Evaluation of residual glandular tissue after skin-sparing mastectomies.

Abstract:

BACKGROUND:The oncological safety of skin-sparing mastectomy (SSM) has been the object of several studies. METHODS:From June 2003 to January 2004, 42 breast cancer patients, stage 0 to IIIA, underwent SSM. Before surgery, two lines were drawn on the breast skin, representing SSM and conventional mastectomy incisions. After surgery, the skin flap that would remain after SSM was removed, and immediate breast reconstruction was begun. The presence and amount of remaining glandular breast tissues were histologically evaluated in the skin flap. Terminal ductal lobular units (TDLUs) and residual disease were identified. These data were correlated with other clinical and pathologic parameters by using Fisher's exact test (P value) and receiver operating characteristic curves. RESULTS:The prevalence of residual breast tissue in the sample was 59.5%, and the presence of TDLUs was significantly associated with skin flaps thicker than 5 mm. Residual disease was found in 9.5% of the women and was associated with skin flaps >5 mm thick and the presence of TDLUs. There was no significant association between the presence of TDLUs and residual disease with age, body mass index, menopausal status, clinical and pathologic staging, breast volume, mammographic density, neoadjuvant chemotherapy, type of surgery, and presence of an extensive in situ component. The receiver operating characteristic curve showed that as skin flaps decrease in thickness, TDLUs also decrease. CONCLUSIONS:A high prevalence of glandular breast tissue and residual disease in the skin flap was associated with a skin flap thickness >5 mm.

journal_name

Ann Surg Oncol

authors

Torresan RZ,dos Santos CC,Okamura H,Alvarenga M

doi

10.1245/ASO.2005.11.027

keywords:

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

1037-44

issue

12

eissn

1068-9265

issn

1534-4681

journal_volume

12

pub_type

杂志文章
  • Laparoscopic abdominoperineal resection with open posterior cylindrical excision and primary transpelvic VRAM flap.

    abstract:BACKGROUND:In our own experience over the last 15 years, the primary transpelvic vertical rectus abdominis myocutaneous (VRAM) flap is a reliable tool to prevent perineal wound complications after cylindrical excision in radical anorectal tumor surgery. To minimize the operative trauma in such patients, we performed a ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1977-8

    authors: Horch RE,D'Hoore A,Holm T,Kneser U,Hohenberger W,Arkudas A

    更新日期:2012-02-01 00:00:00

  • Conservative Re-excision is a Safe and Simple Alternative to Radical Resection in Revision Surgery for Dermatofibrosarcoma Protuberans.

    abstract:BACKGROUND:Dermatofibrosarcoma protuberans (DFSP) is a dermal sarcoma often diagnosed by excision biopsy, and is often incompletely excised, with high recurrence rates. Traditional wide excision involves resection margins of 2-4 cm, often resulting in morbid procedures requiring surgical reconstruction. An alternative ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-08011-5

    authors: Snow H,Davies E,Strauss DC,Smith M,Hayes AJ

    更新日期:2020-03-01 00:00:00

  • Messenger RNA expression of vascular endothelial growth factor and its receptors in primary colorectal cancer and corresponding liver metastasis.

    abstract:BACKGROUND:Antiangiogenic therapies have been developed recently in combination with traditional chemotherapy for patients with metastatic colorectal cancer. The aim of this study was to clarify the association between messenger RNA (mRNA) levels of vascular endothelial growth factor (VEGF) and its receptors (VEGFR) in...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-9811-7

    authors: Kobayashi H,Sugihara K,Uetake H,Higuchi T,Yasuno M,Enomoto M,Kuramochi H,Lenz HJ,Danenberg KD,Danenberg PV

    更新日期:2008-04-01 00:00:00

  • Factors Associated with Reoperation in Breast-Conserving Surgery for Cancer: A Prospective Study of American Society of Breast Surgeon Members.

    abstract:BACKGROUND:More than 20% of patients undergoing initial breast-conserving surgery (BCS) for cancer require reoperation. To address this concern, the American Society of Breast Surgeons (ASBrS) endorsed 10 processes of care (tools) in 2015 to be considered by surgeons to de-escalate reoperations. In a planned follow-up,...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07547-w

    authors: Landercasper J,Borgert AJ,Fayanju OM,Cody H 3rd,Feldman S,Greenberg C,Linebarger J,Pockaj B,Wilke L

