Size of Sentinel Node Metastasis Predicts Non-sentinel Node Involvement in Endometrial Cancer.

Abstract:

PURPOSE:To analyze the relationship between the size of metastatic sentinel lymph nodes (SLNs) and the risk of non-sentinel lymph node (non-SLN) metastasis in endometrial cancer. PATIENTS AND METHODS:From a total of 328 patients with endometrial cancer who underwent SLN mapping from January 2013 to April 2019, 142 patients also underwent systematic completion pelvic ± paraaortic node dissections, and they form the basis of this study. The SLNs were examined by immunohistochemistry (IHC) when the hematoxylin-eosin stain was negative. RESULTS:The median age was 60 years. The overall detection rate for SLNs was 87.5%, and bilateral SLNs were observed in 66.2%, with a median of 2 SLNs resected (range 1-8). Twenty-nine (20.4%) cases had positive SLNs, with a median of one positive SLN. Regarding the size of SLN metastasis, 5 (3.5%) cases had isolated tumor cells (ITCs), 13 (9.2%) had micrometastases, and 11 (7.7%) had macrometastases. Notably, 14/29 (48.3%) had node metastases that were detected after IHC. Eight (27.6%) patients had positive non-SLNs, with a median count of 7 positive nodes (range 2-23). Regarding the size of SLN metastasis, non-SLN involvement was not present in cases with ITC (0/5) but was present in 15.4% (2/13) of cases with micrometastases and 54.5% (6/11) of cases with macrometastases. The only risk factor for positive non-SLNs was the size of SLN metastasis. CONCLUSIONS:Our data suggest that size of SLN metastasis is associated with the risk of non-SLN metastasis. No patients with ITCs in SLNs had another metastatic lymph node in this study.

journal_name

Ann Surg Oncol

authors

Baiocchi G,Mantoan H,Gonçalves BT,Faloppa CC,Kumagai LY,Badiglian-Filho L,da Costa AABA,De Brot L

doi

10.1245/s10434-019-08045-9

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

1589-1594

issue

5

eissn

1068-9265

issn

1534-4681

pii

10.1245/s10434-019-08045-9

journal_volume

27

pub_type

杂志文章
  • Impact of Sarcopenic Obesity on Failure to Rescue from Major Complications Following Pancreaticoduodenectomy for Cancer: Results from a Multicenter Study.

    abstract:BACKGROUND:Failure to rescue (FTR) is a quality-of-care indicator in pancreatic surgery, but may also identify patients who may not tolerate major postoperative complications despite being treated with best available care. Previous studies found that high visceral adipose tissue-to-skeletal muscle ratio is associated w...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-017-6216-5

    authors: Pecorelli N,Capretti G,Sandini M,Damascelli A,Cristel G,De Cobelli F,Gianotti L,Zerbi A,Braga M

    更新日期:2018-01-01 00:00:00

  • Outcome of Patients Treated Within and Outside a Randomized Clinical Trial on Neoadjuvant Chemoradiotherapy Plus Surgery for Esophageal Cancer: Extrapolation of a Randomized Clinical Trial (CROSS).

    abstract:BACKGROUND:Randomized clinical trials (RCTs) can provide a high level of evidence for medical decision making, but it is unclear if the results apply to patients treated outside such trials. OBJECTIVE:The aim of this study was to retrospectively compare outcomes of patients with esophageal cancer treated within and ou...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1245/s10434-018-6554-y

    authors: Toxopeus E,van der Schaaf M,van Lanschot J,Lagergren J,Lagergren P,van der Gaast A,Wijnhoven B

    更新日期:2018-08-01 00:00:00

  • Pleomorphic Lobular Carcinoma In Situ: Radiologic-Pathologic Features and Clinical Management.

    abstract:BACKGROUND:Pleomorphic lobular carcinoma in situ (PLCIS) is an unusual variant of LCIS for which optimal management remains unclear. METHODS:We conducted a 15-year (2000-2014) retrospective chart review of the radiologic, pathologic, clinical management, and recurrence rates of patients with PLCIS on diagnostic biopsy...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4552-x

    authors: Flanagan MR,Rendi MH,Calhoun KE,Anderson BO,Javid SH

    更新日期:2015-12-01 00:00:00

  • Prognosis and Circumferential Margin in Patients with Resected Hilar Cholangiocarcinoma.

