Anti-tumor effects and tumor immunogenicity following IL2 or IL4 cytokine gene transfection of three mouse mammary tumors.


BACKGROUND:The anti-tumor effects of three mouse mammary tumors transfected to express interleukin (IL) 2 or 4 were evaluated. METHODS:Three immunologically different tumors were used: DA3, EMT6, and 410. All three cell lines were successfully transfected using high efficiency viral vectors. Wild-type or transfected tumor cells were injected subcutaneously into Balb/c mice and animals were observed for tumor growth. RESULTS:Overall, there was a significant decrease in the incidence and in the size of palpable transfected tumor compared with control tumors. Animals were immunized with wild-type or transfected cells and challenged with wild-type tumor. In these experiments, animals immunized with transfected tumor cells had a significantly lower incidence of tumor and significantly smaller tumors than controls. Similar experiments were performed by immunization with irradiated cells (wild type and transfected), and significant immune protection was induced. CONCLUSIONS:Each cell line responded differently following gene transfection, with the greatest anti-tumor effects seen in the EMT6 tumor cells transfected with IL2 or IL4.


Ann Surg Oncol


Matory YL,Chen M,Goedegebuure PS,Eberlein TJ




Has Abstract


1995-11-01 00:00:00












  • Intraoperative imprint cytology examination of sentinel lymph nodes after neoadjuvant chemotherapy in breast cancer patients.

    abstract:BACKGROUND:Intraoperative imprint cytology (IC) is one of several accurate, proven methods to detect tumor cells in sentinel lymph nodes (SLN) from patients with operable breast cancer. In patients treated with neoadjuvant chemotherapy (NAC), studies have demonstrated the feasibility and accuracy of SLN biopsy procedur...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Gimbergues P,Dauplat MM,Durando X,Abrial C,Le Bouedec G,Mouret-Reynier MA,Cachin F,Kwiatkowski F,Tchirkov A,Dauplat J,Penault-Llorca F

    更新日期:2010-08-01 00:00:00

  • The Significance of CD44 Variant 9 in Resected Lung Adenocarcinoma: Correlation with Pathological Early-Stage and EGFR Mutation.

    abstract:BACKGROUND:CD44 isoforms serve as a marker for cancer stem cells. CD44 variant 9 (CD44v9) contributes to the defense against reactive oxygen species, resulting in resistance to chemoradiotherapy. However, the significance of CD44v9 in patients with lung adenocarcinoma is unknown. METHODS:We used immunohistochemical an...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Akamine T,Tagawa T,Ijichi K,Toyokawa G,Takamori S,Hirai F,Okamoto T,Oda Y,Maehara Y

    更新日期:2019-05-01 00:00:00

  • A phase I study of hyperthermic isolated hepatic perfusion with oxaliplatin in the treatment of unresectable liver metastases from colorectal cancer.

    abstract::Isolated hepatic perfusion (IHP) is a proven approach for regional delivery of chemotherapy in patients with unresectable primary and metastatic tumors of the liver. Most trials of IHP have utilized melphalan as the active drug in the perfusate. We performed a phase I trial to evaluate the efficacy, safety, and maximu...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Zeh HJ 3rd,Brown CK,Holtzman MP,Egorin MJ,Holleran JL,Potter DM,Bartlett DL

    更新日期:2009-02-01 00:00:00

  • Microsatellite instability in breast cancer.

    abstract:BACKGROUND:Microsatellites are short repetitive nucleotide sequences that, through mutation, can undergo either expansion or contraction. This novel mutational mechanism known as microsatellite instability may play a role in carcinogenesis. We investigated the incidence of microsatellite instability in a series of prim...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Rush EB,Calvano JE,van Zee KJ,Zelenetz AD,Borgen PI

    更新日期:1997-06-01 00:00:00

  • Molecular imaging of tumor-associated angiogenesis using a novel magnetic resonance imaging contrast agent targeting αvβ 3 integrin.

    abstract:BACKGROUND:The recent introduction of biological anticancer therapy has renewed the interest in functional imaging of tumor-associated angiogenesis (TAA) as a tool to monitor early therapy response. The present study evaluated imaging of TAA using P1227, a novel, small molecular magnetic resonance imaging (MRI) probe t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Debergh I,Van Damme N,De Naeyer D,Smeets P,Demetter P,Robert P,Carme S,Pattyn P,Ceelen W

    更新日期:2014-06-01 00:00:00

  • Predictors of surgical margin status in breast-conserving surgery within a breast screening program.

