CpG island methylator phenotype associated with tumor recurrence in tumor-node-metastasis stage I hepatocellular carcinoma.

abstract：BACKGROUND:This study was designed to identify the prevalence of BRAF mutations in Chinese patients with lung adenocarcinoma, and to reveal the association between BRAF mutations and clinicopathological characteristics in these patients. METHODS:From October 2007 to February 2013, patients with newly diagnosed primary...

journal_title：Annals of surgical oncology

authors： Zheng D,Wang R,Pan Y,Zheng S,Zhang Y,Li H,Cheng C,Gong R,Li Y,Shen X,Hu H,Cai D,Cheng X,Sun Y,Chen H

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:Atypical protein kinase C iota (aPKC-iota) and its associated intracellular molecules, E-cadherin and beta-catenin, are important for cell polarization in tumorigenesis and progression. Expression of aPKC-iota, P-aPKC-iota (activated aPKC-iota), E-cadherin, and beta-catenin in hepatocellular carcinoma (HCC) ...

journal_title：Annals of surgical oncology

authors： Du GS,Wang JM,Lu JX,Li Q,Ma CQ,Du JT,Zou SQ

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:The goal of this multicenter study was to clarify the determinants of local excision for patients with T1-T2 lower rectal cancer. METHODS:Data from 567 consecutive patients who underwent radical resection for T1-T2 lower rectal cancer at 12 institutions between 1991 and 1998 were reviewed. Rates of lymph no...

journal_title：Annals of surgical oncology

authors： Kobayashi H,Mochizuki H,Kato T,Mori T,Kameoka S,Shirouzu K,Saito Y,Watanabe M,Morita T,Hida J,Ueno M,Ono M,Yasuno M,Sugihara K

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Thirty-day mortality after surgery for colorectal cancer may vastly underestimate 1-year mortality. This study aimed to quantify the excess mortality in the first postoperative year of stage I-III colorectal cancer patients and to identify risk factors for excess mortality. METHODS:All 2,131 patients who we...

journal_title：Annals of surgical oncology

authors： Gooiker GA,Dekker JW,Bastiaannet E,van der Geest LG,Merkus JW,van de Velde CJ,Tollenaar RA,Liefers GJ

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:In patients with early stage gastric cancer in the middle third of the stomach, pylorus-preserving gastrectomy (PPG) can be an option as function-preserving surgery, although its oncologic safety is not definitively defined. This issues may be overcome using the sentinel node (SN) concept. The aim of this st...

journal_title：Annals of surgical oncology

authors： Shimada A,Takeuchi H,Ono T,Kamiya S,Fukuda K,Nakamura R,Takahashi T,Wada N,Kawakubo H,Saikawa Y,Omori T,Nakahara T,Jinzaki M,Murakami K,Kitagawa Y

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Histologic grade, TNM stage, and Nottingham Prognostic Index are traditional prognostic tools for breast cancer. "IHC-molecular" classification of breast cancer can also identify patients at different recurrence risks and provides insight into cancer therapy. However, cancers in each group are heterogeneous....

journal_title：Annals of surgical oncology

authors： Ni YB,Tsang JY,Chan SK,Tse GM

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Multidisciplinary treatment of rectal cancer, including neoadjuvant treatment, total mesorectal excision, and adjuvant chemotherapy, have improved oncological outcome. Preoperative radiation therapy is advocated by national and international guidelines in all patients with AJCC stage II and III rectal cancer...

journal_title：Annals of surgical oncology

authors： Franz C,Lang HM,Ghamarnejad O,Khajeh E,Mehrabi A,Ulrich A,Schneider M,Büchler MW,Kulu Y

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Preoperative chemoradiotherapy has been widely adopted as the standard of care for stage II-III rectal cancers. However, patients with T3N0 lesions had been shown to have a better prognosis than other categories of locally advanced tumor. Thus, neoadjuvant chemoradiation is likely to be overtreatment in this...

journal_title：Annals of surgical oncology

authors： Lombardi R,Cuicchi D,Pinto C,Di Fabio F,Iacopino B,Neri S,Tardio ML,Ceccarelli C,Lecce F,Ugolini G,Pini S,Di Tullio P,Taffurelli M,Minni F,Martoni A,Cola B

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:To analyze the relationship between the size of metastatic sentinel lymph nodes (SLNs) and the risk of non-sentinel lymph node (non-SLN) metastasis in endometrial cancer. PATIENTS AND METHODS:From a total of 328 patients with endometrial cancer who underwent SLN mapping from January 2013 to April 2019, 142 pat...

journal_title：Annals of surgical oncology

authors： Baiocchi G,Mantoan H,Gonçalves BT,Faloppa CC,Kumagai LY,Badiglian-Filho L,da Costa AABA,De Brot L

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Extramammary Paget's disease (EMPD) is a rare intraepithelial malignancy with poorly described outcomes. EMPD in men is primarily found in the perianal and penoscrotal areas. We assessed incidence and time trends of EMPD in men as well as extent and predictors of survival using the Surveillance, Epidemiology...

