRODUCTION:The "cloaked" bacterial pathogen that is Chlamydia trachomatis continues to cause sexually transmitted infections (STIs) that adversely affect the health and well-being of children, adolescents and adults globally. The reproductive disease sequelae follow unresolved or untreated chronic or recurrent asympt...

journal_title：Expert review of vaccines

authors： Hafner LM,Timms P

更新日期：2018-01-01 00:00:00

abstract：:Pneumococcal disease is a major health problem worldwide. Large, rapid declines in overall invasive pneumococcal disease and mucosal disease in children, reductions in vaccine-type disease in unvaccinated children and adults (indirect effects) and significant drops in antibiotic-resistant infections were observed afte...

journal_title：Expert review of vaccines

authors： Dinleyici EC,Yargic ZA

更新日期：2008-11-01 00:00:00

abstract：:Peptide vaccines represent a potential strategy for the prevention and treatment of pathogenic diseases, cancers and autoimmune disorders; their low cost, ease of synthesis and inherent safety are all attractive features. However, they have remained largely unsuccessful owing to low immunogenicity, predominantly stemm...

journal_title：Expert review of vaccines

authors： Croft NP,Purcell AW

更新日期：2011-02-01 00:00:00

abstract：:Efforts to develop a meningococcal vaccine that will include coverage against serogroup B disease have largely focused on outer membrane protein antigens. The protection offered by currently licensed outer membrane vesicle (OMV) vaccines is specific to epidemic strains as their immunodominant antigens are highly varia...

journal_title：Expert review of vaccines

authors： Sanders H,Feavers IM

更新日期：2011-03-01 00:00:00

abstract：:Nontypeable Haemophilus influenzae (NTHi) is a predominant organism of the upper respiratory nasopharyngeal microbiota. Its disease spectrum includes otitis media, sinusitis, non-bacteremic pneumonia and invasive infections. Protein-based vaccines to prevent NTHi infections are needed to alleviate these infections in ...

journal_title：Expert review of vaccines

authors： Khan MN,Ren D,Kaur R,Basha S,Zagursky R,Pichichero ME

更新日期：2016-07-01 00:00:00

abstract：:There is growing interest in immunotherapy for malignant gliomas. This interest stems from a number of immunological observations, together with the failure of conventional therapeutic agents to produce broad and clinically meaningful improvements in survival and quality of life. The challenges faced in translating la...

journal_title：Expert review of vaccines

authors： Fenstermaker RA,Ciesielski MJ

更新日期：2014-03-01 00:00:00

abstract：:The bacillus Calmette-Guérin (BCG) vaccine, initially developed to provide protection against TB, also protects against leprosy; and the magnitude of this effect varies. Previous meta-analyses did not provide a summary estimate of the efficacy due to the heterogeneity of the results. We conducted a meta-analysis of pu...

journal_title：Expert review of vaccines

authors： Merle CS,Cunha SS,Rodrigues LC

更新日期：2010-02-01 00:00:00

abstract：:Bovine spongiform encephalopathy in cattle is highly suspected to be orally transmitted to humans through contaminated food, causing new variant Creutzfeldt-Jakob disease. However, no prophylactic procedures against these diseases, such as vaccines, in particular those stimulating mucosal protective immunity, have bee...

journal_title：Expert review of vaccines

authors： Sakaguchi S,Arakawa T

更新日期：2007-02-01 00:00:00

abstract：:Immunotherapy is a promising means to fight cancer, prompting a steady increase in clinical trials and correlative laboratory studies in this field. As antitumor T cells play central roles in immunity against malignant diseases, most immunotherapeutic protocols aim to induce and/or strengthen their function. Various t...

journal_title：Expert review of vaccines

authors： Robert-Tissot C,Nguyen LT,Ohashi PS,Speiser DE

更新日期：2013-11-01 00:00:00

abstract：:The cytotoxic CD8(+) T lymphocyte-mediated cellular response is important for the elimination of virus-infected cells and requires the prior recognition of short viral peptide antigens previously translocated to the endoplasmic reticulum by the transporter associated with antigen processing (TAP). However, individuals...

