Abstract:
BACKGROUND:Isolated postchallenge hyperglycemia (IPH) is an early form of type 2 diabetes with fasting glucose <126 mg/dL and 2-hr postchallenge glucose ≥200 mg/dL. The purpose of this study was to explore the relationships of high-sensitivity C-reactive protein (hsCRP) with IPH. METHODS:We recruited 476 naturally postmenopausal women without a history of diabetes mellitus for the study. Fasting blood samples were collected for the measurements of hsCRP and biochemistry. All participants received a 75 g oral glucose tolerance test to examine if they had IPH. The relative contributions of body mass index (BMI) and homeostasis model assessment of insulin resistance (HOMA-IR) to the association of hsCRP with IPH were evaluated by logistic regression. RESULTS:There was an increasing trend in prevalence of IPH with increasing quartiles of hsCRP (2.9%, 3.6%, 5.9%, and 7.6% in quartile 1-4, respectively) (P = 0.001). BMI and HOMA-IR were the most important determinants of hsCRP in this cohort. We observed a significant and positive association between high hsCRP levels and IPH in our subjects. Compared with subjects in the lowest quartile group, individuals with high levels of hsCRP (the 3rd and the 4th quartiles) were 2-2.5 times more likely associated with IPH, before and after adjustments for BMI and HOMA-IR values (all P < 0.05). CONCLUSION:Our results demonstrated that chronic inflammation, measured by elevated serum hsCRP levels, was positively associated with IPH in postmenopausal women. This finding was independent of obesity and insulin resistance.
journal_name
Metab Syndr Relat Disordjournal_title
Metabolic syndrome and related disordersauthors
Hwu CM,Lin YC,Lin MWdoi
10.1089/met.2015.0118subject
Has Abstractpub_date
2016-09-01 00:00:00pages
334-9issue
7eissn
1540-4196issn
1557-8518journal_volume
14pub_type
杂志文章abstract:BACKGROUND:The aim of the study was to evaluate the relative importance of the determinants of the metabolic syndrome in a sample with metabolic syndrome from the Greek population. METHODS:A random sample of 824 male (56 ± 11 years) and 1,199 female (58 ± 10 years) subjects with metabolic syndrome [National Cholestero...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2010.0023
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate insulin sensitivity and secretion in lean and obese Asian (Thai) type 2 diabetic patients. METHODS:Insulin sensitivity and insulin secretion was assessed with the hyperinsulinemic euglycemic (80 mU/m(2) per min) and hyperglycemic clamp technique in 9 lean and 10 obes...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2009.0030
更新日期:2010-04-01 00:00:00
abstract:: Background: Few studies have compared the local and international body mass index (BMI) reference sets for their relationship with metabolic syndrome (MetS) in children. This study aimed to compare the BMI percentiles using Korean, United States Centers for Disease Control...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2018.0126
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:The relationship between the metabolic syndrome and subclinical atherosclerosis among elderly people remains controversial. We seek to investigate the associations of metabolic syndrome and its components with subclinical carotid atherosclerosis in older people living in rural China. METHODS:This cross-sect...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0135
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess clinical and inflammatory markers in nonalcoholic fatty liver disease (NAFLD) in postmenopausal women with metabolic syndrome. METHODS:This cross-sectional study included 180 Brazilian women (age ≥45 years and amenorrhea ≥12 months). Metabolic syndrome was diagnosed by th...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0140
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:The aim of this study was to compare the prevalence of metabolic syndrome in human immunodeficiency virus (HIV)-infected patients treated with highly active antiretroviral therapy (HAART), using the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), European Group for the Study ...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2010.0129
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Previous reports showed a high prevalence of obesity, diabetes, hypertension, and dyslipidemia among people suffering from posttraumatic stress disorder (PTSD). However, there is a lack of reviews that systematically analyze the relationship between PTSD and metabolic syndrome. We conducted a systematic revi...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1089/met.2013.0010
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Obesity and metabolic syndrome (MetS) are increasing rapidly worldwide, but metabolically healthy population exists. Thus, this study evaluated the proportion of obesity and MetS and investigated clinical and body compositional factors associated with MetS in obese Koreans. METHODS:This cross-sectional obse...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2017.0174
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Multiple abnormal metabolic traits are found together or "cluster" within individuals more often than is predicted by chance. The individual and combined role of adiposity and insulin resistance (IR) on metabolic trait clustering is uncertain. We tested the hypothesis that change in trait clustering is a fun...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0148
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Resistin is a peptide hormone secreted mainly from human monocytes and macrophages. It has an unclear association with the metabolic syndrome, which is a cluster of cardiovascular risk factors such as glucose intolerance, central obesity, insulin resistance, dyslipidemia, and hypertension. We examined the as...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2010.0106
更新日期:2011-06-01 00:00:00
abstract::The metabolic syndrome (MS) is a clustering of cardiovascular risk factors, with insulin resistance as a major feature. This syndrome has been variously defined, but generally consists of 3 or more of the following components: hyperglycemia, hypertension, hypertriglyceridemia, low HDL, and increased abdominal circumfe...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2004.2.82
更新日期:2004-06-01 00:00:00
abstract:AIM:This study was designed to evaluate carotid intima media thickness (CIMT) and serum osteoprotegerin (OPG) levels in nonalcoholic fatty liver disease (NAFLD) in comparison to healthy controls and to investigate factors predicting the CIMT increase. MATERIALS AND METHODS:A total of 60 outpatients [median (min-max) a...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0151
更新日期:2014-06-01 00:00:00
abstract::Adipose tissue is an endocrine organ that secretes a number of hormones and metabolically active substances that impact energy metabolism and insulin sensitivity. These inflammatory markers are collectively referred to as adipocytokines, or adipokines. Adipose tissue's functional capacity and metabolic activity vary a...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2013.0090
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome (MetSyn) magnifies risks of cardiovascular disease (CVD) and type 2 diabetes, but its expression varies within the obese population. We examined body mass index (BMI), metabolic traits, and fat distribution in morbidly obese individuals. METHODS:Lipids and inflammatory, oxidative stress a...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2016.0062
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Health care costs increase with the presence of metabolic syndrome and present a significant burden to companies throughout the world. Identifying effective behavioral programs within the workplace can reduce health care costs. We examined the effect of a voluntary worksite program on weight loss and metabol...
