Abstract:
:Type 2 diabetes mellitus (T2DM) and prediabetes (or patients at risk for diabetes) have been increasing in epidemic proportions. Dyslipidemia and hypertension are cardiovascular risk factors frequently associated with diabetes and prediabetes. Bile acid sequestrants (BAS) were initially approved for the treatment of elevated low-density lipoprotein cholesterol (LDL-C), but they were subsequently found to have a glucose-lowering effect as well. Colesevelam hydrochloride (HCl), a BAS, has been approved as an adjunct to diet and exercise to improve glycemic control in adults with T2DM based on several studies that used it as an addition to sulfonylurea-based, metformin-based, and insulin-based therapies. Colesevelam HCl has not been approved for use for glycemic control in type 1 diabetes or for treating diabetic ketoacidosis and has not been studied in T2DM as monotherapy or in combination with dipeptidyl peptidase 4 inhibitors, or extensively with thiazolidinediones. A recent study has examined the combination of colesevelam HCl and metformin as an initial therapy for treatment-naïve patients with T2DM. Another recent study, which looked at colesevelam for the treatment of dyslipidemia of prediabetes, raised the possibility of the use of colesevelam therapy for both dyslipidemia and hyperglycemia of T2DM. This article reviews and summarizes the recent clinical studies regarding colesevelam as therapy for both diabetes and dyslipidemia. This dual mechanism of action is an attractive feature for the treatment of diabetes.
journal_name
Metab Syndr Relat Disordjournal_title
Metabolic syndrome and related disordersauthors
Levy Pdoi
10.1089/met.2010.0087subject
Has Abstractpub_date
2010-12-01 00:00:00pages
S9-13eissn
1540-4196issn
1557-8518journal_volume
8 Suppl 1pub_type
杂志文章,评审abstract:BACKGROUND:Health care costs increase with the presence of metabolic syndrome and present a significant burden to companies throughout the world. Identifying effective behavioral programs within the workplace can reduce health care costs. We examined the effect of a voluntary worksite program on weight loss and metabol...
journal_title:Metabolic syndrome and related disorders
pub_type: 临床试验,杂志文章
doi:10.1089/met.2015.0075
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is a major risk factor for type 2 diabetes, cardiovascular disease, and liver failure. Treatment with n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) produced variable success in improving NAFLD. The purpose of this review is to determine if n-3 LCPUFA will d...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2016.0051
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Multiple abnormal metabolic traits are found together or "cluster" within individuals more often than is predicted by chance. The individual and combined role of adiposity and insulin resistance (IR) on metabolic trait clustering is uncertain. We tested the hypothesis that change in trait clustering is a fun...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0148
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:A potentially atherogenic lipid profile often found in patients with type 2 diabetes mellitus (T2DM) includes increased concentrations of small, low-density lipoprotein (LDL) and intermediate-density lipoprotein (IDL) and decreased concentration of medium/large high-density lipoprotein (HDL) particles. Exten...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1089/met.2012.0005
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:Obesity and high body fat are related to diabetes and metabolic syndrome (MetS) in all ethnic groups. Based on the International Diabetes Federation (IDF) definition of MetS, the aim of the present study was to compare body adiposity indexes (BAIs) and to assess their various cutoff values for the prediction of...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2017.0016
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Previous reports showed a high prevalence of obesity, diabetes, hypertension, and dyslipidemia among people suffering from posttraumatic stress disorder (PTSD). However, there is a lack of reviews that systematically analyze the relationship between PTSD and metabolic syndrome. We conducted a systematic revi...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1089/met.2013.0010
更新日期:2013-10-01 00:00:00
abstract:: Background: Glycated hemoglobin (HbA1c) is an index of the average blood glucose level over the preceding 2-3 months. In experimental studies, the lens responded to changes in osmolarity by forming vacuoles. By observing the vacuoles of the lens during eye examination, can...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2018.0076
更新日期:2018-12-01 00:00:00
abstract::The successful introduction of highly active antiretroviral therapy (HAART), a combination of potent antiretroviral agents, including protease inhibitors, nucleoside reverse transcriptase inhibitors, and nonnucleoside reverse transcriptase inhibitors, has impacted positively on morbidity and mortality among human immu...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2008.0096
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome is increasingly common in U.S. adolescents and has been linked to cognitive dysfunction. Purpose of this study is to explore associations between metabolic syndrome and cognitive impairment in U.S. adolescents using population-based data. STUDY DESIGN:Participants included adolescents age...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2016.0015
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Postprandial hypertrygliceridemia is a known factor for cardiovascular disease and is often observed in patients with type 2 diabetes mellitus (T2DM) and visceral adiposity. Adiponectin is a hormone with antiatherogenic and anti-inflammatory effects, which decreases in obesity and T2DM subjects. The weight l...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2012.0042
更新日期:2013-10-01 00:00:00
abstract::Over the past two decades, there has been a striking increase in the number of people with metabolic syndrome. The prevalence of metabolic syndrome varies due to lack of an internationally agreed upon definition. Considering the increased cardiovascular risk among Asian people, a lower cutoff for waist circumference i...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2008.0005
更新日期:2008-09-01 00:00:00
abstract::Omega-3s are found in oily fish. We have drastically reduced our intake of fish during the last century. Many of us therefore suffer from a deficiency of omega-3s, which has consequences for health. In this review, we focus on structure-functional relationships and the relation of omega-3s to the metabolic syndrome, i...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2006.4.138
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Patients with insulin resistance (IR) have a higher prevalence of thyroid nodules. In the present study, we present original data showing that patients with differentiated thyroid carcinoma (DTC) also have a higher frequency of IR. METHODS:Twenty women with DTC (group 1, G1) and 20 euthyroid individuals (co...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2008.0062
