Abstract：
BACKGROUND:In the fed state, the glucose disposal action of insulin can be attributed in approximately equal part to the direct action of insulin and to a hepatic insulin sensitizing substance (HISS) that acts selectively on skeletal muscle. HISS action is absent in the 24-hour fasted state. The objective of this study was to determine whether alcohol administered with a meal affected meal-induced insulin sensitization (MIS). METHODS:Rats were fasted for 24 hours and anesthetized, and insulin sensitivity was evaluated using the rapid insulin sensitivity test (RIST). A liquid mixed meal was injected into the stomach along with diluted alcohol equivalent to 1, 0.25, and 0.125 mL/kg of ethanol. After 90 minutes, a second RIST was carried out, atropine administered, and a third RIST done. A control fed group received no ethanol and a RIST was determined at 90 minutes; then 1 mL/kg ethanol or water was administered and the RIST was tested 1 hour later. RESULTS:Ethanol co-administered with a meal produced a dose-dependent suppression of MIS. MIS was blocked back to fasting levels by atropine. MIS developed to a maximal level by 90 minutes and was maintained for at least 1 hour more. Ethanol (1 mL/kg) administered after MIS was fully developed resulted in complete suppression of insulin sensitivity back to a fasting level. CONCLUSIONS:MIS can be demonstrated in response to gastric administration of a liquid mixed meal in anesthetized rats. Alcohol produces a dose-related suppression of MIS and can completely reverse MIS once it has been developed. The concentrations of alcohol reached were well within levels attained by social drinkers. MIS was confirmed to act through HISS action, and neither MIS nor alcohol affected the HISS-independent component of insulin action.
journal_name
Metab Syndr Relat Disordjournal_title
Metabolic syndrome and related disordersauthors
Lautt WW,Legare DJ,Reid MA,Sadri P,Ting JW,Prieditis Hdoi
10.1089/met.2005.3.51subject
Has Abstractpub_date
2005-01-01 00:00:00pages
51-9issue
1eissn
1540-4196issn
1557-8518journal_volume
3pub_type
杂志文章abstract：BACKGROUND:Metabolic syndrome is prevalent in adults characterized by increased visceral adiposity and insulin resistance (IR). However, the link between pancreatic β-cell function and metabolic syndrome severity in adults across the glucose spectrum is unknown. We hypothesized that poor β-cell function would independe...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2013.0083
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:The combination of ezetimibe and simvastatin (EZE/SIMVA) inhibits intestinal absorption and hepatic synthesis of cholesterol, providing significantly greater LDL-C-lowering compared to either drug alone. We examined the efficacy and safety of EZE/SIMVAin hypercholesterolemic patients with metabolic syndrome ...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2006.0033
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND:Patients with insulin resistance (IR) have a higher prevalence of thyroid nodules. In the present study, we present original data showing that patients with differentiated thyroid carcinoma (DTC) also have a higher frequency of IR. METHODS:Twenty women with DTC (group 1, G1) and 20 euthyroid individuals (co...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2008.0062
更新日期：2009-08-01 00:00:00
abstract：:Even though insulin resistance, cardiovascular disease (CVD), and type 2 diabetes (T2D) are associated with hypertriglyceridemia, blacks with these conditions usually have normal triglyceride (TG) levels. This is often called a lipid paradox. More precisely, it is a "TG paradox." The pathways that lead to hypertriglyc...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章,评审
doi：10.1089/met.2011.0108
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Health care costs increase with the presence of metabolic syndrome and present a significant burden to companies throughout the world. Identifying effective behavioral programs within the workplace can reduce health care costs. We examined the effect of a voluntary worksite program on weight loss and metabol...
