Impact of Neoadjuvant Chemotherapy on Clinical Risk Scores and Survival in Patients with Colorectal Liver Metastases.

Abstract:

BACKGROUND:Several clinical risk scores for patients with colorectal liver metastases (CLM) were established in cohorts of patients undergoing liver resection (LR) without neoadjuvant chemotherapy (NAC). The purpose of the study was to evaluate the predictive values of four common risk scores in the setting of NAC and the impact of score changes during NAC. METHODS:Risk scores (Fong, Nordlinger, Nagashima, and Konopke) were retrospectively calculated for 336 patients undergoing LR for CLM, including 109 patients without and 227 patients with NAC. In patients with NAC, the scores were calculated before and after NAC. RESULTS:In patients without NAC (n = 109), all risk scores except the Konopke score showed a significant correlation with disease-free survival (DFS). Only the Nagashima score also was predictive for overall survival (OS). In patients with NAC (n = 227), all scores except the Konopke score were predictive for DFS and OS before and after NAC. Score changes in the Fong and the Nagashima score showed a significant correlation with DFS and OS. CONCLUSIONS:Nagashima score was the most universally applicable score and predicted prognosis in all tested scenarios.

journal_name

Ann Surg Oncol

authors

Wimmer K,Schwarz C,Szabo C,Bodingbauer M,Tamandl D,Mittlböck M,Kaczirek K

doi

10.1245/s10434-016-5615-3

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

236-243

issue

1

eissn

1068-9265

issn

1534-4681

pii

10.1245/s10434-016-5615-3

journal_volume

24

pub_type

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