Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy.

abstract：:In a microarray-based gene profiling analysis of Müller glia-derived retinal stem cells in light-damaged retinas from adult zebrafish, we found that 2 genes required for regeneration of fin and heart tissues in zebrafish, hspd1 (heat shock 60-kDa protein 1) and mps1 (monopolar spindle 1), were up-regulated. Expression...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qin Z,Barthel LK,Raymond PA

更新日期：2009-06-09 00:00:00

abstract：:Flowering time (FT) is the developmental transition coupling an internal genetic program with external local and seasonal climate cues. The genetic loci sensitive to predictable environmental signals underlie local adaptation. We dissected natural variation in FT across a new global diversity set of 473 unique accessi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Huang Y,Bergelson J,Nordborg M,Borevitz JO

更新日期：2010-12-07 00:00:00

abstract：:Glycoprotein E (gE) of HSV plays a key role in cell-to-cell spread and virus-induced cell fusion. Here, we report that this function of gE requires the cooperation of tegument proteins UL11, UL16, and UL21. We found that the four proteins come together with very high efficiency to form a complex in transfected cells a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han J,Chadha P,Starkey JL,Wills JW

更新日期：2012-11-27 00:00:00

abstract：:The four principal gut epithelial cell lineages undergo continuous and rapid renewal during a geographically well-organized migration along the crypt-to-villus axis. The molecules that regulate their proliferation and differentiation programs are largely unknown. The large tumor antigen (TAg) of wild-type (wt) simian ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim SH,Roth KA,Coopersmith CM,Pipas JM,Gordon JI

更新日期：1994-07-19 00:00:00

abstract：:KRAS mutant tumors are largely recalcitrant to targeted therapies. Genetically engineered mouse models (GEMMs) of Kras mutant cancer recapitulate critical aspects of this disease and are widely used for preclinical validation of targets and therapies. Through comprehensive profiling of exomes and matched transcriptome...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung WJ,Daemen A,Cheng JH,Long JE,Cooper JE,Wang BE,Tran C,Singh M,Gnad F,Modrusan Z,Foreman O,Junttila MR

更新日期：2017-12-19 00:00:00

abstract：:Hapten coupled to isologous gamma globulin can substitute for anti-idiotypic antibody in the induction of neonatal chronic idiotype suppression. The immunologically suppressed animals fail to express an idiotypically defined subset of anti-hapten antibodies in later life and harbor regulatory T cells that prevent the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tokuhisa T,Rajewsky K

更新日期：1985-06-01 00:00:00

abstract：:The transcription initiation site of the human ribosomal RNA gene (rDNA) was located by using the single-strand specific nuclease protection method and by determining the first nucleotide of the in vitro capped 45S preribosomal RNA. The sequence of 1,211 nucleotides surrounding the initiation site was determined. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Financsek I,Mizumoto K,Mishima Y,Muramatsu M

更新日期：1982-05-01 00:00:00

abstract：:Finding regions of the genome that are significantly recurrent in noisy data are a common but difficult problem in present day computational biology. Cores of recurrent events (CORE) is a computational approach to solving this problem that is based on a formalized notion by which "core" intervals explain the observed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krasnitz A,Sun G,Andrews P,Wigler M

更新日期：2013-06-18 00:00:00

abstract：:Understanding the genetics of susceptibility to infectious agents is of great importance to our ability to combat disease. Here, we show that voltage-gated calcium channels (VGCCs) are critical for cellular binding and entry of the New World arenaviruses Junín and Tacaribe virus, suggesting that zoonosis via these rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarute N,Ross SR

更新日期：2020-08-11 00:00:00

abstract：:An in vitro enzyme system for the conversion of amino acid to oxime in the biosynthesis of glucosinolates has been established by the combined use of an improved isolation medium and jasmonic acid-induced etiolated seedlings of Sinapis alba L. An 8-fold induction of de novo biosynthesis of the L-tyrosine-derived p-hyd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Du L,Lykkesfeldt J,Olsen CE,Halkier BA

更新日期：1995-12-19 00:00:00

abstract：:Pleistocene residential sites with multiple contemporaneous human burials are extremely rare in the Americas. We report mitochondrial genomic variation in the first multiple mitochondrial genomes from a single prehistoric population: two infant burials (USR1 and USR2) from a common interment at the Upward Sun River Si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tackney JC,Potter BA,Raff J,Powers M,Watkins WS,Warner D,Reuther JD,Irish JD,O'Rourke DH

