当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Random phase detection in multidimensional NMR.

Random phase detection in multidimensional NMR.

Abstract：

:Despite advances in resolution accompanying the development of high-field superconducting magnets, biomolecular applications of NMR require multiple dimensions in order to resolve individual resonances, and the achievable resolution is typically limited by practical constraints on measuring time. In addition to the need for measuring long evolution times to obtain high resolution, the need to distinguish the sign of the frequency constrains the ability to shorten measuring times. Sign discrimination is typically accomplished by sampling the signal with two different receiver phases or by selecting a reference frequency outside the range of frequencies spanned by the signal and then sampling at a higher rate. In the parametrically sampled (indirect) time dimensions of multidimensional NMR experiments, either method imposes an additional factor of 2 sampling burden for each dimension. We demonstrate that by using a single detector phase at each time sample point, but randomly altering the phase for different points, the sign ambiguity that attends fixed single-phase detection is resolved. Random phase detection enables a reduction in experiment time by a factor of 2 for each indirect dimension, amounting to a factor of 8 for a four-dimensional experiment, albeit at the cost of introducing sampling artifacts. Alternatively, for fixed measuring time, random phase detection can be used to double resolution in each indirect dimension. Random phase detection is complementary to nonuniform sampling methods, and their combination offers the potential for additional benefits. In addition to applications in biomolecular NMR, random phase detection could be useful in magnetic resonance imaging and other signal processing contexts.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Maciejewski MW,Fenwick M,Schuyler AD,Stern AS,Gorbatyuk V,Hoch JC

doi

10.1073/pnas.1103723108

subject

Has Abstract

pub_date

2011-10-04 00:00:00

pages

16640-4

issue

40

eissn

0027-8424

issn

1091-6490

pii

1103723108

journal_volume

108

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Histidines, heart of the hydrogen ion channel from influenza A virus: toward an understanding of conductance and proton selectivity.

    abstract：:The heart of the H+ conductance mechanism in the homotetrameric M2 H+ channel from influenza A is a set of four histidine side chains. Here, we show that protonation of the third of these imidazoles coincides with acid activation of this transmembrane channel and that, at physiological pH, the channel is closed by two...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0601944103

    authors： Hu J,Fu R,Nishimura K,Zhang L,Zhou HX,Busath DD,Vijayvergiya V,Cross TA

    更新日期：2006-05-02 00:00:00

  • Exon/intron organization and complete nucleotide sequence of an HLA gene.

    abstract：:We have isolated and determined the sequence of a genomic clone containing the gene for a human class I transplantation antigen. The gene contains seven exons. The first five exons code respectively for a signal peptide, for the first, second, and third extracellular domains of the protein molecule, and for the transm...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.79.3.893

    authors： Malissen M,Malissen B,Jordan BR

    更新日期：1982-02-01 00:00:00

  • Composition-based prediction and rational manipulation of prion-like domain recruitment to stress granules.

    abstract：:Mutations in a number of stress granule-associated proteins have been linked to various neurodegenerative diseases. Several of these mutations are found in aggregation-prone prion-like domains (PrLDs) within these proteins. In this work, we examine the sequence features governing PrLD localization to stress granules u...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1912723117

    authors： Boncella AE,Shattuck JE,Cascarina SM,Paul KR,Baer MH,Fomicheva A,Lamb AK,Ross ED

    更新日期：2020-03-17 00:00:00

  • Regulation of Ich-1 pre-mRNA alternative splicing and apoptosis by mammalian splicing factors.

    abstract：:The importance of alternative splicing in regulating apoptosis has been suggested by findings of functionally antagonistic proteins generated by alternative splicing of several genes involved in apoptosis. Among these, Ich-1 (also named as caspase-2) encodes a member of the caspase family of proteases. Two forms of Ic...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.95.16.9155

    authors： Jiang ZH,Zhang WJ,Rao Y,Wu JY

    更新日期：1998-08-04 00:00:00

  • Observations of nucleation of new particles in a volcanic plume.

    abstract：:Volcanic eruptions caused major weather and climatic changes on timescales ranging from hours to centuries in the past. Volcanic particles are injected in the atmosphere both as primary particles rapidly deposited due to their large sizes on time scales of minutes to a few weeks in the troposphere, and secondary parti...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1104923108

    authors： Boulon J,Sellegri K,Hervo M,Laj P

    更新日期：2011-07-26 00:00:00

  • Pseudomonas cytochrome c551 at 2.0 A resolution: enlargement of the cytochrome c family.

