Long-term analysis of gemcitabine-based chemoradiation after surgical resection for pancreatic adenocarcinoma.

Abstract:

PURPOSE:To evaluate the efficacy in terms of local control (LC) of 24 h infusion of gemcitabine plus radiotherapy after surgery for pancreatic cancer. METHODS:Weekly gemcitabine (100 mg/m(2)) was provided as a 24-hour infusion during the course of radiotherapy (50.4 Gy to the tumor, 39.6 Gy to the nodes). Patients subsequently received five cycles of gemcitabine monochemotherapy (1,000 mg/m(2) 1, 8, q21). The primary end point of the study was to achieve a 2-year LC rate of ≥80 % with type I and II errors of 5 and 20 %. The study was designed to accrue a maximum sample size of 35 patients. Secondary end points were toxicity evaluation, metastasis-free survival (MFS), and overall survival (OS). RESULTS:Data of 35 patients were available. Most of the patients (n = 27; 77.1 %) had duodeno-cephalo-pancreatectomy, 5 (14.3 %) distal pancreatectomy, and 3 (8.6 %) total pancreatectomy. The pathological stages were T1-T2 (n = 7; 20.0 %), T3-T4 (n = 28; 80.0 %), N0 (n = 17; 48.6 %), and N1 (n = 18; 51.4 %). Thirty patients (85.7 %) completed chemoradiation. Twenty-three patients (65.7 %) received further sequential chemotherapy. Acute toxicity was acceptable. No late toxicity occurred. The median follow-up period was 64 (range 24-118) months, and 2-year crude rate of LC was 83 (median not reached). Median MFS and OS were 26.5 and 22.5 months, respectively. CONCLUSIONS:The rate of LC met the main goal of the study. The regimen resulted in a high LC rate but failed to show a benefit in terms of OS or MFS, thus suggesting the need for a more intensified multimodal approach.

journal_name

Ann Surg Oncol

authors

Mattiucci GC,Ippolito E,D'Agostino GR,Alfieri S,Antinori A,Crucitti A,Balducci M,Deodato F,Luzi S,Macchia G,Smaniotto D,Morganti AG,Valentini V

doi

10.1245/s10434-012-2767-7

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

423-9

issue

2

eissn

1068-9265

issn

1534-4681

journal_volume

20

pub_type

杂志文章
  • A large cohort of consecutive patients confirmed frequent HER2 positivity in gastric carcinomas with advanced stages.

    abstract:BACKGROUND:Trastuzumab in association with systemic cytotoxic chemotherapy is the standard of care for patients with advanced HER2-positive gastric carcinoma (GC). However, HER2 as a prognostic factor in GC remains controversial. METHODS:HER2 overexpression and amplification was evaluated by immunohistochemistry (IHC)...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2818-0

    authors: Cho J,Jeong J,Sung J,Sung CO,Kim KM,Park CK,Choi MG,Sohn TS,Bae JM,Kim S

    更新日期:2013-12-01 00:00:00

  • Hospitalization in the Year Preceding Major Oncologic Surgery Increases Risk for Adverse Postoperative Events.

    abstract:BACKGROUND:Hospitalization is associated with negative clinical effects that last beyond discharge. This study aimed to determine whether hospitalization in the year before major oncologic surgery is associated with adverse outcomes. METHODS:Patients 18 years of age or older with stomach, pancreas, colon, or rectal ca...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-6032-y

    authors: Sharoky CE,Collier KT,Wirtalla CJ,Sinnamon AJ,Neuwirth MG,Kuo LE,Roses RE,Fraker DL,Karakousis GC,Kelz RR

    更新日期:2017-11-01 00:00:00

  • Clinically-staged T3N0 rectal cancer: is preoperative chemoradiotherapy the optimal treatment?

