Abstract:
BACKGROUND:A potentially atherogenic lipid profile often found in patients with type 2 diabetes mellitus (T2DM) includes increased concentrations of small, low-density lipoprotein (LDL) and intermediate-density lipoprotein (IDL) and decreased concentration of medium/large high-density lipoprotein (HDL) particles. Extended-release niacin/laropiprant (ERN/LRPT) lowers LDL-cholesterol (LDL-C) and triglycerides (TG), and raises HDL cholesterol (HDL-C) levels with attenuation of niacin-induced flushing. METHODS:Plasma HDL, LDL, IDL, very-low-density lipoprotein (VLDL), and chylomicron particle concentration and size at were evaluated at baseline and week 12 using nuclear magnetic resonance (NMR). The data were acquired from a randomized, multicenter, double-blind, placebo-controlled study including 796 patients with T2DM treated with either 1 tablet of ERN 1 gram/LRPT 20 mg or matching placebo daily, increased after 4 weeks to 2 tablets daily. RESULTS:ERN/LRPT significantly (P≤0.001 for all) reduced LDL-C 17.9% and TG 23.1%, and increased HDL-C levels 23.2%. Compared to placebo, ERN/LRPT decreased LDL, IDL, VLDL, and chylomicron particle concentrations [median concentration of smallest LDL particles decreased 16.6%, 95% confidence interval (CI) -22.3, -10.9, whereas the largest LDL particles decreased 11.0%, 95% CI -18.7, -3.2, and total VLDL/chylomicron mean plasma particle concentration decreased 34.7%, 95% CI -41.3, -28.1]. Compared to placebo, ERN/LRPT shifted the distribution of HDL particle diameter from smaller to larger (median concentration of the largest HDL particles increased 32.7% (95% CI 25.30, 40.58), whereas concentration of the smallest HDL particles decreased 8.2% (95% CI -11.29, -5.06). CONCLUSIONS:Compared with placebo in patients with T2DM, ERN/LRPT shifted the lipoprotein profile toward a potentially less atherogenic pattern with reduced atherogenic LDL and IDL particle concentrations, and increased large HDL plasma particle concentrations. (ClinicalTrials.gov: NCT00485758).
journal_name
Metab Syndr Relat Disordjournal_title
Metabolic syndrome and related disordersauthors
Bays H,Giezek H,McKenney JM,O'Neill EA,Tershakovec AMdoi
10.1089/met.2012.0005subject
Has Abstractpub_date
2012-08-01 00:00:00pages
260-6issue
4eissn
1540-4196issn
1557-8518journal_volume
10pub_type
杂志文章,多中心研究,随机对照试验abstract::We assessed 17 middle-aged and older individuals (58.0 +/- 7.9 years, 7 females) at risk for cardiovascular disease regarding: (1) Whether carotid artery stiffness (cAS) would be reduced with a 1-year lifestyle modification program, (2) to what degree cAS would return following washout (mean of 26.9 +/- 4.0 months) fr...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2009.0099
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:We investigated the effect of short-term telmisartan usage in addition to lifestyle changes such as diet and exercise on insulin resistance, lipid metabolism, and serum adiponectin and tumor necrosis factor-alpha (TNF-α) levels in hypertensive patients with metabolic syndrome (MetS). METHODS:A total of 36 h...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,随机对照试验
doi:10.1089/met.2018.0129
更新日期:2019-04-01 00:00:00
abstract:: Background: It is estimated that >30% of young adults attending college are overweight or obese and do not participate in enough physical activity (PA) to maintain a healthy body mass. Many of the known risk factors that are often associated with obesity also place an indi...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2019.0007
更新日期:2019-11-01 00:00:00
abstract::The successful introduction of highly active antiretroviral therapy (HAART), a combination of potent antiretroviral agents, including protease inhibitors, nucleoside reverse transcriptase inhibitors, and nonnucleoside reverse transcriptase inhibitors, has impacted positively on morbidity and mortality among human immu...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2008.0096
更新日期:2009-10-01 00:00:00
abstract::In this communication we discuss the role of the gut for the development of type 2 diabetes mellitus (T2DM). Gastric emptying rates importantly determine postprandial glucose excursions and regulate postprandial secretion of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like p...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2017.0015
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Obesity and metabolic syndrome (MetS) are increasing rapidly worldwide, but metabolically healthy population exists. Thus, this study evaluated the proportion of obesity and MetS and investigated clinical and body compositional factors associated with MetS in obese Koreans. METHODS:This cross-sectional obse...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2017.0174
