Glucose regulation influences treatment outcome in ranibizumab treatment for diabetic macular edema.

Abstract:

PURPOSE:To evaluate the effect of glucose regulation on intravitreal ranibizumab injection for clinically significant diabetic macular edema (DME). METHODS:This retrospective study enrolled 65 eyes of 65 patients with persistent DME treated with intravitreal ranibizumab injection. The main outcome measures were the change in best corrected visual acuity (BCVA), the central subfield macular thickness (CSMT) recorded with optical coherence tomography (OCT), and its correlation with the serum hemoglobin A(1c) values (HbA(1c)). RESULTS:The study included 24 (36.9%) female and 41 (63.1%) male patients with a mean age of 58.90±9.45 years. The mean HbA(1c) of the enrolled patients was 8.25±1.74% (range 5.7-12.7%). The median value of BCVA at baseline examination was 20/80 (52 letters), and the median CSMT was 468 μm (range 255-964 μm). In the final control after 4-6 weeks following injection, the median value of BCVA increased to 20/50 (59.50 letters) and the median CSMT decreased to 310 μm (range 129-652 μm). This change in BCVA and macular thickness was found to be significant (P<.001 for both). There was no correlation between BCVA and the change in macular thickness (coefficient=0.04, P=.78). The serum HbA(1c) values were found to be negatively correlated with the change in CSMT (coefficient=-0.50, P<.001). CONCLUSIONS:The results of intravitreal ranibizumab injection for DME demonstrated a beneficial effect on visual acuity and a decrease in CSMT which is inversely correlated with the serum HbA(1c) level.

authors

Ozturk BT,Kerimoglu H,Adam M,Gunduz K,Okudan S

doi

10.1016/j.jdiacomp.2010.09.006

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

298-302

issue

5

eissn

1056-8727

issn

1873-460X

pii

S1056-8727(10)00102-9

journal_volume

25

pub_type

杂志文章
  • Angiopoietin-related growth factor is independently associated with lower extremity peripheral arterial disease.

    abstract:AIMS:The present study investigated the association of serum levels of angiopoietin-related growth factor (AGF) with lower extremity peripheral arterial disease (LEPAD). METHODS:The study group is comprised of 105 patients with lower extremity peripheral arterial disease. The control group consisted of 80 individuals ...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2016.10.019

    authors: Nie H,Liang Y,Wang HX,Ren HL,Wang YW,Li FD,Zheng YH

    更新日期:2017-02-01 00:00:00

  • Tissue expression of tubular injury markers is associated with renal function decline in diabetic nephropathy.

    abstract:AIMS:The pathogenesis of diabetic kidney disease (DKD) is complex and multifactorial; increasing evidence suggests that tubular injury and inflammatory process are involved in disease progression. We investigated the potential association of renal expression of tubular injury markers, neutrophil gelatinase-associated l...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2017.08.009

    authors: Hwang S,Park J,Kim J,Jang HR,Kwon GY,Huh W,Kim YG,Kim DJ,Oh HY,Lee JE

    更新日期:2017-12-01 00:00:00

  • Impact of differences in glucose tolerance on the prevalence of a negative insulinogenic index.

    abstract:OBJECTIVE:To determine the prevalence of a negative insulinogenic index (change in plasma insulin/change in plasma glucose from 0 to 30 min) from an oral glucose tolerance test according to glucose tolerance category. MATERIALS AND METHODS:Data from the San Antonio Heart Study (n=2494), Japanese American Community Dia...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2012.09.011

    authors: Faulenbach MV,Wright LA,Lorenzo C,Utzschneider KM,Goedecke JH,Fujimoto WY,Boyko EJ,McNeely MJ,Leonetti DL,Haffner SM,Kahn SE,American Diabetes Association GENNID Study Group.

