Induction of specific clonal anergy in human T lymphocytes by Staphylococcus aureus enterotoxins.

abstract：:Behavioral sensitization of the gill-withdrawal reflex of Aplysia is caused by presynaptic facilitation at the synapses of the mechanoreceptor sensory neurons of the reflex onto the motor neurons and interneurons. The presynaptic facilitation has been shown to be simulated by serotonin (the putative presynaptic facili...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klein M,Kandel ER

更新日期：1980-11-01 00:00:00

abstract：:The absence of tools for mapping the forces that drive morphogenetic movements in embryos has impeded our understanding of animal development. Here we describe a unique approach, video force microscopy (VFM), that allows detailed, dynamic force maps to be produced from time-lapse images. The forces at work in an embry...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brodland GW,Conte V,Cranston PG,Veldhuis J,Narasimhan S,Hutson MS,Jacinto A,Ulrich F,Baum B,Miodownik M

更新日期：2010-12-21 00:00:00

abstract：:We studied the organization of the kappa light chain genes in germ-line (sperm) and somatic (embryo) tissues. We constructed a plasmid containing a DNA insert coding for the kappa chain MOPC 167 and used the Southern blotting technique to determine the organization of kappa variable and constant region genes. In the h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joho R,Weissman IL,Early P,Cole J,Hood L

更新日期：1980-02-01 00:00:00

abstract：:The DNA binding activity of p53 is crucial for its tumor suppressor function and is subject to tight regulation. Previous studies revealed that the inhibitory function of the p53 C terminus is implicated in the latent, low affinity sequence-specific DNA binding activity of p53 in the uninduced state. Sequence-specific...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müller-Tiemann BF,Halazonetis TD,Elting JJ

更新日期：1998-05-26 00:00:00

abstract：:Let X(0) be an unknown M by N matrix. In matrix recovery, one takes n < MN linear measurements y(1),…,y(n) of X(0), where y(i) = Tr(A(T)iX(0)) and each A(i) is an M by N matrix. A popular approach for matrix recovery is nuclear norm minimization (NNM): solving the convex optimization problem min ||X||*subject to y(i) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donoho DL,Gavish M,Montanari A

更新日期：2013-05-21 00:00:00

abstract：:P201 is a short (eight-residue) nonacidic peptide that comprises a strong transcriptional activating region when tethered to DNA in yeast. Here we identify the mediator protein Gal11 as an essential target of P201. Deletion of Gal11, which modestly decreases activation elicited by the typical acidic yeast activator, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Z,Ansari AZ,Lu X,Ogirala A,Ptashne M

更新日期：2002-06-25 00:00:00

abstract：:The impact of rapid climate change on contemporary human populations is of global concern. To contextualize our understanding of human responses to rapid climate change it is necessary to examine the archeological record during past climate transitions. One episode of abrupt climate change has been correlated with soc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Armit I,Swindles GT,Becker K,Plunkett G,Blaauw M

更新日期：2014-12-02 00:00:00

abstract：:In the mouse, axons of olfactory sensory neurons (OSNs) that express the same odorant receptor (OR) gene coalesce into one or a few glomeruli in the olfactory bulb. The positions of OR-specific glomeruli are traditionally described as stereotyped. Here, we have assessed quantitatively the positions of OR-specific glom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zapiec B,Mombaerts P

更新日期：2015-10-27 00:00:00

abstract：:The tissue-specific, cell-aggregating component of embryonic neural retina cells was purified from the retina cell-aggregating factor and characterized as a glycoprotein. Its molecular weight in solution is in the range of 50,000, and it contains 10-15% carbohydrate. The amino-acid and carbohydrate compositions have b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hausman RE,Moscona AA

更新日期：1975-03-01 00:00:00

abstract：:p300 acetylates and activates the tumor suppressor p53 after DNA damage. Here, we show that MDM2, a negative-feedback regulator of p53, inhibited p300-mediated p53 acetylation by complexing with these two proteins. First, we purified a p300-MDM2-p53 protein complex from HeLa nuclear extracts, which was inactive in p53...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kobet E,Zeng X,Zhu Y,Keller D,Lu H