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:The association of the rs738409 polymorphism of patatin-like phospholipase-3 (PNPLA3) with nonalcoholic fatty liver disease (NAFLD) has been suggested in other populations, but not in Asian Indians. We investigated the association of the rs738409 polymorphism of PNPLA3 with clinical, anthropometric, and bioc...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2012.0064
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome is prevalent in adults characterized by increased visceral adiposity and insulin resistance (IR). However, the link between pancreatic β-cell function and metabolic syndrome severity in adults across the glucose spectrum is unknown. We hypothesized that poor β-cell function would independe...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0083
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:The present study was conducted to assess the relationship between metabolic syndrome and systolic inter-arm blood pressure difference (sIAD) in Korean adults. METHODS:This study included 410 adults (235 males, 175 females) who were over 30 years old and had undergone a health check from July to December in...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2015.0031
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess clinical and inflammatory markers in nonalcoholic fatty liver disease (NAFLD) in postmenopausal women with metabolic syndrome. METHODS:This cross-sectional study included 180 Brazilian women (age ≥45 years and amenorrhea ≥12 months). Metabolic syndrome was diagnosed by th...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0140
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:We evaluated structural microvascular alterations in the skeletal muscle and left ventricle, as well as endothelium-dependent microvascular reactivity in the skeletal muscle, of diabetic rats subjected to long-term aerobic exercise training. METHODS:Diabetes was experimentally induced by a combination of a ...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2015.0146
更新日期:2016-08-01 00:00:00
abstract:AIM:This study was designed to evaluate carotid intima media thickness (CIMT) and serum osteoprotegerin (OPG) levels in nonalcoholic fatty liver disease (NAFLD) in comparison to healthy controls and to investigate factors predicting the CIMT increase. MATERIALS AND METHODS:A total of 60 outpatients [median (min-max) a...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0151
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:We compared the lipid-altering effects of ezetimibe/simvastatin (EZE/SIMVA) co-administered with fenofibrate (FENO) in mixed hyperlipidemic patients with (MetS) versus those without MetS. METHODS:A total of 611 patients, 20 to 79 years old, with LDL-C 130-220 mg/dL (100-180 mg/dL for patients with type 2 di...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2007.0011
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome (MetSyn) magnifies risks of cardiovascular disease (CVD) and type 2 diabetes, but its expression varies within the obese population. We examined body mass index (BMI), metabolic traits, and fat distribution in morbidly obese individuals. METHODS:Lipids and inflammatory, oxidative stress a...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2016.0062
更新日期:2016-12-01 00:00:00
abstract:AIM:This study aimed to develop age- and sex-specific reference values for body mass index (BMI), percentage body fat (%BF), waist circumference, waist-to-hip circumference ratio, and triceps and subscapular skinfold thicknesses for 14- to 18-year-old urban Asian Indians and to develop BMI cut-off points using specific...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2008.0053
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:We undertook a study to assess β-cell function, metabolic and immunological features of patients with latent autoimmune diabetes in adults (LADA) and investigate heterogeneity within LADA based on low and high glutamic acid decarboxylase autoantibodies (GADA) titers. METHODS:A total of 139 patients with adu...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2017.0103
更新日期:2017-12-01 00:00:00
abstract:: Background: In patients with diabetes mellitus, the serum uric acid (UA) to creatinine (Cr) ratio (UA/Cr) has been reported to be associated with a higher risk of metabolic syndrome (MetS). In healthy subjects, however, this relationship and a possible association with pat...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2019.0024
更新日期:2019-09-01 00:00:00
abstract::To examine the influence of moderate-intensity (50% of VO(2peak)) exercise training (MI) versus high-intensity (75% of VO(2peak)) exercise training (HI) on regional fat distribution and plasma adiponectin, we randomized 18 overweight (body mass index [BMI] = 30 +/- 1 kg/m(2)) elderly (71 +/- 1 years) to HI, MI, or a c...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,随机对照试验
doi:10.1089/met.2008.0060
