Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis.

Abstract:

:Alpinia purpurata or red ginger was studied for its phytochemical constituents as part of our growing interest on Philippine Zingiberaceae plants that may exhibit antimycobacterial activity. The hexane and dichloromethane subextracts of the leaves were fractionated and purified using silica gel chromatography to afford a mixture of C(28)-C(32) fatty alcohols, a 3-methoxyflavone and two steroidal glycosides. The two latter metabolites were spectroscopically identified as kumatakenin (1), sitosteryl-3-O-6-palmitoyl-β-D-glucoside (2) and b-sitosteryl galactoside (3) using ultraviolet (UV), infrared (IR), electron impact mass spectrometer (EIMS) and nuclear magnetic resonance (NMR) experiments, and by comparison with literature data. This study demonstrates for the first time the isolation of these constituents from A. purpurata. In addition to the purported anti-inflammatory activity, its phytomedicinal potential to treat tuberculosis is also described.

journal_name

Pharmacogn Mag

journal_title

Pharmacognosy magazine

authors

Villaflores OB,Macabeo AP,Gehle D,Krohn K,Franzblau SG,Aguinaldo AM

doi

10.4103/0973-1296.71785

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

339-44

issue

24

eissn

0973-1296

issn

0976-4062

journal_volume

6

pub_type

杂志文章
  • Protective effects of bioactive phytochemicals from Mentha piperita with multiple health potentials.

    abstract::Mentha piperita essential oil was bactericidal in order of E. coli> S. aureus > Pseudomonas aeruginosa > S. faecalis > Klebsiella pneumoniae. The oil with total phenolics of 89.43 ± 0.58 µg GAE/mg had 63.82 ± 0.05% DPPH inhibition activity with an IC (50) = 3.9 µg/ml. Lipid peroxidation inhibition was comparable to BH...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.66926

    authors: Sharafi SM,Rasooli I,Owlia P,Taghizadeh M,Astaneh SD

    更新日期:2010-07-01 00:00:00

  • Induction of Apoptosis and Cell Cycle Arrest by Flavokawain C on HT-29 Human Colon Adenocarcinoma via Enhancement of Reactive Oxygen Species Generation, Upregulation of p21, p27, and GADD153, and Inactivation of Inhibitor of Apoptosis Proteins.

    abstract::Chalcones have been shown to exhibit anti-cancer properties by targeting multiple molecular pathways. It was, therefore, of interest to investigate flavokawain C (FKC), a naturally occurring chalcone, which can be isolated from Kava (Piper methysticum Forst) root extract. The aim of this study was to investigate the i...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.210180

    authors: Phang CW,Karsani SA,Abd Malek SN

    更新日期:2017-07-01 00:00:00

  • LC-MS/MS determination and pharmacokinetics study of puerarin and daidzein in rat plasma after oral administration of Gegenqinlian decoction and Radix Puerariae extract.

    abstract:BACKGROUND:Gegenqinlian decoction (GQD) is a famous traditional medicine recipe. It is composed of four herbs including Radix Puerariae (GG), Radix Scutellariae (HQ), Rhizoma Coptidis (HL) and Radix Glycyrrhizae (GC), which is widely used for treating gastro-intestinal disorders in the clinical practice of Traditional ...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.137363

    authors: Zhang Y,Yuan J,Wang Y,Wang Y,An R,Wang X

    更新日期:2014-07-01 00:00:00

  • Effects of Pogostemon cablin Blanco extract on hypoxia induced rabbit cardiomyocyte injury.

    abstract:BACKGROUND:Pogostemonis Herba, the dried aerial part of Pogostemon cablin Blanco, is a well-known materia medica in Asia that is widely used for syndrome of gastrointestinal dysfunctions. OBJECTIVE:This study was undertaken to examine whether Pogostemon cablin extract (PCe) might have any beneficial effect on hypoxia ...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.153084

    authors: Lim CY,Kim BY,Lim SH,Cho SI

    更新日期:2015-04-01 00:00:00

  • Identification and Analysis of Jasmonate Pathway Genes in Coffea canephora (Robusta Coffee) by In Silico Approach.