    更新日期:2013-03-01 00:00:00

  • Epidermal growth factor receptor and podocin predict nephropathy progression in type 2 diabetic patients through interaction with the autophagy influencer ULK-1.

    abstract:AIMS:Diabetic nephropathy (DN) that progress to end stage renal failure is a serious health problem. Autophagy is involved in DN pathogenesis. Finding renal prognostic biomarkers can help in the future renal status prevision. Therefore, the aim of current study was to evaluate and correlate circulating levels of autoph...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2018.11.007

    authors: El-Shazly AAA,Sallam AM,El-Hefnawy MH,El-Mesallamy HO

    更新日期:2019-02-01 00:00:00

  • Poor glycemic control is associated with increased diastolic blood pressure and heart rate in children with Type 1 diabetes.

    abstract::Although higher levels of hemoglobin A1c (HbA1c) and blood pressure precede the development of nephropathy in Type 1 diabetes (T1DM), the relationship between glycemic control and cardiovascular factors early in the course of diabetes is not clear. We conducted a retrospective study from clinic data for a 1-year perio...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/S1056-8727(03)00031-X

    authors: Torchinsky MY,Gomez R,Rao J,Vargas A,Mercante DE,Chalew SA

    更新日期:2004-07-01 00:00:00

  • Screening for type 2 diabetes mellitus in overweight and obese subjects made easy by the FINDRISC score.

    abstract:AIM:To evaluate the use of the FINDRISC score in an overweight and obese population to predict glucose status. METHODS:In 651 overweight/obese subjects (M/F: 193/458, age 43±13 y, BMI 38.2±6.1kg/m(2)) glucose status was tested using OGTT and HbA1c. Furthermore, the FINDRISC questionnaire and CT visceral fat (VAT) and ...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2016.05.004

    authors: Meijnikman AS,De Block CE,Verrijken A,Mertens I,Corthouts B,Van Gaal LF

    更新日期:2016-08-01 00:00:00

  • Cystic fibrosis related diabetes--a new perspective on the optimal management of postprandial glycemia.

    abstract::As the average life expectancy of patients with cystic fibrosis (CF) improves, the long term co-morbidities assume increasing importance. CF related diabetes (CFRD) has adverse effects on both nutrition and pulmonary function, and is associated with increased mortality. Abnormalities of glucose metabolism in CF repres...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,评审

    doi:10.1016/j.jdiacomp.2014.06.012

    authors: Perano S,Rayner CK,Couper J,Martin J,Horowitz M

    更新日期:2014-11-01 00:00:00

  • Hyperglycemia-induced alteration of vascular smooth muscle phenotype.

    abstract::We have previously reported that high glucose stimulates osteopontin (OPN) expression through protein kinase C-dependent pathway, as well as the hexosamine pathway, in cultured rat aortic smooth muscle cells (SMC). The finding prompted us to study in vivo expression of OPN in diabetes mellitus. In the present study, w...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/s1056-8727(01)00189-1

    authors: Mori S,Takemoto M,Yokote K,Asaumi S,Saito Y

    更新日期:2002-01-01 00:00:00

  • Exploratory lipidomics in patients with nascent Metabolic Syndrome.

    abstract:BACKGROUND:Metabolic Syndrome (MetS) is a cardio-metabolic cluster that confers an increased risk of developing both diabetes and atherosclerotic cardiovascular disease (ASCVD). The mechanisms governing the increased ASCVD risk remains to be elucidated. Moreover, lipidomics poses as an exciting new tool that has potent...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2018.05.014

    authors: Ramakrishanan N,Denna T,Devaraj S,Adams-Huet B,Jialal I

    更新日期:2018-08-01 00:00:00

  • Effects of a calcium channel blocker, manidipine, on insulin sensitivity in essential hypertensives.

    abstract::This study was designed to investigate the effects of the calcium channel blocker manidipine on insulin-dependent glucose uptake (insulin sensitivity) and insulin action to renal sodium handling and pressor systems in essential hypertensive (EHT). Seven EHT were hospitalized and a 2-h euglycemic hyperinsulinemic gluco...

    journal_title:Journal of diabetes and its complications

    pub_type: 临床试验,杂志文章

    doi:10.1016/1056-8727(95)80005-y

    authors: Iimura O,Shimamoto K,Masuda A,Higashiura K,Miyazaki Y,Hirata A,Fukuoka M,Murakami H

