当前位置： SCI文献检索 > Metabolic Syndrome and Related Disorders期刊下所有文献 > Basal insulin resistance and secretion in Nigerians with type 2 diabetes mellitus.

Basal insulin resistance and secretion in Nigerians with type 2 diabetes mellitus.

Abstract：

AIM:The objective of this study was to estimate basal insulin resistance (IR) and insulin secretion (IS) in Nigerians with type 2 diabetes mellitus (T2DM). METHODS:The homeostasis model assessment (HOMA) method was used to estimate basal IR and IS in 146 Nigerians with T2DM and in 33 controls at the University of Nigeria Teaching Hospital (UNTH), Enugu, Nigeria. Correlations and multiple regression analysis between Box-Cox-transformed IR and log-transformed IS and anthropometric indices were carried out. RESULTS:IR and reduced IS were present, respectively, in 139 (95.5%) and 109 (74.7%) of the diabetic subjects and in 25 (75.8%) and 4 (12.1%) of the controls. In the diabetic subjects, age at diagnosis, duration of diabetes, waist circumference (WC), and body mass index (BMI) correlated significantly with IR (r = -0.2399, P = 0.0035; r = 0.1993, P = 0.0166; r = 0.2267, P = 0.0059; r = 0.2082, P = 0.0120; respectively), whereas duration of diabetes, WC, and BMI correlated significantly with IS (r = -0.2166, P = 0.0091; r = 0.3062, P = 0.0002; r = 0.2746, P = 0.0008; respectively). Age at diagnosis, WC, and duration of diabetes were significant predictors of IR (beta = -0.0161, P < 0.001; beta = 0.0121, P = 0.002; beta = 0.0138, P = 0.042; respectively), whereas duration of diabetes and WC significantly predicted IS (beta = -0.0159, P = 0.025; beta = 0.0155, P < 0.001). CONCLUSIONS:This study shows that both IR and reduced IS are major features of T2DM in Nigerians and that WC consistently correlated and predicted IR. WC measurement is simple and ideal in resource-poor settings for the detection of IR and abdominal obesity. The apparent rarity of coronary heart disease (CHD) in black Africans with T2DM despite a high prevalence of IR warrants further investigation.

journal_name

Metab Syndr Relat Disord

journal_title

Metabolic syndrome and related disorders

authors

Oli JM,Adeyemo AA,Okafor GO,Ofoegbu EN,Onyenekwe B,Chukwuka CJ,Onwasigwe CN,Ufelle S,Chen G,Rotimi CN

doi

10.1089/met.2009.0002

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

595-9

issue

eissn

1540-4196

issn

1557-8518

journal_volume

pub_type

杂志文章

在线工具

Basal insulin resistance and secretion in Nigerians with type 2 diabetes mellitus.