    abstract:BACKGROUND:Resection margin status is a known prognosticator in patients who undergo resection for hilar cholangiocarcinoma. However, the influence of an isolated positive circumferential margin on clinical outcome is unclear. METHODS:Patients with resected de novo hilar cholangiocarcinoma from two European hepatobili...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09105-1

    authors: Stremitzer S,Stift J,Laengle J,Schwarz C,Kaczirek K,Jones RP,Quinn LM,Fenwick SW,Diaz-Nieto R,Poston GJ,Malik HZ

    更新日期:2020-09-10 00:00:00

  • The usefulness of neoadjuvant chemoradiation therapy for locally advanced esophageal cancer with multiple lymph-node metastases.

    abstract:BACKGROUND:The prognosis of patients with esophageal squamous-cell cancer (ESCC) and multiple lymph-node metastases is quite poor. We examined whether neoadjuvant chemoradiation therapy (CRT) has a beneficial effect in such patients. METHODS:A total of 50 consecutive patients with T3-4 tumors and without organ metasta...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3688-4

    authors: Okumura H,Uchikado Y,Omoto I,Kita Y,Sasaki K,Arigami T,Uenosono Y,Matsushita D,Hiraki Y,Owaki T,Ishigami S,Natsugoe S

    更新日期:2014-09-01 00:00:00

  • Is There a Correlation Between Clinical Complete Response and Pathological Complete Response After Neoadjuvant Chemoradiotherapy for Esophageal Squamous Cell Cancer?

    abstract:OBJECTIVE:The aim of this study was to investigate the correlation between clinical complete response (cCR) and pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (CRT) for esophageal squamous cell cancer (ESCC). METHODS:Between May 2001 and April 2013, a total of 158 patients with thoracic ESCC tr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4764-0

    authors: Liu SL,Xi M,Yang H,Yang YD,Wu YJ,Zhao L,Zhang P,Luo LL,Liu MZ

    更新日期:2016-01-01 00:00:00

  • Adjuvant therapy with capecitabine postpones recurrence of hepatocellular carcinoma after curative resection: a randomized controlled trial.

    abstract:BACKGROUND:Postoperative recurrence of hepatocellular carcinoma (HCC) is a major problem after surgical resection. To date, adjuvant chemotherapy or other adjuvant modalities have not been proven effective in preventing or delaying recurrence. The aim of this prospective randomized study was to evaluate the effectivene...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1245/s10434-010-1148-3

    authors: Xia Y,Qiu Y,Li J,Shi L,Wang K,Xi T,Shen F,Yan Z,Wu M

    更新日期:2010-12-01 00:00:00

  • Dynamics of FLAIR Volume Changes in Glioblastoma and Prediction of Survival.

    abstract:BACKGROUND:The extent of tumor resection (EOTR) calculated by enhanced T1 changes in glioblastomas has been previously reported to predict survival. However, fluid-attenuated inversion recovery (FLAIR) volume may better represent tumor burden. In this study, we report the first assessment of the dynamics of FLAIR volum...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5635-z

    authors: Grossman R,Shimony N,Shir D,Gonen T,Sitt R,Kimchi TJ,Harosh CB,Ram Z

    更新日期:2017-03-01 00:00:00

  • Resection of residual disease after isolated limb infusion (ILI) is equivalent to a complete response after ILI-alone in advanced extremity melanoma.

    abstract:BACKGROUND:Isolated limb infusion (ILI) is a limb-preserving treatment for in-transit extremity melanoma. The benefit of resecting residual disease after ILI is unclear. METHODS:A multi-institutional experience was analyzed comparing patients who underwent ILI plus resection of residual disease (ILI + RES) versus ILI-...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-013-3336-4

    authors: Wong J,Chen YA,Fisher KJ,Beasley GM,Tyler DS,Zager JS

    更新日期:2014-02-01 00:00:00

  • Clinical Significance of Gross Invasion of Strap Muscles in Patients With 1- to 4-cm-Sized Papillary Thyroid Carcinoma Undergoing Lobectomy.