    abstract:BACKGROUND:Preoperative chemoradiotherapy has been widely adopted as the standard of care for stage II-III rectal cancers. However, patients with T3N0 lesions had been shown to have a better prognosis than other categories of locally advanced tumor. Thus, neoadjuvant chemoradiation is likely to be overtreatment in this...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0796-7

    authors: Lombardi R,Cuicchi D,Pinto C,Di Fabio F,Iacopino B,Neri S,Tardio ML,Ceccarelli C,Lecce F,Ugolini G,Pini S,Di Tullio P,Taffurelli M,Minni F,Martoni A,Cola B

    更新日期:2010-03-01 00:00:00

  • Association between recency of last pregnancy and biologic subtype of breast cancer.

    abstract:BACKGROUND:Breast cancers (BCs) diagnosed after a recent pregnancy display features associated with poor prognosis, including hormone receptor negativity, but other tumor markers have not been examined. We sought to define the tumor marker profile of these cancers, including HER-2 and p53 expression, and examine the ti...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-2104-6

    authors: Pilewskie M,Gorodinsky P,Fought A,Hansen N,Bethke K,Jeruss J,Scholtens D,Khan SA

    更新日期:2012-04-01 00:00:00

  • Surgical indication for non-curative endoscopic resection in early gastric cancer.

    abstract:BACKGROUND:Endoscopic resection (ER) is an effective treatment for early gastric cancer (EGC) without lymph node metastasis. However, after ER additional surgery may be needed to manage the risks presented by residual cancer or lymph node metastasis. METHODS:ER was performed on 344 gastric adenocarcinomas between Nove...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9536-z

    authors: Ryu KW,Choi IJ,Doh YW,Kook MC,Kim CG,Park HJ,Lee JH,Lee JS,Lee JY,Kim YW,Bae JM

    更新日期:2007-12-01 00:00:00

  • An outcome study of breast reconstruction: presurgical identification of risk factors for complications.

    abstract:BACKGROUND:Breast reconstruction following mastectomy has been shown to have a salutary effect on the overall psychological well-being of women being treated for breast cancer. Unfortunately, however, not every patient is an ideal candidate for reconstruction. Complications stemming from reconstructive surgery can caus...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/s10434-001-0586-3

    authors: Lin KY,Johns FR,Gibson J,Long M,Drake DB,Moore MM

    更新日期:2001-08-01 00:00:00

  • ASO Author Reflections: Omentoplasty to Improve Perineal Wound Healing After Abdominoperineal Resection.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6799-5

    authors: Blok RD,Tanis PJ

    更新日期:2018-12-01 00:00:00

  • Outcomes after robot-assisted pancreaticoduodenectomy for periampullary lesions.

    abstract:BACKGROUND:There are many theoretical advantages that a minimally invasive approach to the pancreaticoduodenectomy might offer patients with benign and malignant disease of the head of the pancreas over traditional open techniques, including improved recovery time, decreased hospital stay, and earlier initiation of and...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-2045-0

    authors: Zeh HJ,Zureikat AH,Secrest A,Dauoudi M,Bartlett D,Moser AJ

    更新日期:2012-03-01 00:00:00

  • Functional outcome of arthrodesis with a vascularized fibular graft and a rotational latissimus dorsi flap after proximal humerus sarcoma resection.

    abstract:BACKGROUND:The prognosis of humeral sarcomas has improved greatly in the past 20 years. As a result, the challenges for orthopedic oncologists include long-term handicap and local morbidity. METHODS:Shoulder reconstruction after the resection of sarcomas with the proximal humerus was evaluated for 55 patients from 199...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1443-z

    authors: Wang J,Shen J,Dickinson IC

    更新日期:2011-07-01 00:00:00

  • Surgical Upstaging Rates for Vacuum Assisted Biopsy Proven DCIS: Implications for Active Surveillance Trials.

    abstract:PURPOSE:This study was designed to determine invasive cancer upstaging rates at surgical excision following vacuum-assisted biopsy of ductal carcinoma in situ (DCIS) among women meeting eligibility for active surveillance trials. METHODS:Patients with vacuum-assisted, biopsy-proven DCIS at a single center from 2008 to...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-6018-9

    authors: Grimm LJ,Ryser MD,Partridge AH,Thompson AM,Thomas JS,Wesseling J,Hwang ES

