The "metabolic winter" hypothesis: a cause of the current epidemics of obesity and cardiometabolic disease.

abstract：: Background: Ethnic variations have been reported in allelic frequencies of the leptin receptor gene (LEPR) with population-specific effects. We aimed to explore the association of LEPR polymorphisms with obesity, metabolic syndrome (MetS), and leptin levels in Afro-Caribbe...

journal_title：Metabolic syndrome and related disorders

authors： Foucan L,Bassien-Capsa V,Rambhojan C,Lacorte JM,Larifla L

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Concomitant supplementation of 1.5% docosahexaenoic acid (22:6 n-3; DHA) with 0.5% t10, c12-conjugated linoleic acid (18:2 n-6; CLA) prevented the CLA-induced increase in expression of hepatic genes involved in fatty acid synthesis and the decrease in expression of genes involved in fatty acid oxidation. The...

journal_title：Metabolic syndrome and related disorders

authors： Fedor DM,Adkins Y,Newman JW,Mackey BE,Kelley DS

更新日期：2013-02-01 00:00:00

abstract：:Metabolic syndrome is closely associated with morbid obesity and leads to increased risk of cardiovascular diseases and related mortality. Bariatric surgery is considered an effective option for the management of this condition. We searched MEDLINE, Current Contents, and the Cochrane Library for papers published on ba...

journal_title：Metabolic syndrome and related disorders

authors： Shuai X,Tao K,Mori M,Kanda T

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:We compared the lipid-altering effects of ezetimibe/simvastatin (EZE/SIMVA) co-administered with fenofibrate (FENO) in mixed hyperlipidemic patients with (MetS) versus those without MetS. METHODS:A total of 611 patients, 20 to 79 years old, with LDL-C 130-220 mg/dL (100-180 mg/dL for patients with type 2 di...

journal_title：Metabolic syndrome and related disorders

authors： Gil-Extremera B,Mendez G,Zakson M,Meehan A,Shah A,Lin J,Mitchel Y

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Obesity and metabolic syndrome (MetS) are increasing rapidly worldwide, but metabolically healthy population exists. Thus, this study evaluated the proportion of obesity and MetS and investigated clinical and body compositional factors associated with MetS in obese Koreans. METHODS:This cross-sectional obse...

journal_title：Metabolic syndrome and related disorders

authors： Kim YM,Kim S,Kim SH,Won YJ

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Cognitive decline has been shown to be associated with long-term type 2 diabetes mellitus (T2DM). This review analyzes the present literature to ascertain the role of regular physical activity (PA) for the functioning of the diabetic brain. METHODS:PubMed was systematically searched for relevant publication...

journal_title：Metabolic syndrome and related disorders

authors： Podolski N,Brixius K,Predel HG,Brinkmann C

更新日期：2017-12-01 00:00:00

abstract：: Background: Diabetes mellitus (DM) is associated with a higher prevalence of metabolic syndrome (MS) and cardiovascular mortality. However, few Brazilian studies evaluated MS in diabetic individuals with cardiovascular disease (CVD). Nevertheless, the objective of this stu...

journal_title：Metabolic syndrome and related disorders

authors： de Brito Gonçalves Nascimento L,Sahade V,Weber B,Pinheiro JMF,Dias LPP,Figueiredo Neto JA,Carlos Sobral Sousa A,Pinho CPS,Luna AB,Vasconcelos SML,Dantas CF,Penafort AM,Carlos DMO,Daltro C

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Multiple abnormal metabolic traits are found together or "cluster" within individuals more often than is predicted by chance. The individual and combined role of adiposity and insulin resistance (IR) on metabolic trait clustering is uncertain. We tested the hypothesis that change in trait clustering is a fun...

journal_title：Metabolic syndrome and related disorders

authors： Rutter MK,Sullivan LM,Fox CS,Wilson PW,Nathan DM,Vasan RS,D'Agostino RB Sr,Meigs JB

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:The aim of this study was to assess prevalence of metabolic syndrome and its components according to different criteria in the population of bank employees in St. Petersburg, Russia. METHODS:A total of 1,600 office workers were screened at their working places from the Sberbank state bank in St. Petersburg....

journal_title：Metabolic syndrome and related disorders

authors： Konradi AO,Rotar OP,Korostovtseva LS,Ivanenko VV,Solntcev VN,Anokhin SB,Bart VA,Shlyakhto EV

更新日期：2011-10-01 00:00:00

abstract：INTRODUCTION:The association of metabolic syndrome with venous thromboembolism (VTE) remains uncertain. Moreover, the relevance of abdominal obesity as an independent or related risk factor for VTE in the metabolic syndrome cluster is controversial. We aimed to evaluate the impact of metabolic syndrome and its individu...

