Development of a Chlamydia trachomatis vaccine for urogenital infections: novel tools and new strategies point to bright future prospects.

abstract：:Several subtypes of influenza A viruses with pandemic potential are endemic in bird populations throughout Asia, Africa and the Middle East, and evidence suggests that these viruses are adapting to the mammalian host. As emphasized by the high mortality rate of humans infected with H5N1 viruses, this situation present...

journal_title：Expert review of vaccines

authors： Barrett PN,Portsmouth D,Ehrlich HJ

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome, tuberculosis, and malaria are responsible for most human deaths produced by infectious diseases worldwide. Vaccination against HIV requires generation of memory T cells and neutralizing antibodies, mucosal immunity, and stimulation of an inn...

journal_title：Expert review of vaccines

authors： Kilpeläinen A,Maya-Hoyos M,Saubí N,Soto CY,Joseph Munne J

更新日期：2018-11-01 00:00:00

abstract：:Nontypeable Haemophilus influenzae (NTHi) is a predominant organism of the upper respiratory nasopharyngeal microbiota. Its disease spectrum includes otitis media, sinusitis, non-bacteremic pneumonia and invasive infections. Protein-based vaccines to prevent NTHi infections are needed to alleviate these infections in ...

journal_title：Expert review of vaccines

authors： Khan MN,Ren D,Kaur R,Basha S,Zagursky R,Pichichero ME

更新日期：2016-07-01 00:00:00

abstract：:A novel vaccine platform uses DNA immunization to launch live-attenuated virus vaccines in vivo. This technology has been applied for vaccine development against positive-strand RNA viruses with global public health impact including alphaviruses and flaviviruses. The DNA-launched vaccine represents the recombinant pla...

journal_title：Expert review of vaccines

authors： Pushko P,Lukashevich IS,Weaver SC,Tretyakova I

更新日期：2016-09-01 00:00:00

abstract：INTRODUCTION:Human metapneumovirus (hMPV) has become one of the major pathogens causing acute respiratory infections (ARI) mainly affecting young children, immunocompromised patients, and the elderly. Currently there are no licensed vaccines against this virus. Areas covered: Since the discovery of hMPV in 2001, many g...

journal_title：Expert review of vaccines

authors： Márquez-Escobar VA

更新日期：2017-05-01 00:00:00

abstract：:Invasive meningococcal disease is a global public-health concern, with infants and adolescents bearing the majority of the disease burden. Vaccination is the most rational strategy to prevent meningococcal disease. Control of serogroup C disease has largely been achieved by the introduction of glycoconjugate meningoco...

journal_title：Expert review of vaccines

authors： Pace D

更新日期：2009-05-01 00:00:00

abstract：:The WHO has recently recommended the inclusion of rotavirus vaccine in the national immunization programs of all countries. In countries in the Americas, Europe and Australia that have adopted routine childhood immunization against rotavirus, significant reductions in the burden of severe childhood diarrhea have been ...

journal_title：Expert review of vaccines

authors： Tate JE,Patel MM,Steele AD,Gentsch JR,Payne DC,Cortese MM,Nakagomi O,Cunliffe NA,Jiang B,Neuzil KM,de Oliveira LH,Glass RI,Parashar UD

更新日期：2010-04-01 00:00:00

abstract：:The approval of sipuleucel-T has placed cancer vaccines on the verge of becoming an effective modality. However, there is much to define to understand the intricacies from the multiple confounding factors in vaccine immunotherapy. In this article under review, some patients with metastatic cancer who had limited tumor...

journal_title：Expert review of vaccines

authors： Baxevanis CN

更新日期：2012-03-01 00:00:00

abstract：:Francisella tularensis, the causative agent of tularemia, is an organism of concern as a potential biowarfare agent. Progress towards understanding the molecular basis of pathogenicity has been hampered by a lack of tools with which to manipulate the pathogen. However, the availability of genome sequence data for a ra...

journal_title：Expert review of vaccines

authors： Oyston PC,Griffiths R

更新日期：2009-11-01 00:00:00

abstract：INTRODUCTION:Neisseria meningitidis causes invasive meningococcal disease (IMD), with the highest incidence observed in infants and young children. Meningococcal serogroups A, B, C, W, X, and Y account for almost all IMD cases worldwide. Available meningococcal vaccines targeting serogroups A, C, W, and Y (MenACWY) inc...

