The metabolic syndrome and its individual components: its association with venous thromboembolism in a Mediterranean population.

Abstract:

INTRODUCTION:The association of metabolic syndrome with venous thromboembolism (VTE) remains uncertain. Moreover, the relevance of abdominal obesity as an independent or related risk factor for VTE in the metabolic syndrome cluster is controversial. We aimed to evaluate the impact of metabolic syndrome and its individual components on VTE risk. METHODS:We conducted a case-control study to investigate the presence of metaoblic syndrome in 150 healthy individuals (43 ± 13 years) and 146 patients with a first objectively confirmed episode of deep venous thrombosis or pulmonary embolism (44 ± 13 years) who underwent a thrombophilia work up. RESULTS:Metabolic syndrome was present in 19% of cases and 8% of controls (P = 0.008). In the unadjusted analysis, metabolic syndrome was statistically associated with higher VTE risk [odds ratio (OR) = 2.7, 95% confidence interval (CI) 1.3-5.6]. However, hypertriglyceridemia (OR = 2.0, 95% CI 1.1-3.5), high glucose levels (OR = 2.0, 95% CI 1.2-3.5), and abdominal obesity (OR = 5.7, 95% CI 3.4-9.6) were also significantly associated with higher VTE risk. Abdominal obesity was the factor that had the highest OR. Moreover, after multivariate analysis in which each independent factor was adjusted for the others, only abdominal obesity remained statistically associated with higher VTE risk, revealing its relevance. Further adjustment for the presence of thrombophilia did not change the estimation. CONCLUSION:We conclude that, in subjects with a mean age of 44 years, metabolic syndrome increases VTE risk, although abdominal obesity is the pivotal factor.

authors

Vayá A,Martínez-Triguero ML,España F,Todolí JA,Bonet E,Corella D

doi

10.1089/met.2010.0117

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

197-201

issue

3

eissn

1540-4196

issn

1557-8518

journal_volume

9

pub_type

杂志文章
  • Prevalence of metabolic syndrome in Pakistan.

    abstract::Over the past two decades, there has been a striking increase in the number of people with metabolic syndrome. The prevalence of metabolic syndrome varies due to lack of an internationally agreed upon definition. Considering the increased cardiovascular risk among Asian people, a lower cutoff for waist circumference i...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章,评审

    doi:10.1089/met.2008.0005

    authors: Basit A,Shera AS

    更新日期:2008-09-01 00:00:00

  • Postprandial adiponectin levels are associated with improvements in postprandial triglycerides after Roux-en-Y gastric bypass in type 2 diabetic patients.

    abstract:BACKGROUND:Postprandial hypertrygliceridemia is a known factor for cardiovascular disease and is often observed in patients with type 2 diabetes mellitus (T2DM) and visceral adiposity. Adiponectin is a hormone with antiatherogenic and anti-inflammatory effects, which decreases in obesity and T2DM subjects. The weight l...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2012.0042

    authors: Umeda LM,Pereira AZ,Carneiro G,Arasaki CH,Zanella MT

    更新日期:2013-10-01 00:00:00

  • Relationship Between Metabolic Syndrome and Cognitive Abilities in U.S. Adolescents.

    abstract:BACKGROUND:Metabolic syndrome is increasingly common in U.S. adolescents and has been linked to cognitive dysfunction. Purpose of this study is to explore associations between metabolic syndrome and cognitive impairment in U.S. adolescents using population-based data. STUDY DESIGN:Participants included adolescents age...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2016.0015

    authors: Rubens M,Ramamoorthy V,Saxena A,George F,Shehadeh N,Attonito J,McCoy HV,Beck-Sagué CM

    更新日期:2016-10-01 00:00:00

  • Metabolic Syndrome and Physical Activity Levels in College Students.