    更新日期:2019-10-01 00:00:00

  • A contemporary large single-institution evaluation of resected retroperitoneal sarcoma.

    abstract:PURPOSE:Retroperitoneal sarcomas (RPS) are rare malignancies, comprising just 10-15 % of all soft-tissue sarcomas. These are challenging tumors to treat, with surgical resection being the only modality capable of providing a cure. This study analyzed the management and survival of patients resected at a large academic ...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-014-3616-7

    authors: Bremjit PJ,Jones RL,Chai X,Kane G,Rodler ET,Loggers ET,Pollack SM,Pillarisetty VG,Mann GN

    更新日期:2014-07-01 00:00:00

  • Efficacy of different technical procedures for sentinel lymph node biopsy in gastric cancer staging.

    abstract:BACKGROUND:The clinical impact of sentinel lymph node biopsy (SLNB) in gastric cancer is controversial. We performed a prospective trial to compare different methods: radiocolloid method (RM), dye method (DM), and both methods simultaneously (dual method, or DUM) for reliability and therapeutic consequences. METHODS:R...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-007-9367-y

    authors: Gretschel S,Bembenek A,Hünerbein M,Dresel S,Schneider W,Schlag PM

    更新日期:2007-07-01 00:00:00

  • The 1999 James Ewing Lecture: in pursuit of molecules of oncogenesis and neoplastic therapy.

    abstract::Breast cancer is a progressive, phenotypic, genetic and epigenetic alteration, induced by various stimulants of which the principal steroid hormone, estrogen, initiates and promotes neoplastic transformation of normal ductal mammary epithelium to acquire distinct biochemical and molecular characteristics. The molecula...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10434-999-0528-z

    authors: Bland KI

    更新日期:1999-09-01 00:00:00

  • Effect of breast surgery on serum levels of insulin-like growth factors (IGF-I, IGF-II, and IGF binding protein-3) in women with benign and malignant breast lesions.

    abstract:BACKGROUND:There is evidence that insulin-like growth factors play a role in the development of breast cancer. Antiestrogens reduce circulating levels of IGF-I, but the influence of other breast cancer treatments, including surgery, is unknown and is investigated in this study. METHODS:Circulating serum concentrations...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/s10434-001-0025-5

    authors: Holdaway IM,Lethaby AE,Mason BH,Singh V,Harman JE,MacCormick M,Civil ID

    更新日期:2001-01-01 00:00:00

  • Implications of a postoperative rehabilitation program on quality of life in women with primary breast cancer treated with sentinel lymph node biopsy or complete axillary lymph node dissection.

    abstract:BACKGROUND:The aim of this clinical study was to evaluate quality of life (QoL) in early-stage breast cancer patients and to investigate the effects of a comprehensive rehabilitation program comparing women undergoing sentinel node biopsy (SNB) versus complete axillary lymph node dissection (ALND). QoL was assessed wit...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1245/s10434-008-0161-2

    authors: Pinto e Silva MP,Sarian LO,Morais SS,Pace do Amaral MT,Freire de Oliveira MM,Derchain S

    更新日期:2008-12-01 00:00:00

  • Sentinel-Lymph-Node-Based Management or Routine Axillary Clearance? Five-Year Outcomes of the RACS Sentinel Node Biopsy Versus Axillary Clearance (SNAC) 1 Trial: Assessment and Incidence of True Lymphedema.

    abstract:PURPOSE:To determine whether the benefits of sentinel-node-based management (SNBM) over routine axillary clearance (RAC) persisted to 5 years. METHODS:A total of 1088 women with breast cancer less than 3 cm in diameter and clinically negative axillary nodes were randomized to SNBM with axillary clearance if the sentin...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1245/s10434-016-5669-2

    authors: Wetzig N,Gill PG,Espinoza D,Mister R,Stockler MR,Gebski VJ,Ung OA,Campbell I,Simes J

    更新日期:2017-04-01 00:00:00

  • Adnexal Involvement in Endometrial Cancer: Prognostic Factors and Implications for Ovarian Preservation.

