OncotypeDX Recurrence Score Does Not Predict Nodal Burden in Clinically Node Negative Breast Cancer Patients.


BACKGROUND:OncotypeDX recurrence score (RS)® has been found to predict recurrence and disease-free survival in patients with node negative breast cancer. Whether RS is useful in guiding locoregional therapy decisions is unclear. We sought to evaluate the relationship between RS and lymph node burden. METHODS:Patients with invasive breast cancer who underwent sentinel lymph node dissection from 2010 to 2015 were identified from a prospectively maintained database. Patients were excluded if they were clinically node positive or if they received neoadjuvant chemotherapy. RS was classified as low (< 18), intermediate (18-30), or high (> 30). The association between RS, lymph node burden, and disease recurrence was evaluated. Statistical analyses were performed in R version 3.4.0; p < 0.05 was considered significant. RESULTS:A positive SLN was found in 168 (15%) of 1121 patients. Completion axillary lymph node dissection was performed in 84 (50%) of SLN-positive patients. The remaining 84 (50%) patients had one to two positive SLNs and did not undergo further axillary surgery. RS was low in 58.5%, intermediate in 32.6%, and high in 8.9%. RS was not associated with a positive SLN, number of positive nodes, maximum node metastasis size, or extranodal extension. The median follow-up was 23 months. High RS was not associated with locoregional recurrence (p = 0.07) but was significantly associated with distant recurrence (p = 0.0015). CONCLUSIONS:OncotypeDX RS is not associated with nodal burden in women with clinically node-negative breast cancer, suggesting that RS is not useful to guide decisions regarding extent of axillary surgery for these patients.


Ann Surg Oncol


Tevis SE,Bassett R,Bedrosian I,Barcenas CH,Black DM,Caudle AS,DeSnyder SM,Fitzsullivan E,Hunt KK,Kuerer HM,Lucci A,Meric-Bernstam F,Mittendorf EA,Park K,Teshome M,Thompson AM,Hwang RF




Has Abstract


2019-03-01 00:00:00














  • Messenger RNA expression of vascular endothelial growth factor and its receptors in primary colorectal cancer and corresponding liver metastasis.

    abstract:BACKGROUND:Antiangiogenic therapies have been developed recently in combination with traditional chemotherapy for patients with metastatic colorectal cancer. The aim of this study was to clarify the association between messenger RNA (mRNA) levels of vascular endothelial growth factor (VEGF) and its receptors (VEGFR) in...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Kobayashi H,Sugihara K,Uetake H,Higuchi T,Yasuno M,Enomoto M,Kuramochi H,Lenz HJ,Danenberg KD,Danenberg PV

    更新日期:2008-04-01 00:00:00

  • Characterization of the neoplastic potential of solitary solid thyroid lesions with Tc-99m-pertechnetate and Tc-99m-sestamibi scanning.

    abstract:BACKGROUND:Radionuclide scans that use Tc-99m-pertechnetate or I-123 currently lack the specificity to assess the malignant potential of solitary solid lesions of the thyroid gland. Tc-99m-sestamibi scanning was used to determine the neoplastic potential of thyroid lesions. METHODS:Patients with lesions of the thyroid...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Wei JP,Burke GJ

    更新日期:1995-05-01 00:00:00

  • Phosphatase and tensin analog gene overexpression engenders cellular death in human malignant mesothelioma cells via inhibition of AKT phosphorylation.

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    pub_type: 杂志文章


    authors: Mohiuddin I,Cao X,Ozvaran MK,Zumstein L,Chada S,Smythe WR

    更新日期:2002-04-01 00:00:00

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    pub_type: 杂志文章,随机对照试验


    authors: Schnabel F,Boolbol SK,Gittleman M,Karni T,Tafra L,Feldman S,Police A,Friedman NB,Karlan S,Holmes D,Willey SC,Carmon M,Fernandez K,Akbari S,Harness J,Guerra L,Frazier T,Lane K,Simmons RM,Estabrook A,Allweis T

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  • Long-term outcomes comparing surgery to embolization-ablation for treatment of solitary HCC

    abstract:BACKGROUND:Resection has been the standard of care for patients with solitary hepatocellular carcinoma (HCC). Transarterial embolization and percutaneous ablation are alternative therapies often reserved for suboptimal surgical candidates. Here we compare long-term outcomes of patients with solitary HCC treated with re...

