Selecting the Right Tumors for Genomic Testing.

abstract：BACKGROUND:There is evidence that insulin-like growth factors play a role in the development of breast cancer. Antiestrogens reduce circulating levels of IGF-I, but the influence of other breast cancer treatments, including surgery, is unknown and is investigated in this study. METHODS:Circulating serum concentrations...

journal_title：Annals of surgical oncology

authors： Holdaway IM,Lethaby AE,Mason BH,Singh V,Harman JE,MacCormick M,Civil ID

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:CD44 isoforms serve as a marker for cancer stem cells. CD44 variant 9 (CD44v9) contributes to the defense against reactive oxygen species, resulting in resistance to chemoradiotherapy. However, the significance of CD44v9 in patients with lung adenocarcinoma is unknown. METHODS:We used immunohistochemical an...

journal_title：Annals of surgical oncology

authors： Akamine T,Tagawa T,Ijichi K,Toyokawa G,Takamori S,Hirai F,Okamoto T,Oda Y,Maehara Y

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Malignant obstruction of the proximal colon (MOPC) traditionally has been treated with acute resection. However, morbidity and mortality rates following these emergency surgeries are high. Initial bowel decompression by stent placement or stoma construction has been used for distal obstructions as an alterna...

journal_title：Annals of surgical oncology

authors： Amelung FJ,Consten ECJ,Siersema PD,Tanis PJ

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:A positive circumferential radial margin (CRM) after rectal cancer surgery is an important predictor of local recurrence. The definition of a positive CRM differs internationally, and reported rates vary greatly in the literature. This study used time-series population-based data to assess positive CRM rates...

journal_title：Annals of surgical oncology

authors： Keng C,Coates A,Grubac V,Lovrics P,DeNardi F,Thabane L,Simunovic M

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Spleen-preserving laparoscopic distal pancreatectomy would be an ideal approach for benign and borderline malignant tumors in the distal pancreas.1 However, this procedure requires advanced surgical experience and technique because of the disadvantages of conventional laparoscopic surgery.2 METHODS:A 35-yea...

journal_title：Annals of surgical oncology

authors： Choi SH,Kang CM,Lee WJ,Chi HS

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Laparoscopic versus open hepatocellular carcinoma (HCC) resection reduces morbidity without a compromise in oncologic safety.1-4 Moreover, in the subgroup of cirrhotic patients, a decreased risk of prolonged postoperative ascites and liver decompensation has been reported.5-7 METHODS: A 54-year-old homeless,...

journal_title：Annals of surgical oncology

authors： Vega EA,Nicolaescu DC,Salehi O,Kozyreva O,Vellayappan U,Ricklan D,McCarty J,Fontan F,Pomposelli F,Conrad C

更新日期：2020-04-01 00:00:00

abstract：INTRODUCTION:Actual 5-year survival rates of 10-18% have been reported for patients with resected pancreatic adenocarcinoma (PC), but the use of multimodality therapy was uncommon in these series. We evaluated long-term survival and patterns of recurrence in patients treated for PC with contemporary staging and multimo...

journal_title：Annals of surgical oncology

authors： Katz MH,Wang H,Fleming JB,Sun CC,Hwang RF,Wolff RA,Varadhachary G,Abbruzzese JL,Crane CH,Krishnan S,Vauthey JN,Abdalla EK,Lee JE,Pisters PW,Evans DB

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:This international, multicenter, single-arm trial assessed efficacy and safety of intralesional rose bengal (PV-10) in 80 patients with refractory cutaneous or subcutaneous metastatic melanoma. METHODS:Sixty-two stage III and 18 stage IV melanoma patients with disease refractory to a median of six prior interv...

journal_title：Annals of surgical oncology

authors： Thompson JF,Agarwala SS,Smithers BM,Ross MI,Scoggins CR,Coventry BJ,Neuhaus SJ,Minor DR,Singer JM,Wachter EA

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Peritoneal carcinomatosis of colorectal cancer is probably best treated by cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC). In The Netherlands Cancer Institute, this treatment has been performed since 1995. The long tradition of this treatment enabled us to study long-term survival in det...

journal_title：Annals of surgical oncology

authors： Verwaal VJ,van Ruth S,Witkamp A,Boot H,van Slooten G,Zoetmulder FA

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Radical gastrectomy is the cornerstone of the treatment of locally advanced gastric cancer. This study was designed to evaluate factors associated with a tumor-positive resection margin after gastrectomy and to evaluate the influence of hospital volume. METHODS:In this Dutch cohort study, patients with junc...

journal_title：Annals of surgical oncology

authors： van der Werf LR,Cords C,Arntz I,Belt EJT,Cherepanin IM,Coene PLO,van der Harst E,Heisterkamp J,Langenhoff BS,Lamme B,van Berge Henegouwen MI,Lagarde SM,Wijnhoven BPL

