Hematologic toxicities associated with intravenous immunoglobulin therapy.

abstract：:Glabridin has multiple pharmacological activities including anti-microbial, anti-atherosclerotic, anti-nephritic, anti-inflammatory and cardiovascular protective activities. In this study, we investigated the effect of glabridin on dendritic cells, which play an essential role in innate and adaptive immune responses. ...

journal_title：International immunopharmacology

authors： Kim JY,Kang JS,Kim HM,Ryu HS,Kim HS,Lee HK,Kim YJ,Hong JT,Kim Y,Han SB

更新日期：2010-10-01 00:00:00

abstract：:Here, we report the immunomodulating potential of N-palmitoyl-amino-ethyl-rigin amide (PR) and N-cholestanyl-amino-ethyl-rigin amide (CR), the two new structural analogs of rigin (an IgG-derived tetrapeptide). Their activity profiles are compared with native tuftsin (NT) and/or N-palmitoyl-amino-ethyl-tuftsin amide (P...

journal_title：International immunopharmacology

authors： Dutta RC,Puri A,Anand N

更新日期：2001-05-01 00:00:00

abstract：:There is increasing evidence that macrophages play an important role in the development and pathogenesis of diabetic nephropathy (DN) by secreting inflammatory cytokines. Exosomes are a family of extracellular vesicles that are secreted from almost all types of cells and associated with cell-to-cell communications. In...

journal_title：International immunopharmacology

authors： Zhu M,Sun X,Qi X,Xia L,Wu Y

更新日期：2020-07-01 00:00:00

abstract：:The quaternary ammonium salt, sanguinarine (SG) was reported to possess widespread anti-microbial and anti-inflammatory effects in experimental animals and it has been used to treat many inflammatory diseases. The aim of this study was to evaluate the anti-inflammatory effect and the possible mechanisms underlying the...

journal_title：International immunopharmacology

authors： Li W,Li H,Mu Q,Zhang H,Yao H,Li J,Niu X

更新日期：2014-10-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) has emerged as a common public health problem that can progress to end-stage liver disease. Although the function of aquaglyceroporin-9 (AQP9) as a glycerol channel has been proven, the mechanism of AQP9 in the development of NAFLD is poorly understood. To investigate the effe...

journal_title：International immunopharmacology

authors： Cai C,Wang C,Ji W,Liu B,Kang Y,Hu Z,Jiang Z

更新日期：2013-03-01 00:00:00

abstract：:Senescence is an irreversible growth arrest which can be triggered by stresses such as oxidative reaction, telomere shortening, DNA damage, or oncogene signaling. Oxidative stress accelerates vascular endothelial cell senescence, and may promote atherosclerosis in humans. Interleukin-8 (IL-8) has been shown to play an...

journal_title：International immunopharmacology

authors： Shen XH,Xu SJ,Jin CY,Ding F,Zhou YC,Fu GS

更新日期：2013-06-01 00:00:00

abstract：:Acute lung injury (ALI) is an excessive and uncontrolled inflammatory response in lung, of which remains the leading cause of morbidity and mortality in worldwide. Chikusetsusaponin V (CsV), a bioactive compounds derived from Panacis Japonica, has been reported to have anti-inflammatory effects. However, it is still u...

journal_title：International immunopharmacology

authors： Su K,Zhang G,Zhang X,Jiang W

更新日期：2019-05-01 00:00:00

abstract：:Neuroinflammation, characterized by the activation of microglia and astrocytes, is important in the pathogenesis of many neurological disorders, such as Alzheimer's disease. Nonsteroidal anti-inflammatory drugs (NSAIDs), a group of chemically heterogenous medications, are used widely in the treatment of inflammation. ...

journal_title：International immunopharmacology

authors： You M,Miao Z,Sienkiewicz O,Jiang X,Zhao X,Hu F

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:The T-cell immunoglobulin and mucin domain-(Tim)-1 molecule and Tim-3 are mainly expressed on activated T helper (Th) 2 and Th1 cells, respectively, and have been implicated in the pathogenesis of some autoimmune diseases. Immune thrombocytopenia (ITP) is a common autoimmune disorder, and the complex dysregu...

journal_title：International immunopharmacology

authors： Zhang XM,Shan NN,Sun M,Wang X,Feng XM,Liu X,Li Y,Yuan D,Ding M

更新日期：2014-03-01 00:00:00

abstract：:Angiotensin II (Ang II) as an important pathogenic factor, has been implicated in the pathogenesis of hypertension and associated renal injury, and inhibition of Ang II can reduce renal inflammation and exert renal protective effects. In the present study, we determine the infiltration of Th22 cells in kidney and seru...

journal_title：International immunopharmacology

authors： Zhong Y,Tang R,Lu Y,Wang W,Xiao C,Meng T,Ao X,Li X,Peng L,Kwadwo Nuro-Gyina P,Zhou Q