journal_title：Annals of surgical oncology

authors： Herrel LA,Weiss AD,Goodman M,Johnson TV,Osunkoya AO,Delman KA,Master VA

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Preliminary data indicate that tyrosine kinase inhibitors (TKIs) function through rearranged during transfection (RET) in breast cancer. However, TKIs are not specific and can block several receptor tyrosine kinases (RTKs). This study used cell lines and primary breast cancer specimens to determine factors a...

journal_title：Annals of surgical oncology

authors： Spanheimer PM,Lorenzen AW,De Andrade JP,Kulak MV,Carr JC,Woodfield GW,Sugg SL,Weigel RJ

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Resection margin status is a known prognosticator in patients who undergo resection for hilar cholangiocarcinoma. However, the influence of an isolated positive circumferential margin on clinical outcome is unclear. METHODS:Patients with resected de novo hilar cholangiocarcinoma from two European hepatobili...

journal_title：Annals of surgical oncology

authors： Stremitzer S,Stift J,Laengle J,Schwarz C,Kaczirek K,Jones RP,Quinn LM,Fenwick SW,Diaz-Nieto R,Poston GJ,Malik HZ

更新日期：2020-09-10 00:00:00

abstract：BACKGROUND:Attention has been focused on attempts to eliminate breast surgery for breast cancer patients who achieve a pathologic complete response after neoadjuvant chemotherapy (NAC). However, there are few data on ipsilateral breast tumor recurrence (IBTR) among patients with triple-negative or epidermal growth fact...

journal_title：Annals of surgical oncology

authors： Ishitobi M,Matsuda N,Tazo M,Nakayama S,Tokui R,Ogawa T,Yoshida A,Kojima Y,Kuwayama T,Nakayama T,Yamauchi H,Nakamura S,Tsugawa K,Hayashi N

更新日期：2020-10-06 00:00:00

abstract：BACKGROUND:Management of mammographically detected ductal carcinoma in situ (DCIS) at a single institution was reviewed to determine long-term clinical outcomes after treatment with breast-conserving therapy (BCT). METHODS:Data from all patient-cases with DCIS who received BCT between 1980 and 1993 were reviewed. Pati...

journal_title：Annals of surgical oncology

authors： Wilkinson JB,Vicini FA,Shah C,Shaitelman S,Jawad MS,Ye H,Kestin LL,Goldstein NS,Martinez AA,Benitez P,Chen PY

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Findings show that 5-10 % of women with a diagnosis of breast cancer (BCa) have actionable genetic mutations. The National Comprehensive Cancer Network guidelines for testing to detect BRCA1/2 mutations include personal history (PH) variables such as age of 45 years or younger and a family history (FH) varia...

journal_title：Annals of surgical oncology

authors： Kishan AU,Gomez CL,Dawson NA,Dvorak R,Foster NM,Hoyt A,Hurvitz SA,Kusske A,Silver EL,Tseng C,McCloskey SA

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Several clinical risk scores for patients with colorectal liver metastases (CLM) were established in cohorts of patients undergoing liver resection (LR) without neoadjuvant chemotherapy (NAC). The purpose of the study was to evaluate the predictive values of four common risk scores in the setting of NAC and ...

journal_title：Annals of surgical oncology

authors： Wimmer K,Schwarz C,Szabo C,Bodingbauer M,Tamandl D,Mittlböck M,Kaczirek K

更新日期：2017-01-01 00:00:00

abstract：:The surveillance of breast cancer patients after potentially curative treatment may result in the identification of locoregional or distant recurrence. While many patients expect frequent imaging studies to monitor for recurrence, there are no data supporting aggressive imaging surveillance beyond mammography. However...

journal_title：Annals of surgical oncology

authors： Leitch AM

更新日期：2013-10-01 00:00:00

abstract：PURPOSE:Recent studies indicated that the scaffolding adaptor protein GAB2 (GRB2-associated binding protein 2) plays a critical role in the proliferation and migration of various cancers. This study aimed to determine the role of aberrant GAB2 expression in human colorectal cancer (CRC). METHODS:Quantitative real-time...

journal_title：Annals of surgical oncology

authors： Matsumura T,Sugimachi K,Takahashi Y,Uchi R,Sawada G,Ueda M,Hirata H,Sakimura S,Ueo H,Takano Y,Kurashige J,Shinden Y,Eguchi H,Sudo T,Yamamoto H,Doki Y,Mori M,Mimori K

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Extracapsular invasion (ECI) of metastatic axillary lymph nodes has been associated with aggressive nodal disease but its prognostic role in breast cancer is unclear. The present study evaluated nodal ECI as a predictor of breast cancer recurrence. METHODS:We evaluated 154 women with histologically proven n...

journal_title：Annals of surgical oncology

authors： Yajima R,Fujii T,Yanagita Y,Fujisawa T,Miyamoto T,Hirakata T,Tsutsumi S,Iijima M,Kuwano H

