Abstract:
BACKGROUND:Metabolic syndrome is increasingly common in U.S. adolescents and has been linked to cognitive dysfunction. Purpose of this study is to explore associations between metabolic syndrome and cognitive impairment in U.S. adolescents using population-based data. STUDY DESIGN:Participants included adolescents aged 12-16 years who participated in the National Health and Nutrition Examination Survey (NHANES) III. The main outcome measures included assessments of cognitive function using Wide Range Achievement Test-Revised (WRAT-R) and Wechsler Intelligence Scale for Children-Revised (WISC-R) tools. The WRAT-R consisted of mathematics and reading tests. The WISC-R consisted of block design test, which measures spatial visualization and motor skills, and digit span test, which measures working memory and attention. Linear regression models were used to examine associations between metabolic syndrome and cognitive function. We used education levels of the family reference person, while controlling for education levels because of missing data. RESULTS:Presence or absence of metabolic syndrome was tested in 1170 of 2216 NHANES III participants aged 12-16 years. Regression models showed that participants with metabolic syndrome scored an average 1.25 [95% confidence interval (CI) = -2.14 to -0.36] points lower in reading examination and an average 0.89 (95% CI = -1.65 to -0.13) points lower in digit span examination, compared to those without metabolic syndrome. In addition, components of metabolic syndrome-elevated systolic blood pressure and increased waist circumference (WC)-were associated with impaired working memory/attention, and higher fasting glucose and increased WC were associated with poorer reading test scores. CONCLUSIONS:Metabolic syndrome was associated with impaired reading, working memory, and attention among adolescents.
journal_name
Metab Syndr Relat Disordjournal_title
Metabolic syndrome and related disordersauthors
Rubens M,Ramamoorthy V,Saxena A,George F,Shehadeh N,Attonito J,McCoy HV,Beck-Sagué CMdoi
10.1089/met.2016.0015subject
Has Abstractpub_date
2016-10-01 00:00:00pages
397-403issue
8eissn
1540-4196issn
1557-8518journal_volume
14pub_type
杂志文章abstract::In this communication we discuss the role of the gut for the development of type 2 diabetes mellitus (T2DM). Gastric emptying rates importantly determine postprandial glucose excursions and regulate postprandial secretion of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like p...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2017.0015
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to examine effect modifiers of the relationship between family history of diabetes, a proxy for genetic predisposition, and the metabolic syndrome. METHODS:Subjects were a cross-sectional sample of 205 Mexican-Americans patients of the San Ysidro Health Center in San Diego Coun...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2006.0035
更新日期:2007-09-01 00:00:00
abstract:INTRODUCTION:The association of metabolic syndrome with venous thromboembolism (VTE) remains uncertain. Moreover, the relevance of abdominal obesity as an independent or related risk factor for VTE in the metabolic syndrome cluster is controversial. We aimed to evaluate the impact of metabolic syndrome and its individu...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2010.0117
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Multiple abnormal metabolic traits are found together or "cluster" within individuals more often than is predicted by chance. The individual and combined role of adiposity and insulin resistance (IR) on metabolic trait clustering is uncertain. We tested the hypothesis that change in trait clustering is a fun...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0148
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:Obesity and high body fat are related to diabetes and metabolic syndrome (MetS) in all ethnic groups. Based on the International Diabetes Federation (IDF) definition of MetS, the aim of the present study was to compare body adiposity indexes (BAIs) and to assess their various cutoff values for the prediction of...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2017.0016
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome (MetSyn) magnifies risks of cardiovascular disease (CVD) and type 2 diabetes, but its expression varies within the obese population. We examined body mass index (BMI), metabolic traits, and fat distribution in morbidly obese individuals. METHODS:Lipids and inflammatory, oxidative stress a...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2016.0062
更新日期:2016-12-01 00:00:00
abstract:: Background: In patients with diabetes mellitus, the serum uric acid (UA) to creatinine (Cr) ratio (UA/Cr) has been reported to be associated with a higher risk of metabolic syndrome (MetS). In healthy subjects, however, this relationship and a possible association with pat...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2019.0024
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:It has been reported that a continuous intake of a catechin beverage will reduce body fat. Traditionally, improvement of eating and exercise habits has been the basis for prevention and reduction of obesity. In this study, we conducted a trial involving human subjects who ingested a catechin beverage for 1 y...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2008.0061
更新日期:2009-08-01 00:00:00
abstract:: Background: It is estimated that >30% of young adults attending college are overweight or obese and do not participate in enough physical activity (PA) to maintain a healthy body mass. Many of the known risk factors that are often associated with obesity also place an indi...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2019.0007
更新日期:2019-11-01 00:00:00
abstract:: Background: Although metabolic syndrome (MetS) was described in the late 80s, the molecular mechanisms underlying clustering of risk factors in certain individuals are not fully understood. The present study used targeted proteomics to establish cardiometabolic proteins re...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2018.0123
更新日期:2019-06-01 00:00:00
abstract::The perspective presented here is a working hypothesis suggesting a new paradigm for insulin resistance where, analogous to the cause of type 1 diabetes being attributed to lack of insulin, type 2 diabetes is due to lack of action of a hepatic insulin sensitizing substance (HISS). In both cases, the major metabolic dy...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/1540419031361417
更新日期:2003-12-01 00:00:00
abstract::To examine the influence of moderate-intensity (50% of VO(2peak)) exercise training (MI) versus high-intensity (75% of VO(2peak)) exercise training (HI) on regional fat distribution and plasma adiponectin, we randomized 18 overweight (body mass index [BMI] = 30 +/- 1 kg/m(2)) elderly (71 +/- 1 years) to HI, MI, or a c...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,随机对照试验
doi:10.1089/met.2008.0060