    abstract:BACKGROUND:Coffea canephora is the commonly cultivated coffee species in the world along with Coffea arabica. Different pests and pathogens affect the production and quality of the coffee. Jasmonic acid (JA) is a plant hormone which plays an important role in plants growth, development, and defense mechanisms, particul...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/pm.pm_518_16

    authors: Bharathi K,Sreenath HL

    更新日期:2017-07-01 00:00:00

  • Toxicological and biochemical studies on Schinus terebinthifolius concerning its curative and hepatoprotective effects against carbon tetrachloride-induced liver injury.

    abstract:BACKGROUND:Recently, many efforts have been made to discover new products of natural origin which can limit the xenobiotic-induced hepatic injury. Carbon tetrachloride (CCl4) is a highly toxic chemical that is widely used to study hepatotoxicity in animal models. OBJECTIVE:The present study was conducted to investigat...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.157705

    authors: Abdou RH,Saleh SY,Khalil WF

    更新日期:2015-05-01 00:00:00

  • Exploring processing adjuvants' influence on traditional Chinese medicine compatibility of Aconiti Radix Cocta and Pinelliae rhizome using rapid resolution liquid chromatography-quadrupole time-of-flight mass spectrometry.

    abstract:BACKGROUND:It is known that when crude Pinelliae rhizome and Pinelliae rhizoma preparatum are combined with Aconiti Radix Cocta respectively, the toxicity of the combination varies. However, the component's transformation between different compatibility have remained unclear. OBJECTIVE:In this paper, a novel approach ...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.141771

    authors: Wang Y,Li Y,Zhang X,Xu Y,Wang H,Zhang Y

    更新日期:2014-10-01 00:00:00

  • Increased acetylcholine esterase activity produced by the administration of an aqueous extract of the seed kernel of Thevetia peruviana and its role on acute and subchronic intoxication in mice.

    abstract:BACKGROUND:The real mechanism for Thevetia peruviana poisoning remains unclear. Cholinergic activity is important for cardiac function regulation, however, the effect of T. peruviana on cholinergic activity is not well-known. OBJECTIVE:To study the effect of the acute administration of an aqueous extract of the seed k...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.127370

    authors: Marroquín-Segura R,Calvillo-Esparza R,Mora-Guevara JL,Tovalín-Ahumada JH,Aguilar-Contreras A,Hernández-Abad VJ

    更新日期:2014-01-01 00:00:00

  • Effects of Aronia melanocarpa Fruit Juice on Isolated Rat Hepatocytes.

    abstract:BACKGROUND:Aronia melanocarpa (Michx.) Elliot fruits are very rich in polyphenols - procyanidins, flavonoids, and phenolic acids. OBJECTIVE:On rat hepatocytes, isolated by two-stepped collagenase perfusion, we investigated the effect of A. melanocarpa fruit juice (AMFJ) in two models of liver toxicity caused by (i) me...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.172967

    authors: Kondeva-Burdina M,Valcheva-Kuzmanova S,Markova T,Mitcheva M,Belcheva A

    更新日期:2015-10-01 00:00:00

  • Chemical composition and antimicrobial activities of the essential oils from three ecotypes of Zataria multiflora.

    abstract:BACKGROUND:Zataria multiflora Boiss. is a traditional and popular spice in Iran. The effects of 3 ecotypes (ECTPs) of Z. multiflora essential oils (EOs) against most common causes of food-borne and nosocomial infections were evaluated. MATERIALS AND METHODS:The antimicrobial activities of the EOs were examined by brot...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.75902

    authors: Zomorodian K,Saharkhiz MJ,Rahimi MJ,Bandegi A,Shekarkhar G,Bandegani A,Pakshir K,Bazargani A

    更新日期:2011-01-01 00:00:00

  • Evaluation of antidiabetic, antioxidant and antiglycating activities of the Eysenhardtia polystachya.

