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Longitudinal changes in central artery stiffness with lifestyle modification, washout, and drug treatment in individuals at risk for cardiovascular disease.

Abstract：

:We assessed 17 middle-aged and older individuals (58.0 +/- 7.9 years, 7 females) at risk for cardiovascular disease regarding: (1) Whether carotid artery stiffness (cAS) would be reduced with a 1-year lifestyle modification program, (2) to what degree cAS would return following washout (mean of 26.9 +/- 4.0 months) from the active intervention, and (3) whether a 24-week telmisartan treatment would reduce cAS more than our lifestyle modification program. cAS by Doppler ultrasound, cardiovascular disease risk factors, and exercise capacity were assessed at three points: Following the 1-year lifestyle modification, following the washout period, and following a 24-week telmisartan treatment. Following telmisartan, systolic blood pressure (SBP) was significantly decreased (114.8 +/- 12.3 mmHg) compared to baseline (127.9 +/- 12.7 mmHg) and following the washout period (126.1 +/- 14.9 mmHg). Similarly, diastolic blood pressure (DBP) was significantly lower following telmisaratn than following the washout period. Exercise capacity was increased following lifestyle modification but returned to the baseline level following the washout period. Following the lifestyle modification program, cAS was significantly reduced, and this reduction was maintained following the washout period. Conversely, the subsequent telmisartan treatment did not change cAS despite a significant blood pressure reduction. These results suggest that the reduced cAS achieved with lifestyle modification may not necessarily disappear following a cessation of the active program, indicating a possible role that family physicians can play in their clinical practice, and also providing a further rationale to promote lifestyle modification as an initial therapy for this population. In contrast, no additional benefit of telmisartan beyond our lifestyle intervention was observed in this study.

journal_name

Metab Syndr Relat Disord

journal_title

Metabolic syndrome and related disorders

authors

Aizawa K,Shoemaker JK,Overend TJ,Petrella RJ

doi

10.1089/met.2009.0099

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

323-9

issue

eissn

1540-4196

issn

1557-8518

journal_volume

pub_type

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Longitudinal changes in central artery stiffness with lifestyle modification, washout, and drug treatment in individuals at risk for cardiovascular disease.