    abstract:BACKGROUND:Given the emerging evidence supporting the lack of prognostic significance of gross extrathyroidal extension invading only strap muscles (strap-gETE), this study investigated whether lobectomy is feasible for patients with strap-gETE. METHODS:A retrospective cohort study was conducted with 636 patients who ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07778-x

    authors: Song E,Kim WW,Jeon MJ,Sung TY,Song DE,Kim TY,Chung KW,Kim WB,Shong YK,Hong SJ,Lee YM,Kim WG

    更新日期:2019-12-01 00:00:00

  • Survival benefit of hyperthermic intraperitoneal chemotherapy for recurrent ovarian cancer: a multi-institutional case control study.

    abstract:BACKGROUND:Hyperthermic intraperitoneal chemotherapy (HIPEC) and complete surgical removal of the tumor, in relapsing patients may provide a clinical benefit. There is no consensus considering the place of HIPEC for patients who had first ovarian cancer relapse. To assess for possible efficacy of HIPEC on overall survi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-014-3693-7

    authors: Le Brun JF,Campion L,Berton-Rigaud D,Lorimier G,Marchal F,Ferron G,Oger AS,Dravet F,Jaffre I,Classe JM

    更新日期:2014-10-01 00:00:00

  • Biomarkers predict outcomes following cytoreductive surgery for hepatic metastases from functional carcinoid tumors.

    abstract:BACKGROUND:Cytoreductive therapy for metastatic carcinoid provides symptomatic relief and improvement in overall survival. We evaluated whether CgA and 5HIAA could predict symptomatic relief and control of disease progression after cytoreductive surgery. METHODS:We retrospectively reviewed 70 patients who underwent cy...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9148-z

    authors: Jensen EH,Kvols L,McLoughlin JM,Lewis JM,Alvarado MD,Yeatman T,Malafa M,Shibata D

    更新日期:2007-02-01 00:00:00

  • Prospective evaluation of laparoscopic celiac plexus block in patients with unresectable pancreatic adenocarcinoma.

    abstract:INTRODUCTION:The efficacy of laparoscopic celiac plexus block (CPB) in patients with unresectable pancreatic cancer has not been reported. METHODS:Patients with elevated pain scores scheduled for laparoscopy for diagnosis/staging of unresectable pancreatic adenocarcinoma were eligible. The study was designed to evalua...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1372-x

    authors: Allen PJ,Chou J,Janakos M,Strong VE,Coit DG,Brennan MF

    更新日期:2011-03-01 00:00:00

  • Implications of Conversion during Attempted Minimally Invasive Adrenalectomy for Adrenocortical Carcinoma.

    abstract:BACKGROUND:Although advocated by some, minimally invasive adrenalectomy (MIA) for adrenocortical carcinoma (ACC) is controversial. Moreover, the oncologic implications for patients requiring conversion to an open procedure during attempted MIA for ACC are not extensively reported. PATIENTS AND METHODS:The National Can...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08824-9

    authors: Delozier OM,Stiles ZE,Deschner BW,Drake JA,Deneve JL,Glazer ES,Tsao MW,Yakoub D,Dickson PV

    更新日期:2021-01-01 00:00:00

  • Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer.

    abstract:BACKGROUND:The FAK gene encodes a 125-kDa tyrosine kinase (p125FAK) involved in signal transduction pathways used in cell adhesion, motility, and anchorage-independent growth. Because thyroid carcinomas have a wide variability in their propensity for invasion and metastasis, we studied the expression of FAK in a variet...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02409059

    authors: Owens LV,Xu L,Dent GA,Yang X,Sturge GC,Craven RJ,Cance WG

    更新日期:1996-01-01 00:00:00

  • Reoperation for Complications after Lumpectomy and Mastectomy for Breast Cancer from the 2012 National Surgical Quality Improvement Program (ACS-NSQIP).

    abstract:BACKGROUND:Hospital readmissions and reoperations are quality indicators of patient care. In 2012, the National Surgical Quality Improvement Program (ACS-NSQIP) began reporting details regarding unplanned reoperations within 30 days of initial procedure. The main objective of this study was to identify reoperation rate...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4741-7

    authors: Al-Hilli Z,Thomsen KM,Habermann EB,Jakub JW,Boughey JC

    更新日期:2015-12-01 00:00:00

  • Impact of routine cavity shave margins on breast cancer re-excision rates.

