Abstract:
: Background: Glycated hemoglobin (HbA1c) is an index of the average blood glucose level over the preceding 2-3 months. In experimental studies, the lens responded to changes in osmolarity by forming vacuoles. By observing the vacuoles of the lens during eye examination, can we detect changes in osmolarity and glycemia over the last 6 months through HbA1c levels? Methods: In total, 400 patients (mean age, 67.7 ± 9.8 years), including those with diabetes mellitus, hypertension, and heart failure, were included in the study. The control group contained 70 patients matched in terms of age and sex and who had no prior disease (mean age, 67.8 ± 9.4 years). Monthly Na, glucose, and blood urea nitrogen values were used to calculate changes in osmolarity over 6 months. HbA1c values were also recorded. Biomicroscopy was used to evaluate lens vacuolation; all vacuoles were digitally photographed and converted to ImageJ format. Results: The sensitivity and specificity of using large vacuoles to detect HbA1c ≥10% were 88.0% (95% confidence interval [CI]: 68.8-97.4) and 82.6% (95% CI: 74.1-89.2), respectively. The sensitivity and specificity of detecting a 10 mOsm/kg change in osmolarity were 61% (95% CI: 48.9-72.4) and 94.5% (95% CI: 91.5-96.7), respectively. Conclusions: Lens vacuoles, which can be observed with a simple and quick examination, can be used to detect HbA1c levels and osmolarity changes over the last 6 months. Because of their relationship to the severity of retinopathy, vacuoles can also be used as a weak control indicator.
journal_name
Metab Syndr Relat Disordjournal_title
Metabolic syndrome and related disordersauthors
Koç Ş,Baysal S,Koç Z,Yener AÜdoi
10.1089/met.2018.0076subject
Has Abstractpub_date
2018-12-01 00:00:00pages
543-550issue
10eissn
1540-4196issn
1557-8518journal_volume
16pub_type
杂志文章abstract:BACKGROUND:Cognitive decline has been shown to be associated with long-term type 2 diabetes mellitus (T2DM). This review analyzes the present literature to ascertain the role of regular physical activity (PA) for the functioning of the diabetic brain. METHODS:PubMed was systematically searched for relevant publication...
journal_title:Metabolic syndrome and related disorders
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journal_title:Metabolic syndrome and related disorders
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journal_title:Metabolic syndrome and related disorders
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journal_title:Metabolic syndrome and related disorders
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journal_title:Metabolic syndrome and related disorders
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journal_title:Metabolic syndrome and related disorders
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,随机对照试验
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2017.0143
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Niacin increases blood glucose, but whether the degree of increase is associated with increasing body mass index (BMI) is unknown. We evaluated the effect of extended-release niacin initiation on fasting plasma glucose (FPG) and the development of new-onset diabetes mellitus (DM) in relation to body mass ind...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2009.0074
更新日期:2010-02-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2010.0113
更新日期:2011-06-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2018.0126
更新日期:2019-05-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2006.4.138
更新日期:2006-07-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2015.0051
更新日期:2016-02-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
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doi:10.1089/met.2020.0042
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,meta分析,评审
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2017.0016
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,随机对照试验
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
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更新日期:2008-09-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,随机对照试验
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更新日期:2009-04-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
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更新日期:2017-08-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
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journal_title:Metabolic syndrome and related disorders
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doi:10.1089/met.2008.0021
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journal_title:Metabolic syndrome and related disorders
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journal_title:Metabolic syndrome and related disorders
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