更新日期：2015-11-10 00:00:00

abstract：:Although Africa is the origin of modern humans, the pattern and distribution of genetic variation and correlations with cultural and linguistic diversity in Africa have been understudied. Recent advances in genomic technology, however, have led to genomewide studies of African samples. In this article, we discuss gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scheinfeldt LB,Soi S,Tishkoff SA

更新日期：2010-05-11 00:00:00

abstract：:Plant cell wall pectic polysaccharides are arguably the most complex carbohydrates in nature. Progress in understanding pectin synthesis has been slow due to its complex structure and difficulties in purifying and expressing the low-abundance, Golgi membrane-bound pectin biosynthetic enzymes. Arabidopsis galacturonosy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Atmodjo MA,Sakuragi Y,Zhu X,Burrell AJ,Mohanty SS,Atwood JA 3rd,Orlando R,Scheller HV,Mohnen D

更新日期：2011-12-13 00:00:00

abstract：:The gluconate (gnt) operon of Bacillus subtilis consists of four gnt genes; the second and third genes code for gluconate kinase (gluconokinase, EC 2.7.1.12) and gluconate permease, respectively. A fragment carrying the promoter of this operon (gnt promoter) and the first gene (gntR) was subcloned into a promoter prob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fujita Y,Fujita T

更新日期：1987-07-01 00:00:00

abstract：:We have previously linked aging, carcinogenesis, and de novo methylation within the promoter of the estrogen receptor (ER) gene in human colon. We now examine the dynamics of this process for the imprinted gene for insulin-like growth factor II (IGF2). In young individuals, the P2-4 promoters of IGF2 are methylated ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Issa JP,Vertino PM,Boehm CD,Newsham IF,Baylin SB

更新日期：1996-10-15 00:00:00

abstract：:The severity of Helicobacter pylori-related disease is correlated with a pathogenicity island (the Cag region of about 26 genes) whose presence is associated with the up-regulation of an IL-8 cytokine inflammatory response in gastric epithelial cells. Statistical analysis of the Cag gene sequences calculated from the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu G,McDaniel TK,Falkow S,Karlin S

更新日期：1999-06-08 00:00:00

abstract：:Six Rhesus monkeys between 24 and 29 years of age received unilateral transections of the fornix. Three monkeys then received intraventricular transplants of polymer-encapsulated baby hamster kidney (BHK) fibroblasts that had been genetically modified to secrete human nerve growth factor (hNGF). The remaining three mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kordower JH,Winn SR,Liu YT,Mufson EJ,Sladek JR Jr,Hammang JP,Baetge EE,Emerich DF

更新日期：1994-11-08 00:00:00

abstract：:Ocular dominance (OD) plasticity in mouse primary visual cortex (V1) declines during postnatal development and is absent beyond postnatal day 110 if mice are raised in standard cages (SCs). An enriched environment (EE) promotes OD plasticity in adult rats. Here, we explored cellular mechanisms of EE in mouse V1 and th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greifzu F,Pielecka-Fortuna J,Kalogeraki E,Krempler K,Favaro PD,Schlüter OM,Löwel S

更新日期：2014-01-21 00:00:00

abstract：:Resonance Raman and optical absorption spectra of ligand-free (deoxy) myoglobin and CO-bound myoglobin (MbCO) at pH 2.6 have been measured by using continuous-flow/rapid-mixing techniques. The spectra of deoxy myoglobin at low pH within 6 ms of the pH drop demonstrate that the iron-histidine bond has been ruptured but...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han S,Rousseau DL,Giacometti G,Brunori M

更新日期：1990-01-01 00:00:00

abstract：:Despite advances in resolution accompanying the development of high-field superconducting magnets, biomolecular applications of NMR require multiple dimensions in order to resolve individual resonances, and the achievable resolution is typically limited by practical constraints on measuring time. In addition to the ne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maciejewski MW,Fenwick M,Schuyler AD,Stern AS,Gorbatyuk V,Hoch JC