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Resistin is a peptide hormone secreted mainly from human monocytes and macrophages. It has an unclear association with the metabolic syndrome, which is a cluster of cardiovascular risk factors such as glucose intolerance, central obesity, insulin resistance, dyslipidemia, and hypertension. We examined the as...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2010.0106
更新日期:2011-06-01 00:00:00
abstract::The concept of the "Calorie" originated in the 1800 s in an environment with limited food availability, primarily as a means to define economic equivalencies in the energy density of food substrates. Soon thereafter, the energy densities of the major macronutrients-fat, protein, and carbohydrates-were defined. However...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2014.0027
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:The aim of this study was to discover the association of serum high-sensitivity C-reactive protein (hsCRP) with various risk factors for metabolic syndrome in an urban population of Karachi, Pakistan. METHOD:In this cross-sectional study, 337 healthy adults (108 males and 229 females, mean age 40.7 ± 14.2 y...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2010.0113
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome is increasingly common in U.S. adolescents and has been linked to cognitive dysfunction. Purpose of this study is to explore associations between metabolic syndrome and cognitive impairment in U.S. adolescents using population-based data. STUDY DESIGN:Participants included adolescents age...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2016.0015
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess prevalence of metabolic syndrome and its components according to different criteria in the population of bank employees in St. Petersburg, Russia. METHODS:A total of 1,600 office workers were screened at their working places from the Sberbank state bank in St. Petersburg....
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2011.0028
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:This study investigates ethnic disparities in metabolic syndrome in Malaysia. METHODS:Data were obtained from the Malaysia Non-Communicable Disease Surveillance-1 (2005/2006). Logistic regressions of metabolic syndrome health risks on sociodemographic and health-lifestyle factors were conducted using a mult...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2011.0031
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Patients with insulin resistance (IR) have a higher prevalence of thyroid nodules. In the present study, we present original data showing that patients with differentiated thyroid carcinoma (DTC) also have a higher frequency of IR. METHODS:Twenty women with DTC (group 1, G1) and 20 euthyroid individuals (co...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2008.0062
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:Obesity and high body fat are related to diabetes and metabolic syndrome (MetS) in all ethnic groups. Based on the International Diabetes Federation (IDF) definition of MetS, the aim of the present study was to compare body adiposity indexes (BAIs) and to assess their various cutoff values for the prediction of...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2017.0016
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Variants in the fat mass and obesity-associated (FTO) gene are associated with obesity and type 2 diabetes mellitus. AIM OF THE STUDY:This study aims to assess the association of the rs9939609 variant and haplotypes in FTO gene with metabolic syndrome (MetS) components in a Tunisian population sample. METH...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2015.0090
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein secreted by immune cells, endothelial cells, vascular smooth muscle cells, and adipocytes. Recent studies indicate that Gas6 and receptors of the TAM (Tyro3, Axl, and Mer) family may be involved in the pathogenesis of obesity, systemic inflamma...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2017.0143
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:The aim of this was to study the prevalence of diabetes in the rural adult population of Haryana, India. RESEARCH DESIGN AND METHODS:A total of 2606 adults aged ≥ 18 years were randomly selected from two rural blocks of Haryana State. Those without diabetes were subjected to a 75-gram oral glucose tolerance ...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2012.0067
更新日期:2012-12-01 00:00:00
abstract::Omega-3s are found in oily fish. We have drastically reduced our intake of fish during the last century. Many of us therefore suffer from a deficiency of omega-3s, which has consequences for health. In this review, we focus on structure-functional relationships and the relation of omega-3s to the metabolic syndrome, i...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2006.4.138
更新日期:2006-07-01 00:00:00