    abstract:PURPOSE:Breast-conserving therapy (BCT) is an accepted method of treating early breast cancer. We hypothesized that routine excision of additional cavity shave margins (CSM) at time of initial partial mastectomy reduces the need for additional surgery. METHODS:A single-institution retrospective review was performed of...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1420-6

    authors: Kobbermann A,Unzeitig A,Xie XJ,Yan J,Euhus D,Peng Y,Sarode V,Moldrem A,Marilyn Leitch A,Andrews V,Stallings C,Rao R

    更新日期:2011-05-01 00:00:00

  • Association Between Waiting Time from Diagnosis to Treatment and Survival in Patients with Curable Gastric Cancer: A Population-Based Study in the Netherlands.

    abstract:BACKGROUND:In the Netherlands, a maximum waiting time from diagnosis to treatment (WT) of 5 weeks is recommended for curative cancer treatment. This study aimed to evaluate the association between WT and overall survival (OS) in patients undergoing gastrectomy for cancer. METHODS:This nationwide study included data fr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5820-8

    authors: Brenkman HJF,Visser E,van Rossum PSN,Siesling S,van Hillegersberg R,Ruurda JP

    更新日期:2017-07-01 00:00:00

  • Iterative cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for recurrent or progressive diffuse malignant peritoneal mesothelioma: clinicopathologic characteristics and survival outcome.

    abstract:BACKGROUND:Diffuse malignant peritoneal mesothelioma (DMPM) is an aggressive disease for which cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been used with remarkable survival benefits. Our aim was to analyze the clinicopathologic characteristics and prognosis of recurrent DMPM ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3977-y

    authors: Ihemelandu C,Bijelic L,Sugarbaker PH

    更新日期:2015-05-01 00:00:00

  • In Patients with Localized and Resectable Gastric Cancer, What is the Optimal Extent of Lymph Node Dissection-D1 Versus D2 Versus D3?

    abstract:BACKGROUND:Despite advances in the treatment of patients with gastric cancer, the debate over the optimal extent of lymphadenectomy continues. METHOD:A review of the classification, rationale for, and boundaries of lymphadenectomy is presented. A review of the available literature comparing D1 versus D2 versus D3 lymp...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07417-5

    authors: Mogal H,Fields R,Maithel SK,Votanopoulos K

    更新日期:2019-09-01 00:00:00

  • Toward better soft tissue sarcoma staging: building on american joint committee on cancer staging systems versions 6 and 7.

    abstract:BACKGROUND:Based on review of patient data in case conferences over time, we hypothesized that clinically relevant data are omitted in routine soft tissue sarcoma staging. METHODS:We examined subsets of a prospectively collected single institution soft tissue sarcoma database with respect to criteria of the AJCC versi...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-013-3052-0

    authors: Maki RG,Moraco N,Antonescu CR,Hameed M,Pinkhasik A,Singer S,Brennan MF

    更新日期:2013-10-01 00:00:00

  • Profiling Surgeon Performance for Breast Cancer Lumpectomy by Composite Measurement of Reoperations, Cosmetic Outcomes, and Patient Preferences.

    abstract:BACKGROUND:Patients want information to search for destination of care for breast-conserving surgery (BCS). To inform patients wanting a lumpectomy, we aimed to develop a pilot project that communicated composite quality measure (QM) results using a '4-star' rating system. Two patient-centered QMs were included in the ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-6479-5

    authors: Dunham AL,Ramirez LD,Vang CA,Linebarger JH,Landercasper J

    更新日期:2018-07-01 00:00:00

  • Validation of sentinel node mapping in patients with colon cancer.

    abstract:BACKGROUND:Sentinel lymph node (SLN) mapping techniques have been validated in breast cancer and melanoma. This study summarizes our experience with SLN mapping for colon cancer. METHODS:Fifty-five patients with colon cancer underwent intraoperative SLN mapping. One mL of 1% isosulfan blue was injected subserosally ar...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02573890

    authors: Paramo JC,Summerall J,Poppiti R,Mesko TW

    更新日期:2002-07-01 00:00:00

  • Prognostic value of renin-angiotensin system blockade in non-muscle-invasive bladder cancer.