    abstract:BACKGROUND:Many diseases are associated with oxidative stress caused by free radicals. The aim of the present study was to evaluate the antidiabetic, antioxidant and antiglycation properties of Eysenhardtia polystachya (EP) bark methanol-water extract. MATERIALS AND METHODS:: The antioxidant capacities were evaluated ...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.133295

    authors: Gutierrez RM,Baez EG

    更新日期:2014-04-01 00:00:00

  • Neuroprotective activity of the methanolic extract of Lonicera japonica in glutamate-injured primary rat cortical cells.

    abstract:BACKGROUND:We previously reported that the extracts of several Korean medicinal plants showed neuroprotective activity in glutamate-injured primary culutres of rat cortical cells. OBJECTIVE:Among them, the effect of the methanolic extract of Lonicera japonica flower on the glutamate-induced neuronal cell death and its...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.90404

    authors: Weon JB,Yang HJ,Lee B,Yun BR,Ahn JH,Lee HY,Ma CJ

    更新日期:2011-10-01 00:00:00

  • Prim-O-glucosylcimifugin Attenuates Lipopolysaccharideinduced Inflammatory Response in RAW 264.7 Macrophages.

    abstract:BACKGROUND:Radix Saposhnikoviae (RS) exerts anti-inflammatory, analgesic, antipyretic, antioxidation effects and has been used in traditional Chinese medicine to treat common colds, headache, and rheumatoid arthritis. Prim-O-glucosylcimifugin (POG) is the highest content chromone and one of the major active constituent...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/pm.pm_323_16

    authors: Zhou J,Sun YY,Sun MY,Mao WA,Wang L,Zhang J,Zhang H

    更新日期:2017-07-01 00:00:00

  • Antimicrobial activity of Bauhinia tomentosa and Bauhinia vahlii roots.

    abstract::The hexane, ethylacetate and methanol extracts from Bauhinia tomentosa and Bauhinia vahlii roots were tested for their antimicrobial activity against Gram-positive bacteria (four strains), Gram-negative bacteria (three strains) and three fungi strains using microdilution methods, for the determination of minimal inhib...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.66937

    authors: Dugasani S,Balijepalli MK,Tandra S,Pichika MR

    更新日期:2010-07-01 00:00:00

  • Nanostructured Lipid Carriers Loaded with Baicalin: An Efficient Carrier for Enhanced Antidiabetic Effects.

    abstract:CONTEXT:Recent studies have demonstrated that baicalin has antihyperglycemic effects by inhibiting lipid peroxidation. Baicalin is low hydrophilic and poorly absorbed after oral administration. Thus, a suitable formulation is highly desired to overcome the disadvantages of baicalin. OBJECTIVE:The objective of this wor...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.186347

    authors: Shi F,Wei Z,Zhao Y,Xu X

    更新日期:2016-07-01 00:00:00

  • Pyrostegia venusta (Ker Gawl.) Miers Crude Extract and Fractions: Prevention of Dental Biofilm Formation and Immunomodulatory Capacity.

    abstract:BACKGROUND:Caries and periodontal diseases remain as important diseases in the Brazilian population. One important pathogen associated with this situation is Streptococcus mutans and other important factor is this pathogen's ability to adhere firmly to the tooth surface leading to dental biofilm formation and caries de...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.182150

    authors: de Sousa MB,Júnior JO,Barbosa WL,da Silva Valério E,da Mata Lima A,de Araújo MH,Muzitano MF,Nakamura CV,de Mello JC,Teixeira FM

    更新日期:2016-05-01 00:00:00

  • Rapid Screening and Characterization of Acetylcholinesterase Inhibitors from Yinhuang Oral Liquid Using Ultrafiltration-liquid Chromatography-electrospray Ionization Tandem Mass Spectrometry.

    abstract:Background:At present, approximately 17-25 million people in the world suffer from Alzheimer's disease (AD). The most efficacious and acceptable therapeutic drug clinically are the acetylcholinesterase inhibitors (AChEIs). Yinhuang oral liquid is a Chinese medicine preparation which contains AChEIs according to the lit...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/pm.pm_166_17

    authors: Zhang H,Guo Y,Meng L,Sun H,Yang Y,Gao Y,Sun J

    更新日期:2018-04-01 00:00:00

  • Optimization of Ultrasound-assisted extraction of polyphenols, tannins and epigallocatechin gallate from barks of Stryphnodendron adstringens (Mart.) Coville bark extracts.