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:This study was designed to evaluate the outcome of patients with uterine carcinosarcoma undergoing sentinel lymph node (SLN) mapping. METHODS:A prospectively maintained database was reviewed for all women with uterine cancer treated at our institution from January 1, 1998 to August 31, 2014. Patients were grou...

journal_title：Annals of surgical oncology

authors： Schiavone MB,Zivanovic O,Zhou Q,Leitao MM Jr,Levine DA,Soslow RA,Alektiar KM,Makker V,Iasonos A,Abu-Rustum NR

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the usefulness of shear wave elastography (SWE) for predicting cervical lymph node (LN) metastasis and the prognostic implication of SWE as histopathologic factors of papillary thyroid carcinoma (PTC). METHODS:Eighty-four LNs of 66 patients with PTC underwent B-mode ultras...

journal_title：Annals of surgical oncology

authors： Jung WS,Kim JA,Son EJ,Youk JH,Park CS

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The understanding of epidermal growth factor receptor (EGFR) deregulation in carcinogenesis remains incomplete. We investigated the implications of EGFR gene status and EGFR nuclear translocation in gallbladder carcinoma (GBCA). METHODS:Subcellular localization of EGFR and phosphorylated EGFR (pEGFR) was an...

journal_title：Annals of surgical oncology

authors： Li CF,Fang FM,Wang JM,Tzeng CC,Tai HC,Wei YC,Li SH,Lee YT,Wang YH,Yu SC,Shiue YL,Chu PY,Wang WL,Chen LT,Huang HY

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Surgical resection is the standard treatment for hepatocellular carcinoma (HCC). However, the role of surgery in treatment of large tumors (10 cm or more) is controversial. We have analyzed, in a single centre, the long-term outcome associated with surgical resection in patients with such large tumors. METH...

journal_title：Annals of surgical oncology

authors： Pandey D,Lee KH,Wai CT,Wagholikar G,Tan KC

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:The anti-tumor effects of three mouse mammary tumors transfected to express interleukin (IL) 2 or 4 were evaluated. METHODS:Three immunologically different tumors were used: DA3, EMT6, and 410. All three cell lines were successfully transfected using high efficiency viral vectors. Wild-type or transfected t...

journal_title：Annals of surgical oncology

authors： Matory YL,Chen M,Goedegebuure PS,Eberlein TJ

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:The treatment strategy and benefit of extended lymph node dissection among patients with preoperatively diagnosed paraaortic lymph node metastasis (PALNM) in colon cancer remains highly controversial. In the current study, we analyzed the oncologic outcomes of patients who underwent extraregional lymph node ...

journal_title：Annals of surgical oncology

authors： Bae SU,Han YD,Cho MS,Hur H,Min BS,Baik SH,Lee KY,Kim NK

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:To evaluate the results of restaging completely resected stage IIIB/C melanoma prior to start of adjuvant therapy. PATIENTS AND METHODS:One hundred twenty patients with stage IIIB or IIIC (AJCC 2009) melanoma who underwent complete surgical resection were screened for inclusion in our trial investigating adjuv...

journal_title：Annals of surgical oncology

authors： Bloemendal M,van Willigen WW,Bol KF,Boers-Sonderen MJ,Bonenkamp JJ,Werner JEM,Aarntzen EHJG,Koornstra RHT,de Groot JWB,de Vries IJM,van der Hoeven JJM,Gerritsen WR,de Wilt JHW

更新日期：2019-11-01 00:00:00

abstract：PURPOSE:Neuropathic pain (NPP) following breast surgery extends morbidity in the postoperative period. The incidence and etiology of postoperative NPP remains unclear and under-reported in literature. This study aims to define the incidence of neuropathic pain following breast surgery and to identify patient characteri...

journal_title：Annals of surgical oncology

authors： Wilson GC,Quillin RC 3rd,Hanseman DJ,Lewis JD,Edwards MJ,Shaughnessy EA

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:We conducted a phase I clinical trial to evaluate the sensitivity, specificity, and safety of cytoreductive surgery (CRS) under aminolevulinic acid-mediated photodynamic diagnosis (ALA-PDD) plus hyperthermic intraperitoneal chemotherapy (HIPEC) on 20 patients with peritoneal carcinomatosis (PC) from ovarian ...

journal_title：Annals of surgical oncology

authors： Liu Y,Endo Y,Fujita T,Ishibashi H,Nishioka T,Canbay E,Li Y,Ogura S,Yonemura Y

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:The EUropean REgistration of Cancer CAre (EURECCA) consortium aims to investigate differences in treatment and to improve cancer care through Europe. The purpose of this study was to compare neo- and adjuvant chemotherapy (ACT) and outcome after tumor resection for pancreatic adenocarcinoma stage I and II in...