    abstract:BACKGROUND:Breast-conserving surgery (BCS) requires clear surgical margins to minimize local recurrence. We sought to identify groups of patients at higher risk of involved margins who might benefit from preoperative counselling and/or more generous excision at the first operation. METHODS:We reviewed demographic, cli...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Kurniawan ED,Wong MH,Windle I,Rose A,Mou A,Buchanan M,Collins JP,Miller JA,Gruen RL,Mann GB

    更新日期:2008-09-01 00:00:00

  • Factors associated with variance in compliance with a sentinel lymph node dissection quality measure in early-stage breast cancer.

    abstract:BACKGROUND:Guidelines recommend sentinel lymph node dissection (SLND) for patients with clinical stage I/IIA/IIB breast cancer; however, a significant fraction of patients do not undergo this procedure. We sought to identify factors associated with noncompliance with the SLND benchmark in early-stage breast cancer. MA...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Olaya W,Wong J,Morgan JW,Truong C,Roy-Chowdhury S,Kazanjian K,Lum S

    更新日期:2010-10-01 00:00:00

  • The Landmark Series: Randomized Trials Examining Surgical Margins for Cutaneous Melanoma.

    abstract::Between 1980 and 2004, six randomized, controlled trials (RCTs) have been performed to evaluate the width of surgical margin excision for primary cutaneous melanoma and its influence on recurrence and survival. These trials have led to the current recommendation of not more than a 2-cm margin excision and have allowed...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审


    authors: Angeles CV,Wong SL,Karakousis G

    更新日期:2020-01-01 00:00:00

  • Morbidity and mortality associated with gastrectomy for gastric cancer.

    abstract:BACKGROUND:Surgery alone is often inadequate for advanced-stage gastric cancer. Surgical complications may delay adjuvant therapy. Understanding these complications is needed for multidisciplinary planning. MATERIAL AND METHODS:The American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究


    authors: Papenfuss WA,Kukar M,Oxenberg J,Attwood K,Nurkin S,Malhotra U,Wilkinson NW

    更新日期:2014-09-01 00:00:00

  • The keystone flap: not an advance, just a stretch.

    abstract:BACKGROUND:The keystone flap is being promoted as an advance in oncological surgical reconstruction. Wound closure with this island flap involves two V-Y advancements toward the center and along the long axis of the island, at right angles to the line of maximum tension when the wound is closed. It is implied that the ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Douglas CD,Low NC,Seitz MJ

    更新日期:2013-03-01 00:00:00

  • Validation of sentinel node mapping in patients with colon cancer.

    abstract:BACKGROUND:Sentinel lymph node (SLN) mapping techniques have been validated in breast cancer and melanoma. This study summarizes our experience with SLN mapping for colon cancer. METHODS:Fifty-five patients with colon cancer underwent intraoperative SLN mapping. One mL of 1% isosulfan blue was injected subserosally ar...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Paramo JC,Summerall J,Poppiti R,Mesko TW

    更新日期:2002-07-01 00:00:00

  • Stereotactic fine-needle aspiration biopsy for the evaluation of nonpalpable breast lesions: report of an experience based on 2,988 cases.

    abstract:BACKGROUND:The increasing use of mammography has led to a significant increase in the detection of clinically occult lesions, the majority of which prove to be benign. SFNB has been suggested as a means of expediting a diagnosis for lesions that are malignant while limiting surgical biopsies for those that are benign. ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Mitnick JS,Vazquez MF,Pressman PI,Harris MN,Roses DF

    更新日期:1996-03-01 00:00:00

  • Age as a predictor of sentinel node metastasis among patients with localized melanoma: an inverse correlation of melanoma mortality and incidence of sentinel node metastasis among young and old patients.

    abstract:PURPOSE:We have previously reported that older patients with clinical stage I and II primary cutaneous. Melanoma had lower survival rates compared to younger patients. We postulated that the incidence of nodal metastasis would therefore be higher among older melanoma patients. METHODS:The expanded American Joint Commi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Balch CM,Thompson JF,Gershenwald JE,Soong SJ,Ding S,McMasters KM,Coit DG,Eggermont AM,Gimotty PA,Johnson TM,Kirkwood JM,Leong SP,Ross MI,Byrd DR,Cochran AJ,Mihm MC Jr,Morton DL,Atkins MB,Flaherty KT,Sondak VK

    更新日期:2014-04-01 00:00:00

  • Dynamics of FLAIR Volume Changes in Glioblastoma and Prediction of Survival.

