Glucose regulation influences treatment outcome in ranibizumab treatment for diabetic macular edema.


PURPOSE:To evaluate the effect of glucose regulation on intravitreal ranibizumab injection for clinically significant diabetic macular edema (DME). METHODS:This retrospective study enrolled 65 eyes of 65 patients with persistent DME treated with intravitreal ranibizumab injection. The main outcome measures were the change in best corrected visual acuity (BCVA), the central subfield macular thickness (CSMT) recorded with optical coherence tomography (OCT), and its correlation with the serum hemoglobin A(1c) values (HbA(1c)). RESULTS:The study included 24 (36.9%) female and 41 (63.1%) male patients with a mean age of 58.90±9.45 years. The mean HbA(1c) of the enrolled patients was 8.25±1.74% (range 5.7-12.7%). The median value of BCVA at baseline examination was 20/80 (52 letters), and the median CSMT was 468 μm (range 255-964 μm). In the final control after 4-6 weeks following injection, the median value of BCVA increased to 20/50 (59.50 letters) and the median CSMT decreased to 310 μm (range 129-652 μm). This change in BCVA and macular thickness was found to be significant (P<.001 for both). There was no correlation between BCVA and the change in macular thickness (coefficient=0.04, P=.78). The serum HbA(1c) values were found to be negatively correlated with the change in CSMT (coefficient=-0.50, P<.001). CONCLUSIONS:The results of intravitreal ranibizumab injection for DME demonstrated a beneficial effect on visual acuity and a decrease in CSMT which is inversely correlated with the serum HbA(1c) level.


Ozturk BT,Kerimoglu H,Adam M,Gunduz K,Okudan S




Has Abstract


2011-09-01 00:00:00














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    journal_title:Journal of diabetes and its complications

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    更新日期:2017-12-01 00:00:00

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    journal_title:Journal of diabetes and its complications

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    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章


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    journal_title:Journal of diabetes and its complications

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    authors: Meijnikman AS,De Block CE,Verrijken A,Mertens I,Corthouts B,Van Gaal LF

    更新日期:2016-08-01 00:00:00

  • Cystic fibrosis related diabetes--a new perspective on the optimal management of postprandial glycemia.

    abstract::As the average life expectancy of patients with cystic fibrosis (CF) improves, the long term co-morbidities assume increasing importance. CF related diabetes (CFRD) has adverse effects on both nutrition and pulmonary function, and is associated with increased mortality. Abnormalities of glucose metabolism in CF repres...

    journal_title:Journal of diabetes and its complications

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    更新日期:2014-11-01 00:00:00

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    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章


    authors: Mori S,Takemoto M,Yokote K,Asaumi S,Saito Y

    更新日期:2002-01-01 00:00:00

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    journal_title:Journal of diabetes and its complications

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    authors: Ramakrishanan N,Denna T,Devaraj S,Adams-Huet B,Jialal I

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    journal_title:Journal of diabetes and its complications

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    authors: Marseglia A,Xu W,Rizzuto D,Ferrari C,Whisstock C,Brocco E,Fratiglioni L,Crepaldi G,Maggi S

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    journal_title:Journal of diabetes and its complications

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    authors: Morii T,Fujita H,Narita T,Shimotomai T,Fujishima H,Yoshioka N,Imai H,Kakei M,Ito S

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  • Synergistic interaction between semicarbazide-sensitive amine oxidase and angiotensin-converting enzyme in diabetes: functional analysis by gene ontology.

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    journal_title:Journal of diabetes and its complications

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  • Levels of plasma total adrenomedullin are related with two acute phase inflammatory reactants (fibrinogen and sialic acid) but not with markers of endothelial dysfunction in Type 1 diabetes Adrenomedullin and vascular risk factors in Type 1 DM.

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    journal_title:Journal of diabetes and its complications

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    authors: García-Unzueta MT,Berrazueta JR,Pesquera C,Obaya S,Fernández MD,Sedano C,Amado JA

    更新日期:2005-05-01 00:00:00

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    journal_title:Journal of diabetes and its complications

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    journal_title:Journal of diabetes and its complications

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    journal_title:Journal of diabetes and its complications

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    journal_title:Journal of diabetes and its complications

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    authors: Garland JS,Holden RM,Ross R,Adams MA,Nolan RL,Hopman WM,Morton AR

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    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,评审


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    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章


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    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章


    authors: Yuuki T,Kanda T,Kimura Y,Kotajima N,Tamura J,Kobayashi I,Kishi S

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    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章


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    更新日期:2016-08-01 00:00:00