Latent Autoimmune Diabetes in Adults in North Indian Region: Assessment of β-Cell Function, Metabolic and Immunological Features.

Abstract:

BACKGROUND:We undertook a study to assess β-cell function, metabolic and immunological features of patients with latent autoimmune diabetes in adults (LADA) and investigate heterogeneity within LADA based on low and high glutamic acid decarboxylase autoantibodies (GADA) titers. METHODS:A total of 139 patients with adult-onset diabetes were examined cross-sectionally in the National capital region of Northern India. Medical history of all subjects was reviewed with the aim of collecting clinical data. Glucose, glycosylated hemoglobin, lipid profile, creatinine, C-peptide, and GADA were measured in 10-12 hrs fasting blood sample. RESULTS:Assessment of metabolic features revealed lower mean systolic blood pressure in subjects with LADA than in those with type 2 diabetes (DM2). Mean triglyceride levels were lower in LADA subjects compared to DM2 subjects. Compared to DM2 subjects, prevalence of metabolic syndrome (MS) was also lower in LADA subjects. Compared to GADA-low, all GADA-high patients were male, had lower waist circumference, fasting C-peptide (FCP), and prevalence of MS. Compared to DM2 patients, GADA-high patients were younger, had lower age at onset, body mass index, waist circumference, systolic blood pressure, triglycerides, FCP, and prevalence of MS. The rate of patients on insulin was higher in GADA-high compared to DM2. There were no significant differences between characteristics of DM2 and GADA-low patients. CONCLUSIONS:Our results indicate that LADA patients have distinct metabolic features with lower residual β-cell function than DM2 patients. GADA titer is important parameter in defining the severity of the disease as patients with high GADA titer tend to have significant β-cell impairment.

authors

Kumar A,de Leiva A

doi

10.1089/met.2017.0103

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

494-499

issue

10

eissn

1540-4196

issn

1557-8518

journal_volume

15

pub_type

杂志文章
  • A Pilot Study Examining the Effects of GLP-1 Receptor Blockade Using Exendin-(9,39) on Gastric Emptying and Caloric Intake in Subjects With and Without Bariatric Surgery.

    abstract:: Background: Obesity causes significant morbidity and mortality and continues to be a significant public health concern. Unfortunately, lifestyle modification and pharmacotherapy do not produce durable results. This has led to bariatric surgical procedures playing an increa...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2020.0049

    authors: Kittah E,Camilleri M,Jensen MD,Vella A

    更新日期:2020-11-01 00:00:00

  • Characteristics of Metabolic Syndrome in Morbidly Obese Subjects.

    abstract:BACKGROUND:Metabolic syndrome (MetSyn) magnifies risks of cardiovascular disease (CVD) and type 2 diabetes, but its expression varies within the obese population. We examined body mass index (BMI), metabolic traits, and fat distribution in morbidly obese individuals. METHODS:Lipids and inflammatory, oxidative stress a...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2016.0062

    authors: Dusanov S,Heggen E,Tonstad S

    更新日期:2016-12-01 00:00:00

  • Omega-3 Fatty acids: structure, function, and relation to the metabolic syndrome, infertility, and pregnancy.

    abstract::Omega-3s are found in oily fish. We have drastically reduced our intake of fish during the last century. Many of us therefore suffer from a deficiency of omega-3s, which has consequences for health. In this review, we focus on structure-functional relationships and the relation of omega-3s to the metabolic syndrome, i...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2006.4.138

    authors: Saldeen P,Saldeen T

    更新日期:2006-07-01 00:00:00

  • Extended-release niacin/laropiprant effects on lipoprotein subfractions in patients with type 2 diabetes mellitus.

    abstract:BACKGROUND:A potentially atherogenic lipid profile often found in patients with type 2 diabetes mellitus (T2DM) includes increased concentrations of small, low-density lipoprotein (LDL) and intermediate-density lipoprotein (IDL) and decreased concentration of medium/large high-density lipoprotein (HDL) particles. Exten...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1089/met.2012.0005

    authors: Bays H,Giezek H,McKenney JM,O'Neill EA,Tershakovec AM

    更新日期:2012-08-01 00:00:00

  • The Relationship Between the Metabolic Syndrome and Systolic Inter-Arm Systolic Blood Pressure Difference in Korean Adults.

    abstract:BACKGROUND:The present study was conducted to assess the relationship between metabolic syndrome and systolic inter-arm blood pressure difference (sIAD) in Korean adults. METHODS:This study included 410 adults (235 males, 175 females) who were over 30 years old and had undergone a health check from July to December in...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2015.0031

    authors: Yoon H,Choi SW,Park J,Ryu SY,Han MA,Kim GS,Kim SG,Oh HJ,Choi CW

    更新日期:2015-10-01 00:00:00

  • Evaluation of clinical and inflammatory markers of nonalcoholic fatty liver disease in postmenopausal women with metabolic syndrome.