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    authors: Elnekave E,Erinjeri JP,Brown KT,Thornton RH,Petre EN,Maybody M,Maluccio MA,Hsu M,Sofocleous CT,Getrajdman GI,Brody LA,Solomon SB,Alago W,Fong Y,Jarnagin WR,Covey AM

    更新日期:2013-09-01 00:00:00

  • Postoperative Infectious Complications are Associated with Adverse Oncologic Outcomes in Esophageal Cancer Patients Undergoing Preoperative Chemotherapy.

    abstract:BACKGROUND:For some types of cancer, postoperative complications can negatively influence survival, but the association between these complications and oncological outcomes is unclear for patients with esophageal cancer who receive preoperative treatments. METHODS:Data were retrospectively analyzed for patients who un...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Yamashita K,Makino T,Miyata H,Miyazaki Y,Takahashi T,Kurokawa Y,Yamasaki M,Nakajima K,Takiguchi S,Mori M,Doki Y

    更新日期:2016-06-01 00:00:00

  • New metastatic lymph node ratio system reduces stage migration in patients undergoing D1 lymphadenectomy for gastric adenocarcinoma.

    abstract:BACKGROUND:The American Joint Committee on Cancer (AJCC)/International Union Against Cancer (UICC) staging system for gastric cancer incorporates the absolute number of metastatic lymph nodes (N status) and is optimally used when >or=15 nodes are examined. The ratio of metastatic to examined nodes (N ratio) is an effec...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Maduekwe UN,Lauwers GY,Fernandez-Del-Castillo C,Berger DL,Ferguson CM,Rattner DW,Yoon SS

    更新日期:2010-05-01 00:00:00

  • Robotic-Assisted Placement of an Hepatic Artery Infusion Pump and Catheter for Regional Chemotherapy of the Liver.

    abstract:BACKGROUND:Hepatic artery infusion (HAI) chemotherapy is an effective regional therapy for unresectable colorectal liver metastases (U-CRLM).1 , 2 One of its limitations is the need for a laparotomy, which can delay the use of systemic therapy.3 Here, we describe a purely robotic technique for placement of an HAI pump ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Dhir M,Magge D,Novak S,Bartlett DL,Zureikat AH

    更新日期:2016-12-01 00:00:00

  • Clinicopathological Features and Outcomes in Individuals with Breast Cancer and ATM, CHEK2, or PALB2 Mutations.

    abstract:INTRODUCTION:The moderate-penetrance germline mutations ATM, CHEK2, and PALB2 are implicated in an increased risk of the development of breast cancer. Whether these mutations provide clinical utility to guide treatment strategies and prognosis remains unknown. METHODS:A retrospective case-control study from a tertiary...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Bergstrom C,Pence C,Berg J,Partain N,Sadeghi N,Mauer C,Pirzadeh-Miller S,Gao A,Li H,Unni N,Syed S

    更新日期:2020-09-29 00:00:00

  • Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study.

    abstract:BACKGROUND:Cytotoxic T lymphocyte-associated antigen (CTLA)-4 can inhibit T-cell responses and is involved in tolerance against self antigens. We previously reported autoimmune manifestations and objective cancer regressions in patients with metastatic melanoma treated with CTLA-4 blockade. The possibility of activatin...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Maker AV,Phan GQ,Attia P,Yang JC,Sherry RM,Topalian SL,Kammula US,Royal RE,Haworth LR,Levy C,Kleiner D,Mavroukakis SA,Yellin M,Rosenberg SA

    更新日期:2005-12-01 00:00:00

  • Intrathoracic Chemoperfusion Decreases Recurrences in Patients with Full-Thickness Diaphragm Involvement with Mucinous Appendiceal Adenocarcinoma.

    abstract:BACKGROUND:Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) is the preferred treatment for selected patients with mucinous appendiceal adenocarcinoma. Frequently, the hemidiaphragms are infiltrated with tumor, requiring partial diaphragm resection (DR) in order to obtain complete cytoreductio...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Grotz TE,Mansfield PF,Royal RE,Mann GN,Rafeeq S,Beaty KA,Overman MJ,Fournier KF

    更新日期:2016-09-01 00:00:00

  • Urinary pH Levels are Strongly Associated with Bladder Recurrence After Nephroureterectomy in Upper Tract Urothelial Carcinoma Patients with a Smoking History.

    abstract:PURPOSE:Aromatic amines, well-known bladder carcinogens, derived from cigarette smoke are activated by acidic urine. We herein determined whether urinary pH levels are associated with bladder recurrence in upper tract urothelial carcinoma patients with a positive smoking history. METHODS:A total of 256 upper tract uro...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Ide H,Kikuchi E,Hagiwara M,Hayakawa N,Hongo H,Miyajima A,Oya M