journal_title：Metabolic syndrome and related disorders
pub_type： 临床试验,杂志文章
doi：10.1089/met.2015.0075
更新日期：2015-11-01 00:00:00
abstract：:For five millennia, diabetes management has focused on controlling blood sugar and efforts to minimize the complications of this disease have depended on normalizing glucose. Since the 1970's, however, a growing awareness of the adverse effect of hypoglycemic agents on cardiac health has led to an increasing focus on ...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章,评审
doi：10.1089/met.2015.29003.swi
更新日期：2016-02-01 00:00:00
abstract：: Background: In patients with diabetes mellitus, the serum uric acid (UA) to creatinine (Cr) ratio (UA/Cr) has been reported to be associated with a higher risk of metabolic syndrome (MetS). In healthy subjects, however, this relationship and a possible association with pat...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2019.0024
更新日期：2019-09-01 00:00:00
abstract：AIM:This study was designed to evaluate carotid intima media thickness (CIMT) and serum osteoprotegerin (OPG) levels in nonalcoholic fatty liver disease (NAFLD) in comparison to healthy controls and to investigate factors predicting the CIMT increase. MATERIALS AND METHODS:A total of 60 outpatients [median (min-max) a...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2013.0151
更新日期：2014-06-01 00:00:00
abstract：INTRODUCTION:The association of metabolic syndrome with venous thromboembolism (VTE) remains uncertain. Moreover, the relevance of abdominal obesity as an independent or related risk factor for VTE in the metabolic syndrome cluster is controversial. We aimed to evaluate the impact of metabolic syndrome and its individu...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2010.0117
更新日期：2011-06-01 00:00:00
abstract：: Background: Few studies have compared the local and international body mass index (BMI) reference sets for their relationship with metabolic syndrome (MetS) in children. This study aimed to compare the BMI percentiles using Korean, United States Centers for Disease Control...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2018.0126
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Metabolic syndrome (MetSyn) magnifies risks of cardiovascular disease (CVD) and type 2 diabetes, but its expression varies within the obese population. We examined body mass index (BMI), metabolic traits, and fat distribution in morbidly obese individuals. METHODS:Lipids and inflammatory, oxidative stress a...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2016.0062
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein secreted by immune cells, endothelial cells, vascular smooth muscle cells, and adipocytes. Recent studies indicate that Gas6 and receptors of the TAM (Tyro3, Axl, and Mer) family may be involved in the pathogenesis of obesity, systemic inflamma...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2017.0143
更新日期：2019-02-01 00:00:00
abstract：:The metabolic syndrome (MS) is a clustering of cardiovascular risk factors, with insulin resistance as a major feature. This syndrome has been variously defined, but generally consists of 3 or more of the following components: hyperglycemia, hypertension, hypertriglyceridemia, low HDL, and increased abdominal circumfe...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2004.2.82
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:The aim of this study was to discover the association of serum high-sensitivity C-reactive protein (hsCRP) with various risk factors for metabolic syndrome in an urban population of Karachi, Pakistan. METHOD:In this cross-sectional study, 337 healthy adults (108 males and 229 females, mean age 40.7 ± 14.2 y...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2010.0113
更新日期：2011-06-01 00:00:00
abstract：:The successful introduction of highly active antiretroviral therapy (HAART), a combination of potent antiretroviral agents, including protease inhibitors, nucleoside reverse transcriptase inhibitors, and nonnucleoside reverse transcriptase inhibitors, has impacted positively on morbidity and mortality among human immu...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章,评审
doi：10.1089/met.2008.0096
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:Isolated postchallenge hyperglycemia (IPH) is an early form of type 2 diabetes with fasting glucose <126 mg/dL and 2-hr postchallenge glucose ≥200 mg/dL. The purpose of this study was to explore the relationships of high-sensitivity C-reactive protein (hsCRP) with IPH. METHODS:We recruited 476 naturally pos...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2015.0118
更新日期：2016-09-01 00:00:00
abstract：: Background: Although metabolic syndrome (MetS) was described in the late 80s, the molecular mechanisms underlying clustering of risk factors in certain individuals are not fully understood. The present study used targeted proteomics to establish cardiometabolic proteins re...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2018.0123
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:The aim of this study was to assess clinical and inflammatory markers in nonalcoholic fatty liver disease (NAFLD) in postmenopausal women with metabolic syndrome. METHODS:This cross-sectional study included 180 Brazilian women (age ≥45 years and amenorrhea ≥12 months). Metabolic syndrome was diagnosed by th...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2013.0140