journal_title：Annals of surgical oncology

authors： Groen JV,Sibinga Mulder BG,van Eycken E,Valerianova Z,Borras JM,van der Geest LGM,Capretti G,Schlesinger-Raab A,Primic-Zakelj M,Ryzhov A,van de Velde CJH,Bonsing BA,Bastiaannet E,Mieog JSD

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:The prognosis for patients with locally advanced thoracic esophageal cancer is extremely unfavorable. We have been administering neoadjuvant chemoradiotherapy (CRT) followed by esophagectomy to these patients and studying whether REG I expression in untreated endoscopic biopsy specimens is predictive of pati...

journal_title：Annals of surgical oncology

authors： Motoyama S,Sugiyama T,Ueno Y,Okamoto H,Takasawa S,Nanjo H,Watanabe H,Maruyama K,Okuyama M,Ogawa J

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Postesophagectomy diaphragmatic hernia (DH) is an uncommon problem but an important one to recognize and treat because of the risk of significant complications such as incarceration and strangulation. Diaphragmatic hernia appears to occur more frequently following transhiatal esophagectomy (THE) than after t...

journal_title：Annals of surgical oncology

authors： Narayanan S,Sanders RL,Herlitz G,Langenfeld J,August DA

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Accumulated evidence indicates that the incidence of early-onset breast cancer has rapidly increased in Taiwan and other Asian compared to Western countries. The mismatch repair (MMR) pathway might be one of the crucial mechanisms of predisposition to early breast cancer. In this study, we explored whether M...

journal_title：Annals of surgical oncology

authors： Hsieh YC,Cho EC,Tu SH,Wu CH,Hung CS,Hsieh MC,Su CT,Liu YR,Lee CH,Ho YS,Chiou HY

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Sensitive biomarkers are necessary for risk classification of patients with gastric cancer (GC), especially ones at risk of distant metastases. Melanoma-associated antigen (MAGE)-D2 has been reported to play a role in the process of cell adhesion and metastatic potential of tumor cells in colorectal cancer. ...

journal_title：Annals of surgical oncology

authors： Kanda M,Nomoto S,Oya H,Takami H,Shimizu D,Hibino S,Hashimoto R,Kobayashi D,Tanaka C,Yamada S,Fujii T,Nakayama G,Sugimoto H,Koike M,Fujiwara M,Kodera Y

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Despite advances in the treatment of patients with gastric cancer, the debate over the optimal extent of lymphadenectomy continues. METHOD:A review of the classification, rationale for, and boundaries of lymphadenectomy is presented. A review of the available literature comparing D1 versus D2 versus D3 lymp...

journal_title：Annals of surgical oncology

authors： Mogal H,Fields R,Maithel SK,Votanopoulos K

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Recently, many studies have demonstrated the feasibility and accuracy of sentinel lymph node (SLN) biopsy for patients treated with neoadjuvant chemotherapy (NAC). However, no studies have been conducted to evaluate the accuracy of frozen section (FS) analysis of SLN in NAC-treated patients. The aim was to e...

journal_title：Annals of surgical oncology

authors： Shimazu K,Tamaki Y,Taguchi T,Tsukamoto F,Kasugai T,Noguchi S

更新日期：2008-06-01 00:00:00

abstract：: ...

journal_title：Annals of surgical oncology

authors： Yasui W

更新日期：2019-04-01 00:00:00

abstract：:Many examples highlight the power of gene expression profiles, or signatures, to provide an understanding of biological phenotypes. This is best seen in the context of cancer, where expression signatures have tremendous power to identify new cancer subtypes and to predict clinical outcomes. Gene expression profiles ha...

journal_title：Annals of surgical oncology

authors： Stevenson M,Potti A

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Cancer patients have often been reported to have impaired immune function, and the effect of treatment modalities, such as surgery, irradiation, and chemotherapy, in depressing patients' immunity has also been reported. In this investigation, the effect of treatment on the cellular immunity of esophageal can...

journal_title：Annals of surgical oncology

authors： Mafune K,Tanaka Y

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:In patients with early stage gastric cancer in the middle third of the stomach, pylorus-preserving gastrectomy (PPG) can be an option as function-preserving surgery, although its oncologic safety is not definitively defined. This issues may be overcome using the sentinel node (SN) concept. The aim of this st...

journal_title：Annals of surgical oncology

authors： Shimada A,Takeuchi H,Ono T,Kamiya S,Fukuda K,Nakamura R,Takahashi T,Wada N,Kawakubo H,Saikawa Y,Omori T,Nakahara T,Jinzaki M,Murakami K,Kitagawa Y

更新日期：2016-12-01 00:00:00