Abstract:
BACKGROUND:Health care costs increase with the presence of metabolic syndrome and present a significant burden to companies throughout the world. Identifying effective behavioral programs within the workplace can reduce health care costs. We examined the effect of a voluntary worksite program on weight loss and metabolic syndrome. METHODS:Participants (N = 3880, from 93 companies) volunteered within their workplaces to participate in a 10-week weight loss program (Naturally Slim) focused on self-monitoring, eating behaviors, understanding hunger signals, reducing refined carbohydrate and sugar intake, and increasing protein intake to 25%-30%. Primary outcomes included weight loss and metabolic syndrome prevalence. Secondary analyses examined the individual components of metabolic syndrome and a categorical analysis within each World Health Organization body mass index category. RESULTS:Overall, women and men lost 9.4 (-4.8%) and 13.2 pounds (-5.8%), respectively. Each metabolic risk factor for both genders had a significant improvement but men exhibited the largest relative improvement for each risk factor. At baseline, 43% of women and 52% of men presented with metabolic syndrome, which was reduced to 30% in women and 26% in men (P < 0.001 for each) at the conclusion of the program. Secondary analysis demonstrated that individuals with greater baseline levels of metabolic dysfunction had larger metabolic improvements, similar benefits to risk factors across baseline body mass index categories, and the greater the weight loss, the greater the metabolic benefit. CONCLUSION:Our results demonstrate that a worksite program targeting core behavioral skills associated with weight loss is an effective strategy to reduce weight and improve the components of metabolic syndrome amongst at-risk employees.
journal_name
Metab Syndr Relat Disordjournal_title
Metabolic syndrome and related disordersauthors
Earnest CP,Church TSdoi
10.1089/met.2015.0075subject
Has Abstractpub_date
2015-11-01 00:00:00pages
406-14issue
9eissn
1540-4196issn
1557-8518journal_volume
13pub_type
临床试验,杂志文章abstract::We assessed 17 middle-aged and older individuals (58.0 +/- 7.9 years, 7 females) at risk for cardiovascular disease regarding: (1) Whether carotid artery stiffness (cAS) would be reduced with a 1-year lifestyle modification program, (2) to what degree cAS would return following washout (mean of 26.9 +/- 4.0 months) fr...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2009.0099
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:It has been reported that a continuous intake of a catechin beverage will reduce body fat. Traditionally, improvement of eating and exercise habits has been the basis for prevention and reduction of obesity. In this study, we conducted a trial involving human subjects who ingested a catechin beverage for 1 y...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2008.0061
更新日期:2009-08-01 00:00:00
abstract::Even though insulin resistance, cardiovascular disease (CVD), and type 2 diabetes (T2D) are associated with hypertriglyceridemia, blacks with these conditions usually have normal triglyceride (TG) levels. This is often called a lipid paradox. More precisely, it is a "TG paradox." The pathways that lead to hypertriglyc...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2011.0108
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:The aim of this was to study the prevalence of diabetes in the rural adult population of Haryana, India. RESEARCH DESIGN AND METHODS:A total of 2606 adults aged ≥ 18 years were randomly selected from two rural blocks of Haryana State. Those without diabetes were subjected to a 75-gram oral glucose tolerance ...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2012.0067
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:A clustering of metabolic risk factors increases the likelihood of cardiovascular diseases. This study reports the metabolic risk profiles and the prevalence of metabolic risk factors and associated factors among Vietnamese adults in Ho Chi Minh City. METHODS:A cross-sectional study was carried out in a rep...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2009.0018
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:The use of chromium-containing dietary supplements is widespread among patients with type 2 diabetes. Chromium's effects in patients at high risk for developing diabetes, especially those with metabolic syndrome, is unknown. The objective of this study was to determine the effects of chromium picolinate (CrP...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,随机对照试验
doi:10.1089/met.2008.0048
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Overall hemostatic potential (OHP) captures all factors that affect coagulation and fibrinolysis cascade. It has not yet been assessed in polycystic ovary syndrome (PCOS). The aim of the study was to identify the relationship of OHP with a syndrome per se and body mass index (BMI). METHODS:In 90 women with ...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2016.0148
更新日期:2017-05-01 00:00:00
abstract:: Background: Glycated hemoglobin (HbA1c) is an index of the average blood glucose level over the preceding 2-3 months. In experimental studies, the lens responded to changes in osmolarity by forming vacuoles. By observing the vacuoles of the lens during eye examination, can...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2018.0076
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:It is unknown whether severe sarcopenia produces unfavorable effects on cardiovascular risk factors. To examine the influence of severe and moderate sarcopenia on selected cardiovascular risk factors, 687 men were screened; those exhibiting clinically relevant diseases and higher body fat percentage (>25% fa...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2012.0057
更新日期:2012-12-01 00:00:00
abstract::The successful introduction of highly active antiretroviral therapy (HAART), a combination of potent antiretroviral agents, including protease inhibitors, nucleoside reverse transcriptase inhibitors, and nonnucleoside reverse transcriptase inhibitors, has impacted positively on morbidity and mortality among human immu...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2008.0096
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Previous reports showed a high prevalence of obesity, diabetes, hypertension, and dyslipidemia among people suffering from posttraumatic stress disorder (PTSD). However, there is a lack of reviews that systematically analyze the relationship between PTSD and metabolic syndrome. We conducted a systematic revi...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1089/met.2013.0010
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:We investigated the effect of short-term telmisartan usage in addition to lifestyle changes such as diet and exercise on insulin resistance, lipid metabolism, and serum adiponectin and tumor necrosis factor-alpha (TNF-α) levels in hypertensive patients with metabolic syndrome (MetS). METHODS:A total of 36 h...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,随机对照试验
doi:10.1089/met.2018.0129
