Neuroprotective activity of the methanolic extract of Lonicera japonica in glutamate-injured primary rat cortical cells.

Abstract:

BACKGROUND:We previously reported that the extracts of several Korean medicinal plants showed neuroprotective activity in glutamate-injured primary culutres of rat cortical cells. OBJECTIVE:Among them, the effect of the methanolic extract of Lonicera japonica flower on the glutamate-induced neuronal cell death and its potential mechanism of action was investigated. RESULTS:Treatment by the methanolic extract of L. japonica flower significantly protected neuronal cells against glutamate-induced excitotoxicity. It decreased the calcium influx that accompanies the glutamate induced excitotoxicity of neuronal cells, and inhibited the subsequent overproduction of nitric oxide, reactive oxygen species and peroxide to the level of control cells. In addition, it preserved cellular activity of superoxide dismutase, an antioxidative enzyme reduced by glutamate insult. CONCLUSIONS:According to this data, the methanolic extract of L. japonica flower significantly protected neuronal cells against glutamate excitotoxicity via antioxidative activity.

journal_name

Pharmacogn Mag

journal_title

Pharmacognosy magazine

authors

Weon JB,Yang HJ,Lee B,Yun BR,Ahn JH,Lee HY,Ma CJ

doi

10.4103/0973-1296.90404

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

284-8

issue

28

eissn

0973-1296

issn

0976-4062

pii

PM-7-284

journal_volume

7

pub_type

杂志文章