    abstract:PURPOSE:To determine the risk factors related to adnexal involvement in endometrial cancer (EC) and its implications for ovarian preservation in young women. METHODS:We analyzed a series of 802 patients who were treated at AC Camargo Cancer Center from July 1991 to July 2017. Patients who had peritoneal or systemic di...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08261-8

    authors: Baiocchi G,Clemente AG,Mantoan H,da Costa WL Jr,Bovolim G,Guimaraes APG,da Costa AABA,De Brot L,Faloppa CC

    更新日期:2020-08-01 00:00:00

  • Increasing mastectomy rates-the effect of environmental factors on the choice for mastectomy: a comparative analysis between Canada and the United States.

    abstract:PURPOSE:Unilateral mastectomy (UM) and contralateral prophylactic mastectomy (CPM) for early-stage breast cancer (ESBC) have been increasing. Numerous etiological factors for this rise have been suggested, including increasing use of magnetic resonance imaging (MRI) and reconstruction, surgeon's preference, and patient...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3955-4

    authors: Covelli AM,Baxter NN,Fitch MI,Wright FC

    更新日期:2014-10-01 00:00:00

  • Increased expression of ABCB6 enhances protoporphyrin IX accumulation and photodynamic effect in human glioma.

    abstract:BACKGROUND:Glioma recurrence usually occurs close to the tumor resection margins as a result of residual infiltrating glioma cells. 5-aminolevulinic acid (ALA) fluorescence-guided resection of gliomas has been demonstrated to enhance discrimination of tumor tissue and to improve survival. ALA-based photodynamic therapy...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-2201-6

    authors: Zhao SG,Chen XF,Wang LG,Yang G,Han DY,Teng L,Yang MC,Wang DY,Shi C,Liu YH,Zheng BJ,Shi CB,Gao X,Rainov NG

    更新日期:2013-12-01 00:00:00

  • Patterns of Referral for Adjuvant Chemotherapy for Stage II and III Colon Cancer: A Population-Based Study.

    abstract:PURPOSE:Reasons for variable utilization of adjuvant chemotherapy (ACT) for colon cancer have not been well described. We report medical oncology (MO) referral patterns and subsequent use of ACT. METHODS:Treatment records were linked to the population-based Ontario Cancer Registry to describe MO referral and ACT use a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5181-8

    authors: Chandhoke G,Wei X,Nanji S,Biagi J,Peng Y,Krzyzanowska M,Mackillop WJ,Booth CM

    更新日期:2016-08-01 00:00:00

  • Improved Locoregional Control in a Contemporary Cohort of Nonmetastatic Inflammatory Breast Cancer Patients Undergoing Surgery.

    abstract:BACKGROUND:Inflammatory breast cancer (IBC) is an aggressive form of breast cancer characterized by rapid progression and early metastatic dissemination. The purpose of this study was to assess contemporary rates of local regional recurrence (LRR) in the era of trimodality therapy for nonmetastatic IBC and identify ris...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5952-x

    authors: Rosso KJ,Tadros AB,Weiss A,Warneke CL,DeSnyder S,Kuerer H,Ueno NT,Stecklein SR,Woodward WA,Lucci A

    更新日期:2017-10-01 00:00:00

  • The Ethics of Breast Surgery.

    abstract::Breast surgery has evolved as a subspecialty of general surgery and requires a working knowledge of benign and malignant diseases, surgical techniques, shared decision-making with patients, collaboration with a multi-disciplinary team, and a basic foundation in surgical ethics. Ethics is defined as the practice of ana...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-015-4751-5

    authors: Throckmorton A,VanderWalde L,Brackett C,Dominici L,Eisenhauer T,Johnson N,Kong A,Ludwig K,O'Neill J,Pugliese M,Teller P,Sarantou T

    更新日期:2015-10-01 00:00:00

  • Surveillance Endoscopy Guidelines for Postgastrectomy Patients Based on Risk of Developing Remnant Gastric Cancer.

