Abstract：
:The pleural surfaces of the chest wall and lung slide against each other, lubricated by pleural fluid. During sliding motion of soft tissues, shear induced hydrodynamic pressure deforms the surfaces, promoting uniformity of the fluid layer thickness, thereby reducing friction. To assess pleural deformability at length scales comparable to pleural fluid thickness, we measured the modulus of the parietal pleura of rat chest wall using atomic force microscopy (AFM) to indent the pleural surface with spheres (radius 2.5 and 5 μm). The pleura exhibited two distinct indentation responses depending on location, reflecting either homogeneous or significantly heterogeneous tissue properties. We found an elastic modulus of 0.38-0.95 kPa, lower than the values measured using flat-ended cylinders >100 μm radii (Gouldstone et al., 2003, Journal of Applied Physiology 95, 2345-2349). Interestingly, the pleura exhibited a three-fold higher modulus when probed using 2.5 vs. 5 μm spherical tips at the same normalized depth, confirming depth dependent inhomogeneous elastic properties. The observed softness of the pleura supports the hypothesis that unevenness of the pleural surface on this scale is smoothed by local hydrodynamic pressure.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Kim JH,Butler JP,Loring SHdoi
10.1016/j.jbiomech.2011.07.008subject
Has Abstractpub_date
2011-09-23 00:00:00pages
2558-64issue
14eissn
0021-9290issn
1873-2380pii
S0021-9290(11)00503-3journal_volume
44pub_type
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