The 1999 James Ewing Lecture: in pursuit of molecules of oncogenesis and neoplastic therapy.

abstract：BACKGROUND:Adaptor proteins, with multimodular structures, can participate in the regulation of various cellular functions. A novel adaptor protein XB130 has been implicated as a substrate and regulator of tyrosine kinase-mediated signaling and in controlling cell proliferation and apoptosis in thyroid and lung cancer ...

journal_title：Annals of surgical oncology

authors： Shiozaki A,Kosuga T,Ichikawa D,Komatsu S,Fujiwara H,Okamoto K,Iitaka D,Nakashima S,Shimizu H,Ishimoto T,Kitagawa M,Nakou Y,Kishimoto M,Liu M,Otsuji E

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Laparoscopic liver resection (LLR) for large malignant tumors can be technically challenging. Data on this topic are scarce, and many question its feasibility, safety, and oncologic efficiency. This study aimed to assess outcomes of LLR for large (≥ 5 cm) and giant (≥ 10 cm) malignant liver tumors. METHODS:...

journal_title：Annals of surgical oncology

authors： Shelat VG,Cipriani F,Basseres T,Armstrong TH,Takhar AS,Pearce NW,AbuHilal M

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Despite data from randomized trials supporting omission of radiation therapy (RT) for women ≥ 70 years of age with T1, estrogen receptor-positive (ER+) tumors undergoing breast-conserving therapy (BCT), RT usage remains high. We reviewed our institutional experience to determine if risk factors for local rec...

journal_title：Annals of surgical oncology

authors： Downs-Canner S,Zabor EC,Wind T,Cobovic A,McCormick B,Morrow M,Heerdt A

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Patients with palpable melanoma groin metastases have a poor prognosis. There is debate whether a combined superficial and deep groin dissection (CGD) is necessary or if superficial groin dissection (SGD) alone is sufficient. AIM:The aim of this study was to analyze risk factors for deep pelvic nodal involv...

journal_title：Annals of surgical oncology

authors： Oude Ophuis CM,van Akkooi AC,Hoekstra HJ,Bonenkamp JJ,van Wissen J,Niebling MG,de Wilt JH,van der Hiel B,van de Wiel B,Koljenović S,Grünhagen DJ,Verhoef C

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:Atypical protein kinase C iota (aPKC-iota) and its associated intracellular molecules, E-cadherin and beta-catenin, are important for cell polarization in tumorigenesis and progression. Expression of aPKC-iota, P-aPKC-iota (activated aPKC-iota), E-cadherin, and beta-catenin in hepatocellular carcinoma (HCC) ...

journal_title：Annals of surgical oncology

authors： Du GS,Wang JM,Lu JX,Li Q,Ma CQ,Du JT,Zou SQ

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Angiotensin 2 is a key biologic peptide in the renin-angiotensin system (RAS) that regulates blood pressure and renal hemodynamics. The potential role of the RAS in the promotion of tumor growth, angiogenesis, and metastasis also has been shown in the past few decades. This study investigated the prognostic ...

journal_title：Annals of surgical oncology

authors： Miyajima A,Yazawa S,Kosaka T,Tanaka N,Shirotake S,Mizuno R,Kikuchi E,Oya M

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Overall survival (OS) has traditionally been the primary end point in studies evaluating the clinical benefit of first-line chemotherapy in metastatic, locally advanced, or unresectable pancreatic cancer (MLAUPC). Given the prolonged follow-up assessment required to obtain OS and its potential to be confound...

journal_title：Annals of surgical oncology

authors： Makris EA,MacBarb R,Harvey DJ,Poultsides GA

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The EUropean REgistration of Cancer CAre (EURECCA) consortium aims to investigate differences in treatment and to improve cancer care through Europe. The purpose of this study was to compare neo- and adjuvant chemotherapy (ACT) and outcome after tumor resection for pancreatic adenocarcinoma stage I and II in...

journal_title：Annals of surgical oncology

authors： Groen JV,Sibinga Mulder BG,van Eycken E,Valerianova Z,Borras JM,van der Geest LGM,Capretti G,Schlesinger-Raab A,Primic-Zakelj M,Ryzhov A,van de Velde CJH,Bonsing BA,Bastiaannet E,Mieog JSD

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:The prognosis of gastric cancer patients with peritoneal dissemination is poor. Recently, chemotherapy with S-1 plus cisplatin has been shown to be highly effective for advanced gastric cancer. METHODS:In 41 patients diagnosed with either macro- or microscopic peritoneal dissemination by staging laparoscopy...

journal_title：Annals of surgical oncology

authors： Okabe H,Ueda S,Obama K,Hosogi H,Sakai Y

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is standard treatment for peritoneal dissemination from appendiceal cancer (AC); however, its role in high-grade histopathologic subtypes (high-grade mucinous carcinoma peritonei [HGMCP] and HGMCP with signet ring cells [HGMCP-S]...