    更新日期:2017-11-01 00:00:00

  • PRAME as a Potential Biomarker for Liver Metastasis of Gastric Cancer.

    abstract:BACKGROUND:Liver metastasis of gastric cancer (GC) is highly associated with poor prognosis. The development of sensitive biomarkers for detecting and predicting liver metastasis is required for better clinical outcome. OBJECTIVE:In this study, we aimed to identify novel genes associated with liver metastasis of GC. ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07985-6

    authors: Baba H,Kanda M,Sawaki K,Umeda S,Miwa T,Shimizu D,Tanaka C,Kobayashi D,Fujiwara M,Kodera Y,Fujii T

    更新日期:2020-06-01 00:00:00

  • A comparison of clinical and pathologic assessments for the prediction of occult nipple involvement in nipple-sparing mastectomies.

    abstract:BACKGROUND:Nipple-sparing mastectomy (NSM) for both risk reduction and cancer is increasing. In the cancer setting, most studies suggest the use of both clinical and intraoperative biopsy criteria in patient selection. This study examines the use of both biopsy and clinical criteria in women undergoing total nipple-rem...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2511-3

    authors: Stolier A,Stone JC,Moroz K,Hanemann CW,McNabb L,Jones SD,Lacey M

    更新日期:2013-01-01 00:00:00

  • Is hepatic resection for large or multinodular hepatocellular carcinoma justified? Results from a multi-institutional database.

    abstract:BACKGROUND:The role of surgical resection in patients with large or multinodular hepatocellular carcinoma (HCC) remains unclear. This study evaluated the long-term outcome of patients with hepatic resection for large (>5 cm in diameter) or multinodular (more than three nodules) HCC by using a multi-institutional databa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/ASO.2005.06.004

    authors: Ng KK,Vauthey JN,Pawlik TM,Lauwers GY,Regimbeau JM,Belghiti J,Ikai I,Yamaoka Y,Curley SA,Nagorney DM,Ng IO,Fan ST,Poon RT,International Cooperative Study Group on Hepatocellular Carcinoma.

    更新日期:2005-05-01 00:00:00

  • Is there an optimal surgery time after endoscopic resection in early gastric cancer?

    abstract:BACKGROUND:The patients with early gastric cancer who have undergone incomplete endoscopic resection (ER) generally need additional surgery because of the possibility of lymph node metastasis. The aim of study was to evaluate the optimal time interval from ER to additive surgery by evaluating the effect of time interva...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3299-5

    authors: Kim MJ,Kim JH,Lee YC,Kim JW,Choi SH,Hyung WJ,Noh SH,Youn YH,Park H,Lee SI

    更新日期:2014-01-01 00:00:00

  • Society of Surgical Oncology 72nd Annual Cancer Symposium.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 新闻

    doi:10.1245/s10434-019-07174-5

    authors:

    更新日期:2019-02-01 00:00:00

  • Adherence to the National Quality Forum (NQF) breast cancer measures within cancer clinical trials: a review from ACOSOG Z0010.

    abstract:BACKGROUND:In 2007, the National Quality Forum (NQF) released four performance measures for the treatment of breast cancer. We proposed to study the degree of adherence with these measures among participating institutions in a multi-institutional trial. METHODS:American College of Surgeons Oncology Group (ACOSOG) Z001...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-0980-9

    authors: Wilke LG,Ballman KV,McCall LM,Giuliano AE,Whitworth PW,Blumencranz PW,Reintgen DS,Burak WE,Leitch AM,Hunt KK

    更新日期:2010-08-01 00:00:00

  • Size and Location are the Most Important Risk Factors for Malignant Behavior in Resected Solitary Fibrous Tumors.

    abstract:PURPOSE:While previously thought to be clinically indolent, recent data suggest significant late metastatic capacity of solitary fibrous tumors (SFTs). We define prognostic factors for recurrence and disease-specific death (DSD) in resected primary SFTs. METHODS:Resected primary SFTs from 1982 to 2015 were identified ...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-017-6092-z

    authors: Gholami S,Cassidy MR,Kirane A,Kuk D,Zanchelli B,Antonescu CR,Singer S,Brennan M