    更新日期:2016-12-01 00:00:00

  • Levels of Alternatively Spliced Tissue Factor in the Plasma of Patients with Pancreatic Cancer May Help Predict Aggressive Tumor Phenotype.

    abstract:BACKGROUND:Circulating ('blood-borne') tissue factor (TF) is implicated in the pathogenesis of several chronic conditions, most notably cardiovascular disease, diabetes, and cancer. Full-length TF is an integral membrane protein, while alternatively spliced TF (asTF) can be secreted and, owing to its unique C-terminus,...

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    authors: Unruh D,Sagin F,Adam M,Van Dreden P,Woodhams BJ,Hart K,Lindsell CJ,Ahmad SA,Bogdanov VY

    更新日期:2015-12-01 00:00:00

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    abstract:BACKGROUND:Our objective was to correlate the extent of margin positivity and the findings on re-excision specimens of infiltrating mammary carcinoma. METHODS:We selected 50 consecutive cases of infiltrating mammary carcinoma, including both infiltrating ductal carcinoma and infiltrating lobular carcinoma, with positi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Darvishian F,Hajdu SI,DeRisi DC

    更新日期:2003-01-01 00:00:00

  • ASO Author Reflections: Proposal of a New Preoperative Prognostic Model for Solitary Hepatocellular Carcinoma.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章


    authors: Yoh T,Seo S

    更新日期:2018-12-01 00:00:00

  • Follow-Up Recommendations after Diagnosis of Primary Cutaneous Melanoma: A Population-Based Study in New South Wales, Australia.

    abstract:BACKGROUND:Follow-up practices after diagnosis and treatment of primary cutaneous melanoma vary considerably. We aimed to determine factors associated with recommendations for follow-up setting, frequency, skin surveillance, and concordance with clinical guidelines. METHODS:The population-based Melanoma Patterns of Ca...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Read RL,Madronio CM,Cust AE,Goumas C,Watts CG,Menzies S,Curtin AM,Mann G,Thompson JF,Morton RL

    更新日期:2018-03-01 00:00:00

  • Surgery versus intra-arterial therapy for neuroendocrine liver metastasis: a multicenter international analysis.

    abstract:BACKGROUND:Management of patients with neuroendocrine liver metastasis (NELM) remains controversial. We sought to examine the relative efficacy of surgical management versus intra-arterial therapy (IAT) for NELM and determine factors predictive of survival. METHODS:A total of 753 patients who had surgery (n = 339) or ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究


    authors: Mayo SC,de Jong MC,Bloomston M,Pulitano C,Clary BM,Reddy SK,Clark Gamblin T,Celinski SA,Kooby DA,Staley CA,Stokes JB,Chu CK,Arrese D,Ferrero A,Schulick RD,Choti MA,Geschwind JF,Strub J,Bauer TW,Adams RB,Aldrighett

    更新日期:2011-12-01 00:00:00

  • Predictors of re-excision among women undergoing breast-conserving surgery for cancer.

    abstract:BACKGROUND:Up to 60% of breast cancer patients who undergo breast-conserving surgery (BCS) require re-excision to obtain clear margins, causing delays in adjuvant treatment and poor aesthetic results. However, patient and treatment-related factors associated with re-excision are not well defined. METHODS:We surveyed a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Waljee JF,Hu ES,Newman LA,Alderman AK

    更新日期:2008-05-01 00:00:00

  • Sentinel Lymph Node Biopsy Is Prognostic in Thickest Melanoma Cases and Should Be Performed for Thick Melanomas.

    abstract:BACKGROUND:Sentinel lymph node biopsy (SLNB) is recommended for intermediate thickness melanoma, but for thick melanoma, guidelines are less definitive about the use of SLNB in this population. We present a study on thick melanoma evaluating for prognostic factors. PATIENTS AND METHODS:The Sentinel Lymph Node Working ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Han D,Han G,Duque MT,Morrison S,Leong SP,Kashani-Sabet M,Vetto J,White R,Schneebaum S,Pockaj B,Mozzillo N,Sondak VK,Zager JS

    更新日期:2021-02-01 00:00:00

  • Cetuximab shows activity in colorectal cancer patients with tumors for which FISH analysis does not detect an increase in EGFR gene copy number.