更新日期：2000-11-07 00:00:00

abstract：:Droplet manipulation is playing an important role in various fields, including scientific research, industrial production, and daily life. Here, inspired by the microstructures and functions of Namib desert beetles, Nepenthes pitcher plants, and emergent aquatic plants, we present a multibioinspired slippery surface f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang X,Sun L,Wang Y,Bian F,Wang Y,Zhao Y

更新日期：2019-10-15 00:00:00

abstract：:Alfalfa mosaic virus (AlMV) coat protein is involved in systemic infection of host plants, and a specific mutation in this gene prevents the virus from moving into the upper uninoculated leaves. The coat protein also is required for different viral functions during early and late infection. To study the role of the co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spitsin S,Steplewski K,Fleysh N,Belanger H,Mikheeva T,Shivprasad S,Dawson W,Koprowski H,Yusibov V

更新日期：1999-03-02 00:00:00

abstract：:Most human cancers are aneuploid and have chromosomal instability, which contrasts to the inability of human cells to normally tolerate aneuploidy. Noting that aneuploidy in human breast cancer correlates with increased expression levels of the Mps1 checkpoint gene, we investigated whether these high levels of Mps1 co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daniel J,Coulter J,Woo JH,Wilsbach K,Gabrielson E

更新日期：2011-03-29 00:00:00

abstract：:Bone morphogenetic protein 2 (BMP-2) is a potent inducer of differentiation of osteoblasts both in vivo and in vitro. We examined the action of BMP-2 on expression of a helix-loop-helix-type transcription factor, Id (inhibitor of differentiation), in osteoblast-like cells, as well as in osteoblast-enriched cells and p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogata T,Wozney JM,Benezra R,Noda M

更新日期：1993-10-01 00:00:00

abstract：:It has been proposed that horizontal cells of the vertebrate retina have a negative feedback synapse with cone photoreceptors. gamma-Aminobutyric acid (GABA) has been suggested to be a neurotransmitter of monophasic horizontal cells (a subtype of horizontal cells), which have direct connections with red-sensitive and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tachibana M,Kaneko A

更新日期：1984-12-01 00:00:00

abstract：:The development of protein subunit vaccines to combat some of the world's deadliest pathogens such as a malaria parasite, Plasmodium falciparum, is stalled, due in part to the inability to induce and sustain high-titer antibody responses. Here, we show the induction of persistent, high-titer antibody responses to reco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu Y,Przysiecki C,Flanagan E,Bello-Irizarry SN,Ionescu R,Muratova O,Dobrescu G,Lambert L,Keister D,Rippeon Y,Long CA,Shi L,Caulfield M,Shaw A,Saul A,Shiver J,Miller LH

更新日期：2006-11-28 00:00:00

abstract：:The ion transport properties of the rough endoplasmic reticulum (RER) from liver have been defined by using measurements of active and potential gradient-driven transport. The Ca2+ pump is shown to be electrogenic, and both ATP and potential difference is able to drive vanadate-inhibitable Ca2+ uptake into the RER. AT...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muallem S,Schoeffield M,Pandol S,Sachs G

更新日期：1985-07-01 00:00:00

abstract：:Cellular imbalance in the levels of antioxidants and reactive oxygen species resulting in apoptosis is directly associated with a number of parasitic infections, aging, and several genetic and multifactorial diseases. The baculovirus AcNPV-encoded antiapoptotic p35 gene prevents apoptosis induced by a variety of apopt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sah NK,Taneja TK,Pathak N,Begum R,Athar M,Hasnain SE

更新日期：1999-04-27 00:00:00

abstract：:In addition to guiding proteins to defined genomic loci, DNA can act as an allosteric ligand that influences protein structure and activity. Here we compared genome-wide binding, transcriptional regulation, and, using NMR, the conformation of two glucocorticoid receptor (GR) isoforms that differ by a single amino acid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas-Chollier M,Watson LC,Cooper SB,Pufall MA,Liu JS,Borzym K,Vingron M,Yamamoto KR,Meijsing SH

更新日期：2013-10-29 00:00:00

abstract：:Aggregation of p53 is initiated by first-order processes that generate an aggregation-prone state with parallel pathways of major or partial unfolding. Here, we elaborate the mechanism and explore its consequences, beginning with the core domain and extending to the full-length p53 mutant Y220C. Production of large li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang G,Fersht AR