    abstract:BACKGROUND:The aim of this study was to assess clinical and inflammatory markers in nonalcoholic fatty liver disease (NAFLD) in postmenopausal women with metabolic syndrome. METHODS:This cross-sectional study included 180 Brazilian women (age ≥45 years and amenorrhea ≥12 months). Metabolic syndrome was diagnosed by th...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2013.0140

    authors: Rodrigues MH,Bruno AS,Nahas-Neto J,Sandrim VC,Muniz LG,Nahas EA

    更新日期:2014-08-01 00:00:00

  • Review of studies on the effect of bile acid sequestrants in patients with type 2 diabetes mellitus.

    abstract::Type 2 diabetes mellitus (T2DM) and prediabetes (or patients at risk for diabetes) have been increasing in epidemic proportions. Dyslipidemia and hypertension are cardiovascular risk factors frequently associated with diabetes and prediabetes. Bile acid sequestrants (BAS) were initially approved for the treatment of e...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章,评审

    doi:10.1089/met.2010.0087

    authors: Levy P

    更新日期:2010-12-01 00:00:00

  • Comparison of Body Mass Index Percentiles to Detect Metabolic Syndrome Using the Korean, United States Centers for Disease Control and Prevention, and World Health Organization References in Korean Children Aged 10-16 Years.

    abstract:: Background: Few studies have compared the local and international body mass index (BMI) reference sets for their relationship with metabolic syndrome (MetS) in children. This study aimed to compare the BMI percentiles using Korean, United States Centers for Disease Control...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2018.0126

    authors: Lee K

    更新日期:2019-05-01 00:00:00

  • Variable contributions of fat content and distribution to metabolic syndrome risk factors.

    abstract:BACKGROUND:Previous reports indicate that both distribution and amount of body fat confers susceptibility to metabolic syndrome. However, the relative contributions of these two different parameters of body fat to the various components of the metabolic syndrome have not been well defined. METHODS:Dual-energy X-ray ab...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2008.0026

    authors: Grundy SM,Adams-Huet B,Vega GL

    更新日期:2008-12-01 00:00:00

  • Is there any association of serum high-sensitivity C-reactive protein with various risk factors for metabolic syndrome in a healthy adult population of karachi, pakistan?

    abstract:BACKGROUND:The aim of this study was to discover the association of serum high-sensitivity C-reactive protein (hsCRP) with various risk factors for metabolic syndrome in an urban population of Karachi, Pakistan. METHOD:In this cross-sectional study, 337 healthy adults (108 males and 229 females, mean age 40.7 ± 14.2 y...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2010.0113

    authors: Riaz M,Fawwad A,Hydrie MZ,Basit A,Shera AS

    更新日期:2011-06-01 00:00:00

  • Influence of K656N Polymorphism of the Leptin Receptor Gene on Obesity-Related Traits in Nondiabetic Afro-Caribbean Individuals.

    abstract:: Background: Ethnic variations have been reported in allelic frequencies of the leptin receptor gene (LEPR) with population-specific effects. We aimed to explore the association of LEPR polymorphisms with obesity, metabolic syndrome (MetS), and leptin levels in Afro-Caribbe...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2018.0133

    authors: Foucan L,Bassien-Capsa V,Rambhojan C,Lacorte JM,Larifla L

    更新日期:2019-05-01 00:00:00

  • The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle.

    abstract:BACKGROUND:Concomitant supplementation of 1.5% docosahexaenoic acid (22:6 n-3; DHA) with 0.5% t10, c12-conjugated linoleic acid (18:2 n-6; CLA) prevented the CLA-induced increase in expression of hepatic genes involved in fatty acid synthesis and the decrease in expression of genes involved in fatty acid oxidation. The...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2012.0116

    authors: Fedor DM,Adkins Y,Newman JW,Mackey BE,Kelley DS

    更新日期:2013-02-01 00:00:00

  • Resistin is an indicator of the metabolic syndrome according to five different definitions in the Finnish Health 2000 survey.

    abstract:BACKGROUND:Resistin is a peptide hormone secreted mainly from human monocytes and macrophages. It has an unclear association with the metabolic syndrome, which is a cluster of cardiovascular risk factors such as glucose intolerance, central obesity, insulin resistance, dyslipidemia, and hypertension. We examined the as...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2010.0106

    authors: Malo E,Ukkola O,Jokela M,Moilanen L,Kähönen M,Nieminen MS,Salomaa V,Jula A,Kesäniemi YA

    更新日期:2011-06-01 00:00:00

  • The triglyceride paradox in people of African descent.