journal_title：Expert review of vaccines

authors： Martinón-Torres F,Serra L,Safadi MAP

更新日期：2020-04-01 00:00:00

abstract：:Many vaccine candidates are highly purified, sometimes monomeric antigens and as a result, not very immunogenic. Antigen delivery systems optimize the presentation of antigens. They also play a major role in solving the problem of there being an increasing number of vaccines but limited opportunities in which to inclu...

journal_title：Expert review of vaccines

authors： Kersten G,Hirschberg H

更新日期：2004-08-01 00:00:00

abstract：:Lipopolysaccharide (LPS), a dominant component of the Gram-negative bacterial outer membrane, is a strong activator of the innate immune system, and thereby an important determinant in the adaptive immune response following bacterial infection. This adjuvant activity can be harnessed following immunization with bacter...

journal_title：Expert review of vaccines

authors： Zariri A,van der Ley P

更新日期：2015-06-01 00:00:00

abstract：:Psychological stress has been shown to be associated with poorer antibody levels following vaccination in both animals and humans, although the mechanisms underlying this relationship remain unclear. However, animal research has enabled investigation of how this relationship may be affected by the influence of individ...

journal_title：Expert review of vaccines

authors： Burns V

更新日期：2004-04-01 00:00:00

abstract：:Evaluation of: Böckl K, Wild J, Bredl S et al. Altering an artificial Gagpolnef polyprotein and mode of Env co-administration affects the immunogenicity of a clade C HIV-1 DNA vaccine. PLoS ONE 7(4), e34723 (2012). SIV vaccination studies in monkeys have revealed that Env-directed antibodies are critical for protect...

journal_title：Expert review of vaccines

authors： van Montfort T,Sanders RW

更新日期：2012-10-01 00:00:00

abstract：:Through the continuous efforts of several generations, China has become one of the few countries in the world that is capable of independently addressing all the requirements by the Expanded Program on Immunization. Regulatory science is applied to continuously improve the vaccine regulatory system. Passing the prequa...

journal_title：Expert review of vaccines

authors： Xu M,Liang Z,Xu Y,Wang J

更新日期：2015-05-01 00:00:00

abstract：:The available vaccines against human papillomavirus have some limitations such as low coverage due to their high cost, reduced immune coverage and the lack of therapeutic effects. Recombinant vaccines produced in plants (genetically engineered using stable or transient expression systems) offer the possibility to obta...

journal_title：Expert review of vaccines

authors： Rosales-Mendoza S,Govea-Alonso DO

更新日期：2015-07-01 00:00:00

abstract：:As pregnant women are considered a high-risk group for severe influenza illness, current recommendations advise vaccination of all pregnant women with inactivated influenza vaccine. Nevertheless, rates of maternal influenza vaccination have historically been low, possibly reflecting ongoing concerns about vaccine safe...

journal_title：Expert review of vaccines

authors： Fell DB,Dodds L,MacDonald NE,Allen VM,McNeil S

更新日期：2013-12-01 00:00:00

abstract：:Serogroup B Neisseria meningitidis is the leading cause of meningococcal disease in developed countries. There is currently no vaccine offering wide-ranging protection. Development of a serogroup B polysaccharide-based vaccine has been hindered by potential risks of autoantibodies that cross-react with glycosylated ho...

journal_title：Expert review of vaccines

authors： Bai X,Borrow R

更新日期：2010-10-01 00:00:00

abstract：:This review describes several enzyme-linked immunosorbent assay (ELISA) techniques proposed to replace the neutralization test for detecting neutralization-relevant antibodies to polioviruses in recipients of inactivated poliovirus vaccine and oral poliovirus vaccine, and for seroepidemiologic studies. Comparisons of ...

journal_title：Expert review of vaccines

authors： Ivanov AP,Dragunsky EM

更新日期：2005-04-01 00:00:00

abstract：:Vaccine distribution and delivery has become an issue of significant interest, given the threat of a pandemic influenza outbreak and the resulting need for coordinated efforts to distribute and deliver pandemic influenza vaccines into the hands of healthcare workers responsible for administering them. This review prov...