    更新日期:1995-10-01 00:00:00

  • Cognitive functioning among patients with diabetic foot.

    abstract:AIMS:Using diabetic foot (DF) as an indicator of severe diabetes, we aimed to investigate the cognitive profile of DF patients and the relations between cognitive functioning and both diabetes complications and comorbidities. METHODS:Dementia-free patients with DF aged 30-90 (n=153) were assessed through medical recor...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2014.07.005

    authors: Marseglia A,Xu W,Rizzuto D,Ferrari C,Whisstock C,Brocco E,Fratiglioni L,Crepaldi G,Maggi S

    更新日期:2014-11-01 00:00:00

  • Complications and comorbidities of T2DM in adolescents: findings from the TODAY clinical trial.

    abstract::With the rise in childhood obesity, type 2 diabetes mellitus (T2DM) has been recognized to occur in adolescents with increasing frequency. Although much is known about T2DM in adults, few studies have examined the treatment and complications of T2DM in youth. The Treatment Options for type 2 Diabetes in Adolescents an...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,评审

    doi:10.1016/j.jdiacomp.2014.10.009

    authors: Tryggestad JB,Willi SM

    更新日期:2015-03-01 00:00:00

  • Association between diabetes mellitus and hearing impairment in American and Korean populations.

    abstract:AIMS:The aim of this study was to evaluate ethnic- and sex-specific associations between DM and hearing impairment. METHODS:For this cross-sectional study using National Health and Nutrition Examination Survey in the U.S. and Korea, the total number of eligible participants included was 7081 in the U.S. and 15,704 in ...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2018.04.004

    authors: Moon S,Park JH,Yu JM,Choi MK,Yoo HJ

    更新日期:2018-07-01 00:00:00

  • Association of monocyte chemoattractant protein-1 with renal tubular damage in diabetic nephropathy.

    abstract::Monocyte chemoattractant protein-1 (MCP-1), is a chemokine that mediates renal interstitial inflammation, tubular atrophy, and interstitial fibrosis by recruiting monocytes/macrophages into renal tubulointerstitium. Recent studies have demonstrated that protein overload in renal tubular cells up-regulates MCP-1 gene a...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/s1056-8727(02)00176-9

    authors: Morii T,Fujita H,Narita T,Shimotomai T,Fujishima H,Yoshioka N,Imai H,Kakei M,Ito S

    更新日期:2003-01-01 00:00:00

  • Mutation H63D in the HFE gene confers risk for the development of type 2 diabetes mellitus but not for chronic complications.

    abstract:PURPOSE:To evaluate the frequency of mutations in the HFE gene (C282Y and H63D) in type 2 diabetes mellitus (DM) patients and their possible association with diabetic chronic complications. METHODS:A case-control study with 723 subjects was performed. All diabetic subjects (n=519) underwent a clinical and laboratory e...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2009.12.002

    authors: Colli ML,Gross JL,Canani LH

    更新日期:2011-01-01 00:00:00

  • Synergistic interaction between semicarbazide-sensitive amine oxidase and angiotensin-converting enzyme in diabetes: functional analysis by gene ontology.

    abstract::Plasma semicarbazide-sensitive amine oxidase (SSAO) and angiotensin-converting enzyme (ACE) were studied for their correlation with diabetes (DM) complication. The effect of interaction between SSAO and ACE in DM complication is of interest. Studying the functional change due to interaction between SSAO and ACE is dif...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2007.02.007

    authors: Wiwanitkit V

    更新日期:2008-11-01 00:00:00

  • The influence of time in range on daily mood in adults with type 1 diabetes.

    abstract:AIMS:To investigate the impact of time in range (TIR) on mood in adults with type 1 diabetes (T1D). METHODS:We followed a cohort of 219 T1D adults, all currently employing a real-time continuous glucose monitoring system (RT-CGM), to investigate how daily changes in CGM metrics were associated with nightly reports of ...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2020.107746

    authors: Polonsky WH,Fortmann AL

    更新日期:2020-12-01 00:00:00

  • Dietary instructions focusing on meal-sequence and nutritional balance for prediabetes subjects: An exploratory, cluster-randomized, prospective, open-label, clinical trial.

