DNA-damaging drug-induced apoptosis sensitized by N-myc in neuroblastoma cells.

Abstract:

:Neuroblastoma is one of the most common solid tumours in children (8-10% of all malignancies). Over 22% of cases have N-myc amplification associated with aggressively growing neuroblastomas. Oncogene-induced sensitization of cells to apoptosis is an important mechanism for suppression of tumorigenesis. Tumour suppressors often play a critical role in linking oncogenes to apoptotic machinery. For example, activated p53 then targets both intrinsic and extrinsic pathways to promote apoptosis through transcription-dependent and -independent mechanisms. Understanding of the involved mechanisms has important clinical implications. We have employed DNA-damaging drug-induced apoptosis sensitized by oncogene N-myc as a model. DNA damaging drugs trigger high levels of p53, leading to caspase-9 activation in neuroblastoma cells. Inactivation of p53 protects cells from drug-triggered apoptosis sensitized by N-myc. These findings thus define a molecular pathway for mediating DNA-damaging drug-induced apoptosis sensitized by oncogene, and suggest that inactivation of p53 or other components of this apoptotic pathway may confer drug resistance in neuroblastoma cells. The data also suggests that inactivation of apoptotic pathways through co-operating oncogenes may be necessary for the pathogenesis of neuroblastoma with N-myc amplification.

journal_name

Cell Biol Int

authors

Li T,Wang L,Ke XX,Gong XY,Wan JH,Hao XW,Xu M,Xiang Z,Cui ZB,Cui H

doi

10.1042/CBI20110231

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

331-7

issue

4

eissn

1065-6995

issn

1095-8355

pii

CBI20110231

journal_volume

36

pub_type

杂志文章
  • Erythrocyte sodium/hydrogen exchange inhibition by (-) epicatechin.

    abstract::Epicatechin, a flavonoid belonging to the group of compounds collectively called catechins, have been reported to possess insulin-like properties. Besides their anti-diabetic properties, catechins also show growth inhibition. Since cytosolic pH (pHi) plays a role in cell proliferation and the Na/H exchanger (NHE) is t...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1006/cbir.2000.0719

    authors: Matteucci E,Rizvi SI,Giampietro O

    更新日期:2001-01-01 00:00:00

  • Stimulation of the side population fraction of ATDC5 chondroprogenitors by hypoxia.

    abstract::The influence of oxygen tension on the side population (SP) fraction sorted from ATDC5 chondroprogenitor cells was investigated. ATDC5 cells cultured in normoxia (20%) or hypoxia (1% oxygen) were compared. The SP fraction was significantly higher in the cells cultured in hypoxia. The gene expression of 3 ABC transport...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1016/j.cellbi.2009.06.009

    authors: Kishimoto KN,Oxford CL,Reddi AH

    更新日期:2009-12-01 00:00:00

  • Fructose sensitizes Jurkat cells oxidative stress-induced apoptosis via caspase-dependent and caspase-independent mechanisms.

    abstract::Whether fructose (FRU), as the sole energy source, confers a metabolic advantage on cancer cells against noxious stimuli is unknown. The aim of this study was to evaluate the effects of low (11 mM), moderate (25 mM), and high (55 mM) FRU concentrations alone or in combination with rotenone (ROT) or doxorubicin (DOX) i...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.10653

    authors: Diaz-Aguirre V,Velez-Pardo C,Jimenez-Del-Rio M

    更新日期:2016-11-01 00:00:00

  • LncRNA MAFG-AS1 facilitates the migration and invasion of NSCLC cell via sponging miR-339-5p from MMP15.

    abstract::Non-small-cell carcinoma (NSCLC) is the most common cancer along with high mortality rate worldwide. In the present study, our data showed that lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAFG-AS1) was over-expressed in NSCLC tissues and cell lines. Overexpression of MAFG-AS1 promoted the migration, invasi...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.11092

    authors: Jia YC,Wang JY,Liu YY,Li B,Guo H,Zang AM

    更新日期:2019-04-01 00:00:00

  • The living cell: a complex autodynamic multi-oscillator system?

    abstract::Life cannot be simply defined in biochemical terms but it is associated with autodynamic behaviour. This fact implies that all aspects of cell biology should be viewed in terms of the resultant temporal features. Theoretical arguments indicate that the dynamic state can be explained only by the existence of periodicit...

    journal_title:Cell biology international

    pub_type: 杂志文章,评审

    doi:10.1006/cbir.2000.0571

    authors: Gilbert D,Lloyd D

    更新日期:2000-01-01 00:00:00

  • Phenotypic and functional comparison of optimum culture conditions for upscaling of dental pulp stem cells.