journal_title：Annals of surgical oncology

authors： Munoz-Zuluaga C,Sardi A,King MC,Nieroda C,Sittig M,MacDonald R,Gushchin V

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:It is unclear whether hepatic resection (HR) or transarterial chemoembolization (TACE) is associated with better outcomes for patients with hepatocellular carcinoma (HCC) in Barcelona Clinic Liver Cancer (BCLC) stage A. The present study compared survival for patients with BCLC stage A HCC treated by HR or T...

journal_title：Annals of surgical oncology

authors： Guo Z,Zhong JH,Jiang JH,Zhang J,Xiang BD,Li LQ

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Preoperative injection of radiocolloid before a sentinel lymph node (SLN) biopsy is painful for patients with breast cancer. Injection after anesthesia eliminates this discomfort but allows less time for radiocolloid migration. Our goal was to validate the efficacy of intraoperative injection. METHODS:In th...

journal_title：Annals of surgical oncology

authors： Stell VH,Flippo-Morton TS,Norton HJ,White RL Jr

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:The risk of tumor recurrence after resection of soft tissue sarcoma (STS) necessitates surveillance in follow-up. The objective of this study was to determine the frequency/timing of metastasis and local recurrence following treatment for soft tissue sarcoma, and to use these data to justify an evidence-based f...

journal_title：Annals of surgical oncology

authors： Wilson DAJ,Gazendam A,Visgauss J,Perrin D,Griffin AM,Chung PW,Catton CN,Shultz D,Ferguson PC,Wunder JS

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the introduction of diagnostic laparoscopy (DLS) in patients with colorectal peritoneal metastases (PM) to prevent non-therapeutic laparotomies during cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS + HIPEC). METHODS:Patients with histologically...

journal_title：Annals of surgical oncology

authors： Hentzen JEKR,Constansia RDN,Been LB,Hoogwater FJH,van Ginkel RJ,van Dam GM,Hemmer PHJ,Kruijff S

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:This study was designed to determine the role of laparoscopic adrenalectomy (LA) in the surgical management of adrenocortical carcinoma (ACC). METHODS:A systematic literature review was performed on January 2, 2015 using PubMed. Article selection proceeded according to PRISMA criteria. Studies comparing open a...

journal_title：Annals of surgical oncology

authors： Autorino R,Bove P,De Sio M,Miano R,Micali S,Cindolo L,Greco F,Nicholas J,Fiori C,Bianchi G,Kim FJ,Porpiglia F

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Patients with borderline resectable pancreatic ductal adenocarcinoma (PDA) represent a high-risk group of patients due to tumor or patient-related characteristics. The optimal management of these patients has not been fully defined. MATERIALS AND METHODS:All patients undergoing evaluation for PDA between 20...

journal_title：Annals of surgical oncology

authors： Stokes JB,Nolan NJ,Stelow EB,Walters DM,Weiss GR,de Lange EE,Rich TA,Adams RB,Bauer TW

更新日期：2011-03-01 00:00:00

abstract：: ...

journal_title：Annals of surgical oncology

authors： Chan DL,Hallet J

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:To investigate the influence of the introduction of total mesorectal excision (TME) on local recurrence rate and survival in patients with rectal cancer. METHODS:A total of 171 consecutive patients underwent anterior or abdominoperineal resection for primary rectal cancer. When the TME technique was introduced...

journal_title：Annals of surgical oncology

authors： Maurer CA,Renzulli P,Kull C,Käser SA,Mazzucchelli L,Ulrich A,Büchler MW

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Postoperative recurrence of hepatocellular carcinoma (HCC) is a major problem after surgical resection. To date, adjuvant chemotherapy or other adjuvant modalities have not been proven effective in preventing or delaying recurrence. The aim of this prospective randomized study was to evaluate the effectivene...

journal_title：Annals of surgical oncology

authors： Xia Y,Qiu Y,Li J,Shi L,Wang K,Xi T,Shen F,Yan Z,Wu M

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Parenchyma-preserving resections (PPRs), including enucleation and middle pancreatectomy (MP), are accepted procedures for insulinomas, but their role in the treatment of nonfunctioning pancreatic endocrine tumors (NF-PETs) is debated. The aim of this study was to evaluate perioperative and long-term outcome...

journal_title：Annals of surgical oncology

authors： Falconi M,Zerbi A,Crippa S,Balzano G,Boninsegna L,Capitanio V,Bassi C,Di Carlo V,Pederzoli P

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:While previously thought to be clinically indolent, recent data suggest significant late metastatic capacity of solitary fibrous tumors (SFTs). We define prognostic factors for recurrence and disease-specific death (DSD) in resected primary SFTs. METHODS:Resected primary SFTs from 1982 to 2015 were identified ...