更新日期：2011-10-04 00:00:00

abstract：:Whereas the laws of thermodynamics prohibit extraction of useful work from the Brownian motion of particles in equilibrium, these motions can be "rectified" under nonequilibrium conditions, for example, in the presence of asymmetric geometrical obstacles. Here, we describe a class of systems in which aerobic bacteria ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sokolov A,Apodaca MM,Grzybowski BA,Aranson IS

更新日期：2010-01-19 00:00:00

abstract：:Pair-bond formation depends vitally on neuromodulatory signaling within the nucleus accumbens, but the neuronal dynamics underlying this behavior remain unclear. Using 1-photon in vivo Ca2+ imaging in monogamous prairie voles, we found that pair bonding does not elicit differences in overall nucleus accumbens Ca2+ act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scribner JL,Vance EA,Protter DSW,Sheeran WM,Saslow E,Cameron RT,Klein EM,Jimenez JC,Kheirbek MA,Donaldson ZR

更新日期：2020-05-19 00:00:00

abstract：:The expression of interleukin-4 (IL-4) is viewed as the hallmark of a Th2 lymphocyte, whereas the subsequent action of IL-4 and IL-13, mediated through the STAT6 signaling pathway, is seen as a prerequisite for the full development of Th2 immune responses to parasites and allergens. G4 mice, whose IL-4 gene locus cont...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Panhuys N,Tang SC,Prout M,Camberis M,Scarlett D,Roberts J,Hu-Li J,Paul WE,Le Gros G

更新日期：2008-08-26 00:00:00

abstract：:Vascular endothelial cells (ECs) sense and respond to hemodynamic shear stress, which is critical for circulatory homeostasis and the pathophysiology of vascular diseases. The mechanisms of shear stress mechanotransduction, however, remain elusive. We previously demonstrated a direct role of mitochondria in the purine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamamoto K,Nogimori Y,Imamura H,Ando J

更新日期：2020-12-29 00:00:00

abstract：:Transferrin, a nonheme iron-binding protein, is polymorphic in most vertebrate species that have been examined. In pigeons, it is controlled by an autosomal gene, with two known codominant alleles, Tf(A) and Tf(B). The two alleles are found in nearly equal frequencies and the three genotypes are at Hardy-Weinberg equi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frelinger JA

更新日期：1972-02-01 00:00:00

abstract：:We construct a C*-algebra that has only one irreducible representation up to unitary equivalence but is not isomorphic to the algebra of compact operators on any Hilbert space. This answers an old question of Naimark. Our construction uses a combinatorial statement called the diamond principle, which is known to be co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akemann C,Weaver N

更新日期：2004-05-18 00:00:00

abstract：:Small RNAs (sRNAs) are hypothesized to contribute to hybrid vigor because they maintain genome integrity, contribute to genetic diversity, and control gene expression. We used Illumina sequencing to assess how sRNA populations vary between two maize inbred lines (B73 and Mo17) and their hybrid. We sampled sRNAs from t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barber WT,Zhang W,Win H,Varala KK,Dorweiler JE,Hudson ME,Moose SP

更新日期：2012-06-26 00:00:00

abstract：:The exotoxins produced by certain strains of Staphylococcus aureus are able to stimulate powerful polyclonal proliferative responses and to induce nonresponsiveness by clonal deletion of T lymphocytes expressing the appropriate T-cell antigen receptor V beta gene products. This paper examines the ability of S. aureus ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Hehir RE,Lamb JR

更新日期：1990-11-01 00:00:00

abstract：:To identify mannosyl (Man)-containing intermediates of the human glycoinositol phospholipid (GPI) anchor pathway and examine their expression in paroxysmal nocturnal hemoglobinuria (PNH), mannolipid products deriving from in vitro guanosine diphosphate [3H]Man labeling of HeLa cell microsomes were characterized. The d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirose S,Ravi L,Prince GM,Rosenfeld MG,Silber R,Andresen SW,Hazra SV,Medof ME

更新日期：1992-07-01 00:00:00

abstract：:The turnover rates of junctional acetylcholine receptors were measured in innervated and denervated mouse sternomastoid neuromuscular junctions by 125I-labeled alpha-bungarotoxin binding. First, we determined that the density of labeled toxin initially bound to the neuromuscular junction was essentially unchanged up t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loring RH,Salpeter MM

更新日期：1980-04-01 00:00:00