    abstract::Advances in dental pulp stem cell (DPSC) biology and behaviour have promised much in the field of regenerative medicine. Their recent use in clinical trials for bone repair enforces the notion that DPSCs can be used successfully in patients; however they display diverse characteristics under different culture conditio...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.10021

    authors: Kanafi MM,Pal R,Gupta PK

    更新日期:2013-02-01 00:00:00

  • Role of bone marrow-derived mesenchymal stem cells in the prevention of hyperoxia-induced lung injury in newborn mice.

    abstract::BPD (bronchopulmonary dysplasia) is predominantly characterized by persistent abnormalities in lung structure and arrested lung development, but therapy can be palliative. While promising, the use of BMSC (bone marrow-derived mesenchymal stem cell) in the treatment of lung diseases remains controversial. We have asses...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1042/CBI20110447

    authors: Zhang X,Wang H,Shi Y,Peng W,Zhang S,Zhang W,Xu J,Mei Y,Feng Z

    更新日期:2012-06-01 00:00:00

  • Retention and transmission of active transcription memory from progenitor to progeny cells via ligand-modulated transcription factors: elucidation of a concept by BIOPIT model.

    abstract::Observations made in live cells have clearly demonstrated that agonist-activated steroid/nuclear receptors reorganize in the nucleoplasm into hundreds of discrete speckled structures commonly referred to as nuclear foci. Subsequent studies have shown that nuclear foci are formed only with agonist- and not with pure an...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1042/CBI20090329

    authors: Kumar S,Saradhi M,Chaturvedi NK,Tyagi RK

    更新日期:2012-02-01 00:00:00

  • The role of reactive oxygen metabolites in the transcriptional regulation of IFN-gamma gene expression by histamine in NK cells following IL-2 stimulation.

    abstract::The secretion of interferon-gamma (IFN-gamma) by natural killer (NK) cells following in vitro stimulation with interleukin-2 (IL-2) is inhibited by co-incubation with autologous monocytes at a transcriptional level by more than sixty-fold. In this study, we investigate the nature of the inhibitory signal and particula...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1006/cbir.1996.0077

    authors: Houze TA,Larsson PA,Hellstrand K,Gustavsson B

    更新日期:1996-09-01 00:00:00

  • Glycolipid patterns during Xenopus embryo development.

    abstract::Glycolipid patterns have been studied during the first six days of Xenopus embryo development. Glycolipid contents showed a sharp increase more evident after the third day of development. Glucosylceramide and sulphatide are not only the most represented species, but also those which exhibit a statistically significant...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1006/cbir.1995.1061

    authors: Gornati R,Rizzo AM,Tong XW,Berra B,Bernardini G

    更新日期:1995-03-01 00:00:00

  • YY1-induced upregulation of FOXP4-AS1 and FOXP4 promote the proliferation of esophageal squamous cell carcinoma cells.

    abstract::Esophageal squamous cell carcinoma (ESCC) belongs to one of the most common malignant tumors worldwide and possesses high mortality. Long non-coding RNAs (lncRNAs) have been demonstrated to be essential biological participants in the progression of ESCC. On the basis of bio-informatics prediction, forkhead box P4 anti...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.11338

    authors: Li Y,Li T,Yang Y,Kang W,Dong S,Cheng S

    更新日期:2020-07-01 00:00:00

  • Automated detection of morphological alterations during apoptosis.

    abstract::A convenient means of measuring apoptosis is described using an automated analyzer (MF-1; Sysmex), which normally provides rapid measurement of malarial parasites. By means of this MF-1 procedure, apoptotic cells exhibited characteristic changes of light scatter (size) and fluorescence (DNA content) relating to cell s...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1006/cbir.2000.0560

    authors: Lertworasirikul T,Bunyaratvej A,Kubota F

    更新日期:2000-01-01 00:00:00

  • Decreased intracellular proteolysis correlates with the maintenance of a specific isoenzyme of cytochrome P-450.

    abstract::The rates of intracellular protein degradation, of identically labelled populations of proteins, were compared in hepatocytes cultured at 37 degrees (on an adsorbed collagen layer) and in cells preserved on gelatin gels at 10 degrees C. The half-lives of the long-lived proteins were 35.4+/-8.6 h (N=4) and 692.9+/-216....