    abstract::Even though insulin resistance, cardiovascular disease (CVD), and type 2 diabetes (T2D) are associated with hypertriglyceridemia, blacks with these conditions usually have normal triglyceride (TG) levels. This is often called a lipid paradox. More precisely, it is a "TG paradox." The pathways that lead to hypertriglyc...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章,评审

    doi:10.1089/met.2011.0108

    authors: Yu SS,Castillo DC,Courville AB,Sumner AE

    更新日期:2012-04-01 00:00:00

  • Diabetes Management and Cardiovascular Risk: Are SGLT-2 Inhibitors the Safest?

    abstract::For five millennia, diabetes management has focused on controlling blood sugar and efforts to minimize the complications of this disease have depended on normalizing glucose. Since the 1970's, however, a growing awareness of the adverse effect of hypoglycemic agents on cardiac health has led to an increasing focus on ...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章,评审

    doi:10.1089/met.2015.29003.swi

    authors: Swislocki AL,Jialal I

    更新日期:2016-02-01 00:00:00

  • Association of rs9939609 Polymorphism with Metabolic Parameters and FTO Risk Haplotype Among Tunisian Metabolic Syndrome.

    abstract:BACKGROUND:Variants in the fat mass and obesity-associated (FTO) gene are associated with obesity and type 2 diabetes mellitus. AIM OF THE STUDY:This study aims to assess the association of the rs9939609 variant and haplotypes in FTO gene with metabolic syndrome (MetS) components in a Tunisian population sample. METH...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2015.0090

    authors: Elouej S,Belfki-Benali H,Nagara M,Lasram K,Attaoua R,Sallem OK,Kamoun I,Chargui M,Romdhane L,Jamoussi H,Turki Z,Abid A,Ben Slama C,Bahri S,Abdelhak S,Grigorescu F,Ben Romdhane H,Kefi R

    更新日期:2016-03-01 00:00:00

  • Cardiometabolic Proteins Associated with Metabolic Syndrome.

    abstract:: Background: Although metabolic syndrome (MetS) was described in the late 80s, the molecular mechanisms underlying clustering of risk factors in certain individuals are not fully understood. The present study used targeted proteomics to establish cardiometabolic proteins re...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2018.0123

    authors: Lind L,Elmståhl S,Ingelsson E

    更新日期:2019-06-01 00:00:00

  • Cardiovascular fitness, activity, and metabolic syndrome among college men and women.

    abstract:BACKGROUND:The purpose of this cross-sectional study was to examine the impact of below-average cardiovascular fitness and inactivity on the metabolic syndrome among an understudied population-undergraduate men and women, ages 18-24 years. METHODS:Between January, 2010, and May, 2012, we assessed anthropometric, bioch...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2013.0011

    authors: Morrell JS,Cook SB,Carey GB

    更新日期:2013-10-01 00:00:00

  • Chromium picolinate does not improve key features of metabolic syndrome in obese nondiabetic adults.

    abstract:BACKGROUND:The use of chromium-containing dietary supplements is widespread among patients with type 2 diabetes. Chromium's effects in patients at high risk for developing diabetes, especially those with metabolic syndrome, is unknown. The objective of this study was to determine the effects of chromium picolinate (CrP...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/met.2008.0048

    authors: Iqbal N,Cardillo S,Volger S,Bloedon LT,Anderson RA,Boston R,Szapary PO

    更新日期:2009-04-01 00:00:00

  • Prevalence of diabetes mellitus among the adult population in rural blocks of Haryana, India: a community-based study.

    abstract:OBJECTIVE:The aim of this was to study the prevalence of diabetes in the rural adult population of Haryana, India. RESEARCH DESIGN AND METHODS:A total of 2606 adults aged ≥ 18 years were randomly selected from two rural blocks of Haryana State. Those without diabetes were subjected to a 75-gram oral glucose tolerance ...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2012.0067

    authors: Rajput R,Rajput M,Singh J,Bairwa M

    更新日期:2012-12-01 00:00:00

  • Prevalence of metabolic syndrome components in a population of bank employees from St. Petersburg, Russia.

    abstract:BACKGROUND:The aim of this study was to assess prevalence of metabolic syndrome and its components according to different criteria in the population of bank employees in St. Petersburg, Russia. METHODS:A total of 1,600 office workers were screened at their working places from the Sberbank state bank in St. Petersburg....