    abstract：:The structure of respiratory cytochrome c551 of Pseudomonas aeruginosa, with 82 amino acids, has been solved by x-ray analysis and refined to a crystallographic R factor of 16.2%. It has the same basic folding pattern and hydrophobic heme environment as cytochromes c, c2, and c550, except for a large deletion at the b...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.75.6.2674

    authors： Almassy RJ,Dickerson RE

    更新日期：1978-06-01 00:00:00

  • A novel function for Myc: inhibition of C/EBP-dependent gene activation.

    abstract：:We have investigated the effect of the v-Myc oncoprotein on gene expression in myelomonocytic cells. We find that v-Myc dramatically down-regulates the expression of myelomonocytic-specific genes, such as the chicken mim-1 and lysozyme genes, both of which are known targets for C/EBP transcription factors. We present ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.93.13.6635

    authors： Mink S,Mutschler B,Weiskirchen R,Bister K,Klempnauer KH

    更新日期：1996-06-25 00:00:00

  • Comparative genomics of the restriction-modification systems in Helicobacter pylori.

    abstract：:Helicobacter pylori is a Gram-negative bacterial pathogen with a small genome of 1.64-1.67 Mb. More than 20 putative DNA restriction-modification (R-M) systems, comprising more than 4% of the total genome, have been identified in the two completely sequenced H. pylori strains, 26695 and J99, based on sequence similari...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.051612298

    authors： Lin LF,Posfai J,Roberts RJ,Kong H

    更新日期：2001-02-27 00:00:00

  • Monoclonal antibodies distinguish subtypes of retinal horizontal cells.

    abstract：:Sixteen hybridomas have been identified that secrete antibodies specific to horizontal cells in the carp retina. The hybridomas have been classified into three groups based on their antibody staining patterns: group I, staining associated with all horizontal cells; group II, staining associated with the most abundant ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.81.19.6255

    authors： Young LH,Dowling JE

    更新日期：1984-10-01 00:00:00

  • Thermodynamic origins of protein folding, allostery, and capsid formation in the human hepatitis B virus core protein.

    abstract：:HBc, the capsid-forming "core protein" of human hepatitis B virus (HBV), is a multidomain, α-helical homodimer that aggressively forms human HBV capsids. Structural plasticity has been proposed to be important to the myriad functions HBc mediates during viral replication. Here, we report detailed thermodynamic analyse...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1308846110

    authors： Alexander CG,Jürgens MC,Shepherd DA,Freund SM,Ashcroft AE,Ferguson N

    更新日期：2013-07-23 00:00:00

  • Bad-deficient mice develop diffuse large B cell lymphoma.

    abstract：:The proapoptotic activity of the "BH3-only" molecule BAD can be differentially regulated by survival factor signaling. Bad-deficient mice lacking both BAD long and BAD short proteins proved viable, and most cell types appeared to develop normally. BAD did not exclusively account for cell death after withdrawal of surv...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1533446100

    authors： Ranger AM,Zha J,Harada H,Datta SR,Danial NN,Gilmore AP,Kutok JL,Le Beau MM,Greenberg ME,Korsmeyer SJ

    更新日期：2003-08-05 00:00:00

  • Cross-polarization/magic-angle sample-spinning C NMR spectroscopic study of chlorophyll a in the solid state.

    abstract：:Solid-state cross-polarization/magic-angle sample-spinning (13)C NMR spectra have been recorded on chlorophyll a-water aggregates, methyl pyrochlorophyllide a, and methyl pyropheophorbide a (derivatives that lack a phytyl chain). Spectra have also been collected under a decoupling regime in which resonances of certain...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.81.2.641

    authors： Brown CE,Spencer RB,Burger VT,Katz JJ

    更新日期：1984-01-01 00:00:00

  • Site of anticonvulsant action on sodium channels: autoradiographic and electrophysiological studies in rat brain.

    abstract：:The anticonvulsants phenytoin and carbamazepine interact allosterically with the batrachotoxin binding site of sodium channels. In the present study, we demonstrate an autoradiographic technique to localize the batrachotoxin binding site on sodium channels in rat brain using [3H]batrachotoxinin-A 20-alpha-benzoate (BT...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.84.9.3051

    authors： Worley PF,Baraban JM

    更新日期：1987-05-01 00:00:00

  • Room-temperature single-electron junction.

