Abstract:
BACKGROUND:The circadian pattern of adipokines is blunted in obese subjects, and we tested the hypothesis that bariatric surgery could normalize the 24-hr pattern of adipokines. Therefore, this study was designed to examine the early impact of the newly designed sleeve gastrectomy with transit bipartition (SGTB) surgery on the circadian pattern of leptin, adiponectin, and resistin in morbidly obese subjects. METHODS:The study group included six morbidly obese women [body mass index (BMI) 41.3 ± 1.53 kg/m(2)] who underwent SGTB and four lean women (BMI 18.61 ± 0.92 kg/m(2)). Blood from all subjects was collected before and 3 months after bariatric surgery every 6 hr throughout the 24-hr period. The circadian pattern of leptin, adiponectin, and resistin was measured by enzyme-linked immunosorbent assay or Luminex techniques. RESULTS:Lean women exhibited rise of plasma leptin levels at nighttime, whereas obese women had an increase in the overall plasma leptin levels throughout the 24-hr period, lacking the physiological rise of nocturnal leptin levels compared to controls. Obese women had a decrease in 24-hr adiponectin levels and similar plasma resistin levels compared to controls. Three months after SGTB, obese women lost 16.0% (P < 0.005) of their initial body weight and had a decrease in overall 24-hr leptin levels. However, there was no recovery of the nocturnal rise in leptin levels 3 months after SGTB. The 24-hr adiponectin levels were still decreased after SGTB surgery compared to controls, while resistin levels were decreased only during night time after SGTB. CONCLUSIONS:These results suggested that SGTB is an efficient innovative procedure to rapidly decrease 24-hr leptin levels. However, after 3 months, SGTB was not enough to recover the physiological nocturnal rise of leptin levels present in lean subjects.
journal_name
Metab Syndr Relat Disordjournal_title
Metabolic syndrome and related disordersauthors
Costa Justus JF,Ligocki Campos AC,Figueroa AL,Gomis R,Santo MA,Fávero GM,Milléo FQ,Vieira Edoi
10.1089/met.2015.0051subject
Has Abstractpub_date
2016-02-01 00:00:00pages
16-22issue
1eissn
1540-4196issn
1557-8518journal_volume
14pub_type
杂志文章abstract:BACKGROUND:This study investigates ethnic disparities in metabolic syndrome in Malaysia. METHODS:Data were obtained from the Malaysia Non-Communicable Disease Surveillance-1 (2005/2006). Logistic regressions of metabolic syndrome health risks on sociodemographic and health-lifestyle factors were conducted using a mult...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2011.0031
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:The aim of this was to study the prevalence of diabetes in the rural adult population of Haryana, India. RESEARCH DESIGN AND METHODS:A total of 2606 adults aged ≥ 18 years were randomly selected from two rural blocks of Haryana State. Those without diabetes were subjected to a 75-gram oral glucose tolerance ...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2012.0067
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Concomitant supplementation of 1.5% docosahexaenoic acid (22:6 n-3; DHA) with 0.5% t10, c12-conjugated linoleic acid (18:2 n-6; CLA) prevented the CLA-induced increase in expression of hepatic genes involved in fatty acid synthesis and the decrease in expression of genes involved in fatty acid oxidation. The...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2012.0116
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome is prevalent in adults characterized by increased visceral adiposity and insulin resistance (IR). However, the link between pancreatic β-cell function and metabolic syndrome severity in adults across the glucose spectrum is unknown. We hypothesized that poor β-cell function would independe...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0083
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:High blood concentrations of inflammatory markers, including white blood cell (WBC) count, are closely related to the metabolic syndrome. Both conditions predict dismal survival. We determined prospective associations between mortality and factors derived by a factor analysis of WBC count and the basic compo...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2012.0100
更新日期:2013-04-01 00:00:00
abstract:: Background: In patients with diabetes mellitus, the serum uric acid (UA) to creatinine (Cr) ratio (UA/Cr) has been reported to be associated with a higher risk of metabolic syndrome (MetS). In healthy subjects, however, this relationship and a possible association with pat...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2019.0024
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome is increasingly common in U.S. adolescents and has been linked to cognitive dysfunction. Purpose of this study is to explore associations between metabolic syndrome and cognitive impairment in U.S. adolescents using population-based data. STUDY DESIGN:Participants included adolescents age...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2016.0015
更新日期:2016-10-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) and prediabetes (or patients at risk for diabetes) have been increasing in epidemic proportions. Dyslipidemia and hypertension are cardiovascular risk factors frequently associated with diabetes and prediabetes. Bile acid sequestrants (BAS) were initially approved for the treatment of e...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2010.0087
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Sirtuin (SirT), a family of conserved histone deacetylases and transferases, has been proposed to function in inflammatory, cancer, and metabolic diseases. However, it is unclear how SirT modulates these processes. In this study, the effect of metformin on senescence and antisenescence mediators (SirT1-7, p5...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2014.0168
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome increases the risk of diabetes and cardiovascular disease. Yoga improves some metabolic parameters, but it has not been studied in persons with metabolic syndrome. We conducted a randomized controlled pilot trial to determine whether a restorative yoga intervention was feasible and accepta...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,随机对照试验
doi:10.1089/met.2008.0016
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:The association of the rs738409 polymorphism of patatin-like phospholipase-3 (PNPLA3) with nonalcoholic fatty liver disease (NAFLD) has been suggested in other populations, but not in Asian Indians. We investigated the association of the rs738409 polymorphism of PNPLA3 with clinical, anthropometric, and bioc...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2012.0064
更新日期:2013-10-01 00:00:00
abstract::The concept of the "Calorie" originated in the 1800 s in an environment with limited food availability, primarily as a means to define economic equivalencies in the energy density of food substrates. Soon thereafter, the energy densities of the major macronutrients-fat, protein, and carbohydrates-were defined. However...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2014.0027
