Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis.

Abstract:

:Alpinia purpurata or red ginger was studied for its phytochemical constituents as part of our growing interest on Philippine Zingiberaceae plants that may exhibit antimycobacterial activity. The hexane and dichloromethane subextracts of the leaves were fractionated and purified using silica gel chromatography to afford a mixture of C(28)-C(32) fatty alcohols, a 3-methoxyflavone and two steroidal glycosides. The two latter metabolites were spectroscopically identified as kumatakenin (1), sitosteryl-3-O-6-palmitoyl-β-D-glucoside (2) and b-sitosteryl galactoside (3) using ultraviolet (UV), infrared (IR), electron impact mass spectrometer (EIMS) and nuclear magnetic resonance (NMR) experiments, and by comparison with literature data. This study demonstrates for the first time the isolation of these constituents from A. purpurata. In addition to the purported anti-inflammatory activity, its phytomedicinal potential to treat tuberculosis is also described.

journal_name

Pharmacogn Mag

journal_title

Pharmacognosy magazine

authors

Villaflores OB,Macabeo AP,Gehle D,Krohn K,Franzblau SG,Aguinaldo AM

doi

10.4103/0973-1296.71785

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

339-44

issue

24

eissn

0973-1296

issn

0976-4062

journal_volume

6

pub_type

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