journal_title：Expert review of vaccines

authors： Jacobson SH,Sewell EC,Jokela JA

更新日期：2007-12-01 00:00:00

abstract：INTRODUCTION:It has been almost fifty years since the Towne strain was used by Plotkin and collaborators as the first vaccine candidate for cytomegalovirus (CMV). While that approach showed partial efficacy, there have been a multitude of challenges to improve on the promise of a CMV vaccine. Efforts have been dichotom...

journal_title：Expert review of vaccines

authors： Diamond DJ,La Rosa C,Chiuppesi F,Contreras H,Dadwal S,Wussow F,Bautista S,Nakamura R,Zaia JA

更新日期：2018-10-01 00:00:00

abstract：:Synthetic oligodeoxynucleotides containing unmethylated CpG motifs act as immune adjuvants, accelerating and boosting antigen-specific antibody responses by up to 500-fold. CpG motifs promote the production of T-helper 1 and pro-inflammatory cytokines and induce the maturation/activation of professional antigen-presen...

journal_title：Expert review of vaccines

authors： Klinman DM

更新日期：2003-04-01 00:00:00

abstract：:Plasmid DNA is a promising vaccine modality that is regularly examined in prime-boost immunization regimens. Recent advances in skin immunity increased our understanding of the sophisticated cutaneous immune network, which revived scientific interest in delivering vaccines to the skin. Intradermal administration of pl...

journal_title：Expert review of vaccines

authors： Elnekave M,Furmanov K,Hovav AH

更新日期：2011-08-01 00:00:00

abstract：:Tumor-associated antigens (TAAs) have been formulated into vaccines that, combined with adjuvants, cytokines or other strategies to boost the immune response, are now in clinical development. Both humoral and cellular immune responses to TAAs have been generated using these vaccines. This approach relies on the patien...

journal_title：Expert review of vaccines

authors： Acres B,Bonnefoy JY

更新日期：2008-09-01 00:00:00

abstract：INTRODUCTION:Due to overcome the hardness of the vaccine design, computational vaccinology is emerging widely. Prediction of T cell and B cell epitopes, antigen processing analysis, antigenicity analysis, population coverage, conservancy analysis, allergenicity assessment, toxicity prediction, and protein-peptide docki...

journal_title：Expert review of vaccines

authors： Kardani K,Bolhassani A,Namvar A

更新日期：2020-08-01 00:00:00

abstract：:Plants offer an attractive alternative for the production and delivery of subunit vaccines. Various antigens have been expressed at sufficiently high levels in plants to render vaccine development practical. An increasing body of evidence demonstrates that these plant-produced antigens can induce immunogenic responses...

journal_title：Expert review of vaccines

authors： Streatfield SJ,Howard JA

更新日期：2003-12-01 00:00:00

abstract：:In addition to the use of traditional vaccines in the National Immunization Program, the introduction: of additional vaccines in Indonesia appears to be important to further reduce rates of childhood mortality. However, it typically takes at least two decades for additional vaccines to be introduced into the National ...

journal_title：Expert review of vaccines

authors： Suwantika AA,Postma MJ

更新日期：2014-12-01 00:00:00

abstract：:The concept of cancer vaccines is as a therapeutic strategy to immunize the body against cancer antigens that may not be presented by the cancer itself, due to the marked immunosuppressive effects of the disease, which has been demonstrated in many different tumors. ...

journal_title：Expert review of vaccines

authors： Dalgleish AG

更新日期：2004-12-01 00:00:00

abstract：:Interview by Jenaid Rees, Commissioning Editor Jeffrey Schlom obtained his PhD from Rutgers University (NJ, USA). After obtaining his PhD, he worked at Columbia University (NY, USA) before moving in 1973 to the National Cancer Institute, National Institutes of Health (MD, USA). Since then he has served as the Chief of...

journal_title：Expert review of vaccines

authors： Schlom J

更新日期：2013-10-01 00:00:00

abstract：INTRODUCTION:To describe the impact following a 1-dose Varicella vaccination schedule introduced in Costa Rica in September 2007. Areas covered: This is a retrospective review using epidemiologic surveillance national databases of varicella cases and hospitalizations, period 2000-2015. We analyzed age-related varicella...

journal_title：Expert review of vaccines

authors： Avila-Aguero ML,Ulloa-Gutierrez R,Camacho-Badilla K,Soriano-Fallas A,Arroba-Tijerino R,Morice-Trejos A

更新日期：2017-03-01 00:00:00