    abstract:: Background: It is estimated that >30% of young adults attending college are overweight or obese and do not participate in enough physical activity (PA) to maintain a healthy body mass. Many of the known risk factors that are often associated with obesity also place an indi...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2019.0007

    authors: Miller JM,Street BD

    更新日期:2019-11-01 00:00:00

  • Prevention of cardiovascular complications of the metabolic syndrome: focus on pharmacotherapy.

    abstract::The metabolic syndrome increases the risk of atherothrombotic cardiovascular disease (CVD) and diabetes. In turn, diabetes promotes the development of atheroma and is regarded as a coronary heart disease risk equivalent. A multifactorial therapeutic strategy is advocated for patients with the metabolic syndrome to imp...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2006.4.328

    authors: Krentz AJ

    更新日期:2006-01-01 00:00:00

  • Effects of coadministered ezetimibe plus fenofibrate in mixed dyslipidemic patients with metabolic syndrome.

    abstract:OBJECTIVE:Patients with metabolic syndrome are at increased risk of atherosclerotic coronary heart disease, often have mixed dyslipidemia, and may thus require more aggressive treatment of multiple lipid parameters. The objective of this investigation was to compare the treatment response of ezetimibe co-administered w...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/met.2010.0068

    authors: Bays HE,Shah A,Macdonell G,Taggart WV,Gumbiner B

    更新日期:2011-04-01 00:00:00

  • Relationship between the preoperative body mass index and the resolution of metabolic syndrome following Roux-en-Y gastric bypass.

    abstract:BACKGROUND:The increased prevalence of overweight and obesity has reached alarming proportions worldwide and has serious health implications, including an association with an increase in metabolic syndrome. Among the methods to control metabolic syndrome, bariatric surgery plays an important role and can provide a sign...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2012.0014

    authors: Saboya C,Arasaki CH,Matos D,Lopes-Filho GJ

    更新日期:2012-08-01 00:00:00

  • Influence of exercise intensity on abdominal fat and adiponectin in elderly adults.

    abstract::To examine the influence of moderate-intensity (50% of VO(2peak)) exercise training (MI) versus high-intensity (75% of VO(2peak)) exercise training (HI) on regional fat distribution and plasma adiponectin, we randomized 18 overweight (body mass index [BMI] = 30 +/- 1 kg/m(2)) elderly (71 +/- 1 years) to HI, MI, or a c...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/met.2008.0060

    authors: Coker RH,Williams RH,Kortebein PM,Sullivan DH,Evans WJ

    更新日期:2009-08-01 00:00:00

  • Ethnic disparities in metabolic syndrome in malaysia: an analysis by risk factors.

    abstract:BACKGROUND:This study investigates ethnic disparities in metabolic syndrome in Malaysia. METHODS:Data were obtained from the Malaysia Non-Communicable Disease Surveillance-1 (2005/2006). Logistic regressions of metabolic syndrome health risks on sociodemographic and health-lifestyle factors were conducted using a mult...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2011.0031

    authors: Tan AK,Dunn RA,Yen ST

    更新日期:2011-12-01 00:00:00

  • The relation between carotid intima media thickness and serum osteoprotegerin levels in nonalcoholic fatty liver disease.

    abstract:AIM:This study was designed to evaluate carotid intima media thickness (CIMT) and serum osteoprotegerin (OPG) levels in nonalcoholic fatty liver disease (NAFLD) in comparison to healthy controls and to investigate factors predicting the CIMT increase. MATERIALS AND METHODS:A total of 60 outpatients [median (min-max) a...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2013.0151

    authors: Ayaz T,Kirbas A,Durakoglugil T,Durakoglugil ME,Sahin SB,Sahin OZ,Kirvar A,Tasci F

    更新日期:2014-06-01 00:00:00

  • Detection of Glycemia and Osmolarity Changes Using Eye Examinations.