    abstract：:The design, realization, and test performances of an electronic junction based on single-electron phenomena that works in the air at room temperature are hereby reported. The element consists of an electrochemically etched sharp tungsten stylus over whose tip a nanometer-size crystal was synthesized. Langmuir-Blodgett...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.93.20.10556

    authors： Facci P,Erokhin V,Carrara S,Nicolini C

    更新日期：1996-10-01 00:00:00

  • Body map proto-organization in newborn macaques.

    abstract：:Topographic sensory maps are a prominent feature of the adult primate brain. Here, we asked whether topographic representations of the body are present at birth. Using functional MRI (fMRI), we find that the newborn somatomotor system, spanning frontoparietal cortex and subcortex, comprises multiple topographic repres...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1912636116

    authors： Arcaro MJ,Schade PF,Livingstone MS

    更新日期：2019-12-03 00:00:00

  • Autogenous control of the S10 ribosomal protein operon of Escherichia coli: genetic dissection of transcriptional and posttranscriptional regulation.

    abstract：:The S10 ribosomal protein operon is regulated autogenously by the product of one of the genes of the operon, the gene encoding ribosomal protein L4. We have used site-directed mutagenesis to isolate leader mutations affecting L4 control. The phenotypes of these mutants demonstrate that L4 regulates both transcription ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.84.18.6516

    authors： Freedman LP,Zengel JM,Archer RH,Lindahl L

    更新日期：1987-09-01 00:00:00

  • Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains.

    abstract：:We used integrin alphaLbeta2 heterodimers containing I domains locked open (active) or closed (inactive) with disulfide bonds to investigate regulatory interactions among domains in integrins. mAbs to the alphaL I domain and beta2 I-like domain inhibit adhesion of wild-type alphaLbeta2 to intercellular adhesion molecu...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.041618598

    authors： Lu C,Shimaoka M,Zang Q,Takagi J,Springer TA

    更新日期：2001-02-27 00:00:00

  • Viscosity of α-pinene secondary organic material and implications for particle growth and reactivity.

    abstract：:Particles composed of secondary organic material (SOM) are abundant in the lower troposphere. The viscosity of these particles is a fundamental property that is presently poorly quantified yet required for accurate modeling of their formation, growth, evaporation, and environmental impacts. Using two unique techniques...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1219548110

    authors： Renbaum-Wolff L,Grayson JW,Bateman AP,Kuwata M,Sellier M,Murray BJ,Shilling JE,Martin ST,Bertram AK

    更新日期：2013-05-14 00:00:00

  • Hydrolysis of human platelet membrane glycoproteins with a Serratia marcescens metalloprotease: effect on response to thrombin and von Willebrand factor.

    abstract：:Metalloproteases from at least two Gram-negative organisms selectively hydrolyze the surface of human fixed washed platelets. The protease-treated platelets lose their ability to aggregate with bovine von Willebrand factor and human von Willebrand factor plus ristocetin. The present study reports the membrane glycopro...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.79.5.1433

    authors： Cooper HA,Bennett WP,White GC 2nd,Wagner RH

    更新日期：1982-03-01 00:00:00

  • Inhibition of human immunodeficiency virus type 1 expression by a hairpin ribozyme.

    abstract：:Ribozymes are RNAs that possess the dual properties of RNA sequence-specific recognition, analogous to conventional antisense molecules, and RNA substrate destruction via site-specific cleavage. The cleavage reaction is catalytic in that more than one substrate molecule is processed per ribozyme molecule. We have desi...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.89.22.10802

    authors： Ojwang JO,Hampel A,Looney DJ,Wong-Staal F,Rappaport J

    更新日期：1992-11-15 00:00:00

  • Conformational changes of calmodulin upon Ca2+ binding studied with a microfluidic mixer.

    abstract：:A microfluidic mixer is applied to study the kinetics of calmodulin conformational changes upon Ca2+ binding. The device facilitates rapid, uniform mixing by decoupling hydrodynamic focusing from diffusive mixing and accesses time scales of tens of microseconds. The mixer is used in conjunction with multiphoton micros...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0710810105

    authors： Park HY,Kim SA,Korlach J,Rhoades E,Kwok LW,Zipfel WR,Waxham MN,Webb WW,Pollack L

    更新日期：2008-01-15 00:00:00

  • Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism.

