Abstract：
BACKGROUND:Resistin is a peptide hormone secreted mainly from human monocytes and macrophages. It has an unclear association with the metabolic syndrome, which is a cluster of cardiovascular risk factors such as glucose intolerance, central obesity, insulin resistance, dyslipidemia, and hypertension. We examined the association of resistin with metabolic syndrome and its components in a population-based cohort. METHODS:A subsample of a large Finnish cross-sectional health examination survey (the Health 2000 Survey) was studied. Resistin was measured using an in-house assay based on the DELFIA® technique in 1,508 Finnish men and women aged 45-74 years. Metabolic syndrome was defined according to five different definitions. RESULTS:Resistin levels were higher in the subjects with metabolic syndrome when compared to the subjects without metabolic syndrome (P < 0.05 for every metabolic syndrome criterion). In logistic regression analysis, a high resistin level was an independent predictor of the prevalence of metabolic syndrome (P < 0.05 for every criterion). Resistin was positively associated with waist circumference, tumor necrosis factor-α, and insulin resistance assessed by the homeostasis model and inversely with total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol after adjusting for age, gender, and body mass index (P < 0.05 for all). CONCLUSIONS:These results clarify the controversial association of resistin in obesity and metabolic syndrome, suggesting that a high resistin level is associated with clustering of metabolic disturbances.
journal_name
Metab Syndr Relat Disordjournal_title
Metabolic syndrome and related disordersauthors
Malo E,Ukkola O,Jokela M,Moilanen L,Kähönen M,Nieminen MS,Salomaa V,Jula A,Kesäniemi YAdoi
10.1089/met.2010.0106subject
Has Abstractpub_date
2011-06-01 00:00:00pages
203-10issue
3eissn
1540-4196issn
1557-8518journal_volume
9pub_type
杂志文章abstract：: Background: Glycated hemoglobin (HbA1c) is an index of the average blood glucose level over the preceding 2-3 months. In experimental studies, the lens responded to changes in osmolarity by forming vacuoles. By observing the vacuoles of the lens during eye examination, can...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2018.0076
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Patients with insulin resistance (IR) have a higher prevalence of thyroid nodules. In the present study, we present original data showing that patients with differentiated thyroid carcinoma (DTC) also have a higher frequency of IR. METHODS:Twenty women with DTC (group 1, G1) and 20 euthyroid individuals (co...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2008.0062
更新日期：2009-08-01 00:00:00
abstract：BACKGROUND:The aim of this study was to study (1) weight gain in type 2 diabetics with different treatment modalities and (2) relationship of weight gain with stable adult weight. METHODS:A study of 469 type 2 diabetics on regular follow-up was undertaken to determine the effect of modality of therapy on patient's wei...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2005.3.130
更新日期：2005-07-01 00:00:00
abstract：BACKGROUND:High blood concentrations of inflammatory markers, including white blood cell (WBC) count, are closely related to the metabolic syndrome. Both conditions predict dismal survival. We determined prospective associations between mortality and factors derived by a factor analysis of WBC count and the basic compo...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2012.0100
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:This study aimed to evaluate the association between decreased estimated glomerular filtration rate (eGFR <60 mL/min/1.73 m2) and metabolic syndrome (MetS) according to muscle mass. METHODS:Body composition was measured in 3351 men and 4394 women aged between 19 and 97 years using the 2010-2011 Korea Nation...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2016.0017
更新日期：2016-10-01 00:00:00
abstract：:In this communication we discuss the role of the gut for the development of type 2 diabetes mellitus (T2DM). Gastric emptying rates importantly determine postprandial glucose excursions and regulate postprandial secretion of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like p...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章,评审
doi：10.1089/met.2017.0015
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Sirtuin (SirT), a family of conserved histone deacetylases and transferases, has been proposed to function in inflammatory, cancer, and metabolic diseases. However, it is unclear how SirT modulates these processes. In this study, the effect of metformin on senescence and antisenescence mediators (SirT1-7, p5...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2014.0168
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:A clustering of metabolic risk factors increases the likelihood of cardiovascular diseases. This study reports the metabolic risk profiles and the prevalence of metabolic risk factors and associated factors among Vietnamese adults in Ho Chi Minh City. METHODS:A cross-sectional study was carried out in a rep...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2009.0018
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:The association of the rs738409 polymorphism of patatin-like phospholipase-3 (PNPLA3) with nonalcoholic fatty liver disease (NAFLD) has been suggested in other populations, but not in Asian Indians. We investigated the association of the rs738409 polymorphism of PNPLA3 with clinical, anthropometric, and bioc...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2012.0064
更新日期：2013-10-01 00:00:00
abstract：:Nonalcoholic fatty liver disease (NAFLD) is a major form of chronic liver disease in adults and children. It is one of the consequences of the current obesity epidemic, and can progress to nonalcoholic steatohepatitis (NASH), characterized by steatosis, inflammation, and progressive fibrosis, ultimately leading to cir...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章,评审
doi：10.1089/met.2007.0026
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:Previous reports indicate that both distribution and amount of body fat confers susceptibility to metabolic syndrome. However, the relative contributions of these two different parameters of body fat to the various components of the metabolic syndrome have not been well defined. METHODS:Dual-energy X-ray ab...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2008.0026
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:In contrast to the definition of metabolic syndrome (MetS) in adults, there is no standard definition of MetS in pediatric populations. We aimed at assessing the differences in the prevalence of MetS in children and adolescents aged 9-17 years using four different operational definitions for these age groups...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2016.0058
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:In the fed state, the glucose disposal action of insulin can be attributed in approximately equal part to the direct action of insulin and to a hepatic insulin sensitizing substance (HISS) that acts selectively on skeletal muscle. HISS action is absent in the 24-hour fasted state. The objective of this study...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2005.3.51