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2011.0028

    authors: Konradi AO,Rotar OP,Korostovtseva LS,Ivanenko VV,Solntcev VN,Anokhin SB,Bart VA,Shlyakhto EV

    更新日期:2011-10-01 00:00:00

  • Size at birth, obesity and blood pressure at age five.

    abstract:BACKGROUND:The fetal origins hypothesis indicates that morphometric evidence of fetal nutritional deprivation is predictive of excessive weight gain/obesity, insulin resistance, and cardiovascular disease after birth. However, it is unclear whether these effects are present in offspring with "normal" birth weights in c...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2006.0026

    authors: Clapp Iii JF,Lopez B

    更新日期:2007-06-01 00:00:00

  • Pubertal Status and Gonadal Functions in Obese Boys with Fatty Liver.

    abstract:BACKGROUND:In adult studies, obese subjects with nonalcoholic fatty liver disease (NAFLD) have been shown to have poor sperm quality, and lower testosterone and luteinizing hormone levels. The aim of this study was to investigate the pubertal status and gonadal functions in obese boys with NAFLD. MATERIALS AND METHODS...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2018.0050

    authors: Kurku H,Atar M,Pirgon Ö,Büyükinan M,Erdem SS,Deniz İ,Gederet YT

    更新日期:2019-03-01 00:00:00

  • Effectiveness and safety of 1-year ad libitum consumption of a high-catechin beverage under nutritional guidance.

    abstract:BACKGROUND:It has been reported that a continuous intake of a catechin beverage will reduce body fat. Traditionally, improvement of eating and exercise habits has been the basis for prevention and reduction of obesity. In this study, we conducted a trial involving human subjects who ingested a catechin beverage for 1 y...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2008.0061

    authors: Yoneda T,Shoji K,Takase H,Hibi M,Hase T,Meguro S,Tokimitsu I,Kambe H

    更新日期:2009-08-01 00:00:00

  • Restorative yoga in adults with metabolic syndrome: a randomized, controlled pilot trial.

    abstract:BACKGROUND:Metabolic syndrome increases the risk of diabetes and cardiovascular disease. Yoga improves some metabolic parameters, but it has not been studied in persons with metabolic syndrome. We conducted a randomized controlled pilot trial to determine whether a restorative yoga intervention was feasible and accepta...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/met.2008.0016

    authors: Cohen BE,Chang AA,Grady D,Kanaya AM

    更新日期:2008-09-01 00:00:00

  • Ethnic disparities in metabolic syndrome in malaysia: an analysis by risk factors.

    abstract:BACKGROUND:This study investigates ethnic disparities in metabolic syndrome in Malaysia. METHODS:Data were obtained from the Malaysia Non-Communicable Disease Surveillance-1 (2005/2006). Logistic regressions of metabolic syndrome health risks on sociodemographic and health-lifestyle factors were conducted using a mult...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2011.0031

    authors: Tan AK,Dunn RA,Yen ST

    更新日期:2011-12-01 00:00:00

  • Metabolic Syndrome and Physical Activity Levels in College Students.

    abstract:: Background: It is estimated that >30% of young adults attending college are overweight or obese and do not participate in enough physical activity (PA) to maintain a healthy body mass. Many of the known risk factors that are often associated with obesity also place an indi...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2019.0007

    authors: Miller JM,Street BD

    更新日期:2019-11-01 00:00:00

  • Markers of inflammation are heritable and associated with subcutaneous and ectopic skeletal muscle adiposity in African ancestry families.

    abstract:UNLABELLED:Abstract Background: Skeletal muscle adipose tissue (AT) infiltration, or myosteatosis, appears to be greater in African compared with European ancestry individuals and may play a role in type 2 diabetes mellitus (T2DM), a disease that disproportionally affects African ancestry populations. Inflammation is o...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2010.0133

    authors: Miljkovic I,Kuipers AL,Kammerer CM,Wang X,Bunker CH,Patrick AL,Wheeler VW,Kuller LH,Evans RW,Zmuda JM

    更新日期:2011-08-01 00:00:00

  • Diabetic Patients with Cardiovascular Disease Show More Metabolic Syndrome than Nondiabetic Patients: Multicentric Study in the Northeast of Brazil.

    abstract:: Background: Diabetes mellitus (DM) is associated with a higher prevalence of metabolic syndrome (MS) and cardiovascular mortality. However, few Brazilian studies evaluated MS in diabetic individuals with cardiovascular disease (CVD). Nevertheless, the objective of this stu...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章

    doi:10.1089/met.2020.0064

    authors: de Brito Gonçalves Nascimento L,Sahade V,Weber B,Pinheiro JMF,Dias LPP,Figueiredo Neto JA,Carlos Sobral Sousa A,Pinho CPS,Luna AB,Vasconcelos SML,Dantas CF,Penafort AM,Carlos DMO,Daltro C

    更新日期:2021-02-01 00:00:00

  • Bariatric surgery for metabolic syndrome in obesity.

    abstract::Metabolic syndrome is closely associated with morbid obesity and leads to increased risk of cardiovascular diseases and related mortality. Bariatric surgery is considered an effective option for the management of this condition. We searched MEDLINE, Current Contents, and the Cochrane Library for papers published on ba...

    journal_title:Metabolic syndrome and related disorders

    pub_type: 杂志文章,评审

    doi:10.1089/met.2014.0115

    authors: Shuai X,Tao K,Mori M,Kanda T

    更新日期:2015-05-01 00:00:00