Abstract:
:We have isolated a human cDNA (kup), encoding a new protein with two distantly spaced zinc fingers of the C2H2 type. This gene is highly conserved in mammals and is expressed mainly in hematopoietic cells and testis. Its expression was not higher in the various transformed cells tested than in the normal corresponding tissues. The kup gene is located in region q23-q24 of the long arm of human chromosome 14. The kup protein is 433 a.a. long, has a M.W. close to 50 kD and binds to DNA. Although the structure of the kup protein is unusual, the isolated fingers resemble closely those of the Krüppel family, suggesting that this protein is also a transcription factor. The precise function and DNA motif recognized by the kup protein remain to be determined.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Chardin P,Courtois G,Mattei MG,Gisselbrecht Sdoi
10.1093/nar/19.7.1431subject
Has Abstractpub_date
1991-04-11 00:00:00pages
1431-6issue
7eissn
0305-1048issn
1362-4962journal_volume
19pub_type
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