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Patients with morbid obesity have a high risk of developing type 2 diabetes mellitus (T2DM). Important risk factors include body mass index (BMI), waist circumference, and insulin resistance. In this prospective study, we investigated if preoperative lifestyle changes followed by bariatric surgery could redu...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0085
更新日期:2013-12-01 00:00:00
abstract::Omega-3s are found in oily fish. We have drastically reduced our intake of fish during the last century. Many of us therefore suffer from a deficiency of omega-3s, which has consequences for health. In this review, we focus on structure-functional relationships and the relation of omega-3s to the metabolic syndrome, i...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2006.4.138
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:The association of metabolic syndrome with coronary artery disease (CAD) has been studied extensively. However, little is known about the effect of Framingham risk score (FRS) and metabolic syndrome components on the association of metabolic syndrome with angiographically significant CAD. Our aim was to inve...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2009.0059
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess clinical and inflammatory markers in nonalcoholic fatty liver disease (NAFLD) in postmenopausal women with metabolic syndrome. METHODS:This cross-sectional study included 180 Brazilian women (age ≥45 years and amenorrhea ≥12 months). Metabolic syndrome was diagnosed by th...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0140
更新日期:2014-08-01 00:00:00
abstract:: Background: Evidence suggests that metabolic syndrome (MetS) is highly prevalent in patients with obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD). However, data on the prevalence of MetS in patients having both OSAS and COPD, or ove...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2019.0126
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Obesity and metabolic syndrome are significant global health issues, with current public health messages predominately focused on altering dietary and physical activity behaviors. Resveratrol is a polyphenol (stilbenoid) commonly found in grapes, and human trials to date have shown conflicting and limited be...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2016.0035
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:The fetal origins hypothesis indicates that morphometric evidence of fetal nutritional deprivation is predictive of excessive weight gain/obesity, insulin resistance, and cardiovascular disease after birth. However, it is unclear whether these effects are present in offspring with "normal" birth weights in c...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2006.0026
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:The relationship between the metabolic syndrome and subclinical atherosclerosis among elderly people remains controversial. We seek to investigate the associations of metabolic syndrome and its components with subclinical carotid atherosclerosis in older people living in rural China. METHODS:This cross-sect...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0135
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Previous reports indicate that both distribution and amount of body fat confers susceptibility to metabolic syndrome. However, the relative contributions of these two different parameters of body fat to the various components of the metabolic syndrome have not been well defined. METHODS:Dual-energy X-ray ab...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2008.0026
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:The increased prevalence of overweight and obesity has reached alarming proportions worldwide and has serious health implications, including an association with an increase in metabolic syndrome. Among the methods to control metabolic syndrome, bariatric surgery plays an important role and can provide a sign...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2012.0014
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:In adult studies, obese subjects with nonalcoholic fatty liver disease (NAFLD) have been shown to have poor sperm quality, and lower testosterone and luteinizing hormone levels. The aim of this study was to investigate the pubertal status and gonadal functions in obese boys with NAFLD. MATERIALS AND METHODS...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2018.0050
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein secreted by immune cells, endothelial cells, vascular smooth muscle cells, and adipocytes. Recent studies indicate that Gas6 and receptors of the TAM (Tyro3, Axl, and Mer) family may be involved in the pathogenesis of obesity, systemic inflamma...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2017.0143
更新日期:2019-02-01 00:00:00
abstract::We assessed 17 middle-aged and older individuals (58.0 +/- 7.9 years, 7 females) at risk for cardiovascular disease regarding: (1) Whether carotid artery stiffness (cAS) would be reduced with a 1-year lifestyle modification program, (2) to what degree cAS would return following washout (mean of 26.9 +/- 4.0 months) fr...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2009.0099
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome is one of the most important health issues worldwide. Obesity causes insulin resistance, hyperlipidemia, diabetes, and various diseases throughout the body. The liver phenotype, which is called nonalcoholic steatohepatitis (NASH), frequently progresses to hepatocellular carcinoma. We recen...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2016.0114
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:We investigated the effect of short-term telmisartan usage in addition to lifestyle changes such as diet and exercise on insulin resistance, lipid metabolism, and serum adiponectin and tumor necrosis factor-alpha (TNF-α) levels in hypertensive patients with metabolic syndrome (MetS). METHODS:A total of 36 h...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,随机对照试验
doi:10.1089/met.2018.0129
更新日期:2019-04-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) and prediabetes (or patients at risk for diabetes) have been increasing in epidemic proportions. Dyslipidemia and hypertension are cardiovascular risk factors frequently associated with diabetes and prediabetes. Bile acid sequestrants (BAS) were initially approved for the treatment of e...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2010.0087
更新日期:2010-12-01 00:00:00
abstract:: Background: Obesity causes significant morbidity and mortality and continues to be a significant public health concern. Unfortunately, lifestyle modification and pharmacotherapy do not produce durable results. This has led to bariatric surgical procedures playing an increa...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2020.0049
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Cognitive decline has been shown to be associated with long-term type 2 diabetes mellitus (T2DM). This review analyzes the present literature to ascertain the role of regular physical activity (PA) for the functioning of the diabetic brain. METHODS:PubMed was systematically searched for relevant publication...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1089/met.2017.0120
更新日期:2017-12-01 00:00:00