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Breast cancers (BCs) diagnosed after a recent pregnancy display features associated with poor prognosis, including hormone receptor negativity, but other tumor markers have not been examined. We sought to define the tumor marker profile of these cancers, including HER-2 and p53 expression, and examine the ti...

journal_title：Annals of surgical oncology

authors： Pilewskie M,Gorodinsky P,Fought A,Hansen N,Bethke K,Jeruss J,Scholtens D,Khan SA

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:The aim of this review was to examine the incidence of nipple-areola complex (NAC) involvement, the rates of NAC recurrence, and the data regarding the role of radiation therapy (RT) following nipple-sparing mastectomy (NSM). METHODS:A literature review was performed using the PubMed search engine, with articl...

journal_title：Annals of surgical oncology

authors： Gomez C,Shah C,McCloskey S,Foster N,Vicini F

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Touch imprint cytology (TIC) is a fast, cheap and specific intraoperative examination of the sentinel lymph nodes (SLNs) in early breast cancer patients. The results of TIC in patients with ultrasonically (US) uninvolved axillary lymph nodes are not known. The objective of our study was to compare the result...

journal_title：Annals of surgical oncology

authors： Perhavec A,Besić N,Hocevar M,Zgajnar J

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:The patients with early gastric cancer who have undergone incomplete endoscopic resection (ER) generally need additional surgery because of the possibility of lymph node metastasis. The aim of study was to evaluate the optimal time interval from ER to additive surgery by evaluating the effect of time interva...

journal_title：Annals of surgical oncology

authors： Kim MJ,Kim JH,Lee YC,Kim JW,Choi SH,Hyung WJ,Noh SH,Youn YH,Park H,Lee SI

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Hepatitis B (HBV)-associated hepatocellular carcinoma (HCC) is often associated with alpha-fetoprotein (AFP) production. Although serum AFP has been demonstrated to be a prognostic factor for patient survival, optimal cutoff levels remain unclear. METHODS:Patients with HBV-associated HCC treated by primary ...

journal_title：Annals of surgical oncology

authors： Blank S,Wang Q,Fiel MI,Luan W,Kim KW,Kadri H,Mandeli J,Hiotis SP

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:When pathological diagnosis following endoscopic resection (ER) for early gastric cancer (EGC) suggests probable lymph node metastasis, additional surgery with lymphadenectomy should be performed. The sentinel node (SN) concept has yet to be applied to tumors following ER. The aim of this study was to evalua...

journal_title：Annals of surgical oncology

authors： Mayanagi S,Takeuchi H,Kamiya S,Niihara M,Nakamura R,Takahashi T,Wada N,Kawakubo H,Saikawa Y,Omori T,Nakahara T,Mukai M,Kitagawa Y

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:This study compared two homogeneous groups of patients submitted to either surgical resection (HR) or laparoscopic radiofrequency ablation (LRFA) for the treatment of hepatocellular carcinoma (HCC). When compatible with the liver functional reserve, HR remains the treatment of choice for HCC, while LRFA seem...

journal_title：Annals of surgical oncology

authors： Santambrogio R,Opocher E,Zuin M,Selmi C,Bertolini E,Costa M,Conti M,Montorsi M

更新日期：2009-12-01 00:00:00

abstract：:Investigators at many cancer centers have verified that the sentinel node (SN) is the first lymph node to receive lymphatic drainage from a primary breast cancer and therefore the node most likely to contain metastatic tumor cells. When sentinel lymph node dissection (SLND) is undertaken by an experienced multidiscipl...

journal_title：Annals of surgical oncology

authors： Giuliano AE

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:A recent study showed that circulating exosomal PD-L1 is an effective predictor for anti-PD-1 therapy in melanomas. Exosomal PD-L1 induced immunosuppression microenvironments in cancer patients. However, its prognostic value and immunosuppressive effect in gastric cancer (GC) were poorly understood. METHODS...

journal_title：Annals of surgical oncology

authors： Fan Y,Che X,Qu J,Hou K,Wen T,Li Z,Li C,Wang S,Xu L,Liu Y,Qu X

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Several studies have proven that neoadjuvant endocrine therapy (NET) has a similar beneficial therapeutic effect in estrogen-positive (ER+) breast cancer (BC) with improved breast conservation rate in patients undergoing NET versus neoadjuvant chemotherapy (NAC). The impact of axillary complete pathologic re...

journal_title：Annals of surgical oncology

authors： Stafford A,Williams A,Edmiston K,Cocilovo C,Cohen R,Bruce S,Yoon-Flannery K,De La Cruz L

更新日期：2020-11-01 00:00:00

abstract：:Tumors treated with preoperative chemotherapy or radiation often demonstrate evidence of response in the resection specimen. Pathologic response is often interpreted as a surrogate for recurrence or survival outcomes. With a valid surrogate for long-term outcomes, investigators can explore treatment strategies with im...

journal_title：Annals of surgical oncology

authors： Mansour JC,Schwarz RE

更新日期：2009-06-01 00:00:00