Abstract:
BACKGROUND:Long interspersed nuclear element-1 (LINE-1) methylation status, representing global DNA methylation levels, is associated with patient prognosis in several types of cancer. This study was designed to examine the prognostic significance of LINE-1 methylation in patients with hepatocellular carcinoma (HCC) and the possible mechanisms related to oncogene activation. METHODS:Seventy-five HCC patients who underwent hepatectomy between 2006 and 2012 were enrolled in this study. Quantitative pyrosequencing was performed to quantify the methylation level of three CpG sites in the LINE-1 promoter. Clinicopathological variables and prognosis were compared between LINE-1 hypo- and hypermethylation groups. LINE-1-inserted c-MET (L1-MET) gene expression and its correlation with LINE-1 methylation levels also were analyzed. RESULTS:LINE-1 was significantly hypomethylated in tumor tissues compared with nontumor tissues (48.3 ± 12.2 % vs. 68.2 ± 2.0 %, respectively, p < 0.0001). LINE-1 hypomethylation was not associated with any clinicopathological factors in HCC patients, except sex (p < 0.05). However, patients with LINE-1 hypomethylation exhibited significantly poorer outcome, and multivariate analysis revealed that LINE-1 hypomethylation was an independent risk factor for overall survival (hazard ratio (HR) = 6.1, p = 0.031) and disease-free survival (HR = 2.34, p = 0.045). L1-MET expression was significantly higher in tumor tissues (p < 0.01). L1-MET expression levels were inversely correlated with LINE-1 methylation levels, and positively correlated with c-MET expression (p < 0.05). Furthermore, higher c-MET protein expression was observed in the LINE-1 hypomethylated tumor tissues compared with hypermethylated tumor tissues (p = 0.032). CONCLUSIONS:LINE-1 hypomethylation is significantly associated with poor prognosis in patients with HCC, possibly due to activation of c-MET expression.
journal_name
Ann Surg Oncoljournal_title
Annals of surgical oncologyauthors
Zhu C,Utsunomiya T,Ikemoto T,Yamada S,Morine Y,Imura S,Arakawa Y,Takasu C,Ishikawa D,Imoto I,Shimada Mdoi
10.1245/s10434-014-3874-4subject
Has Abstractpub_date
2014-12-01 00:00:00pages
S729-35eissn
1068-9265issn
1534-4681journal_volume
21 Suppl 4pub_type
杂志文章abstract:BACKGROUND:In past decade, the treatment of gastric adenocarcinoma has evolved as a result of the publication of two seminal randomized controlled trials. We aimed to examine treatment trends for resectable gastric cancer (stage I-III) using the National Cancer Data Base (NCDB). Our hypothesis was that the use of chemo...
journal_title:Annals of surgical oncology
pub_type: 杂志文章
doi:10.1245/s10434-013-3314-x
更新日期:2014-02-01 00:00:00
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journal_title:Annals of surgical oncology
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
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abstract:BACKGROUND:Hospitalization is associated with negative clinical effects that last beyond discharge. This study aimed to determine whether hospitalization in the year before major oncologic surgery is associated with adverse outcomes. METHODS:Patients 18 years of age or older with stomach, pancreas, colon, or rectal ca...
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journal_title:Annals of surgical oncology
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abstract:BACKGROUND:The serum neutrophil-lymphocyte ratio (NLR) is associated with outcomes in several solid organ cancers, including hepatocellular carcinoma (HCC). METHODS:We reviewed our experience in patients with HCC who underwent transarterial chemoembolization (TACE) as the initial treatment. Serum complete blood counts...
journal_title:Annals of surgical oncology
pub_type: 杂志文章
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更新日期:2013-03-01 00:00:00
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journal_title:Annals of surgical oncology
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更新日期:2012-01-01 00:00:00
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journal_title:Annals of surgical oncology
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journal_title:Annals of surgical oncology
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
doi:10.1245/s10434-020-08706-0
更新日期:2021-02-01 00:00:00
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journal_title:Annals of surgical oncology
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abstract:: ...
journal_title:Annals of surgical oncology
pub_type: 评论,杂志文章
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更新日期:2018-12-01 00:00:00
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更新日期:2020-08-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
doi:10.1245/ASO.2006.03.096
更新日期:2006-02-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章,评审
doi:10.1007/BF02574482
更新日期:2002-08-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
doi:10.1245/s10434-011-1569-7
更新日期:2011-07-01 00:00:00
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journal_title:Annals of surgical oncology
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journal_title:Annals of surgical oncology
pub_type: 杂志文章,meta分析
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
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更新日期:2020-09-12 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
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更新日期:2019-04-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章,评审
doi:10.1245/s10434-013-3446-z
更新日期:2014-07-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
doi:10.1245/s10434-015-4612-2
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Surgical resection is the most important therapeutic intervention for eligible patients with pancreatic cancer; however, a majority of patients never receive surgery for a variety of reasons, including patient refusal. Utilizing the National Cancer Database, we investigated the associated sociodemographic an...
journal_title:Annals of surgical oncology
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Sarcopenia is recognized as an important prognostic factor in various types of cancer, including gastric cancer. While long-term survival analyses typically focus on overall and disease-specific survival, death from other causes has received far less attention. METHODS:We reviewed medical records of 491 gas...
journal_title:Annals of surgical oncology
pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00