Abstract:
BACKGROUND:Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein secreted by immune cells, endothelial cells, vascular smooth muscle cells, and adipocytes. Recent studies indicate that Gas6 and receptors of the TAM (Tyro3, Axl, and Mer) family may be involved in the pathogenesis of obesity, systemic inflammation, and insulin resistance. The aim of this study was to investigate the association between plasma Gas6 protein and the c.843 + 7G>A Gas6 polymorphism in metabolic syndrome (MetS). METHODS:Two hundred five adults (88 men and 117 women) were recruited in this study. Plasma Gas6 concentration, general, and biochemical data were measured. All subjects were genotyped for the c.843 + 7G>A Gas6 polymorphism. RESULTS:Plasma Gas6 concentrations decreased in parallel with various MetS components in all groups (P = 0.017 for trend). Patients in the second and third tertiles of Gas6 level had higher high-density lipoprotein cholesterol (HDL-C) levels than those in the first tertile overall and in the female group. Plasma Gas6 levels were significantly positively correlated with HDL-C level and negatively with fasting glucose level in the female patients. The A allele and genotype AA in single nucleotide polymorphism c.843 + 7G>A were less frequent in the subjects with MetS compared to those without MetS. CONCLUSIONS:Our results demonstrated a positive correlation between Gas6 protein values and HDL-C and reinforce the association with fasting glucose. In addition, the presence of c.843 + 7G>A Gas6 polymorphisms, especially the AA genotype, had an association with MetS. The potential role of the Gas6/TAM system in MetS deserves further investigation.
journal_name
Metab Syndr Relat Disordjournal_title
Metabolic syndrome and related disordersauthors
Li YH,Lu CH,Lin FH,Su SC,Liu JS,Hsieh CH,Hung YJ,Shieh YS,Lee CHdoi
10.1089/met.2017.0143subject
Has Abstractpub_date
2019-02-01 00:00:00pages
22-28issue
1eissn
1540-4196issn
1557-8518journal_volume
17pub_type
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journal_title:Metabolic syndrome and related disorders
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journal_title:Metabolic syndrome and related disorders
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journal_title:Metabolic syndrome and related disorders
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journal_title:Metabolic syndrome and related disorders
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journal_title:Metabolic syndrome and related disorders
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journal_title:Metabolic syndrome and related disorders
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journal_title:Metabolic syndrome and related disorders
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doi:10.1089/1540419031361417
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pub_type: 杂志文章,随机对照试验
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,随机对照试验
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更新日期:2011-12-01 00:00:00
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journal_title:Metabolic syndrome and related disorders
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journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,随机对照试验
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