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:This study investigates ethnic disparities in metabolic syndrome in Malaysia. METHODS:Data were obtained from the Malaysia Non-Communicable Disease Surveillance-1 (2005/2006). Logistic regressions of metabolic syndrome health risks on sociodemographic and health-lifestyle factors were conducted using a mult...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2011.0031
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Currently, guidelines for obesity thresholds relating to metabolic risk in South African women have not been established. Therefore, the aim of the study was to investigate the level and diagnostic ability of obesity measures [waist circumference (WC), waist-to-height ratio (WHtR), and visceral adipose tissu...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2011.0034
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome (MetSyn) magnifies risks of cardiovascular disease (CVD) and type 2 diabetes, but its expression varies within the obese population. We examined body mass index (BMI), metabolic traits, and fat distribution in morbidly obese individuals. METHODS:Lipids and inflammatory, oxidative stress a...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2016.0062
更新日期:2016-12-01 00:00:00
abstract::Even though insulin resistance, cardiovascular disease (CVD), and type 2 diabetes (T2D) are associated with hypertriglyceridemia, blacks with these conditions usually have normal triglyceride (TG) levels. This is often called a lipid paradox. More precisely, it is a "TG paradox." The pathways that lead to hypertriglyc...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2011.0108
更新日期:2012-04-01 00:00:00
abstract:: Background: Although metabolic syndrome (MetS) was described in the late 80s, the molecular mechanisms underlying clustering of risk factors in certain individuals are not fully understood. The present study used targeted proteomics to establish cardiometabolic proteins re...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2018.0123
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Concomitant supplementation of 1.5% docosahexaenoic acid (22:6 n-3; DHA) with 0.5% t10, c12-conjugated linoleic acid (18:2 n-6; CLA) prevented the CLA-induced increase in expression of hepatic genes involved in fatty acid synthesis and the decrease in expression of genes involved in fatty acid oxidation. The...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2012.0116
更新日期:2013-02-01 00:00:00
abstract:: Background: Diabetes mellitus (DM) is associated with a higher prevalence of metabolic syndrome (MS) and cardiovascular mortality. However, few Brazilian studies evaluated MS in diabetic individuals with cardiovascular disease (CVD). Nevertheless, the objective of this stu...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2020.0064
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:We compared the lipid-altering effects of ezetimibe/simvastatin (EZE/SIMVA) co-administered with fenofibrate (FENO) in mixed hyperlipidemic patients with (MetS) versus those without MetS. METHODS:A total of 611 patients, 20 to 79 years old, with LDL-C 130-220 mg/dL (100-180 mg/dL for patients with type 2 di...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2007.0011
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Patients with morbid obesity have a high risk of developing type 2 diabetes mellitus (T2DM). Important risk factors include body mass index (BMI), waist circumference, and insulin resistance. In this prospective study, we investigated if preoperative lifestyle changes followed by bariatric surgery could redu...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0085
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:We undertook a study to assess β-cell function, metabolic and immunological features of patients with latent autoimmune diabetes in adults (LADA) and investigate heterogeneity within LADA based on low and high glutamic acid decarboxylase autoantibodies (GADA) titers. METHODS:A total of 139 patients with adu...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2017.0103
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome is one of the most important health issues worldwide. Obesity causes insulin resistance, hyperlipidemia, diabetes, and various diseases throughout the body. The liver phenotype, which is called nonalcoholic steatohepatitis (NASH), frequently progresses to hepatocellular carcinoma. We recen...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2016.0114
更新日期:2017-05-01 00:00:00
abstract:: Background: In patients with diabetes mellitus, the serum uric acid (UA) to creatinine (Cr) ratio (UA/Cr) has been reported to be associated with a higher risk of metabolic syndrome (MetS). In healthy subjects, however, this relationship and a possible association with pat...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2019.0024
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Obesity and metabolic syndrome are significant global health issues, with current public health messages predominately focused on altering dietary and physical activity behaviors. Resveratrol is a polyphenol (stilbenoid) commonly found in grapes, and human trials to date have shown conflicting and limited be...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2016.0035
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein secreted by immune cells, endothelial cells, vascular smooth muscle cells, and adipocytes. Recent studies indicate that Gas6 and receptors of the TAM (Tyro3, Axl, and Mer) family may be involved in the pathogenesis of obesity, systemic inflamma...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2017.0143
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:We evaluated structural microvascular alterations in the skeletal muscle and left ventricle, as well as endothelium-dependent microvascular reactivity in the skeletal muscle, of diabetic rats subjected to long-term aerobic exercise training. METHODS:Diabetes was experimentally induced by a combination of a ...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2015.0146
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Isolated postchallenge hyperglycemia (IPH) is an early form of type 2 diabetes with fasting glucose <126 mg/dL and 2-hr postchallenge glucose ≥200 mg/dL. The purpose of this study was to explore the relationships of high-sensitivity C-reactive protein (hsCRP) with IPH. METHODS:We recruited 476 naturally pos...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2015.0118
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess prevalence of metabolic syndrome and its components according to different criteria in the population of bank employees in St. Petersburg, Russia. METHODS:A total of 1,600 office workers were screened at their working places from the Sberbank state bank in St. Petersburg....
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2011.0028
更新日期:2011-10-01 00:00:00