journal_title:Metabolic syndrome and related disorders
pub_type: 临床试验,杂志文章
doi:10.1089/met.2015.0075
更新日期:2015-11-01 00:00:00
abstract::The successful introduction of highly active antiretroviral therapy (HAART), a combination of potent antiretroviral agents, including protease inhibitors, nucleoside reverse transcriptase inhibitors, and nonnucleoside reverse transcriptase inhibitors, has impacted positively on morbidity and mortality among human immu...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2008.0096
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Concomitant supplementation of 1.5% docosahexaenoic acid (22:6 n-3; DHA) with 0.5% t10, c12-conjugated linoleic acid (18:2 n-6; CLA) prevented the CLA-induced increase in expression of hepatic genes involved in fatty acid synthesis and the decrease in expression of genes involved in fatty acid oxidation. The...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2012.0116
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Currently, guidelines for obesity thresholds relating to metabolic risk in South African women have not been established. Therefore, the aim of the study was to investigate the level and diagnostic ability of obesity measures [waist circumference (WC), waist-to-height ratio (WHtR), and visceral adipose tissu...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2011.0034
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:It has been reported that a continuous intake of a catechin beverage will reduce body fat. Traditionally, improvement of eating and exercise habits has been the basis for prevention and reduction of obesity. In this study, we conducted a trial involving human subjects who ingested a catechin beverage for 1 y...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2008.0061
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:It is unknown whether severe sarcopenia produces unfavorable effects on cardiovascular risk factors. To examine the influence of severe and moderate sarcopenia on selected cardiovascular risk factors, 687 men were screened; those exhibiting clinically relevant diseases and higher body fat percentage (>25% fa...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2012.0057
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:The increased prevalence of overweight and obesity has reached alarming proportions worldwide and has serious health implications, including an association with an increase in metabolic syndrome. Among the methods to control metabolic syndrome, bariatric surgery plays an important role and can provide a sign...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2012.0014
更新日期:2012-08-01 00:00:00
abstract::A 20-year-old woman with epilepsy had resolution of features of polycystic ovary syndrome on discontinuing valproic acid; they reappeared with the newer antiepileptic divalproex sodium. ...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2006.4.215
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:The aim of this study was to study (1) weight gain in type 2 diabetics with different treatment modalities and (2) relationship of weight gain with stable adult weight. METHODS:A study of 469 type 2 diabetics on regular follow-up was undertaken to determine the effect of modality of therapy on patient's wei...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2005.3.130
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Fibronectin type III domain containing 5 (FNDC5) and its protein product Irisin are therapeutic targets for obesity-associated disorders. Irisin plays an important role in energy regulation, inducing browning of white adipocytes, and improving obesity. We aimed to investigate the association between muscle I...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2016.0109
更新日期:2017-05-01 00:00:00
abstract:AIM:This study aimed to develop age- and sex-specific reference values for body mass index (BMI), percentage body fat (%BF), waist circumference, waist-to-hip circumference ratio, and triceps and subscapular skinfold thicknesses for 14- to 18-year-old urban Asian Indians and to develop BMI cut-off points using specific...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2008.0053
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:Patients with metabolic syndrome are at increased risk of atherosclerotic coronary heart disease, often have mixed dyslipidemia, and may thus require more aggressive treatment of multiple lipid parameters. The objective of this investigation was to compare the treatment response of ezetimibe co-administered w...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,随机对照试验
doi:10.1089/met.2010.0068
更新日期:2011-04-01 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is a major form of chronic liver disease in adults and children. It is one of the consequences of the current obesity epidemic, and can progress to nonalcoholic steatohepatitis (NASH), characterized by steatosis, inflammation, and progressive fibrosis, ultimately leading to cir...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2007.0026
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess prevalence of metabolic syndrome and its components according to different criteria in the population of bank employees in St. Petersburg, Russia. METHODS:A total of 1,600 office workers were screened at their working places from the Sberbank state bank in St. Petersburg....
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2011.0028
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Sirtuin (SirT), a family of conserved histone deacetylases and transferases, has been proposed to function in inflammatory, cancer, and metabolic diseases. However, it is unclear how SirT modulates these processes. In this study, the effect of metformin on senescence and antisenescence mediators (SirT1-7, p5...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2014.0168
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Overall hemostatic potential (OHP) captures all factors that affect coagulation and fibrinolysis cascade. It has not yet been assessed in polycystic ovary syndrome (PCOS). The aim of the study was to identify the relationship of OHP with a syndrome per se and body mass index (BMI). METHODS:In 90 women with ...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2016.0148
更新日期:2017-05-01 00:00:00