更新日期：2005-01-01 00:00:00
abstract：PURPOSE:Obesity and high body fat are related to diabetes and metabolic syndrome (MetS) in all ethnic groups. Based on the International Diabetes Federation (IDF) definition of MetS, the aim of the present study was to compare body adiposity indexes (BAIs) and to assess their various cutoff values for the prediction of...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2017.0016
更新日期：2017-09-01 00:00:00
abstract：: Background: Although metabolic syndrome (MetS) was described in the late 80s, the molecular mechanisms underlying clustering of risk factors in certain individuals are not fully understood. The present study used targeted proteomics to establish cardiometabolic proteins re...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2018.0123
更新日期：2019-06-01 00:00:00
abstract：:Even though insulin resistance, cardiovascular disease (CVD), and type 2 diabetes (T2D) are associated with hypertriglyceridemia, blacks with these conditions usually have normal triglyceride (TG) levels. This is often called a lipid paradox. More precisely, it is a "TG paradox." The pathways that lead to hypertriglyc...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章,评审
doi：10.1089/met.2011.0108
更新日期：2012-04-01 00:00:00
abstract：: Background: The problem of obesity in young women leads to future chronic diseases, effects on reproductive health, and next-generation obesity. Thus, it is necessary to provide effective support for these women's behavioral change. The purpose of this study was to evaluat...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2020.0042
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:A potentially atherogenic lipid profile often found in patients with type 2 diabetes mellitus (T2DM) includes increased concentrations of small, low-density lipoprotein (LDL) and intermediate-density lipoprotein (IDL) and decreased concentration of medium/large high-density lipoprotein (HDL) particles. Exten...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1089/met.2012.0005
更新日期：2012-08-01 00:00:00
abstract：: Background: Obesity causes significant morbidity and mortality and continues to be a significant public health concern. Unfortunately, lifestyle modification and pharmacotherapy do not produce durable results. This has led to bariatric surgical procedures playing an increa...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2020.0049
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:This study investigates ethnic disparities in metabolic syndrome in Malaysia. METHODS:Data were obtained from the Malaysia Non-Communicable Disease Surveillance-1 (2005/2006). Logistic regressions of metabolic syndrome health risks on sociodemographic and health-lifestyle factors were conducted using a mult...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2011.0031
更新日期：2011-12-01 00:00:00
abstract：:Omega-3s are found in oily fish. We have drastically reduced our intake of fish during the last century. Many of us therefore suffer from a deficiency of omega-3s, which has consequences for health. In this review, we focus on structure-functional relationships and the relation of omega-3s to the metabolic syndrome, i...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2006.4.138
更新日期：2006-07-01 00:00:00
abstract：:We assessed 17 middle-aged and older individuals (58.0 +/- 7.9 years, 7 females) at risk for cardiovascular disease regarding: (1) Whether carotid artery stiffness (cAS) would be reduced with a 1-year lifestyle modification program, (2) to what degree cAS would return following washout (mean of 26.9 +/- 4.0 months) fr...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2009.0099
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND:The fetal origins hypothesis indicates that morphometric evidence of fetal nutritional deprivation is predictive of excessive weight gain/obesity, insulin resistance, and cardiovascular disease after birth. However, it is unclear whether these effects are present in offspring with "normal" birth weights in c...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2006.0026
更新日期：2007-06-01 00:00:00
abstract：:The metabolic syndrome increases the risk of atherothrombotic cardiovascular disease (CVD) and diabetes. In turn, diabetes promotes the development of atheroma and is regarded as a coronary heart disease risk equivalent. A multifactorial therapeutic strategy is advocated for patients with the metabolic syndrome to imp...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2006.4.328
更新日期：2006-01-01 00:00:00
abstract：:Type 2 diabetes mellitus (T2DM) and prediabetes (or patients at risk for diabetes) have been increasing in epidemic proportions. Dyslipidemia and hypertension are cardiovascular risk factors frequently associated with diabetes and prediabetes. Bile acid sequestrants (BAS) were initially approved for the treatment of e...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章,评审
doi：10.1089/met.2010.0087
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:In adult studies, obese subjects with nonalcoholic fatty liver disease (NAFLD) have been shown to have poor sperm quality, and lower testosterone and luteinizing hormone levels. The aim of this study was to investigate the pubertal status and gonadal functions in obese boys with NAFLD. MATERIALS AND METHODS...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2018.0050
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to examine effect modifiers of the relationship between family history of diabetes, a proxy for genetic predisposition, and the metabolic syndrome. METHODS:Subjects were a cross-sectional sample of 205 Mexican-Americans patients of the San Ysidro Health Center in San Diego Coun...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2006.0035
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:It has been reported that a continuous intake of a catechin beverage will reduce body fat. Traditionally, improvement of eating and exercise habits has been the basis for prevention and reduction of obesity. In this study, we conducted a trial involving human subjects who ingested a catechin beverage for 1 y...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2008.0061
更新日期：2009-08-01 00:00:00
abstract：BACKGROUND:Multiple abnormal metabolic traits are found together or "cluster" within individuals more often than is predicted by chance. The individual and combined role of adiposity and insulin resistance (IR) on metabolic trait clustering is uncertain. We tested the hypothesis that change in trait clustering is a fun...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2013.0148
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:We investigated the effect of short-term telmisartan usage in addition to lifestyle changes such as diet and exercise on insulin resistance, lipid metabolism, and serum adiponectin and tumor necrosis factor-alpha (TNF-α) levels in hypertensive patients with metabolic syndrome (MetS). METHODS:A total of 36 h...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章,随机对照试验
doi：10.1089/met.2018.0129
更新日期：2019-04-01 00:00:00