journal_title：Expert review of vaccines

authors： López D,Lorente E,Barriga A,Johnstone C,Mir C

更新日期：2013-09-01 00:00:00

abstract：:The 9th Canadian Immunization Conference was held on 5-8 December 2010 in Quebec City, Canada. Over 1000 academic, public health and vaccine industry scientists, nurses, pharmacists, physicians and policy makers attended the conference, which was organized by the Public Health Agency of Canada-Centre for Immunization ...

journal_title：Expert review of vaccines

authors： Langley JM,Naus M

更新日期：2011-04-01 00:00:00

abstract：INTRODUCTION:Fluzone® High-Dose (IIV3-HD) is a trivalent, inactivated, split-virus influenza vaccine indicated for use in older adults (≥65 years of age). It contains 60 µg hemagglutinin of each influenza strain, which is four times the hemagglutinin content of standard-dose influenza vaccines, including Fluzone (IIV3-...

journal_title：Expert review of vaccines

authors： Robertson CA,DiazGranados CA,Decker MD,Chit A,Mercer M,Greenberg DP

更新日期：2016-12-01 00:00:00

abstract：:Introduction: For over 40 years, ebolaviruses have been responsible for sporadic outbreaks of severe and often fatal hemorrhagic fever in humans and nonhuman primates across western and central Africa. In December 2013, an unprecedented Ebola virus (EBOV) epidemic began in West Africa and resulted in the largest outbr...

journal_title：Expert review of vaccines

authors： O'Donnell K,Marzi A

更新日期：2020-03-01 00:00:00

abstract：:Combination vaccines have been used for many years in the USA as part of the primary infant immunization series. However, the current program still requires up to 24 injections by 18 months of age. The Advisory Committee on Immunization Practices in the USA recommends the use of combination vaccines whenever possible....

journal_title：Expert review of vaccines

authors： White C,Halperin SA,Scheifele DW

更新日期：2009-07-01 00:00:00

abstract：:The management of advanced prostate cancer, specifically metastatic castrate-resistant prostate cancer (mCRPC), remains a therapeutic challenge. Sipuleucel-T (Provenge; APC8015) was approved by the FDA in 2010 for the treatment of asymptomatic or minimally symptomatic mCRPC patients, and it remains the only FDA-approv...

journal_title：Expert review of vaccines

authors： Wei XX,Fong L,Small EJ

更新日期：2015-01-01 00:00:00

abstract：:The need for an affordable, safe and effective HIV vaccine has never been greater. As the immunogenicity of all the vaccine vectors being evaluated currently in human populations is limited, novel vaccine strategies are needed to stimulate the innate immune system, to generate high levels of neutralizing antibodies an...

journal_title：Expert review of vaccines

authors： Joseph J,Saubi N,Pezzat E,Gatell JM

更新日期：2006-12-01 00:00:00

abstract：INTRODUCTION:Pertussis is a highly contagious disease of the respiratory tract which is caused by the bacterium Bordetella pertussis and is most severe in those <1 year of age. A vaccine against pertussis, introduced in the 1950's, led to a significant decrease in incidence of the disease, but recent increases in outbr...

journal_title：Expert review of vaccines

authors： Martinón-Torres F,Heininger U,Thomson A,Wirsing von König CH

更新日期：2018-04-01 00:00:00

abstract：:Introduction: Controlling the preventable infectious diseases is the main goal of vaccination. Among the vaccines, combined vaccines are of great importance for their social, public health, and economic values. It is stated that the combined vaccines are as efficient and safe as the monovalent vaccines. However, a con...

journal_title：Expert review of vaccines

authors： Tafreshi SH

更新日期：2020-10-01 00:00:00

abstract：:Serogroup B Neisseria meningitidis is the leading cause of meningococcal disease in developed countries. There is currently no vaccine offering wide-ranging protection. Development of a serogroup B polysaccharide-based vaccine has been hindered by potential risks of autoantibodies that cross-react with glycosylated ho...

