Abstract:
AIMS:The present study aimed to examine the nonlinear associations between risk factors and mild hypoglycemia in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS:From May 2013 to August 2013, we conducted a cross sectional survey of 6633 inpatients with T2DM and without severe hypoglycemia, aged 21-77 years, from 81 top tertiary hospitals in China. Mild hypoglycemia was defined as having hypoglycemia with symptoms in one month. Binary logistic regression analysis with restricted cubic splines was used to estimate odds ratio curves of non-linear risk factors for mild hypoglycemia. RESULTS:Increasing body mass index was associated with decreasing risk of mild hypoglycemia in a linear manner while age, duration of diabetes, glycated hemoglobin (HbA1c), mean artery pressure and lipids were associated with mild hypoglycemia in non-linear manners. Age ≥40 years, duration ≥2 years, HbA1c ≥7.0-<11.5% (≥53-<102 mmol/mol), triglyceride ≥1.7-<3.6 mmol/L, low-density lipoprotein cholesterol (LDL-C) ≥2.6-<4.8 mmol/L, and high-density lipoprotein cholesterol (HDL-C) ≥1.2-<4.8 mmol/L were associated with increased risks of mild hypoglycemia. CONCLUSIONS:Chinese T2DM patients with age≥40 years, duration of diabetes ≥2-<6 years, HbA1c ≥7.0-<11.5% (≥53-<102 mmol/mol), LDL-C ≥2.6-<4.8mmol/L, HDL-C ≥1.2-<4.8 mmol/L or triglyceride ≥1.7-<3.6 mmol/L were at particularly high risk for mild hypoglycemia.
journal_name
J Diabetes Complicationsjournal_title
Journal of diabetes and its complicationsauthors
Gu W,Ren Y,Ji L,Hong T,Mu Y,Guo L,Li Q,Tian Q,Yang Xdoi
10.1016/j.jdiacomp.2015.12.024subject
Has Abstractpub_date
2016-04-01 00:00:00pages
462-8issue
3eissn
1056-8727issn
1873-460Xpii
S1056-8727(15)00513-9journal_volume
30pub_type
杂志文章abstract:OBJECTIVE:To investigate the effect of angiotensin converting enzyme inhibition (ACE-I) or angiotensin receptor blockade (ARB), and their combination, on both diabetic autonomic neuropathy (DAN) and left ventricular (LV) diastolic dysfunction (LVDD) in asymptomatic patients with diabetes mellitus (DM). MATERIALS AND M...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jdiacomp.2005.05.002
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The goal of this study was to examine the self-rated health (SRH) of adolescents with type 1 diabetes (T1D). METHODS:A logistic regression analysis of baseline data from adolescents in the United States included in the T1D Exchange Clinic Registry in 2010-2012 was conducted. Participants were 13-18years old...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2012.05.022
更新日期:2012-11-01 00:00:00
abstract:AIMS:The efficacy of the once-daily prandial GLP-1 receptor agonist lixisenatide plus basal insulin in T2DM was assessed by pooling results of phase III trials. METHODS:A meta-analysis was performed of results from three trials in the GetGoal clinical program concerning lixisenatide or placebo plus basal insulin with/...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章,meta分析
doi:10.1016/j.jdiacomp.2014.07.007
更新日期:2014-11-01 00:00:00
abstract:PURPOSE:To evaluate the frequency of mutations in the HFE gene (C282Y and H63D) in type 2 diabetes mellitus (DM) patients and their possible association with diabetic chronic complications. METHODS:A case-control study with 723 subjects was performed. All diabetic subjects (n=519) underwent a clinical and laboratory e...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2009.12.002
更新日期:2011-01-01 00:00:00
abstract:AIMS:This study investigated the association between severe hypoglycemia (SH) and new onset atrial fibrillation (AF) and all-cause mortality in adult patients with type 2 diabetes mellitus (T2DM). METHODS:Retrospective data on patients with T2DM aged between 30 and 75years who received healthcare checkups from January...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2017.09.009
更新日期:2018-02-01 00:00:00
abstract:AIM:To evaluate the efficacy, safety, and tolerability of multiple doses of ipragliflozin. This novel selective inhibitor of sodium glucose co-transporter 2 is in clinical development for the treatment of patients with type 2 diabetes mellitus (T2DM). METHODS:In a 12-week, multicenter, double-blind, randomized, active...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.jdiacomp.2012.11.005
更新日期:2013-05-01 00:00:00
abstract:AIM:The present study aimed to identify the characteristics of genetically modified pigs carrying a mutant human gene as a research model for diabetes and its complications. METHODS:We developed a transgenic cloned pig (founder, male) carrying a mutant gene, i.e., human HNF-1α (P291fsinsC), which is responsible for ma...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2017.01.025
更新日期:2017-05-01 00:00:00
abstract:AIMS:To investigate the predictive capability of insulin resistance surrogate markers for insulin resistance and arterial stiffness based on sex. METHODS:We assessed the association of triglyceride glucose (TyG) index, triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C), visceral adiposity index (VAI...