更新日期：2012-08-21 00:00:00

abstract：:The corticotropin-releasing factor (CRF) ligand family has diverse effects on the CNS, including the modulation of the stress response. The ligands' effects are mediated by binding to CRF G protein-coupled receptors. We have determined the 3D NMR structure of the N-terminal extracellular domain (ECD1) of the mouse CRF...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grace CR,Perrin MH,DiGruccio MR,Miller CL,Rivier JE,Vale WW,Riek R

更新日期：2004-08-31 00:00:00

abstract：:Flowering plants often prevent selfing through mechanisms of self-incompatibility (S.I.). The loss of S.I. has occurred many times independently, because it provides short-term advantages in situations where pollinators or mates are rare. The genus Capsella, which is closely related to Arabidopsis, contains a pair of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo YL,Bechsgaard JS,Slotte T,Neuffer B,Lascoux M,Weigel D,Schierup MH

更新日期：2009-03-31 00:00:00

abstract：:The 2.1-A resolution crystal structure of wild-type green fluorescent protein and comparison of it with the recently determined structure of the Ser-65 --> Thr (S65T) mutant explains the dual wavelength absorption and photoisomerization properties of the wild-type protein. The two absorption maxima are caused by a cha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brejc K,Sixma TK,Kitts PA,Kain SR,Tsien RY,Ormö M,Remington SJ

更新日期：1997-03-18 00:00:00

abstract：:Atrial natriuretic factor (ANF) is a group of peptides, originally isolated from the cardiac atria, that have a number of important effects on blood pressure, renal function, and salt balance. In the current study, expression of the ANF gene in certain extra-atrial tissues of the rat has been examined by radioimmunoas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gardner DG,Deschepper CF,Ganong WF,Hane S,Fiddes J,Baxter JD,Lewicki J

更新日期：1986-09-01 00:00:00

abstract：:Transgenic mice have provided invaluable information about gene function and regulation. However, because of marked differences between rodents and primates, some areas of human biology such as early embryonic development, aging, and maternal-fetal interactions would be best studied in a nonhuman primate model. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolfgang MJ,Eisele SG,Browne MA,Schotzko ML,Garthwaite MA,Durning M,Ramezani A,Hawley RG,Thomson JA,Golos TG

更新日期：2001-09-11 00:00:00

abstract：:Cancer stem-like cells (CSCs) are a highly tumorigenic cell type present as a minority population in developmentally diverse tumors and cell lines. Using a genetic screen in an inducible model of CSC formation in a breast cell line, we identify microRNAs (miRNAs) that inhibit CSC growth and are down-regulated in CSCs....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polytarchou C,Iliopoulos D,Struhl K

更新日期：2012-09-04 00:00:00

abstract：:Gliogenesis in animal development is spatiotemporally regulated so that correct numbers of glia are present to support various neuronal functions. During Drosophila embryonic development, the glial regulatory gene, glial cell missing/glial cell deficient (gcm/glide), promotes glial cell fate and differentiation. Here ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho MS,Chen H,Chen M,Jacques C,Giangrande A,Chien CT

更新日期：2009-04-21 00:00:00

abstract：:Obesity is a major public health problem and is often associated with type 2 diabetes mellitus, cardiovascular disease, and metabolic syndrome. Leptin is the crucial adipostatic hormone that controls food intake and body weight through the activation of specific leptin receptors (OB-R) in the hypothalamic arcuate nucl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Couturier C,Sarkis C,Séron K,Belouzard S,Chen P,Lenain A,Corset L,Dam J,Vauthier V,Dubart A,Mallet J,Froguel P,Rouillé Y,Jockers R

更新日期：2007-12-04 00:00:00

abstract：:We have identified, cultured, characterized, and propagated adult pluripotent stem cells (PSC) from a subset of human peripheral blood monocytes. These cells, which in appearance resemble fibroblasts, expand in the presence of macrophage colony-stimulating factor and display monocytic and hematopoietic stem cell marke...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao Y,Glesne D,Huberman E

更新日期：2003-03-04 00:00:00

abstract：:Insulin-like growth factors I and II (IGF-I and -II) are potent mitogens for various cancers, including carcinoma of the prostate. In several experimental cancers, treatment with antagonists of growth hormone-releasing hormone (GH-RH) produces a reduction in IGF-I and -II, concomitant to inhibition of tumor growth. To...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamharzi N,Schally AV,Koppán M,Groot K

更新日期：1998-07-21 00:00:00