    abstract:BACKGROUND:The extent of tumor resection (EOTR) calculated by enhanced T1 changes in glioblastomas has been previously reported to predict survival. However, fluid-attenuated inversion recovery (FLAIR) volume may better represent tumor burden. In this study, we report the first assessment of the dynamics of FLAIR volum...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Grossman R,Shimony N,Shir D,Gonen T,Sitt R,Kimchi TJ,Harosh CB,Ram Z

    更新日期:2017-03-01 00:00:00

  • Inhibition of poly(ADP-ribose) polymerase enhances the effect of chemotherapy in an animal model of regional therapy for the treatment of advanced extremity malignant melanoma.

    abstract:BACKGROUND:Poly(ADP-ribose) polymerase (PARP) is an important regulator of programmed cell death in response to alkylating agents such as temozolomide (TMZ). The goal of this study was to determine if a systemically administered PARP-inhibitor (INO-1001) could augment the efficacy of TMZ in a rat model of extremity mal...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Toshimitsu H,Yoshimoto Y,Augustine CK,Padussis JC,Yoo JS,Angelica Selim M,Pruitt SK,Friedman HS,Ali-Osman F,Tyler DS

    更新日期:2010-08-01 00:00:00

  • Pylorus-Preserving Surgery Based on the Sentinel Node Concept in Early Gastric Cancer.

    abstract:BACKGROUND:In patients with early stage gastric cancer in the middle third of the stomach, pylorus-preserving gastrectomy (PPG) can be an option as function-preserving surgery, although its oncologic safety is not definitively defined. This issues may be overcome using the sentinel node (SN) concept. The aim of this st...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Shimada A,Takeuchi H,Ono T,Kamiya S,Fukuda K,Nakamura R,Takahashi T,Wada N,Kawakubo H,Saikawa Y,Omori T,Nakahara T,Jinzaki M,Murakami K,Kitagawa Y

    更新日期:2016-12-01 00:00:00

  • ASO Author Reflections: Survival Benefit of Adjuvant Chemoradiotherapy for Gallbladder Cancer: The Role of Radiation Therapy Revisited.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章


    authors: Kim BH,Chie EK,Kim K

    更新日期:2018-12-01 00:00:00

  • Outcomes After Mastectomy and Lumpectomy in Elderly Patients with Early-Stage Breast Cancer.

    abstract:INTRODUCTION:Survival in elderly patients undergoing mastectomy or lumpectomy has not been specifically analyzed. METHODS:Patients older than 70 years of age with clinical stage I invasive breast cancer, undergoing mastectomy or lumpectomy with or without radiation, and surveyed within 3 years of their diagnosis, were...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Mogal HD,Clark C,Dodson R,Fino NF,Howard-McNatt M

    更新日期:2017-01-01 00:00:00

  • Technical details of sentinel lymph node mapping in colorectal cancer and its impact on staging.

    abstract:BACKGROUND:Sentinel lymph node (SLN) mapping for melanoma and breast cancer has greatly enhanced the identification of micrometastases in many patients, thereby upstaging a subset of these patients. The purpose of this study was to see if SLN mapping technique could be used to identify SLNs in colorectal cancer and to ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Saha S,Wiese D,Badin J,Beutler T,Nora D,Ganatra BK,Desai D,Kaushal S,Nagaraju M,Arora M,Singh T

    更新日期:2000-03-01 00:00:00

  • Lymph node metastases in diffuse malignant peritoneal mesothelioma.

    abstract:BACKGROUND:Improved survival has been reported for diffuse malignant peritoneal mesothelioma (DMPM) treated by surgical cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC). The significance of lymph node involvement in this disease is still poorly understood. METHODS:Prospectively collected clinical da...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Baratti D,Kusamura S,Cabras AD,Laterza B,Balestra MR,Deraco M

    更新日期:2010-01-01 00:00:00

  • The Suggestion of Revised Criteria for Endoscopic Resection of Differentiated-Type Submucosal Gastric Cancer.

    abstract:BACKGROUND:Early gastric cancer that meets the expanded criteria for endoscopic resection (ER) is expected to be associated with a negligible risk for lymph node metastasis (LNM); however, recent studies have reported LNM in submucosal gastric cancer patients who met the existing criteria. In this study, we develop the...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究


    authors: Ma DW,Lee SJ,Kook MC,Park DY,Ahn S,Ryu KW,Choi IJ,Noh SH,Kim H,Lee YC,Kim JH

    更新日期:2020-03-01 00:00:00

  • Endoscopic Retrograde Biliary Drainage Causes Intra-Abdominal Abscess in Pancreaticoduodenectomy Patients: An Important But Neglected Risk Factor.