    abstract:: Background: Glycated hemoglobin (HbA1c) is an index of the average blood glucose level over the preceding 2-3 months. In experimental studies, the lens responded to changes in osmolarity by forming vacuoles. By observing the vacuoles of the lens during eye examination, can...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2018.0076

    authors: Koç Ş,Baysal S,Koç Z,Yener AÜ

    更新日期:2018-12-01 00:00:00

  • Metabolic Syndrome in Patients with Coexistent Obstructive Sleep Apnea Syndrome and Chronic Obstructive Pulmonary Disease (Overlap Syndrome).

    abstract:: Background: Evidence suggests that metabolic syndrome (MetS) is highly prevalent in patients with obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD). However, data on the prevalence of MetS in patients having both OSAS and COPD, or ove...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2019.0126

    authors: Archontogeorgis K,Voulgaris A,Papanas N,Nena E,Xanthoudaki M,Pataka A,Schiza S,Rizzo M,Froudarakis ME,Steiropoulos P

    更新日期:2020-08-01 00:00:00

  • Diabetic Patients with Cardiovascular Disease Show More Metabolic Syndrome than Nondiabetic Patients: Multicentric Study in the Northeast of Brazil.

    abstract:: Background: Diabetes mellitus (DM) is associated with a higher prevalence of metabolic syndrome (MS) and cardiovascular mortality. However, few Brazilian studies evaluated MS in diabetic individuals with cardiovascular disease (CVD). Nevertheless, the objective of this stu...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2020.0064

    authors: de Brito Gonçalves Nascimento L,Sahade V,Weber B,Pinheiro JMF,Dias LPP,Figueiredo Neto JA,Carlos Sobral Sousa A,Pinho CPS,Luna AB,Vasconcelos SML,Dantas CF,Penafort AM,Carlos DMO,Daltro C

    更新日期:2021-02-01 00:00:00

  • Lipopolysaccharides-Induced Inflammatory Response in White Blood Cells Is Associated with Alterations in Senescence Mediators: Modulation by Metformin.

    abstract:BACKGROUND:Sirtuin (SirT), a family of conserved histone deacetylases and transferases, has been proposed to function in inflammatory, cancer, and metabolic diseases. However, it is unclear how SirT modulates these processes. In this study, the effect of metformin on senescence and antisenescence mediators (SirT1-7, p5...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2014.0168

    authors: Aljada A

    更新日期:2015-08-01 00:00:00

  • Variable contributions of fat content and distribution to metabolic syndrome risk factors.

    abstract:BACKGROUND:Previous reports indicate that both distribution and amount of body fat confers susceptibility to metabolic syndrome. However, the relative contributions of these two different parameters of body fat to the various components of the metabolic syndrome have not been well defined. METHODS:Dual-energy X-ray ab...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2008.0026

    authors: Grundy SM,Adams-Huet B,Vega GL

    更新日期:2008-12-01 00:00:00

  • Genetic variation in the patatin-like phospholipase domain-containing protein-3 (PNPLA-3) gene in Asian Indians with nonalcoholic fatty liver disease.

    abstract:BACKGROUND:The association of the rs738409 polymorphism of patatin-like phospholipase-3 (PNPLA3) with nonalcoholic fatty liver disease (NAFLD) has been suggested in other populations, but not in Asian Indians. We investigated the association of the rs738409 polymorphism of PNPLA3 with clinical, anthropometric, and bioc...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2012.0064

    authors: Bhatt SP,Nigam P,Misra A,Guleria R,Pandey RM,Pasha MA

    更新日期:2013-10-01 00:00:00

  • Human immunodeficiency virus and highly active antiretroviral therapy-associated metabolic disorders and risk factors for cardiovascular disease.

    abstract::The successful introduction of highly active antiretroviral therapy (HAART), a combination of potent antiretroviral agents, including protease inhibitors, nucleoside reverse transcriptase inhibitors, and nonnucleoside reverse transcriptase inhibitors, has impacted positively on morbidity and mortality among human immu...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章,评审

    doi:10.1089/met.2008.0096

    authors: Anuurad E,Semrad A,Berglund L

    更新日期:2009-10-01 00:00:00

  • Exercise Training Reverses Structural Microvascular Rarefaction and Improves Endothelium-Dependent Microvascular Reactivity in Rats with Diabetes.