    abstract:BACKGROUND:EGFR (epidermal growth factor receptor) gene gain assessed by FISH (fluorescence in situ hybridization) has been shown to be predictive of response to EGFR-targeted therapies in patients with non-small cell lung cancer. The aim or our study was to relate the EGFR gene copy number to therapeutic results in pa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究


    authors: Italiano A,Follana P,Caroli FX,Badetti JL,Benchimol D,Garnier G,Gugenheim J,Haudebourg J,Keslair F,Lesbats G,Lledo G,Roussel JF,Pedeutour F,François E

    更新日期:2008-02-01 00:00:00

  • ASO Author Reflections: Redefining the Ki-67 Index Stratification for Low-Grade Pancreatic Neuroendocrine Tumors.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章


    authors: Lopez-Aguiar AG,Cardona K

    更新日期:2018-12-01 00:00:00

  • Locoregional recurrence after mastectomy with immediate transverse rectus abdominis myocutaneous (TRAM) flap reconstruction.

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    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Patterson SG,Teller P,Iyengar R,Carlson GW,Gabram-Mendola SG,Losken A,Styblo T,Torres M,Wood WC,Perez SD,Mosunjac M,Rizzo M

    更新日期:2012-08-01 00:00:00

  • Is pT2 subclassification feasible to predict patient outcome in colorectal cancer?

    abstract:BACKGROUND:This study aimed to evaluate the prognostic impact of pT2 subclassification according to the depth of muscularis propria (MP) invasion and to explore the clinicopathologic factors correlated with lymph node metastasis (LNM) and postoperative hematogenous metastasis in pT2 colorectal cancer. METHODS:A total ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Tong LL,Gao P,Wang ZN,Yue ZY,Song YX,Sun Z,Lu Y,Xing CZ,Xu HM

    更新日期:2011-05-01 00:00:00

  • High serum vascular endothelial growth factor levels predict poor prognosis after radiofrequency ablation of hepatocellular carcinoma: importance of tumor biomarker in ablative therapies.

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    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Poon RT,Lau C,Pang R,Ng KK,Yuen J,Fan ST

    更新日期:2007-06-01 00:00:00

  • mTHPC-mediated photodynamic therapy of early stage oral squamous cell carcinoma: a comparison to surgical treatment.

    abstract:BACKGROUND:mTHPC-mediated photodynamic therapy (PDT) is used for treatment of early head and neck squamous cell carcinoma. This study is a retrospective comparison of PDT with transoral surgery in the treatment of early primary squamous cell carcinoma of the oral cavity/oropharynx. METHODS:PDT data were retrieved from...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章


    authors: de Visscher SA,Melchers LJ,Dijkstra PU,Karakullukcu B,Tan IB,Hopper C,Roodenburg JL,Witjes MJ

    更新日期:2013-09-01 00:00:00

  • Resection Margins in Merkel Cell Carcinoma: Is a 1-cm Margin Wide Enough?

    abstract:BACKGROUND:Guidelines regarding specific resection margins for primary Merkel cell carcinoma (MCC) are not well established. The current National Comprehensive Cancer Network (NCCN) guidelines recommend 1- to 2-cm resection margins. This study aimed to determine the impact of margin width on local recurrence (LR), dise...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Perez MC,de Pinho FR,Holstein A,Oliver DE,Naqvi SMH,Kim Y,Messina JL,Burke E,Gonzalez RJ,Sarnaik AA,Cruse CW,Wuthrick EJ,Harrison LB,Sondak VK,Zager JS

    更新日期:2018-10-01 00:00:00

  • Determining the association between preoperative computed tomography findings and postoperative outcomes after cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei.

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    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Chua TC,Al-Zahrani A,Saxena A,Glenn D,Liauw W,Zhao J,Morris DL

    更新日期:2011-06-01 00:00:00

  • Systematic para-aortic and pelvic lymphadenectomy in early stage epithelial ovarian cancer: a prospective study.

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    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Ditto A,Martinelli F,Reato C,Kusamura S,Solima E,Fontanelli R,Haeusler E,Raspagliesi F

    更新日期:2012-11-01 00:00:00

  • Selecting the Right Tumors for Genomic Testing.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 社论


    authors: Euhus DM

    更新日期:2019-02-01 00:00:00

  • Survival data justifies resection for pancreatic metastases.

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    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Strobel O,Hackert T,Hartwig W,Bergmann F,Hinz U,Wente MN,Fritz S,Schneider L,Büchler MW,Werner J

    更新日期:2009-12-01 00:00:00