journal_title：Metabolic syndrome and related disorders

authors： Vayá A,Martínez-Triguero ML,España F,Todolí JA,Bonet E,Corella D

更新日期：2011-06-01 00:00:00

abstract：: Background: Obesity causes significant morbidity and mortality and continues to be a significant public health concern. Unfortunately, lifestyle modification and pharmacotherapy do not produce durable results. This has led to bariatric surgical procedures playing an increa...

journal_title：Metabolic syndrome and related disorders

authors： Kittah E,Camilleri M,Jensen MD,Vella A

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:It has been reported that a continuous intake of a catechin beverage will reduce body fat. Traditionally, improvement of eating and exercise habits has been the basis for prevention and reduction of obesity. In this study, we conducted a trial involving human subjects who ingested a catechin beverage for 1 y...

journal_title：Metabolic syndrome and related disorders

authors： Yoneda T,Shoji K,Takase H,Hibi M,Hase T,Meguro S,Tokimitsu I,Kambe H

更新日期：2009-08-01 00:00:00

abstract：: Background: Glycated hemoglobin (HbA1c) is an index of the average blood glucose level over the preceding 2-3 months. In experimental studies, the lens responded to changes in osmolarity by forming vacuoles. By observing the vacuoles of the lens during eye examination, can...

journal_title：Metabolic syndrome and related disorders

authors： Koç Ş,Baysal S,Koç Z,Yener AÜ

更新日期：2018-12-01 00:00:00

abstract：:The metabolic syndrome increases the risk of atherothrombotic cardiovascular disease (CVD) and diabetes. In turn, diabetes promotes the development of atheroma and is regarded as a coronary heart disease risk equivalent. A multifactorial therapeutic strategy is advocated for patients with the metabolic syndrome to imp...

journal_title：Metabolic syndrome and related disorders

authors： Krentz AJ

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Overall hemostatic potential (OHP) captures all factors that affect coagulation and fibrinolysis cascade. It has not yet been assessed in polycystic ovary syndrome (PCOS). The aim of the study was to identify the relationship of OHP with a syndrome per se and body mass index (BMI). METHODS:In 90 women with ...

journal_title：Metabolic syndrome and related disorders

authors： Rakusa M,Jensterle M,Božič-Mijovski M,Janez A

更新日期：2017-05-01 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) and prediabetes (or patients at risk for diabetes) have been increasing in epidemic proportions. Dyslipidemia and hypertension are cardiovascular risk factors frequently associated with diabetes and prediabetes. Bile acid sequestrants (BAS) were initially approved for the treatment of e...

journal_title：Metabolic syndrome and related disorders

authors： Levy P

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the association between decreased estimated glomerular filtration rate (eGFR <60 mL/min/1.73 m2) and metabolic syndrome (MetS) according to muscle mass. METHODS:Body composition was measured in 3351 men and 4394 women aged between 19 and 97 years using the 2010-2011 Korea Nation...

journal_title：Metabolic syndrome and related disorders

authors： Lee K

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate insulin sensitivity and secretion in lean and obese Asian (Thai) type 2 diabetic patients. METHODS:Insulin sensitivity and insulin secretion was assessed with the hyperinsulinemic euglycemic (80 mU/m(2) per min) and hyperglycemic clamp technique in 9 lean and 10 obes...

journal_title：Metabolic syndrome and related disorders

authors： Suraamornkul S,Kwancharoen R,Ovartlarnporn M,Rawdaree P,Bajaj M

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:The aim of this study was to study (1) weight gain in type 2 diabetics with different treatment modalities and (2) relationship of weight gain with stable adult weight. METHODS:A study of 469 type 2 diabetics on regular follow-up was undertaken to determine the effect of modality of therapy on patient's wei...

journal_title：Metabolic syndrome and related disorders

authors： Chandalia HB,Lamba PS,Chandalia SH,Singh DK,Modi SV,Shaikh SA

更新日期：2005-07-01 00:00:00

abstract：AIM:This study was designed to evaluate carotid intima media thickness (CIMT) and serum osteoprotegerin (OPG) levels in nonalcoholic fatty liver disease (NAFLD) in comparison to healthy controls and to investigate factors predicting the CIMT increase. MATERIALS AND METHODS:A total of 60 outpatients [median (min-max) a...