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:The association of metabolic syndrome with coronary artery disease (CAD) has been studied extensively. However, little is known about the effect of Framingham risk score (FRS) and metabolic syndrome components on the association of metabolic syndrome with angiographically significant CAD. Our aim was to inve...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2009.0059
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The use of chromium-containing dietary supplements is widespread among patients with type 2 diabetes. Chromium's effects in patients at high risk for developing diabetes, especially those with metabolic syndrome, is unknown. The objective of this study was to determine the effects of chromium picolinate (CrP...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,随机对照试验
doi:10.1089/met.2008.0048
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Cognitive decline has been shown to be associated with long-term type 2 diabetes mellitus (T2DM). This review analyzes the present literature to ascertain the role of regular physical activity (PA) for the functioning of the diabetic brain. METHODS:PubMed was systematically searched for relevant publication...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1089/met.2017.0120
更新日期:2017-12-01 00:00:00
abstract::Metabolic syndrome is closely associated with morbid obesity and leads to increased risk of cardiovascular diseases and related mortality. Bariatric surgery is considered an effective option for the management of this condition. We searched MEDLINE, Current Contents, and the Cochrane Library for papers published on ba...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2014.0115
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Currently, guidelines for obesity thresholds relating to metabolic risk in South African women have not been established. Therefore, the aim of the study was to investigate the level and diagnostic ability of obesity measures [waist circumference (WC), waist-to-height ratio (WHtR), and visceral adipose tissu...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2011.0034
更新日期:2011-10-01 00:00:00
abstract:: Background: Obesity causes significant morbidity and mortality and continues to be a significant public health concern. Unfortunately, lifestyle modification and pharmacotherapy do not produce durable results. This has led to bariatric surgical procedures playing an increa...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2020.0049
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:The aim of this study was to study (1) weight gain in type 2 diabetics with different treatment modalities and (2) relationship of weight gain with stable adult weight. METHODS:A study of 469 type 2 diabetics on regular follow-up was undertaken to determine the effect of modality of therapy on patient's wei...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2005.3.130
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:The aim of this study was to compare the prevalence of metabolic syndrome in human immunodeficiency virus (HIV)-infected patients treated with highly active antiretroviral therapy (HAART), using the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), European Group for the Study ...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2010.0129
更新日期:2011-10-01 00:00:00
abstract:: Background: It is estimated that >30% of young adults attending college are overweight or obese and do not participate in enough physical activity (PA) to maintain a healthy body mass. Many of the known risk factors that are often associated with obesity also place an indi...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2019.0007
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to examine effect modifiers of the relationship between family history of diabetes, a proxy for genetic predisposition, and the metabolic syndrome. METHODS:Subjects were a cross-sectional sample of 205 Mexican-Americans patients of the San Ysidro Health Center in San Diego Coun...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2006.0035
更新日期:2007-09-01 00:00:00
abstract::In this communication we discuss the role of the gut for the development of type 2 diabetes mellitus (T2DM). Gastric emptying rates importantly determine postprandial glucose excursions and regulate postprandial secretion of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like p...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2017.0015
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:A potentially atherogenic lipid profile often found in patients with type 2 diabetes mellitus (T2DM) includes increased concentrations of small, low-density lipoprotein (LDL) and intermediate-density lipoprotein (IDL) and decreased concentration of medium/large high-density lipoprotein (HDL) particles. Exten...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1089/met.2012.0005
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Resistin is a peptide hormone secreted mainly from human monocytes and macrophages. It has an unclear association with the metabolic syndrome, which is a cluster of cardiovascular risk factors such as glucose intolerance, central obesity, insulin resistance, dyslipidemia, and hypertension. We examined the as...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2010.0106
更新日期:2011-06-01 00:00:00
abstract:: Background: Glycated hemoglobin (HbA1c) is an index of the average blood glucose level over the preceding 2-3 months. In experimental studies, the lens responded to changes in osmolarity by forming vacuoles. By observing the vacuoles of the lens during eye examination, can...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2018.0076
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:The aim of the study was to evaluate the relative importance of the determinants of the metabolic syndrome in a sample with metabolic syndrome from the Greek population. METHODS:A random sample of 824 male (56 ± 11 years) and 1,199 female (58 ± 10 years) subjects with metabolic syndrome [National Cholestero...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2010.0023
更新日期:2010-12-01 00:00:00
abstract::Over the past two decades, there has been a striking increase in the number of people with metabolic syndrome. The prevalence of metabolic syndrome varies due to lack of an internationally agreed upon definition. Considering the increased cardiovascular risk among Asian people, a lower cutoff for waist circumference i...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2008.0005
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:A clustering of metabolic risk factors increases the likelihood of cardiovascular diseases. This study reports the metabolic risk profiles and the prevalence of metabolic risk factors and associated factors among Vietnamese adults in Ho Chi Minh City. METHODS:A cross-sectional study was carried out in a rep...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2009.0018
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:The relationship between the metabolic syndrome and subclinical atherosclerosis among elderly people remains controversial. We seek to investigate the associations of metabolic syndrome and its components with subclinical carotid atherosclerosis in older people living in rural China. METHODS:This cross-sect...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0135
更新日期:2014-06-01 00:00:00