Abstract:
BACKGROUND:We previously reported that the extracts of several Korean medicinal plants showed neuroprotective activity in glutamate-injured primary culutres of rat cortical cells. OBJECTIVE:Among them, the effect of the methanolic extract of Lonicera japonica flower on the glutamate-induced neuronal cell death and its potential mechanism of action was investigated. RESULTS:Treatment by the methanolic extract of L. japonica flower significantly protected neuronal cells against glutamate-induced excitotoxicity. It decreased the calcium influx that accompanies the glutamate induced excitotoxicity of neuronal cells, and inhibited the subsequent overproduction of nitric oxide, reactive oxygen species and peroxide to the level of control cells. In addition, it preserved cellular activity of superoxide dismutase, an antioxidative enzyme reduced by glutamate insult. CONCLUSIONS:According to this data, the methanolic extract of L. japonica flower significantly protected neuronal cells against glutamate excitotoxicity via antioxidative activity.
journal_name
Pharmacogn Magjournal_title
Pharmacognosy magazineauthors
Weon JB,Yang HJ,Lee B,Yun BR,Ahn JH,Lee HY,Ma CJdoi
10.4103/0973-1296.90404subject
Has Abstractpub_date
2011-10-01 00:00:00pages
284-8issue
28eissn
0973-1296issn
0976-4062pii
PM-7-284journal_volume
7pub_type
杂志文章abstract:Objective:Wine grape sap or bleeding sap of grapes (GBS) is commonly used in Xinjiang (China) for therapeutic aims. Do variations in composition related to region and variety affect its properties? Methods:GBS samples originating in various parts of Xinjiang (Turpan, Hotan, Kashgar, and Atush) were tested for phenols ...
journal_title:Pharmacognosy magazine
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journal_title:Pharmacognosy magazine
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journal_title:Pharmacognosy magazine
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journal_title:Pharmacognosy magazine
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journal_title:Pharmacognosy magazine
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更新日期:2016-01-01 00:00:00
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更新日期:2014-08-01 00:00:00
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