    abstract:BACKGROUND:We evaluated structural microvascular alterations in the skeletal muscle and left ventricle, as well as endothelium-dependent microvascular reactivity in the skeletal muscle, of diabetic rats subjected to long-term aerobic exercise training. METHODS:Diabetes was experimentally induced by a combination of a ...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2015.0146

    authors: Machado MV,Martins RL,Borges J,Antunes BR,Estato V,Vieira AB,Tibiriçá E

    更新日期:2016-08-01 00:00:00

  • Extended-release niacin/laropiprant effects on lipoprotein subfractions in patients with type 2 diabetes mellitus.

    abstract:BACKGROUND:A potentially atherogenic lipid profile often found in patients with type 2 diabetes mellitus (T2DM) includes increased concentrations of small, low-density lipoprotein (LDL) and intermediate-density lipoprotein (IDL) and decreased concentration of medium/large high-density lipoprotein (HDL) particles. Exten...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1089/met.2012.0005

    authors: Bays H,Giezek H,McKenney JM,O'Neill EA,Tershakovec AM

    更新日期:2012-08-01 00:00:00

  • Characteristics of Metabolic Syndrome in Morbidly Obese Subjects.

    abstract:BACKGROUND:Metabolic syndrome (MetSyn) magnifies risks of cardiovascular disease (CVD) and type 2 diabetes, but its expression varies within the obese population. We examined body mass index (BMI), metabolic traits, and fat distribution in morbidly obese individuals. METHODS:Lipids and inflammatory, oxidative stress a...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2016.0062

    authors: Dusanov S,Heggen E,Tonstad S

    更新日期:2016-12-01 00:00:00

  • Chromium picolinate does not improve key features of metabolic syndrome in obese nondiabetic adults.

    abstract:BACKGROUND:The use of chromium-containing dietary supplements is widespread among patients with type 2 diabetes. Chromium's effects in patients at high risk for developing diabetes, especially those with metabolic syndrome, is unknown. The objective of this study was to determine the effects of chromium picolinate (CrP...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/met.2008.0048

    authors: Iqbal N,Cardillo S,Volger S,Bloedon LT,Anderson RA,Boston R,Szapary PO

    更新日期:2009-04-01 00:00:00

  • β-Cell dysfunction is associated with metabolic syndrome severity in adults.

    abstract:BACKGROUND:Metabolic syndrome is prevalent in adults characterized by increased visceral adiposity and insulin resistance (IR). However, the link between pancreatic β-cell function and metabolic syndrome severity in adults across the glucose spectrum is unknown. We hypothesized that poor β-cell function would independe...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2013.0083

    authors: Malin SK,Finnegan S,Fealy CE,Filion J,Rocco MB,Kirwan JP

    更新日期:2014-03-01 00:00:00

  • Blood pressure levels constitute the most important determinant of the metabolic syndrome in a Mediterranean population: a discrimination analysis.

    abstract:BACKGROUND:The aim of the study was to evaluate the relative importance of the determinants of the metabolic syndrome in a sample with metabolic syndrome from the Greek population. METHODS:A random sample of 824 male (56 ± 11 years) and 1,199 female (58 ± 10 years) subjects with metabolic syndrome [National Cholestero...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2010.0023

    authors: Chimonas T,Karagiannis A,Athyros VG,Achimastos A,Elisaf M,Panagiotakos DB,Assessing The Treatment Effect in Metabolic Syndrome Without Perceptible diabeTes (ATTEMPT) Collaborative Group.

