Abstract:
:At the end of transcardial perfusions with ice-cold physiological saline for 30 min or with isoosmotic potassium chloride for 5 min, but immediately before perfusion fixation, condenser-discharge electric shocks were administered to rats through surface electrodes pressed onto the temporal muscles of the scalped skull. As a result, striking ultrastructural compaction came about in numerous neurons thinly scattered in certain brain areas. Its features displayed a high degree of similarity to those previously observed following the in vivo administration of the same kind of electric shocks. This surprising independence from the actual state of metabolism questions whether the ultrastructural compaction, induced either in vivo or post mortem, is the result of any cascade of enzyme-mediated processes. On the other hand, a physical mechanism, phase transition propagated by non-covalent free energy stored in a cytoplasmic gel structure, which was proposed recently to explain a mechanically induced similar ultrastructural compaction, appears to apply also to the present case.
journal_name
Cell Biol Intjournal_title
Cell biology internationalauthors
Kellermayer R,Zsombok A,Auer T,Gallyas Fdoi
10.1016/j.cellbi.2005.11.002keywords:
subject
Has Abstractpub_date
2006-02-01 00:00:00pages
175-82issue
2eissn
1065-6995issn
1095-8355pii
S1065-6995(05)00275-1journal_volume
30pub_type
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