journal_title：Metabolic syndrome and related disorders

authors： Ayaz T,Kirbas A,Durakoglugil T,Durakoglugil ME,Sahin SB,Sahin OZ,Kirvar A,Tasci F

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:We evaluated structural microvascular alterations in the skeletal muscle and left ventricle, as well as endothelium-dependent microvascular reactivity in the skeletal muscle, of diabetic rats subjected to long-term aerobic exercise training. METHODS:Diabetes was experimentally induced by a combination of a ...

journal_title：Metabolic syndrome and related disorders

authors： Machado MV,Martins RL,Borges J,Antunes BR,Estato V,Vieira AB,Tibiriçá E

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Previous reports indicate that both distribution and amount of body fat confers susceptibility to metabolic syndrome. However, the relative contributions of these two different parameters of body fat to the various components of the metabolic syndrome have not been well defined. METHODS:Dual-energy X-ray ab...

journal_title：Metabolic syndrome and related disorders

authors： Grundy SM,Adams-Huet B,Vega GL

更新日期：2008-12-01 00:00:00

abstract：:In this communication we discuss the role of the gut for the development of type 2 diabetes mellitus (T2DM). Gastric emptying rates importantly determine postprandial glucose excursions and regulate postprandial secretion of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like p...

journal_title：Metabolic syndrome and related disorders

authors： Holst JJ,Pedersen J,Wewer Albrechtsen NJ,Knop FK

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:High blood concentrations of inflammatory markers, including white blood cell (WBC) count, are closely related to the metabolic syndrome. Both conditions predict dismal survival. We determined prospective associations between mortality and factors derived by a factor analysis of WBC count and the basic compo...

journal_title：Metabolic syndrome and related disorders

authors： Nilsson G,Hedberg P,Ohrvik J

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Sirtuin (SirT), a family of conserved histone deacetylases and transferases, has been proposed to function in inflammatory, cancer, and metabolic diseases. However, it is unclear how SirT modulates these processes. In this study, the effect of metformin on senescence and antisenescence mediators (SirT1-7, p5...

journal_title：Metabolic syndrome and related disorders

authors： Aljada A

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Metabolic syndrome is prevalent in adults characterized by increased visceral adiposity and insulin resistance (IR). However, the link between pancreatic β-cell function and metabolic syndrome severity in adults across the glucose spectrum is unknown. We hypothesized that poor β-cell function would independe...

journal_title：Metabolic syndrome and related disorders

authors： Malin SK,Finnegan S,Fealy CE,Filion J,Rocco MB,Kirwan JP

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Metabolic syndrome occurs commonly in the United States. The purpose of this study was to measure the prevalence of metabolic syndrome among American Indian and Alaska Native people. METHODS:We measured the prevalence rates of metabolic syndrome, as defined by the National Cholesterol Education Program, amo...

journal_title：Metabolic syndrome and related disorders

authors： Schumacher C,Ferucci ED,Lanier AP,Slattery ML,Schraer CD,Raymer TW,Dillard D,Murtaugh MA,Tom-Orme L

更新日期：2008-12-01 00:00:00

abstract：AIM:The objective of this study was to estimate basal insulin resistance (IR) and insulin secretion (IS) in Nigerians with type 2 diabetes mellitus (T2DM). METHODS:The homeostasis model assessment (HOMA) method was used to estimate basal IR and IS in 146 Nigerians with T2DM and in 33 controls at the University of Nige...

journal_title：Metabolic syndrome and related disorders

authors： Oli JM,Adeyemo AA,Okafor GO,Ofoegbu EN,Onyenekwe B,Chukwuka CJ,Onwasigwe CN,Ufelle S,Chen G,Rotimi CN

更新日期：2009-12-01 00:00:00

abstract：:Even though insulin resistance, cardiovascular disease (CVD), and type 2 diabetes (T2D) are associated with hypertriglyceridemia, blacks with these conditions usually have normal triglyceride (TG) levels. This is often called a lipid paradox. More precisely, it is a "TG paradox." The pathways that lead to hypertriglyc...

journal_title：Metabolic syndrome and related disorders

authors： Yu SS,Castillo DC,Courville AB,Sumner AE

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:The aim of this study was to discover the association of serum high-sensitivity C-reactive protein (hsCRP) with various risk factors for metabolic syndrome in an urban population of Karachi, Pakistan. METHOD:In this cross-sectional study, 337 healthy adults (108 males and 229 females, mean age 40.7 ± 14.2 y...

journal_title：Metabolic syndrome and related disorders

authors： Riaz M,Fawwad A,Hydrie MZ,Basit A,Shera AS

更新日期：2011-06-01 00:00:00