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1006/cbir.1998.0333

    authors: Evans PJ

    更新日期:1999-01-01 00:00:00

  • The CLIC5 (chloride intracellular channel 5) involved in C2C12 myoblasts proliferation and differentiation.

    abstract::CLIC5 (chloride intracellular channel 5) is a CLIC (chloride intracellular channel) with various functions. Its high expression in skeletal muscle and association with actin-based cytoskeleton suggests that it may play an important role in muscle tissue. This study was conducted to examine whether CLIC5 regulates the ...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1042/CBI20090334

    authors: Li F,Yin J,Yue T,Liu L,Zhang H

    更新日期:2010-03-08 00:00:00

  • Murine osteoclastogenesis suppression using conditioned media produced by melanoma or activated and non-activated Jurkat-E6 cells.

    abstract::Conditioned medium (CM) (cell secretome) is a cocktail of growth factors, cytokines, and other soluble mediators secreted by cells into a culture medium. These growth factors are fundamental in many cellular processes such as cell growth, differentiation, and others and the composition of these factors is individual f...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.11317

    authors: Mambelli-Lisboa NC,Frare EO,da Costa-Neves A,Prieto da Silva ÁRB,Kerkis I

    更新日期:2020-05-01 00:00:00

  • Cholesterol esterification in human monocyte-derived macrophages is inhibited by protein kinase C with dual roles for mitogen activated protein kinases.

    abstract::The possible role of protein kinase C (PKC) and mitogen activated protein (MAP) kinases in the stimulation of cholesterol esterification by acetylated low density lipoprotein (acLDL) in human monocyte-derived macrophages (HMDM) was studied. Cholesterol esterification, as assessed by the rate of incorporation of [3H]-o...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1016/j.cellbi.2004.07.007

    authors: Napolitano M,Avella M,Goode NT,Botham KM,Bravo E

    更新日期:2004-01-01 00:00:00

  • Behaviour of dissociated hypoblast cells on the basal lamina and on extracellular fibrils in the gastrulating chicken embryo.

    abstract::The spreading behaviour of dissociated hypoblast cells on and besides a band of aligned fibrils associated with the basal lamina of the epiblast was investigated by the use of scanning electron microscopy. A horse-shaped band of aligned fibrils, first demonstrated by Wakely and England (1979), is present during the ga...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1006/cbir.1994.1102

    authors: Andries L,Harrisson F,Vakaet L

    更新日期:1994-07-01 00:00:00

  • CFTR inhibits the invasion and growth of esophageal cancer cells by inhibiting the expression of NF-κB.

    abstract::Our study aimed to explore the function of cystic fibrosis transmembrane conductance regulator (CFTR) in esophageal cancer. Twenty patients with esophageal squamous cell carcinoma (ESCC) and 20 patients with esophageal adenocarcinoma (EA) were enrolled in this study. The levels of CFTR and NF-κB in tumor tissues and a...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.11069

    authors: Li W,Wang C,Peng X,Zhang H,Huang H,Liu H

    更新日期:2018-12-01 00:00:00

  • Plant tubulin intronics.

    abstract::Introns of plant tubulin genes are useful molecular tools to study IME (Intron Mediated Enhancement of gene expression) and to define plant genetic and evolutionary relationships through ILP (Intron Length Polymorphism). Here we show that the intron present within the 5'UTR sequence of some rice beta-tubulin genes can...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1016/j.cellbi.2007.11.013

    authors: Breviario D,Gianì S,Ponzoni E,Mastromauro F,Morello L

    更新日期:2008-05-01 00:00:00

  • Expression of osteoclastogenic factor transcripts in osteoblast-like UMR-106 cells after exposure to FGF-23 or FGF-23 combined with parathyroid hormone.

    abstract::As a bone-derived hormone, fibroblast growth factor-23 (FGF-23) negatively regulates phosphate and calcium metabolism, while retaining growth-promoting action for mesenchymal cell differentiation. Elevated FGF-23 levels, together with hyperparathyroidism, are often observed in chronic kidney disease, which is associat...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.10573

    authors: Teerapornpuntakit J,Wongdee K,Krishnamra N,Charoenphandhu N

    更新日期:2016-03-01 00:00:00

  • Ricin-binding proteins along the endocytic pathway: the major endosomal ricin-binding protein is endosome-specific.

    abstract::Ricin is internalized after binding at the cell surface via lectin activity of the B-chain recognizing terminal galactose residues. Ricin-A chain is then translocated to the cytosol from various endocytic structures. Cell death is the result of catalytic inactivation of protein synthesis. Using (125)I-ricin overlays, ...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1006/cbir.1996.0120

    authors: Alami M,Taupiac MP,Beaumelle B

    更新日期:1997-03-01 00:00:00

  • MiR-21 inhibitor suppressed the progression of retinoblastoma via the modulation of PTEN/PI3K/AKT pathway.

    abstract::MicroRNA-21 (miR-21) was reported to act as an oncogene during the development of many human tumors. However, little was revealed about the function of miR-21 in retinoblastoma (RB). In this study, we examined the expression of miR-21 in RB tissues and explored the relationship between miR-21 and phosphatase and tensi...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.10678

    authors: Gui F,Hong Z,You Z,Wu H,Zhang Y

    更新日期:2016-12-01 00:00:00

  • Vertebrate primary cilia: a sensory part of centrosomal complex in tissue cells, but a "sleeping beauty" in cultured cells?