journal_title：Annals of surgical oncology

authors： Gholami S,Cassidy MR,Kirane A,Kuk D,Zanchelli B,Antonescu CR,Singer S,Brennan M

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Near-infrared (NIR) fluorescent sentinel lymph node (SLN) mapping in breast cancer requires optimized imaging systems and lymphatic tracers. MATERIALS AND METHODS:A small, portable version of the FLARE imaging system, termed Mini-FLARE, was developed for capturing color video and two semi-independent channe...

journal_title：Annals of surgical oncology

authors： Mieog JS,Troyan SL,Hutteman M,Donohoe KJ,van der Vorst JR,Stockdale A,Liefers GJ,Choi HS,Gibbs-Strauss SL,Putter H,Gioux S,Kuppen PJ,Ashitate Y,Löwik CW,Smit VT,Oketokoun R,Ngo LH,van de Velde CJ,Frangioni JV,Vahrme

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Reactive oxygen species (free radicals) play an important role in carcinogenesis. Extensive antioxidant defense mechanisms counteract free radicals in mammalian cells. Oxidative stress is a disturbance in the balance between the production of free radicals and antioxidant defenses. There is direct evidence t...

journal_title：Annals of surgical oncology

authors： Kilic N,Yavuz Taslipinar M,Guney Y,Tekin E,Onuk E

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Resection of melanoma metastatic to the liver remains controversial. We evaluated the efficacy of hepatic resection in patients with metastatic ocular and cutaneous melanoma and assessed factors that could affect survival after resection. METHODS:Forty patients with hepatic melanoma metastasis underwent res...

journal_title：Annals of surgical oncology

authors： Pawlik TM,Zorzi D,Abdalla EK,Clary BM,Gershenwald JE,Ross MI,Aloia TA,Curley SA,Camacho LH,Capussotti L,Elias D,Vauthey JN

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:To investigate the efficacy and safety of adding continuous occlusion of hepatic artery proper to intermittent Pringle maneuver in partial hepatectomy for ruptured hepatocellular carcinoma. MATERIALS AND METHODS:This is a retrospective study on data that were prospectively collected and entered into a compu...

journal_title：Annals of surgical oncology

authors： Xia F,Lau WY,Qian C,Ma K,Li X,Bie P

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Sensitive biomarkers are necessary for risk classification of patients with gastric cancer (GC), especially ones at risk of distant metastases. Melanoma-associated antigen (MAGE)-D2 has been reported to play a role in the process of cell adhesion and metastatic potential of tumor cells in colorectal cancer. ...

journal_title：Annals of surgical oncology

authors： Kanda M,Nomoto S,Oya H,Takami H,Shimizu D,Hibino S,Hashimoto R,Kobayashi D,Tanaka C,Yamada S,Fujii T,Nakayama G,Sugimoto H,Koike M,Fujiwara M,Kodera Y

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Local treatment of colorectal cancer, including endoscopic removal of colonic polyps and transanal resection of rectal tumors, has become widely accepted. However, risk factors predicting the presence of lymph node metastasis have not been fully investigated. To determine the criteria for local excision of c...

journal_title：Annals of surgical oncology

authors： Adachi Y,Yasuda K,Kakisako K,Sato K,Shiraishi N,Kitano S

更新日期：1999-06-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy in terms of local control (LC) of 24 h infusion of gemcitabine plus radiotherapy after surgery for pancreatic cancer. METHODS:Weekly gemcitabine (100 mg/m(2)) was provided as a 24-hour infusion during the course of radiotherapy (50.4 Gy to the tumor, 39.6 Gy to the nodes). Patients sub...

journal_title：Annals of surgical oncology

authors： Mattiucci GC,Ippolito E,D'Agostino GR,Alfieri S,Antinori A,Crucitti A,Balducci M,Deodato F,Luzi S,Macchia G,Smaniotto D,Morganti AG,Valentini V

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Genetic and epigenetic alterations during development of pancreatic ductal adenocarcinomas (PDAC) are well known. Genetic and epigenetic data were correlated with tumor biology to find specific alterations responsible for invasion and metastasis in pancreatic ductal adenocarcinomas. METHODS:A total of 16 hu...

journal_title：Annals of surgical oncology

authors： Mees ST,Mardin WA,Sielker S,Willscher E,Senninger N,Schleicher C,Colombo-Benkmann M,Haier J

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Studies assessing outcomes in occult breast cancer have often included women treated before the routine use of magnetic resonance imaging (MRI). This study examined outcomes for patients presenting with axillary adenopathy and no primary breast tumor detectable by MRI or other imaging methods. METHODS:All p...

journal_title：Annals of surgical oncology

authors： McCartan DP,Zabor EC,Morrow M,Van Zee KJ,El-Tamer MB

更新日期：2017-10-01 00:00:00