    更新日期:2017-12-01 00:00:00

  • Learning curve for percutaneous radiofrequency ablation of pulmonary metastases from colorectal carcinoma: a prospective study of 70 consecutive cases.

    abstract:BACKGROUND:Percutaneous radiofrequency ablation (RFA) for inoperable colorectal pulmonary metastases is associated with a morbidity rate of 30% to 40%. A learning curve in this treatment approach has not been documented before. METHODS:The clinical and treatment-related data regarding 70 consecutive percutaneous RFA p...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9010-3

    authors: Yan TD,King J,Sjarif A,Glenn D,Steinke K,Morris DL

    更新日期:2006-12-01 00:00:00

  • Trends in the treatment and outcome of pancreatic cancer in the United States.

    abstract:BACKGROUND:Although pancreatic cancer is the fourth leading cause of cancer death, few studies have evaluated population-based trends in diagnosis, management, and outcome. METHODS:We used the Surveillance, Epidemiology, and End Results (SEER) registry to evaluate treatment trends and outcomes for patients 18 or older...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9249-8

    authors: Baxter NN,Whitson BA,Tuttle TM

    更新日期:2007-04-01 00:00:00

  • Institutional learning curve of cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion for peritoneal malignancies.

    abstract:BACKGROUND:Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemoperfusion (HIPEC) is routinely used to treat certain peritoneal carcinomatoses (PC), but it can be associated with relatively high complication rates, prolonged hospital length of stay, and potential mortality. Our objective was to determine ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4111-x

    authors: Polanco PM,Ding Y,Knox JM,Ramalingam L,Jones H,Hogg ME,Zureikat AH,Holtzman MP,Pingpank J,Ahrendt S,Zeh HJ,Bartlett DL,Choudry HA

    更新日期:2015-05-01 00:00:00

  • Clinical Importance of CD200 Expression in Colorectal Liver Metastasis.

    abstract:BACKGROUND:Approximately 30% of patients diagnosed with colorectal cancer (CRC) develop liver metastases. We evaluated the role of CD200, a potent immunosuppressive molecule, in colorectal liver metastases (CRLM). METHODS:We examined 110 patients who underwent curative liver resection for CRLM at our institution betwe...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09471-w

    authors: Matsuo Y,Sho M,Nomi T,Hokuto D,Yoshikawa T,Kamitani N,Nakamura K,Iwasa Y

    更新日期:2021-01-03 00:00:00

  • Optimal Cutoff Values of Skeletal Muscle Index to Define Sarcopenia for Prediction of Survival in Patients with Advanced Gastric Cancer.

    abstract:BACKGROUND:Sarcopenia, characterized by loss of skeletal muscle mass, is recognized as a prognostic factor in patients with gastric cancer. However, wide variability exists in the cutoff values of muscle mass for defining sarcopenia across previous studies, and the best cutoff values to predict survival remain unknown....

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-6728-7

    authors: Nishigori T,Tsunoda S,Obama K,Hisamori S,Hashimoto K,Itatani Y,Okada K,Sakai Y

    更新日期:2018-11-01 00:00:00

  • Levels of Alternatively Spliced Tissue Factor in the Plasma of Patients with Pancreatic Cancer May Help Predict Aggressive Tumor Phenotype.

    abstract:BACKGROUND:Circulating ('blood-borne') tissue factor (TF) is implicated in the pathogenesis of several chronic conditions, most notably cardiovascular disease, diabetes, and cancer. Full-length TF is an integral membrane protein, while alternatively spliced TF (asTF) can be secreted and, owing to its unique C-terminus,...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4592-2

    authors: Unruh D,Sagin F,Adam M,Van Dreden P,Woodhams BJ,Hart K,Lindsell CJ,Ahmad SA,Bogdanov VY

    更新日期:2015-12-01 00:00:00

  • Predictors of Bowel Function in Long-term Rectal Cancer Survivors with Anastomosis.