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:The circadian pattern of adipokines is blunted in obese subjects, and we tested the hypothesis that bariatric surgery could normalize the 24-hr pattern of adipokines. Therefore, this study was designed to examine the early impact of the newly designed sleeve gastrectomy with transit bipartition (SGTB) surger...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2015.0051
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:Patients with morbid obesity have a high risk of developing type 2 diabetes mellitus (T2DM). Important risk factors include body mass index (BMI), waist circumference, and insulin resistance. In this prospective study, we investigated if preoperative lifestyle changes followed by bariatric surgery could redu...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2013.0085
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Currently, guidelines for obesity thresholds relating to metabolic risk in South African women have not been established. Therefore, the aim of the study was to investigate the level and diagnostic ability of obesity measures [waist circumference (WC), waist-to-height ratio (WHtR), and visceral adipose tissu...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2011.0034
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:Niacin increases blood glucose, but whether the degree of increase is associated with increasing body mass index (BMI) is unknown. We evaluated the effect of extended-release niacin initiation on fasting plasma glucose (FPG) and the development of new-onset diabetes mellitus (DM) in relation to body mass ind...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2009.0074
更新日期：2010-02-01 00:00:00
abstract：:Metabolic syndrome is closely associated with morbid obesity and leads to increased risk of cardiovascular diseases and related mortality. Bariatric surgery is considered an effective option for the management of this condition. We searched MEDLINE, Current Contents, and the Cochrane Library for papers published on ba...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章,评审
doi：10.1089/met.2014.0115
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:A clustering of metabolic risk factors increases the likelihood of cardiovascular diseases. This study reports the metabolic risk profiles and the prevalence of metabolic risk factors and associated factors among Vietnamese adults in Ho Chi Minh City. METHODS:A cross-sectional study was carried out in a rep...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2009.0018
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:This study investigates ethnic disparities in metabolic syndrome in Malaysia. METHODS:Data were obtained from the Malaysia Non-Communicable Disease Surveillance-1 (2005/2006). Logistic regressions of metabolic syndrome health risks on sociodemographic and health-lifestyle factors were conducted using a mult...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2011.0031
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:The present study was conducted to assess the relationship between metabolic syndrome and systolic inter-arm blood pressure difference (sIAD) in Korean adults. METHODS:This study included 410 adults (235 males, 175 females) who were over 30 years old and had undergone a health check from July to December in...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2015.0031
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Metabolic syndrome is increasingly common in U.S. adolescents and has been linked to cognitive dysfunction. Purpose of this study is to explore associations between metabolic syndrome and cognitive impairment in U.S. adolescents using population-based data. STUDY DESIGN:Participants included adolescents age...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2016.0015
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is a major risk factor for type 2 diabetes, cardiovascular disease, and liver failure. Treatment with n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) produced variable success in improving NAFLD. The purpose of this review is to determine if n-3 LCPUFA will d...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章,评审
doi：10.1089/met.2016.0051
更新日期：2016-11-01 00:00:00
abstract：:The metabolic syndrome increases the risk of atherothrombotic cardiovascular disease (CVD) and diabetes. In turn, diabetes promotes the development of atheroma and is regarded as a coronary heart disease risk equivalent. A multifactorial therapeutic strategy is advocated for patients with the metabolic syndrome to imp...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2006.4.328
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:It is unknown whether severe sarcopenia produces unfavorable effects on cardiovascular risk factors. To examine the influence of severe and moderate sarcopenia on selected cardiovascular risk factors, 687 men were screened; those exhibiting clinically relevant diseases and higher body fat percentage (>25% fa...
journal_title：Metabolic syndrome and related disorders
pub_type： 杂志文章
doi：10.1089/met.2012.0057
更新日期：2012-12-01 00:00:00