    abstract:BACKGROUND:Remnant gastric cancer (RGC) has a major impact on the long-term survival of postgastrectomy patients. In this study, we established surveillance endoscopy guidelines for postgastrectomy patients based on the risk of RGC. PATIENTS AND METHODS:A total of 6365 patients who underwent gastrectomy at Seoul St. M...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08517-3

    authors: Han ES,Seo HS,Kim JH,Lee HH

    更新日期:2020-10-01 00:00:00

  • Significance of linear extent of breast carcinoma at surgical margin.

    abstract:BACKGROUND:Our objective was to correlate the extent of margin positivity and the findings on re-excision specimens of infiltrating mammary carcinoma. METHODS:We selected 50 consecutive cases of infiltrating mammary carcinoma, including both infiltrating ductal carcinoma and infiltrating lobular carcinoma, with positi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/aso.2003.05.030

    authors: Darvishian F,Hajdu SI,DeRisi DC

    更新日期:2003-01-01 00:00:00

  • Prognostic Factors and Significance of Gastrointestinal Leak After Cytoreductive Surgery (CRS) with Heated Intraperitoneal Chemotherapy (HIPEC).

    abstract:BACKGROUND:Gastrointestinal leak (GIL) after cytoreductive surgery with heated intraperitoneal chemotherapy (CRS/HIPEC) is associated with significant morbidity and mortality. This study aimed to identify GIL prognostic factors and its impact on overall survival. METHODS:A retrospective analysis of a prospectively mai...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5738-6

    authors: Chouliaras K,Levine EA,Fino N,Shen P,Votanopoulos KI

    更新日期:2017-04-01 00:00:00

  • Pleural extension of mucinous tumor in patients with pseudomyxoma peritonei syndrome.

    abstract:BACKGROUND:Pseudomyxoma peritonei syndrome is a rare disease arising from perforation of an adenoma of the appendix. The syndrome is characterized by progressive accumulation of mucinous fluid and tumor within the abdomen and pelvis. Although this tumor is only superficially invasive and does not metastasize, it is a f...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02523654

    authors: Pestieau SR,Esquivel J,Sugarbaker PH

    更新日期:2000-04-01 00:00:00

  • Concurrent Selective Lymph Node Radiotherapy and S-1 Plus Cisplatin for Esophageal Squamous Cell Carcinoma: A Phase II Study.

    abstract:BACKGROUND:The efficacy, toxicity, and patterns of failure of esophageal squamous cell carcinoma (ESCC) treated with selective lymph node (SLN) conventional fraction radiotherapy (CFRT) and S-1 plus cisplatin (CDDP) were evaluated. PATIENTS AND METHODS:67 Patients with clinical stage II-IVa ESCC were enrolled. The tot...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07264-4

    authors: Wang X,Liu X,Li D,Wang X,Huang W,Li B

    更新日期:2019-06-01 00:00:00

  • Prognostic Factors of 30-Day Mortality After Palliative Procedures in Patients with Malignant Pleural Effusion.

    abstract:BACKGROUND:The aim of this study was to identify predictors of 30-day mortality in patients with malignant pleural effusion (MPE) who need pleural palliative procedures. METHODS:Data was prospectively collected from our database, between January 2013 and July 2014 on 86 patients with MPE and complete follow-up 30 days...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4491-6

    authors: Abrao FC,de Abreu IR,Fogarolli M,Caxeiro G,Bezerra CB,de Cerqueira Cesar FP,Rocha PS,Younes RN

    更新日期:2015-11-01 00:00:00

  • Serum carcinoembryonic antigen monitoring after curative resection for colorectal cancer: clinical significance of the preoperative level.

    abstract:AIM:We evaluated preoperative serum carcinoembryonic antigen (CEA) as a prognostic factor for colorectal cancer and determined when surveillance of this marker was useful. METHODS:Serum CEA was measured preoperatively in 1,263 patients who underwent curative resection for colorectal cancer at 3-month intervals for the...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0625-z

    authors: Park IJ,Choi GS,Lim KH,Kang BM,Jun SH

    更新日期:2009-11-01 00:00:00

  • OncotypeDX Recurrence Score Does Not Predict Nodal Burden in Clinically Node Negative Breast Cancer Patients.