    更新日期:2010-12-01 00:00:00

  • Diabetes Management and Cardiovascular Risk: Are SGLT-2 Inhibitors the Safest?

    abstract::For five millennia, diabetes management has focused on controlling blood sugar and efforts to minimize the complications of this disease have depended on normalizing glucose. Since the 1970's, however, a growing awareness of the adverse effect of hypoglycemic agents on cardiac health has led to an increasing focus on ...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章,评审

    doi:10.1089/met.2015.29003.swi

    authors: Swislocki AL,Jialal I

    更新日期:2016-02-01 00:00:00

  • Prevalence of diabetes mellitus among the adult population in rural blocks of Haryana, India: a community-based study.

    abstract:OBJECTIVE:The aim of this was to study the prevalence of diabetes in the rural adult population of Haryana, India. RESEARCH DESIGN AND METHODS:A total of 2606 adults aged ≥ 18 years were randomly selected from two rural blocks of Haryana State. Those without diabetes were subjected to a 75-gram oral glucose tolerance ...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2012.0067

    authors: Rajput R,Rajput M,Singh J,Bairwa M

    更新日期:2012-12-01 00:00:00

  • Omega-3 Fatty acids: structure, function, and relation to the metabolic syndrome, infertility, and pregnancy.

    abstract::Omega-3s are found in oily fish. We have drastically reduced our intake of fish during the last century. Many of us therefore suffer from a deficiency of omega-3s, which has consequences for health. In this review, we focus on structure-functional relationships and the relation of omega-3s to the metabolic syndrome, i...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2006.4.138

    authors: Saldeen P,Saldeen T

    更新日期:2006-07-01 00:00:00

  • Treatment of Nonalcoholic Fatty Liver Disease with Long-Chain n-3 Polyunsaturated Fatty Acids in Humans.

    abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is a major risk factor for type 2 diabetes, cardiovascular disease, and liver failure. Treatment with n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) produced variable success in improving NAFLD. The purpose of this review is to determine if n-3 LCPUFA will d...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章,评审

    doi:10.1089/met.2016.0051

    authors: Kelley NS

    更新日期:2016-11-01 00:00:00

  • The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle.

    abstract:BACKGROUND:Concomitant supplementation of 1.5% docosahexaenoic acid (22:6 n-3; DHA) with 0.5% t10, c12-conjugated linoleic acid (18:2 n-6; CLA) prevented the CLA-induced increase in expression of hepatic genes involved in fatty acid synthesis and the decrease in expression of genes involved in fatty acid oxidation. The...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2012.0116

    authors: Fedor DM,Adkins Y,Newman JW,Mackey BE,Kelley DS

    更新日期:2013-02-01 00:00:00

  • Even Short-Term Telmisartan Treatment Ameliorated Insulin Resistance But Had No Influence on Serum Adiponectin and Tumor Necrosis Factor-Alpha Levels in Hypertensive Patients with Metabolic Syndrome.

    abstract:BACKGROUND:We investigated the effect of short-term telmisartan usage in addition to lifestyle changes such as diet and exercise on insulin resistance, lipid metabolism, and serum adiponectin and tumor necrosis factor-alpha (TNF-α) levels in hypertensive patients with metabolic syndrome (MetS). METHODS:A total of 36 h...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/met.2018.0129

    authors: Kiyici S,Guclu M,Budak F,Sigirli D,Tuncel E

    更新日期:2019-04-01 00:00:00

  • Adipokines and lipoproteins: modulation by antihyperglycemic and hypolipidemic agents.

    abstract::Adipose tissue is an endocrine organ that secretes a number of hormones and metabolically active substances that impact energy metabolism and insulin sensitivity. These inflammatory markers are collectively referred to as adipocytokines, or adipokines. Adipose tissue's functional capacity and metabolic activity vary a...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章,评审

    doi:10.1089/met.2013.0090

    authors: Rizvi AA,Nikolic D,Sallam HS,Montalto G,Rizzo M,Abate N

    更新日期:2014-02-01 00:00:00