Abstract:
:Spinal arthrodesis continues to expand in clinical indications and surgical practice. Despite a century of study, failure of bone formation or pseudarthrosis can occur in individual patients with debilitating clinical symptoms. Here we review biological and technical aspects of spinal fusion under active investigation, describe relevant biomechanics in health and disease, and identify the possibilities and limitations of translational animal models. The purpose of this article is to foster collaborative efforts with researchers who model bone hierarchy. The induction of heterotopic osteosynthesis requires a complex balance of biologic factors and operative technique to achieve successful fusion. Anatomical considerations of each spinal region including blood supply, osteology, and biomechanics predispose a fusion site to robust or insufficient bone formation. Careful preparation of the fusion site and appropriate selection of graft materials remains critical but is sometimes guided by conflicting evidence from the long-bone literature. Modern techniques of graft site preparation and instrumentation have evolved for every segment of the vertebral column. Despite validated biomechanical studies of modern instrumentation, a correlation with superior clinical outcomes is difficult to demonstrate. In many cases, adjuvant biologic therapies with allograft and synthetic cages have been used successfully to reproduce the enhancement of fusion rates observed with cancellous and tricortical autograft. Current areas of investigation comprise materials science, stem cell therapies, recombinant growth factors, scaffolds and biologic delivery systems, and minimally invasive surgical techniques to optimize the biologic response to intervention. Diverse animal models are required to approach the breadth of spinal pathology and novel therapeutics.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Reid JJ,Johnson JS,Wang JCdoi
10.1016/j.jbiomech.2010.10.021subject
Has Abstractpub_date
2011-01-11 00:00:00pages
213-20issue
2eissn
0021-9290issn
1873-2380pii
S0021-9290(10)00577-4journal_volume
44pub_type
杂志文章,评审abstract::External perturbations during pushing tasks have been suggested to be a risk factor for low-back symptoms. An experiment was designed to investigate whether self-induced and externally induced sudden stops while pushing a high inertia cart influence trunk motions, and how flexor and extensor muscles counteract these p...
journal_title:Journal of biomechanics
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journal_title:Journal of biomechanics
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pub_type: 杂志文章
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journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2013.04.016
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pub_type: 杂志文章
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journal_title:Journal of biomechanics
pub_type: 杂志文章,评审
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journal_title:Journal of biomechanics
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更新日期:1996-12-01 00:00:00
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更新日期:2014-10-17 00:00:00
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journal_title:Journal of biomechanics
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更新日期:2008-12-05 00:00:00
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journal_title:Journal of biomechanics
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