journal_title:Journal of diabetes and its complications
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2015.03.006
更新日期:2015-05-01 00:00:00
abstract:PURPOSE:To evaluate the effect of glucose regulation on intravitreal ranibizumab injection for clinically significant diabetic macular edema (DME). METHODS:This retrospective study enrolled 65 eyes of 65 patients with persistent DME treated with intravitreal ranibizumab injection. The main outcome measures were the ch...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2010.09.006
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Rotator cuff tears are the most common cause of shoulder disability in people older than 50years, and surgical intervention is usually required for restoring functioning. However, in patients undergoing rotator cuff repair surgery, patients with DM had poorer functional outcomes than those without DM, and he...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2016.07.015
更新日期:2016-01-01 00:00:00
abstract:AIMS:Investigate the importance of treating diabetes by evaluating mortality risk of untreated and medically-treated diabetic patients. METHODS:Historical prospectively collected observational data of hospitalized patient ≥18years, admitted for any-cause to medical wards, between January 2011 and December 2013. Main o...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2016.04.011
更新日期:2016-08-01 00:00:00
abstract:AIMS:To quantify the risk of hospitalization for infections in Indigenous Australian adults with diabetes in rural and remote communities. METHODS:2787 Indigenous adults including 396 with diabetes at baseline from 19 communities in North Queensland from 1998 to 2007 were included in the study. Main measures were weig...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2016.04.022
更新日期:2016-08-01 00:00:00
abstract::Cardiovascular diseases are the major cause of mortality in diabetes patients. Increased levels of glycated low density lipoprotein (glyLDL) are detected in diabetic patients. Endothelial nitric oxide synthase (eNOS) generates nitric oxide, which is responsible to endothelium-dependent vasodilation. The impact of glyL...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2016.01.008
更新日期:2016-04-01 00:00:00
abstract::The long-term effects of angiotensin-converting enzyme inhibitors (captopril and enalapril), calcium-entry blockers (diltiazem and nicardipine), and good glycemic control on plasma lipids and lipoproteins were studied in streptozotocin diabetic rats. Diabetic rats had increased plasma cholesterol, tryiglycerides, very...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/1056-8727(94)00045-p
更新日期:1995-07-01 00:00:00
abstract:AIM:Posttransplantation diabetes mellitus (PTDM) is a common complication after renal transplantation leading to increased cardiovascular morbidity and mortality. In subjects with type 2 diabetes (T2DM) increased glycemic variability and poor glycemic control have been associated with cardiovascular complications. We t...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2015.07.014
更新日期:2015-11-01 00:00:00
abstract::Fifty-six type I diabetic patients with microalbuminuria (albumin excretion rate 20-200 micrograms/min) were characterized as to sex, age, duration of diabetes, smoking habits, blood pressure, glomerular filtration rate, urinary NC1 (the carboxy-terminal domain of collagen IV), and Tamm-Horsfall protein excretion rate...
journal_title:Journal of diabetes and its complications
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journal_title:Journal of diabetes and its complications
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
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journal_title:Journal of diabetes and its complications
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00
abstract::Intact lenses from New Zealand white rabbits were incubated in tissue culture media containing either 5 mM glucose or 5 mM glucose plus 30 mM galactose. The standard media did not contain taurine. Lenses were also cultured in a third medium containing 30 mM galactose plus 0.2 mM taurine. The frequency of cataract form...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
abstract:AIMS:This study determined the joint association between physical activity, pharmacotherapy, and HbA1c control on all-cause and cardiovascular disease (CVD) mortality risk in adults with and without type 2 diabetes (T2D). METHODS:12,060 adults from NHANES III and NHANES continuous (1999-2002) surveys were used. Cox pr...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2013.06.005
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:The ASGR1 was recently shown to play a key role in the development of coronary artery disease (CAD), but its exact mechanism of action in the CAD pathogenesis is not yet known. This study evaluates the possible association between the expression level of ASGR1 and its downstream transcription factor FOXM1 in...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
abstract:AIMS:To investigate the impact of time in range (TIR) on mood in adults with type 1 diabetes (T1D). METHODS:We followed a cohort of 219 T1D adults, all currently employing a real-time continuous glucose monitoring system (RT-CGM), to investigate how daily changes in CGM metrics were associated with nightly reports of ...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
abstract:AIMS:The pathogenesis of diabetic kidney disease (DKD) is complex and multifactorial; increasing evidence suggests that tubular injury and inflammatory process are involved in disease progression. We investigated the potential association of renal expression of tubular injury markers, neutrophil gelatinase-associated l...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2017.08.009
更新日期:2017-12-01 00:00:00
abstract::Plasma semicarbazide-sensitive amine oxidase (SSAO) and angiotensin-converting enzyme (ACE) were studied for their correlation with diabetes (DM) complication. The effect of interaction between SSAO and ACE in DM complication is of interest. Studying the functional change due to interaction between SSAO and ACE is dif...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2007.02.007
更新日期:2008-11-01 00:00:00
abstract:AIMS:To assess the impact of diabetic foot care delivery in preventing lower extremity amputation (LEA). METHODS:We systematically searched the MEDLINE database for research evaluating the association between any aspect of diabetic foot care delivery and risk of LEA. Meta-analysis was conducted by calculating a pooled...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2020.107837
更新日期:2020-12-31 00:00:00
abstract:BACKGROUND:There are significant regional variations in prevalence of diabetes and diabetic chronic renal insufficiency (CRI) in India. Oxidative stress plays an important role in the development of diabetic complications. To determine the importance of the polymorphisms in the genes involved in maintenance of cellular...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00