    abstract:BACKGROUND:Stryphnodendron adstringens (Mar.) Coville is a native plant from Brazil, rich in phenolic compounds and used on popular medicine as a wound healing agent, in the treatment of gastric lesions and as antimicrobial. MATERIALS AND METHODS:Ultrassound-assisted extraction (UAE) was applied to extraction of epiga...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.133287

    authors: Sousa JN,Pedroso NB,Borges LL,Oliveira GA,Paula JR,Conceição EC

    更新日期:2014-04-01 00:00:00

  • Preparation of Sesquiterpenoids from Tussilago farfara L. by High-speed Counter-current Chromatography.

    abstract:BACKGROUND:Sesquiterpenoids, such as tussilagone, has effects of raising blood pressure, antiplatelet aggregation, and anti-inflammation activities, which is regarded as index compound for quality control of Tussilago farfara L. OBJECTIVE:This study was aimed to obtain an effective method for fast isolation of sesquit...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.192196

    authors: Cao K,Xu Y,Zhao TM,Zhang Q

    更新日期:2016-10-01 00:00:00

  • In vitro Anti-Proliferative Effect of Tephrosia purpurea on Human Hepatocellular Carcinoma Cells.

    abstract:BACKGROUND:Tephrosia purpurea is an Indian herb used in traditional medicine to treat various diseases such as jaundice, asthma, liver and urinary disorders. However, the anti-cancer potential of T. purpurea on hepatocellular carcinoma (HCC) is poorly understood. Therefore, this study aims to investigate the anti-cance...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.203981

    authors: Padmapriya R,Gayathri L,Ronsard L,Akbarsha MA,Raveendran R

    更新日期:2017-01-01 00:00:00

  • Immunomodulatory, Cytotoxicity, and Antioxidant Activities of Roots of Ziziphus mauritiana.

    abstract:AIMS:The study is conducted to evaluate the immunomodulatory, cytotoxicity, and antioxidant potential of Ziziphus mauritiana (Rhamnaceae). Phytochemical analysis of Z. mauritiana revealed the presence of alkaloids, anthraquinone glycoside, cardiac glycoside, saponin, tannin, and flavonoids. METHODOLOGY:The cytotoxicit...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/pm.pm_398_16

    authors: Afzal S,Batool M,Ch BA,Ahmad A,Uzair M,Afzal K

    更新日期:2017-07-01 00:00:00

  • Phytoecdysteroids of the East Asian Caryophyllaceae.

    abstract:BACKGROUND:Occurrence of integristerone A (1), 20-hydroxyecdysone (2), ecdysone (3), 2-deoxy-20-hydroxyecdysone (4) has been analyzed in 64 species of the East Asian Caryophyllaceae. MATERIALS AND METHODS:Ecdysteroid content was determinate by high-performance liquid chromatography (HPLC). HPLC with a high-resolution ...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.157746

    authors: Novozhilova E,Rybin V,Gorovoy P,Gavrilenko I,Doudkin R

    更新日期:2015-05-01 00:00:00

  • Species identification of Rhododendron (Ericaceae) using the chloroplast deoxyribonucleic acid PsbA-trnH genetic marker.

    abstract:BACKGROUND:Rhododendron is a group of famous landscape plants with high medicinal value. However, there is no simple or universal manner to discriminate the various species of this group. Deoxyribonucleic acid (DNA) barcoding technique is a new biological tool that can accurately and objectively identify species by usi...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.93311

    authors: Liu Y,Zhang L,Liu Z,Luo K,Chen S,Chen K

    更新日期:2012-01-01 00:00:00

  • 7-hydroxycalamenene Effects on Secreted Aspartic Proteases Activity and Biofilm Formation of Candida spp.