    abstract:BACKGROUND:To determine whether the administration of renin-angiotensin system (RAS) inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs), affect disease outcome in non-muscle-invasive bladder cancer (NMIBC). METHODS:A total of 330 patients with initially diag...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2568-z

    authors: Yuge K,Miyajima A,Tanaka N,Shirotake S,Kosaka T,Kikuchi E,Oya M

    更新日期:2012-11-01 00:00:00

  • Population-based outcome of stage IA-IIA resected gastric adenocarcinoma: who should get adjuvant treatment?

    abstract:BACKGROUND:The benefit of adjuvant treatment in gastric adenocarcinoma was demonstrated by randomized, controlled trials of patients with locally advanced tumors. Thus, its role for stage IIB-IIIC disease is widely accepted. We aimed to identify patients with stage IA-IIA gastric adenocarcinoma who have a poor prognosi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2852-y

    authors: Gold JS,Al Natour RH,Saund MS,Yoon C,Sharma AM,Huang Q,Boosalis VA,Whang EE

    更新日期:2013-07-01 00:00:00

  • Incidental thyroid carcinoma by FDG-PET/CT: a study of clinicopathological characteristics.

    abstract:BACKGROUND:The rising incidence of incidental thyroid carcinoma (ITC) detected during fluoro-2-deoxy-D: -glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) scanning poses a challenge to clinicians. The present study aims to critically evaluate the clinicopathological characteristics of ITC detect...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1287-6

    authors: Law TT,Lang BH

    更新日期:2011-02-01 00:00:00

  • Microsatellite instability in breast cancer.

    abstract:BACKGROUND:Microsatellites are short repetitive nucleotide sequences that, through mutation, can undergo either expansion or contraction. This novel mutational mechanism known as microsatellite instability may play a role in carcinogenesis. We investigated the incidence of microsatellite instability in a series of prim...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02303580

    authors: Rush EB,Calvano JE,van Zee KJ,Zelenetz AD,Borgen PI

    更新日期:1997-06-01 00:00:00

  • Hiatal Hernia After Open versus Minimally Invasive Esophagectomy: A Systematic Review and Meta-analysis.

    abstract::Hiatal hernia (HH) is an infrequent yet potentially life-threatening complication after esophagectomy. Several studies have reported the incidence of this complication after both open and minimally invasive esophagectomy (MIE). This meta-analysis aimed to determine the pooled incidence of HH after both types of esopha...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1245/s10434-016-5155-x

    authors: Oor JE,Wiezer MJ,Hazebroek EJ

    更新日期:2016-08-01 00:00:00

  • Implementing the Prospective Surveillance Model (PSM) of Rehabilitation for Breast Cancer Patients with 1-Year Postoperative Follow-up, a Prospective, Observational Study.

    abstract:BACKGROUND:The Prospective Surveillance Model (PSM) of rehabilitation for patients with breast cancer aims for early identification, treatment, and support of physical impairments postoperatively. The purpose of this study was to describe the incidence of impairments during the first postoperative year and the differen...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5315-z

    authors: Lai L,Binkley J,Jones V,Kirkpatrick S,Furbish C,Stratford P,Thompson W,Sidhu A,Farley C,Okoli J,Beech D,Gabram S

    更新日期:2016-10-01 00:00:00

  • Neoadjuvant chemoradiotherapy affects the indications for lateral pelvic node dissection in mid/low rectal cancer with clinically suspected lateral node involvement: a multicenter retrospective cohort study.

    abstract:BACKGROUND:Although lateral pelvic node dissection (LPND) is recommended for rectal cancer with clinically metastatic lateral pelvic lymph nodes (LPNs), LPNs may respond to neoadjuvant chemoradiotherapy (nCRT). Our aim was to determine the optimal indication for LPND after nCRT for mid/low rectal cancer. METHODS:Of 2,...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-014-3559-z

    authors: Oh HK,Kang SB,Lee SM,Lee SY,Ihn MH,Kim DW,Park JH,Kim YH,Lee KH,Kim JS,Kim JW,Kim JH,Chang TY,Park SC,Sohn DK,Oh JH,Park JW,Ryoo SB,Jeong SY,Park KJ

    更新日期:2014-07-01 00:00:00