    abstract:BACKGROUND:Patients with periampullary cancer frequently suffer obstructive jaundice and commonly require preoperative biliary drainage (PBD) for relief and to avoid related complications. Although research has established a correlation between PBD and surgical wound infection, the impact of PBD on major infectious com...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Wu JM,Ho TW,Yen HH,Wu CH,Kuo TC,Yang CY,Tien YW

    更新日期:2019-04-01 00:00:00

  • MSH2 rs2303425 Polymorphism is Associated with Early-Onset Breast Cancer in Taiwan.

    abstract:BACKGROUND:Accumulated evidence indicates that the incidence of early-onset breast cancer has rapidly increased in Taiwan and other Asian compared to Western countries. The mismatch repair (MMR) pathway might be one of the crucial mechanisms of predisposition to early breast cancer. In this study, we explored whether M...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Hsieh YC,Cho EC,Tu SH,Wu CH,Hung CS,Hsieh MC,Su CT,Liu YR,Lee CH,Ho YS,Chiou HY

    更新日期:2017-02-01 00:00:00

  • Impact of Patient Age on the Postoperative Survival in Pancreatic Head Cancer.

    abstract:BACKGROUND:Some reports have stated that pancreatoduodenectomy for elderly patients have comparable morbidity and mortality to that of young patients. However, the long-term outcomes of these patients have not been fully evaluated, especially for pancreatic head cancer. METHODS:A total of 227 patients who underwent pa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Sugiura T,Okamura Y,Ito T,Yamamoto Y,Ashida R,Uesaka K

    更新日期:2017-10-01 00:00:00

  • Extranodal Spread is Associated with Recurrence and Poor Survival in Stage III Cutaneous Melanoma Patients.

    abstract:BACKGROUND:Inconsistent data suggests extranodal spread (ENS) is an adverse prognostic factor in Stage III melanoma patients but it remains contentious. By rigorously matching cohorts, this study sought to clarify associations with recurrence and survival. METHODS:Melanoma patients with lymph node metastases (AJCC Sta...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Crookes TR,Scolyer RA,Lo S,Drummond M,Spillane AJ

    更新日期:2017-05-01 00:00:00

  • Validation of lymphatic mapping in colorectal cancer: in vivo, ex vivo, and laparoscopic techniques.

    abstract:BACKGROUND:The use of lymphatic mapping (LM) is being investigated to improve the staging of colorectal cancer (CRC) and thereby identify patients who might benefit from adjuvant chemotherapy. This study evaluated in vivo, laparoscopic, and ex vivo approaches for the ultrastaging of CRC. METHODS:Seventy-five CRC patie...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Wood TF,Saha S,Morton DL,Tsioulias GJ,Rangel D,Hutchinson W Jr,Foshag LJ,Bilchik AJ

    更新日期:2001-03-01 00:00:00

  • Nutritional support with endoluminal stenting during neoadjuvant therapy for esophageal malignancy.

    abstract:BACKGROUND:Perioperative nutrition remains a significant problem in patients undergoing neoadjuvant treatment for esophageal cancer. The aim of this study was to evaluate the effectiveness of esophageal stenting, feeding tube placement, or observation among esophageal cancer patients receiving neoadjuvant therapy. MET...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Bower M,Jones W,Vessels B,Scoggins C,Martin R

    更新日期:2009-11-01 00:00:00

  • ASO Author Reflections: Moving Forward De-escalation of Axillary Surgery After Neoadjuvant Treatment in Breast Cancer.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章


    authors: Rubio IT

    更新日期:2018-12-01 00:00:00

  • Experience with seed localization for nonpalpable breast lesions in a public health care system.

    abstract:BACKGROUND:Seed localization uses a radioactive source to identify nonpalpable breast lesions for excision; it is an emerging alternative to wire localization (WL). Previous single health system studies report decreased rates of re-excision and improved patient convenience with this technique. This study is the first t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Rao R,Moldrem A,Sarode V,White J,Amen M,Rao M,Andrews V,Euhus D,Radford L,Ulissey M

    更新日期:2010-12-01 00:00:00

  • Preoperative needle biopsy as a potential quality measure in breast cancer surgery.

    abstract::Preoperative needle diagnosis (PND) is being considered as a quality measure in breast cancer surgery. This criterion has not been thoroughly evaluated in the literature. The purpose of this study is to assess ease of access to these data and rate of compliance in a tertiary care center. We retrospectively reviewed al...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Pocock B,Taback B,Klein L,Joseph KA,El-Tamer M

    更新日期:2009-05-01 00:00:00