    abstract:BACKGROUND:The 7-hydroxycalamenenene-rich essential oil (EO) obtained from the leaves of Croton cajucara (red morphotype) have been described as active against bacteria, protozoa, and fungi species. In this work, we aimed to evaluate the effectiveness of 7-hydroxycalamenenene against Candida albicans and nonalbicans sp...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.176022

    authors: Azevedo MM,Almeida CA,Chaves FC,Rodrigues IA,Bizzo HR,Alviano CS,Alviano DS

    更新日期:2016-01-01 00:00:00

  • In vitro α-amylase and α-glucosidase inhibitory effects and cytotoxic activity of Albizia antunesiana extracts.

    abstract:CONTEXT:Diabetes mellitus is a chronic disease, and its incidence is tremendously increasing globally. Decreasing postprandial hyperglycemia by retarding glucose absorption through inhibiting carbohydrates digesting enzymes (α-amylase and α-glucosidase) is one of many approaches used for the management of this disease....

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.166018

    authors: Chipiti T,Ibrahim MA,Singh M,Islam MS

    更新日期:2015-10-01 00:00:00

  • Chemical Composition of Moringa oleifera Ethyl Acetate Fraction and Its Biological Activity in Diabetic Human Dermal Fibroblasts.

    abstract:Background:Moringa oleifera (MO), commonly known as the drumstick tree, is used in folklore medicine for the treatment of skin disease. Objective:The objective of this study is to evaluate the ethyl acetate (EtOAc) fraction of MO leaves for in vitro antibacterial, antioxidant, and wound healing activities and conduct ...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/pm.pm_368_16

    authors: Gothai S,Muniandy K,Zarin MA,Sean TW,Kumar SS,Munusamy MA,Fakurazi S,Arulselvan P

    更新日期:2017-10-01 00:00:00

  • A Comprehensive Study on Fast Dispersible and Slow-Releasing Characteristic of Orange Peel Pectin in Relation to Established Synthetic Polymer.

    abstract:Introduction:In the present work, the method to extract, isolate, and characterize orange peel pectin using soxhlation, and thereafter, the use of this polymer-polymer in the formulation of fast dispersable and slow-releasing tablet has been studied. Thereafter, the evaluation and comparison of fast dispersible/slow-re...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/pm.pm_193_17

    authors: Srivastava P,Singh M,Bhargava S

    更新日期:2017-10-01 00:00:00

  • Determination of oleanolic acid and ursolic acid in Chinese medicinal plants using HPLC with PAH polymeric C18.

    abstract:BACKGROUND:The RP-HPLC resolution of two triterpenic acid isomers was unstable. OBJECTIVE:To separate the oleanolic acid (OA) and ursolic acid (UA) simply within RP-HPLC. MATERIALS AND METHODS:The separation ability of five stationary phases was studied with the retention effect of their carbon loads. Also the resolu...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.117853

    authors: Zhang Y,Xue K,Zhao EY,Li Y,Yao L,Yang X,Xie X

    更新日期:2013-10-01 00:00:00

  • Anticancer potential of Conium maculatum extract against cancer cells in vitro: Drug-DNA interaction and its ability to induce apoptosis through ROS generation.

    abstract:OBJECTIVE:Conium maculatum extract is used as a traditional medicine for cervix carcinoma including homeopathy. However, no systematic work has so far been carried out to test its anti-cancer potential against cervix cancer cells in vitro. Thus, in this study, we investigated whether ethanolic extract of conium is capa...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.139792

    authors: Mondal J,Panigrahi AK,Khuda-Bukhsh AR

    更新日期:2014-08-01 00:00:00

  • Microwave-assisted extraction of polysaccharides from Yupingfeng powder and their antioxidant activity.

    abstract:BACKGROUND:Microwave-assisted reflux extraction of polysaccharides YPF-P from the famous Chinese traditional drug, Yupingfeng powder, optimization of extracting conditions and evaluation of their antioxidant activity were conducted in this study. RESULTS:Single factor effect trends were achieved through yields and con...

    journal_title:Pharmacognosy magazine

    pub_type: 杂志文章

    doi:10.4103/0973-1296.160468

    authors: Wang D,Zhang BB,Qu XX,Gao F,Yuan MY

    更新日期:2015-07-01 00:00:00