    abstract:BACKGROUND:Bowel function in long-term rectal cancer survivors with anastomosis has not been characterized adequately. We hypothesized that bowel function is associated with patient, disease, and treatment characteristics. METHODS:The cohort study included Kaiser Permanente members who were long-term (≥5 years) rectal...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-6017-x

    authors: Alavi M,Wendel CS,Krouse RS,Temple L,Hornbrook MC,Bulkley JE,McMullen CK,Grant M,Herrinton LJ

    更新日期:2017-11-01 00:00:00

  • The utility of intraoperative evaluation of sentinel lymph nodes in breast cancer.

    abstract:BACKGROUND:In breast cancer treatment, intraoperative sentinel lymph node (SLN) evaluation is used to identify patients who may potentially benefit from immediate completion of axillary lymph node dissection. METHODS:Prospectively collected breast cancer registry data identified 516 SLN biopsies between January 2003 a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9270-y

    authors: Pugliese MS,Tickman R,Wang NP,Atwood M,Beatty JD

    更新日期:2007-03-01 00:00:00

  • Readmission After Pancreaticoduodenectomy: The Influence of the Volume Effect Beyond Mortality.

    abstract:BACKGROUND:As increased focus is placed on quality of care in surgery, readmission is an increasingly important metric by which hospital and surgeon quality is measured. For complex pancreatic surgery, we hypothesized that increased pancreaticoduodenectomy (PD) volume may mitigate readmission rates. METHODS:The Univer...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4451-1

    authors: Sutton JM,Wilson GC,Wima K,Hoehn RS,Cutler Quillin R 3rd,Hanseman DJ,Paquette IM,Sussman JJ,Ahmad SA,Shah SA,Abbott DE

    更新日期:2015-11-01 00:00:00

  • Complete hepatic venous isolation and extracorporeal chemofiltration as treatment for human hepatocellular carcinoma: a phase I study.

    abstract:BACKGROUND:We performed a phase I study of a novel system of complete hepatic venous isolation and extracorporeal chemofiltration in patients with unresectable hepatocellular carcinoma (HCC) to determine (a) whether systemic exposure to doxorubicin could be limited after high-dose hepatic arterial infusion (HAI), and (...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02303811

    authors: Curley SA,Newman RA,Dougherty TB,Fuhrman GM,Stone DL,Mikolajek JA,Guercio S,Guercio A,Carrasco CH,Kuo MT

    更新日期:1994-09-01 00:00:00

  • The illusion of the learning phase for lymphatic mapping.

    abstract:BACKGROUND:We provide a statistical analysis of the learning phase for sentinel node biopsy. METHODS:Four learning phases were analyzed: 25, 50, 75, and 150 procedures with a corresponding number of 10, 20, 30, and 60 tumor-positive cases. Critical values of nonidentification rate and false-negative rate were defined....

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02557365

    authors: Tanis PJ,Nieweg OE,Hart AA,Kroon BB

    更新日期:2002-03-01 00:00:00

  • Molecular profiling of micrometastatic cancer cells.

    abstract::Malignant tumors of epithelial tissue are the most common form of cancer and are responsible for the majority of cancer-related deaths in Western industrialized countries. As a result of progress in surgical treatment of these tumors, lethality is linked increasingly to early metastasis, which is generally occult at t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Pantel K,Hosch SB

    更新日期:2001-10-01 00:00:00

  • Implications of Conversion during Attempted Minimally Invasive Adrenalectomy for Adrenocortical Carcinoma.

    abstract:BACKGROUND:Although advocated by some, minimally invasive adrenalectomy (MIA) for adrenocortical carcinoma (ACC) is controversial. Moreover, the oncologic implications for patients requiring conversion to an open procedure during attempted MIA for ACC are not extensively reported. PATIENTS AND METHODS:The National Can...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08824-9

    authors: Delozier OM,Stiles ZE,Deschner BW,Drake JA,Deneve JL,Glazer ES,Tsao MW,Yakoub D,Dickson PV

    更新日期:2021-01-01 00:00:00