The effect of macrophage colony-stimulating factor (M-CSF) on the progression of lipid-induced nephrotoxicity in diabetic nephropathy.

Abstract:

:In order to elucidate the role of macrophage in lipid-induced nephrotoxicity in diabetic nephropathy, we examined the effect of macrophage colony-stimulating factor (M-CSF) on the progression of renal lesions in hypercholesterolemic steptozotocin (STZ)-diabetic rats fed with high cholesterol chow. Hypercholesterolemia aggravated albuminuria in diabetic rats accompanied by infiltration of macrophages in glomeruli. Treatment with M-CSF suppressed simultaneously infiltration of glomerular macrophages and urinary albumin excretion in hypercholesterolemic diabetic rats. These results suggest that infiltration of glomerular macrophage has a primary role in lipid-induced nephrotoxicity in diabetic nephropathy, and M-CSF is involved in this process as a preventive factor.

authors

Utsunomiya K,Ohta H,Kurata H,Tajima N,Isogai Y

doi

10.1016/1056-8727(95)80025-a

subject

Has Abstract

pub_date

1995-10-01 00:00:00

pages

292-5

issue

4

eissn

1056-8727

issn

1873-460X

pii

105687279580025A

journal_volume

9

pub_type

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