    abstract:BACKGROUND:OncotypeDX recurrence score (RS)® has been found to predict recurrence and disease-free survival in patients with node negative breast cancer. Whether RS is useful in guiding locoregional therapy decisions is unclear. We sought to evaluate the relationship between RS and lymph node burden. METHODS:Patients ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-7059-4

    authors: Tevis SE,Bassett R,Bedrosian I,Barcenas CH,Black DM,Caudle AS,DeSnyder SM,Fitzsullivan E,Hunt KK,Kuerer HM,Lucci A,Meric-Bernstam F,Mittendorf EA,Park K,Teshome M,Thompson AM,Hwang RF

    更新日期:2019-03-01 00:00:00

  • Adjuvant brachytherapy for primary high-grade soft tissue sarcoma of the extremity.

    abstract:BACKGROUND:We reviewed single-institution experience using brachytherapy alone for primary high-grade soft tissue sarcoma of the extremity. METHODS:Between July 1982 and September 1997, 202 adult patients with primary high-grade soft tissue sarcoma of the extremity were treated with limb-sparing surgery and adjuvant b...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/aso.2002.9.1.48

    authors: Alektiar KM,Leung D,Zelefsky MJ,Healey JH,Brennan MF

    更新日期:2002-01-01 00:00:00

  • Multicystic and well-differentiated papillary peritoneal mesothelioma treated by surgical cytoreduction and hyperthermic intra-peritoneal chemotherapy (HIPEC).

    abstract:BACKGROUND:Multicystic peritoneal mesothelioma (MPM) and well-differentiated papillary peritoneal mesothelioma (WDPPM) are exceedingly uncommon lesions with uncertain malignant potential and no uniform treatment strategy. The aim of the current study was to review our experience with cytoreduction and hyperthermic intr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9475-8

    authors: Baratti D,Kusamura S,Nonaka D,Oliva GD,Laterza B,Deraco M

    更新日期:2007-10-01 00:00:00

  • The Dual Inhibition of Met and EGFR by ME22S, a Novel Met/EGFR Bispecific Monoclonal Antibody, Suppresses the Proliferation and Invasion of Laryngeal Cancer.

    abstract:PURPOSE:It has been reported that the abnormal activation of receptor tyrosine kinases is associated with the development of many human carcinomas and the high activation of EGFR and Met mediates the tumorigenicity of laryngeal carcinoma. In this study, we have done the therapeutic efficacy of ME22S (a novel EGFR/Met b...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-5084-0

    authors: Lee BS,Kim HJ,Hwang JW,Cheong KH,Kim KA,Cha HY,Lee JM,Kim CH

    更新日期:2016-06-01 00:00:00

  • Robotic-Assisted Placement of an Hepatic Artery Infusion Pump and Catheter for Regional Chemotherapy of the Liver.

    abstract:BACKGROUND:Hepatic artery infusion (HAI) chemotherapy is an effective regional therapy for unresectable colorectal liver metastases (U-CRLM).1 , 2 One of its limitations is the need for a laparotomy, which can delay the use of systemic therapy.3 Here, we describe a purely robotic technique for placement of an HAI pump ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5484-9

    authors: Dhir M,Magge D,Novak S,Bartlett DL,Zureikat AH

    更新日期:2016-12-01 00:00:00

  • Anti-tumor effects and tumor immunogenicity following IL2 or IL4 cytokine gene transfection of three mouse mammary tumors.

    abstract:BACKGROUND:The anti-tumor effects of three mouse mammary tumors transfected to express interleukin (IL) 2 or 4 were evaluated. METHODS:Three immunologically different tumors were used: DA3, EMT6, and 410. All three cell lines were successfully transfected using high efficiency viral vectors. Wild-type or transfected t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02307083

    authors: Matory YL,Chen M,Goedegebuure PS,Eberlein TJ

    更新日期:1995-11-01 00:00:00

  • Nonoperative management of primary colorectal cancer in patients with stage IV disease.

    abstract:BACKGROUND:Traditional teaching maintains that patients with primary colorectal adenocarcinoma require timely resection to prevent bleeding, perforation, or obstruction. The true benefits of primary tumor resection remain undocumented for patients presenting with metastatic disease, however. We postulated that resectio...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/s10434-999-0651-x

    authors: Scoggins CR,Meszoely IM,Blanke CD,Beauchamp RD,Leach SD

    更新日期:1999-10-01 00:00:00