更新日期：2020-10-01 00:00:00

abstract：:Severe acute pancreatitis (SAP) is a severe clinical condition with significant morbidity and mortality. Multiple organs dysfunction (MOD) is the leading cause of SAP-related death. The over-release of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α is the underlying mechanism of MOD; however, there is no ef...

journal_title：International immunopharmacology

authors： Cen Y,Liu C,Li X,Yan Z,Kuang M,Su Y,Pan X,Qin R,Liu X,Zheng J,Zhou H

更新日期：2016-09-01 00:00:00

abstract：:Recent experimental data suggest that immunity can be activated to prevent tumors. The rationale for prevention is strong because the setting is one endowed with an immune system that is neither impaired by tumor and treatment-induced suppression, nor tolerant to tumor-associated antigens. Oncogenic growth factor rece...

journal_title：International immunopharmacology

authors： Forni G,Curcio C,Spadaro M,Iliffe J,Quaglino E,Di Carlo E,Musiani P,Lollini PL

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Accumulating evidence has revealed the roles of microRNAs (miRs) in sepsis, hence, the aim of the present study was to investigate whether miR-208a-5p affects sepsis whilst attempting to elucidate the mechanisms by which the suppressors of cytokine signaling 2 (SOCS2)-mediated nuclear factor-kappaB/hypoxia-i...

journal_title：International immunopharmacology

authors： Ouyang H,Tan Y,Li Q,Xia F,Xiao X,Zheng S,Lu J,Zhong J,Hu Y

更新日期：2020-04-01 00:00:00

abstract：:3, 5,7-trihydroxy-4'-methoxy-8-(3-hydroxy-3-methylbutyl)-flavone (ICT) is a novel derivative of Icariin (ICA), the major active ingredient of Herba Epimedii, a herb used in traditional Chinese and alternative medicine. We previously demonstrated its anti-inflammatory effect in murine innate immune cells and activated ...

journal_title：International immunopharmacology

authors： Zhou J,Wu J,Chen X,Fortenbery N,Eksioglu E,Kodumudi KN,Pk EB,Dong J,Djeu JY,Wei S

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:This study investigated some T helper cytokines' association with different ANA positive sera. METHODS:Sera of 53 ANA-positive subjects (11 were stained of homogeneous pattern, 12 of speckled particle pattern, 9 of nucleolar pattern, 15 of centromere pattern, and 6 of the peripheral nuclear type) were collec...

journal_title：International immunopharmacology

authors： Hu J,Zhang Y,Liu X,Wei L,Zhang D

更新日期：2015-02-01 00:00:00

abstract：:Recent studies showed that Madecassoside (MAD), a pentacyclic triterpene isolated from Centella asitica (L.), was used as a therapeutic agent in wound healing and also as an anti-inflammatory, anti-oxidative activities and anti-aging agent. However, its role in cancer has not been elucidated. In our present study, hep...

journal_title：International immunopharmacology

authors： Li Z,You K,Li J,Wang Y,Xu H,Gao B,Wang J

更新日期：2016-04-01 00:00:00

abstract：:Antrodia camphorata (AC) is a commonly used fungus in folk medicine for the treatment of viral hepatitis and cancer. AC polysaccharides (AC-PS) are reported to possess anti-inflammatory, anti-hepatitis B virus, and anticancer activities. In this study, we tested the in vivo effect of AC-PS on immune function by evalua...

journal_title：International immunopharmacology

authors： Chen YJ,Cheng PC,Lin CN,Liao HF,Chen YY,Chen CC,Lee KM

更新日期：2008-03-01 00:00:00

abstract：:To study the intramolecular signal transduction, we performed single point and cassette mutations in transmembranal and intracellular regions of the bradykinin B2 receptor. We studied the influence of the two intramembranal Cys residues at positions 304 and 348, the role of Arg at position 177 in the highly conserved ...

journal_title：International immunopharmacology

authors： Mueller S,Liebmann C,Reissmann S

更新日期：2002-12-01 00:00:00

abstract：:There are few studies regarding the evaluation of the kinin system in patients with systemic lupus erythematosus (SLE). In this study, we evaluated the plasma levels of high-molecular weight kininogen (HKg), low-molecular weight kininogen (LKg) and plasma kallikrein; the plasma activity of tissue kallikrein and kinina...

journal_title：International immunopharmacology

authors： Dellalibera-Joviliano R,Reis ML,Donadi EA

更新日期：2001-09-01 00:00:00

abstract：:BAY 41-2272 increases guanosine 3', 5'-cyclic monophosphate (cGMP) levels by stimulating soluble guanylate cyclase (sGC). In this study, we evaluated the effect of BAY 41-2272 on human T lymphocyte functions. Pretreating T cells for 24 h with BAY 41-2272 at 3 μM and 30 μM, followed by activation with 90 nM phorbol myr...