journal_title：Expert review of vaccines

authors： Bai X,Borrow R

更新日期：2010-10-01 00:00:00

abstract：INTRODUCTION:Vaccination against group B Streptococcus (GBS) during pregnancy could provide protection against disease in the mother, fetus, and newborn. Immunity through transplacental acquired antibodies in the newborns could persist through early infancy, reducing the risk of early-onset (<7 days age) and late-onset...

journal_title：Expert review of vaccines

authors： Dzanibe S,Madhi SA

更新日期：2018-07-01 00:00:00

abstract：:The production of long-lived, high-affinity antibodies forms the basis of many successful vaccination strategies. Although much is known of the proteins and pathways of the immune system that lead to the production of these antibodies, there are also many processes that remain unexplained or poorly explained. Some vac...

journal_title：Expert review of vaccines

authors： Randall KL

更新日期：2010-09-01 00:00:00

abstract：:Adjuvants are essential components of most clinically used vaccines. This is because the majority of nonliving vaccines are relatively poor inducers of adaptive immunity unless effective adjuvants are co-administered. Aluminum salts (alum) have been used as adjuvants with great success for almost a century and have be...

journal_title：Expert review of vaccines

authors： Schijns VE,Lavelle EC

更新日期：2011-04-01 00:00:00

abstract：:Toxoplasma gondii, a significant public health risk, is able to infect almost all warm-blooded animals including humans, and it results in economic losses in production animals. In the last three years, a large number of vaccination experiments have been performed to control T. gondii infection, with the target of lim...

journal_title：Expert review of vaccines

authors： Zhang NZ,Wang M,Xu Y,Petersen E,Zhu XQ

更新日期：2015-01-01 00:00:00

abstract：:Several new TB vaccines are currently undergoing clinical trials. Among the most promising is a vaccine based upon the modified vaccinia virus Ankara-expressing mycobacterial antigen 85A (MVA85A). Given the widespread use of the current TB vaccine, BCG, many of the new TB vaccines are being tested for their ability to...

journal_title：Expert review of vaccines

authors： McMurray DN

更新日期：2011-12-01 00:00:00

abstract：INTRODUCTION:There is a growing interest in developing curative strategies for HIV infection. Therapeutic vaccines are one of the most promising approaches. We will review the current knowledge and the new challenges in this research field. Areas covered: PubMed and ClinicalTrial.gov databases were searched to review t...

journal_title：Expert review of vaccines

authors： Leal L,Lucero C,Gatell JM,Gallart T,Plana M,García F

更新日期：2017-06-01 00:00:00

abstract：:Therapeutic prospects of particulates are increasingly recognized for vaccination purposes. Compared with biologic particulates, such as live or attenuated bacterial vectors and viral vectors, synthetic particulates may be expected to ease the hurdles of quality assurance and validation in vaccine development and prod...

journal_title：Expert review of vaccines

authors： Thiele L,Merkle HP,Walter E

更新日期：2002-08-01 00:00:00

abstract：:Current treatments for lung cancer are far from optimal. Several immunotherapeutic strategies involving vaccines incorporating different tumor-associated antigens to induce immune responses against tumors are being tested in clinical trials internationally. Although small, benefits have indeed been observed from the e...

journal_title：Expert review of vaccines

authors： Simmons O,Magee M,Nemunaitis J

更新日期：2010-03-01 00:00:00

abstract：:Conjugate vaccines using diphtheria toxoid variant (CRM(197)), diphtheria toxoid and tetanus toxoid (TT) as carrier protein may induce immune interactions (interference or impairment as measured by lower antibody levels, or enhancement [higher antibody levels]) when coadministered with other vaccines. Immune enhanceme...

journal_title：Expert review of vaccines

authors： Borrow R,Dagan R,Zepp F,Hallander H,Poolman J

更新日期：2011-11-01 00:00:00