    abstract::Primary cilium development along with other components of the centrosome in mammalian cells was analysed ultrastructurally and by immunofluorescent staining with anti-acetylated tubulin antibodies. We categorized two types of primary cilia, nascent cilia that are about 1microm long located inside the cytoplasm, and tr...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1016/j.cellbi.2003.11.013

    authors: Alieva IB,Vorobjev IA

    更新日期:2004-01-01 00:00:00

  • Immunological identification of types I and III collagen in bovine lens epithelium and its anterior lens capsule.

    abstract::To define the molecular structure of bovine lens epithelium and its anterior lens capsule, we investigated the composition of lens capsule basement membrane proteins. Immunofluorescence and immunogold techniques were used to demonstrate the presence of type I and type III collagen in the lens capsule and in primary ex...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1016/j.cellbi.2004.09.012

    authors: Sawhney RS

    更新日期:2005-02-01 00:00:00

  • Attenuation of Smad2 activity shows resistance to TGF-β signalling in mammary adenocarcinoma (MCF-7) cells.

    abstract::Transforming growth factor-β (TGF-β) is a potent inhibitor of the growth of normal mammary epithelial cells, and has a pleiotropic, context-dependent, concentration-dependent action. We found attenuation of TGF-β signalling in mammary adenoma carcinoma cells. Phosphorylation at the linker site of Smad2 occurred in a c...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.10061

    authors: Sengupta S,Kundu S,Bhattacharyya A

    更新日期:2013-05-01 00:00:00

  • Electrically induced gel-to-gel phase-transition in neurons.

    abstract::At the end of transcardial perfusions with ice-cold physiological saline for 30 min or with isoosmotic potassium chloride for 5 min, but immediately before perfusion fixation, condenser-discharge electric shocks were administered to rats through surface electrodes pressed onto the temporal muscles of the scalped skull...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1016/j.cellbi.2005.11.002

    authors: Kellermayer R,Zsombok A,Auer T,Gallyas F

    更新日期:2006-02-01 00:00:00

  • Magnesium regulates neural stem cell proliferation in the mouse hippocampus by altering mitochondrial function.

    abstract::In the adult brain, neural stem cells from the subgranular zone (SGZ) of the hippocampus and the subventricular zone (SVZ) of the cortex progress through the following five developmental stages: radial glia-like cells, neural progenitor cells, neuroblasts, immature neurons, and mature neurons. These developmental stag...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1002/cbin.10569

    authors: Jia S,Mou C,Ma Y,Han R,Li X

    更新日期:2016-04-01 00:00:00

  • Smart mechanosensing machineries enable migration of vascular smooth muscle cells in atherosclerosis-relevant 3D matrices.

    abstract::At the early stage of atherosclerosis, neointima is formed due to the migration of vascular smooth muscle cells (VSMCs) from the media to the intima. VSMCs are surrounded by highly adhesive 3D matrices. They take specific strategies to cross various 3D matrices in the media, including heterogeneous collagen and mechan...

    journal_title:Cell biology international

    pub_type: 杂志文章,评审

    doi:10.1002/cbin.10764

    authors: Chi Q,Shan J,Ding X,Yin T,Wang Y,Jia D,Wang G

    更新日期:2017-06-01 00:00:00

  • Prevention of intracellular oxidation in yeast: the role of vitamin E analogue, Trolox (6-hydroxy-2,5,7,8-tetramethylkroman-2-carboxyl acid).

    abstract::Reactive oxygen species (ROS) are not only generated in conditions of cellular stress but are also constitutively produced in most cell types by specific metabolic processes. This research focused on a potential antioxidant Trolox (model compound for alpha-tocopherol), with the aim to establish exact mechanisms of Tro...

    journal_title:Cell biology international

    pub_type: 杂志文章

    doi:10.1016/j.cellbi.2004.11.010

    authors: Raspor P,Plesnicar S,Gazdag Z,Pesti M,Miklavcic M,Lah B,Logar-Marinsek R,Poljsak B

    更新日期:2005-01-01 00:00:00

  • The effect of inflammatory factors and their inhibitors on the hematopoietic stem cells fate.

    abstract::Inflammatory cytokines exert different effects on hematopoietic stem cells (HSCs), lead to the development of various cell lineages in bone marrow (BM) and are thus a differentiation axis for HSCs. The content used in this article has been obtained by searching PubMed database and Google Scholar search engine of Engli...

    journal_title:Cell biology international

    pub_type: 杂志文章,评审

    doi:10.1002/cbin.11545

    authors: Najafi S,Ghanavat M,Shahrabi S,Gatavizadeh Z,Saki N

    更新日期:2021-01-02 00:00:00