journal_title：International immunopharmacology

authors： Carvalho MUWB,Vendramini P,Kubo CA,Soreiro-Pereira PV,de Albuquerque RS,Antunes E,Condino-Neto A

更新日期：2019-12-01 00:00:00

abstract：:Despite scopolin is a main coumarin constituent in the stems of Erycibe obtusifolia Benth, a herb drug that has long been utilized in traditional Chinese medicine for the treatment of rheumatoid arthritis, little information is available about the pharmacological activities of this compound. The present study was perf...

journal_title：International immunopharmacology

authors： Pan R,Dai Y,Gao X,Xia Y

更新日期：2009-07-01 00:00:00

abstract：:Melatonin has anti-oxidant, anti-inflammatory and anti-apoptotic properties. We aimed to investigate the effect of melatonin on the structure and function of mice ovaries following autograft transplantation. NMRI mice were divided into: control, autografted + saline, autografted + melatonin (20 mg/kg/day i.p. injectio...

journal_title：International immunopharmacology

authors： Noori Hassanvand M,Soleimani Mehranjani M,Shojafar E

更新日期：2019-09-01 00:00:00

abstract：:The key goal in clinical transplantation is the induction of donor-specific transplantation tolerance to minimise the morbidity and mortality associated with long-term immunosuppression. Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) expressing forkhead transcript factor FoxP3 play a crucial role in the ...

journal_title：International immunopharmacology

authors： Jiang S,Golshayan D,Tsang J,Lombardi G,Lechler RI

更新日期：2006-12-20 00:00:00

abstract：:Prostaglandin E2 (PGE2), a very potent lipid mediator produced from arachidonic acid (AA) through the action of cyclooxygenase (COX) enzymes, is implicated in the regulation of dendritic cell (DC) functions such as differentiation ability, cytokine-producing capacity, Th-cell polarizing ability, migration and maturati...

journal_title：International immunopharmacology

authors： Jia XY,Chang Y,Sun XJ,Dai X,Wei W

更新日期：2014-11-01 00:00:00

abstract：:Monocytes and macrophages of individuals with allergic diseases express increased levels of the low-affinity IgE receptors (FcepsilonRII or CD23) on their surfaces. The cross-linking of CD23-bound IgE antibody by allergen activates the cells to release inflammatory mediators. In mast cells, the binding of IgE to the h...

journal_title：International immunopharmacology

authors： Ezeamuzie CI,Al-Attiyah R,Shihab PK,Al-Radwan R

更新日期：2009-08-01 00:00:00

abstract：:The global panic of the novel coronavirus disease 2019 (COVID-19) triggered by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an urgent requirement for effective therapy. COVID-19 infection, especially in severely ill patients, is likely to be associated with immune dysregulation, promptin...

journal_title：International immunopharmacology

authors： Razmi M,Hashemi F,Gheytanchi E,Dehghan Manshadi M,Ghods R,Madjd Z

更新日期：2020-11-01 00:00:00

abstract：:Macrophages are myeloid immune cells which are strategically positioned throughout the body, where they engulf and degrade debris, dead cells, and foreign substances, and coordinating the inflammatory processes. Macrophages can be divided into two extreme subsets, classical activation (M1), and alternatively activatio...

journal_title：International immunopharmacology

authors： Wang Y,Han CC,Cui D,Li Y,Ma Y,Wei W

更新日期：2017-09-01 00:00:00

abstract：:The activities of dectin-1 and mannose receptors on phagocytosis of Candida albicans and the production of TNF-α by macrophages from mice pretreated for 3 days with extract of Artocarpus intergrifolia seeds (jack extract), Artin M or jacalin were studied. Macrophages from these mice were coincubated with C. albicans C...

journal_title：International immunopharmacology

authors： Loyola W,Custodio LA,Felipe I,Conchon-Costa I,Carvalho PG,Quirino GF,Silva LF,Gaziri LC

更新日期：2012-02-01 00:00:00

abstract：:The proteasome influences cellular homeostasis through the degradation of regulatory proteins, many of which are also involved in disease pathogenesis. In particular, numerous regulatory proteins associated with tumor growth, such as cyclins, cyclin-dependent kinase inhibitors, tumor suppressors, and NF-κB inhibitors ...

journal_title：International immunopharmacology

authors： Momose I,Kawada M

更新日期：2016-08-01 00:00:00

abstract：:Rheumatoid arthritis is a common autoimmune disease primarily characterized by chronic inflammation, the formation of an invasive pannus, and destruction of the joints. In the present study, we employed real-time PCR and western blot analysis to investigate the role of dulaglutide in human fibroblast-like synoviocytes...

journal_title：International immunopharmacology

authors： Zheng W,Pan H,Wei L,Gao F,Lin X

更新日期：2019-09-01 00:00:00