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:In adult studies, obese subjects with nonalcoholic fatty liver disease (NAFLD) have been shown to have poor sperm quality, and lower testosterone and luteinizing hormone levels. The aim of this study was to investigate the pubertal status and gonadal functions in obese boys with NAFLD. MATERIALS AND METHODS...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2018.0050
更新日期:2019-03-01 00:00:00
abstract:: Background: Several studies showed that lipid accumulation in the pancreas (NAFPD: nonalcoholic fatty pancreas disease) may lead to different pancreatic disorders, including beta-cell dysfunction. The role of genetic and environmental factors in pancreatic lipid accumulati...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2020.0038
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Sirtuin (SirT), a family of conserved histone deacetylases and transferases, has been proposed to function in inflammatory, cancer, and metabolic diseases. However, it is unclear how SirT modulates these processes. In this study, the effect of metformin on senescence and antisenescence mediators (SirT1-7, p5...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2014.0168
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is a major risk factor for type 2 diabetes, cardiovascular disease, and liver failure. Treatment with n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) produced variable success in improving NAFLD. The purpose of this review is to determine if n-3 LCPUFA will d...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2016.0051
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:The aim of this study was to compare the prevalence of metabolic syndrome in human immunodeficiency virus (HIV)-infected patients treated with highly active antiretroviral therapy (HAART), using the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), European Group for the Study ...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2010.0129
更新日期:2011-10-01 00:00:00
abstract:: Background: Few studies have compared the local and international body mass index (BMI) reference sets for their relationship with metabolic syndrome (MetS) in children. This study aimed to compare the BMI percentiles using Korean, United States Centers for Disease Control...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2018.0126
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:This study aimed to evaluate the association between decreased estimated glomerular filtration rate (eGFR <60 mL/min/1.73 m2) and metabolic syndrome (MetS) according to muscle mass. METHODS:Body composition was measured in 3351 men and 4394 women aged between 19 and 97 years using the 2010-2011 Korea Nation...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2016.0017
更新日期:2016-10-01 00:00:00
abstract::The metabolic syndrome (MS) is a clustering of cardiovascular risk factors, with insulin resistance as a major feature. This syndrome has been variously defined, but generally consists of 3 or more of the following components: hyperglycemia, hypertension, hypertriglyceridemia, low HDL, and increased abdominal circumfe...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2004.2.82
更新日期:2004-06-01 00:00:00
abstract::For five millennia, diabetes management has focused on controlling blood sugar and efforts to minimize the complications of this disease have depended on normalizing glucose. Since the 1970's, however, a growing awareness of the adverse effect of hypoglycemic agents on cardiac health has led to an increasing focus on ...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2015.29003.swi
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate insulin sensitivity and secretion in lean and obese Asian (Thai) type 2 diabetic patients. METHODS:Insulin sensitivity and insulin secretion was assessed with the hyperinsulinemic euglycemic (80 mU/m(2) per min) and hyperglycemic clamp technique in 9 lean and 10 obes...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2009.0030
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to examine effect modifiers of the relationship between family history of diabetes, a proxy for genetic predisposition, and the metabolic syndrome. METHODS:Subjects were a cross-sectional sample of 205 Mexican-Americans patients of the San Ysidro Health Center in San Diego Coun...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2006.0035
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is strongly associated to oxidative stress, metabolic syndrome, and cardiovascular risk. Hepatocytes overloaded with fatty acids (FA) could generate substances that interfere with endothelial function, providing a potential explanation for this association. We have in...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2010.0140
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:High blood concentrations of inflammatory markers, including white blood cell (WBC) count, are closely related to the metabolic syndrome. Both conditions predict dismal survival. We determined prospective associations between mortality and factors derived by a factor analysis of WBC count and the basic compo...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2012.0100
更新日期:2013-04-01 00:00:00
abstract::Over the past two decades, there has been a striking increase in the number of people with metabolic syndrome. The prevalence of metabolic syndrome varies due to lack of an internationally agreed upon definition. Considering the increased cardiovascular risk among Asian people, a lower cutoff for waist circumference i...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2008.0005
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:The circadian pattern of adipokines is blunted in obese subjects, and we tested the hypothesis that bariatric surgery could normalize the 24-hr pattern of adipokines. Therefore, this study was designed to examine the early impact of the newly designed sleeve gastrectomy with transit bipartition (SGTB) surger...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2015.0051
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome is prevalent in adults characterized by increased visceral adiposity and insulin resistance (IR). However, the link between pancreatic β-cell function and metabolic syndrome severity in adults across the glucose spectrum is unknown. We hypothesized that poor β-cell function would independe...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0083
更新日期:2014-03-01 00:00:00
abstract::Adipose tissue is an endocrine organ that secretes a number of hormones and metabolically active substances that impact energy metabolism and insulin sensitivity. These inflammatory markers are collectively referred to as adipocytokines, or adipokines. Adipose tissue's functional capacity and metabolic activity vary a...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章,评审
doi:10.1089/met.2013.0090
更新日期:2014-02-01 00:00:00
abstract:AIM:This study was designed to evaluate carotid intima media thickness (CIMT) and serum osteoprotegerin (OPG) levels in nonalcoholic fatty liver disease (NAFLD) in comparison to healthy controls and to investigate factors predicting the CIMT increase. MATERIALS AND METHODS:A total of 60 outpatients [median (min-max) a...
journal_title:Metabolic syndrome and related disorders
pub_type: 杂志文章
doi:10.1089/met.2013.0151
更新日期:2014-06-01 00:00:00