    abstract:BACKGROUND:Although lifestyle modifications are known to be effective in type 2 diabetes (T2D) as well as in prediabetes, adherence to a healthy diet is difficult for some, and interventions of lifestyle modifications need to be revised occasionally. Meal sequence has been gaining attention as a part of a healthy diet ...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2019.107450

    authors: Yabe D,Kuwata H,Fujiwara Y,Sakaguchi M,Moyama S,Makabe N,Murotani K,Asano H,Ito S,Mishima H,Takase H,Ota N,Seino Y,Hamamoto Y,Kurose T,Seino Y

    更新日期:2019-12-01 00:00:00

  • Exendin-4 treatment of nonobese diabetic mice increases beta-cell proliferation and fractional insulin reactive area.

    abstract:OBJECTIVE:The notion of combining immunomodulatory agents with the incretin exendin-4 (Ex-4) has seen considerable favor as a potential therapy for the reversal of type 1 diabetes in man. While the addition of Ex-4 provides modest improvement to the effectiveness of immunological-based monotherapies in reversing hyperg...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2008.12.004

    authors: Xue S,Wasserfall C,Parker M,McGrail S,McGrail K,Campbell-Thompson M,Schatz DA,Atkinson MA,Haller MJ

    更新日期:2010-05-01 00:00:00

  • Levels of plasma total adrenomedullin are related with two acute phase inflammatory reactants (fibrinogen and sialic acid) but not with markers of endothelial dysfunction in Type 1 diabetes Adrenomedullin and vascular risk factors in Type 1 DM.

    abstract::Adrenomedullin (AM), an ubiquitous regulatory peptide with different actions, is known to be elevated in different clinical situations, including diabetes mellitus (DM), but its potential role in the pathogenesis of diabetic vascular complications is not clear. In the present study, we examined plasma total AM levels,...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2004.08.002

    authors: García-Unzueta MT,Berrazueta JR,Pesquera C,Obaya S,Fernández MD,Sedano C,Amado JA

    更新日期:2005-05-01 00:00:00

  • Increasing the miR-126 expression in the peripheral blood of patients with diabetic foot ulcers treated with maggot debridement therapy.

    abstract:BACKGROUND:miR-126 may increase angiogenesis in patients with diabetic foot ulcers (DFUs) treated with maggot debridement therapy (MDT). METHODS:Real-time quantitative PCR was used to detect expression of miR-126 mRNA in the peripheral blood among the non-diabetic population, type 2 diabetes mellitus patients without ...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2016.07.026

    authors: Zhang J,Sun XJ,Chen J,Hu ZW,Wang L,Gu DM,Wang AP

    更新日期:2017-01-01 00:00:00

  • Microvascular and macrovascular complications in type 2 diabetes Ghanaian residents in Ghana and Europe: The RODAM study.

    abstract:AIMS:To compare microvascular and macrovascular complication rates among Ghanaians with type 2 diabetes (T2D) living in Ghana and in three European cities (Amsterdam, London and Berlin). METHODS:Data from the multicenter Research on Obesity and Diabetes among African Migrants (RODAM) study were analyzed. 650 Ghanaian ...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2019.04.016

    authors: Hayfron-Benjamin C,van den Born BJ,Maitland-van der Zee AH,Amoah AGB,Meeks KAC,Klipstein-Grobusch K,Bahendeka S,Spranger J,Danquah I,Mockenhaupt F,Beune E,Smeeth L,Agyemang C

    更新日期:2019-08-01 00:00:00

  • Comparison of glycemic control and variability in patients with type 2 and posttransplantation diabetes mellitus.

    abstract:AIM:Posttransplantation diabetes mellitus (PTDM) is a common complication after renal transplantation leading to increased cardiovascular morbidity and mortality. In subjects with type 2 diabetes (T2DM) increased glycemic variability and poor glycemic control have been associated with cardiovascular complications. We t...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2015.07.014

    authors: Werzowa J,Pacini G,Hecking M,Fidler C,Haidinger M,Brath H,Thomas A,Säemann MD,Tura A

    更新日期:2015-11-01 00:00:00

  • Abnormalities of small intestinal endocrine cells in non-obese diabetic mice.

    abstract::The endocrine cells in the duodenum of pre-diabetic and diabetic female non-obese diabetic (NOD) mice aged 22-24 weeks were studied by means of immunohistochemistry and computed image analysis as well as by radioimmunoassays of tissue extracts. As controls, 12 female BALB/cJ mice of the same age as NOD mice were used....