    abstract：:Gram-negative bacteria possess a characteristic outer membrane, of which the lipid A constituent elicits a strong host immune response through the Toll-like receptor 4 complex, and acts as a component of the permeability barrier to prevent uptake of bactericidal compounds. Lipid A species comprise the bulk of the oute...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1610746113

    authors： Dovala D,Rath CM,Hu Q,Sawyer WS,Shia S,Elling RA,Knapp MS,Metzger LE 4th

    更新日期：2016-10-11 00:00:00

  • Discrete fracture patterns of virus shells reveal mechanical building blocks.

    abstract：:Viral shells are self-assembled protein nanocontainers with remarkable material properties. They combine simplicity of construction with toughness and complex functionality. These properties make them interesting for bionanotechnology. To date we know little about how virus structure determines assembly pathways and s...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1105586108

    authors： Ivanovska IL,Miranda R,Carrascosa JL,Wuite GJ,Schmidt CF

    更新日期：2011-08-02 00:00:00

  • Experimental measurement of an effective temperature for jammed granular materials.

    abstract：:A densely packed granular system is an example of an out-of-equilibrium system in the jammed state. It has been a longstanding problem to determine whether this class of systems can be described by concepts arising from equilibrium statistical mechanics, such as an effective temperature and compactivity. The measureme...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0409911102

    authors： Song C,Wang P,Makse HA

    更新日期：2005-02-15 00:00:00

  • The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface.

    abstract：:Neuromelanin (NM) isolated from the substantia nigra region of the human brain was studied by scanning probe and photoelectron emission microscopies. Atomic force microscopy reveals that NM granules are comprised of spherical structures with a diameter of approximately 30 nm, similar to that observed for Sepia cuttlef...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0604010103

    authors： Bush WD,Garguilo J,Zucca FA,Albertini A,Zecca L,Edwards GS,Nemanich RJ,Simon JD

    更新日期：2006-10-03 00:00:00

  • An action spectrum (290-320 nm) for TNFalpha protein in human skin in vivo suggests that basal-layer epidermal DNA is the chromophore.

    abstract：:Terrestrial solar UVB radiation ( approximately 295-320 nm) readily induces cyclobutane pyrimidine dimers (CPDs) in human skin DNA that result in characteristic mutations associated with nonmelanoma skin cancer. The proinflammatory cytokine TNFalpha is important in mouse skin chemical carcinogenesis and is thought to ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0703385104

    authors： Walker SL,Young AR

    更新日期：2007-11-27 00:00:00

  • Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor.

    abstract：:Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least eight differently regulated mRNAs whose protein products function as the principal means to eliminate a vast array of steroids, heme metabolites, environmental toxins, and drugs. The orphan nuclear re...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0438010100

    authors： Xie W,Yeuh MF,Radominska-Pandya A,Saini SP,Negishi Y,Bottroff BS,Cabrera GY,Tukey RH,Evans RM

    更新日期：2003-04-01 00:00:00

  • Inverted-region electron transfer as a mechanism for enhancing photosynthetic solar energy conversion efficiency.

    abstract：:In all photosynthetic organisms, light energy is used to drive electrons from a donor chlorophyll species via a series of acceptors across a biological membrane. These light-induced electron-transfer processes display a remarkably high quantum efficiency, indicating a near-complete inhibition of unproductive charge re...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1704855114

    authors： Makita H,Hastings G

    更新日期：2017-08-29 00:00:00

  • The La antigen binds 5' noncoding region of the hepatitis C virus RNA in the context of the initiator AUG codon and stimulates internal ribosome entry site-mediated translation.

    abstract：:Translation initiation of the hepatitis C virus (HCV) RNA genome occurs through an internal ribosome entry site in a cap-independent manner. Here, we have examined the interaction between La antigen and the HCV 5' noncoding region (5'NCR). In this analysis, competitor RNAs derived from HCV 5'NCR carrying deletions and...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.94.6.2249

    authors： Ali N,Siddiqui A

    更新日期：1997-03-18 00:00:00

  • Thymic nurse cells provide microenvironment for secondary T cell receptor α rearrangement in cortical thymocytes.

    abstract：:Distinct subsets of thymic epithelial cells (TECs) support T-cell development and selection. Isolated TECs contain multicellular complexes that enclose many viable thymocytes. However, the functions of those TECs, termed thymic nurse cells (TNCs), are unclear and the idea that TNCs are present in vivo is questioned. H...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1213069109

    authors： Nakagawa Y,Ohigashi I,Nitta T,Sakata M,Tanaka K,Murata S,Kanagawa O,Takahama Y

    更新日期：2012-12-11 00:00:00