Abstract:
BACKGROUND:Previous reports indicate that both distribution and amount of body fat confers susceptibility to metabolic syndrome. However, the relative contributions of these two different parameters of body fat to the various components of the metabolic syndrome have not been well defined. METHODS:Dual-energy X-ray absorptiometry (DXA) was used to measure and compare the relative amounts of total body fat, truncal fat, and lower body fat in a representative sample of 2587 black, white, and Hispanic men and women from the Dallas Heart Study (DHS). The relationships among these variables and fasting plasma levels of lipids, glucose, insulin, C-reactive protein (CRP), and leptin as well as blood pressure were analyzed. RESULTS:Beyond total body fat, fat distribution had the greatest impact on plasma triglycerides in all subjects and on high-density lipoprotein cholesterol (HDL-C) levels in women only. An intermediate effect of fat distribution was observed for homeostasis model assessment of insulin resistance (HOMA-IR) and for blood pressure. Plasma CRP levels were much more sensitive to body fat content than to body fat distribution and leptin levels were determined almost exclusively by body fat content. Although there were minor differences among the different ethnic groups, the major relationship patterns between these variables were similar. CONCLUSION:For most metabolic risk factors, both body fat content and distribution independently contributed to levels, although significant differences were seen between the relative contributions of each variable to individual risk factors.
journal_name
Metab Syndr Relat Disordjournal_title
Metabolic syndrome and related disordersauthors
Grundy SM,Adams-Huet B,Vega GLdoi
10.1089/met.2008.0026subject
Has Abstractpub_date
2008-12-01 00:00:00pages
281-8issue
4eissn
1540-4196issn
1557-8518journal_volume
6pub_type
杂志文章abstract:BACKGROUND:The circadian pattern of adipokines is blunted in obese subjects, and we tested the hypothesis that bariatric surgery could normalize the 24-hr pattern of adipokines. Therefore, this study was designed to examine the early impact of the newly designed sleeve gastrectomy with transit bipartition (SGTB) surger...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2015.0051
更新日期:2016-02-01 00:00:00
abstract:INTRODUCTION:The association of metabolic syndrome with venous thromboembolism (VTE) remains uncertain. Moreover, the relevance of abdominal obesity as an independent or related risk factor for VTE in the metabolic syndrome cluster is controversial. We aimed to evaluate the impact of metabolic syndrome and its individu...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2010.0117
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2010.0129
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:The aim of this study was to study (1) weight gain in type 2 diabetics with different treatment modalities and (2) relationship of weight gain with stable adult weight. METHODS:A study of 469 type 2 diabetics on regular follow-up was undertaken to determine the effect of modality of therapy on patient's wei...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2005.3.130
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess clinical and inflammatory markers in nonalcoholic fatty liver disease (NAFLD) in postmenopausal women with metabolic syndrome. METHODS:This cross-sectional study included 180 Brazilian women (age ≥45 years and amenorrhea ≥12 months). Metabolic syndrome was diagnosed by th...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0140
更新日期:2014-08-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2015.0146
更新日期:2016-08-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0135
更新日期:2014-06-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2004.2.82
更新日期:2004-06-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,随机对照试验
doi:10.1089/met.2018.0129
更新日期:2019-04-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2016.0035
更新日期:2016-09-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2012.0067
更新日期:2012-12-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0085
更新日期:2013-12-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2016.0109
更新日期:2017-05-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0011
更新日期:2013-10-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2009.0030
更新日期:2010-04-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2013.0090
更新日期:2014-02-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2009.0074
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:In the fed state, the glucose disposal action of insulin can be attributed in approximately equal part to the direct action of insulin and to a hepatic insulin sensitizing substance (HISS) that acts selectively on skeletal muscle. HISS action is absent in the 24-hour fasted state. The objective of this study...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2005.3.51
更新日期:2005-01-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2011.0028
更新日期:2011-10-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2019.0126
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
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更新日期:2012-04-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2010.0066
更新日期:2011-04-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2009.0059
更新日期:2010-06-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2009.0002
更新日期:2009-12-01 00:00:00
abstract::Over the past two decades, there has been a striking increase in the number of people with metabolic syndrome. The prevalence of metabolic syndrome varies due to lack of an internationally agreed upon definition. Considering the increased cardiovascular risk among Asian people, a lower cutoff for waist circumference i...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2008.0005
更新日期:2008-09-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2019.0007
更新日期:2019-11-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2006.4.138
更新日期:2006-07-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2017.0103
更新日期:2017-12-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2011.0034
更新日期:2011-10-01 00:00:00