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/s1056-8727(97)00110-4

    authors: El-Salhy M,Zachrisson S,Spångéus A

    更新日期:1998-07-01 00:00:00

  • Prognostic indices for intra-hospital mortality in Nigerian diabetic NIDDM patients. Role of gender and hypertension.

    abstract::Hypertension and diabetes mellitus are independently associated with a high rate of target organ complications, which is particularly accentuated in the Negroid race. The aims of this study were to evaluate the mortality associated with diabetes mellitus and concurrent hypertension and diabetes mellitus in indigenous ...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/s1056-8727(00)00069-6

    authors: Kolawole BA,Ajayi AA

    更新日期:2000-03-01 00:00:00

  • Insulin resistance is associated with Fibroblast Growth Factor-23 in stage 3-5 chronic kidney disease patients.

    abstract:AIM:To determine the associations between insulin resistance, fibroblast growth factor 23 (FGF-23), and coronary artery calcification (CAC) in chronic kidney disease (CKD) patients. INTRODUCTION:FGF-23 is associated with atherosclerosis and cardiovascular disease, but its association with insulin resistance in CKD has...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2013.09.004

    authors: Garland JS,Holden RM,Ross R,Adams MA,Nolan RL,Hopman WM,Morton AR

    更新日期:2014-01-01 00:00:00

  • The prediabetic problem: development of non-insulin-dependent diabetes mellitus and related abnormalities.

    abstract::Non-insulin-dependent diabetes mellitus (NIDDM) is associated with approximately two fold increase in coronary heart disease (CHD) in men and fourfold increase in CHD in women. In most studies, the duration of diabetes and severity of glycemia are only weakly related to CHD in NIDDM, suggesting that the prediabetic pe...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,评审

    doi:10.1016/s1056-8727(96)00099-2

    authors: Haffner SM

    更新日期:1997-03-01 00:00:00

  • Diabetes Complications Severity Index (DCSI)-Update and ICD-10 translation.

    abstract:AIMS:The Diabetes Complications Severity Index (DCSI) converts diagnostic codes and laboratory results into a 14-level metric quantifying the long-term effects of diabetes on seven body systems. Adoption of the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) necessitates tran...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2017.02.018

    authors: Glasheen WP,Renda A,Dong Y

    更新日期:2017-06-01 00:00:00

  • Inflammatory cytokines in vitreous fluid and serum of patients with diabetic vitreoretinopathy.

    abstract::To determine whether inflammatory cytokines are increased in proliferative diabetic retinopathy. We measured concentrations of interleukin-6, 8 (IL-6, 8) and tumor necrosis factor (TNF)-alpha by enzyme-linked immunosorbent assay (ELISA) in vitreous and serum from 47 patients with proliferative diabetic retinopathy and...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/s1056-8727(01)00155-6

    authors: Yuuki T,Kanda T,Kimura Y,Kotajima N,Tamura J,Kobayashi I,Kishi S

    更新日期:2001-09-01 00:00:00

  • High absolute risk of severe infections among Indigenous adults in rural northern Australia is amplified by diabetes - A 7 year follow up study.

    abstract:AIMS:To quantify the risk of hospitalization for infections in Indigenous Australian adults with diabetes in rural and remote communities. METHODS:2787 Indigenous adults including 396 with diabetes at baseline from 19 communities in North Queensland from 1998 to 2007 were included in the study. Main measures were weig...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2016.04.022

    authors: Li M,McDermott R

    更新日期:2016-08-01 00:00:00