Phase 2 Study of Intralesional PV-10 in Refractory Metastatic Melanoma.

abstract：BACKGROUND:Whether routinely prescribed opioids are necessary for pain control after discharge among lumpectomy/sentinel node biopsy (Lump/SLNB) patients is unclear. We hypothesize that Lump/SLNB patients could be discharged without opioids, with a failure rate < 10%. This study prospectively examines outcomes after ch...

journal_title：Annals of surgical oncology

authors： Moo TA,Pawloski KR,Sevilimedu V,Charyn J,Simon BA,Sclafani LM,Plitas G,Barrio AV,Kirstein LJ,Van Zee KJ,Morrow M

更新日期：2020-11-01 00:00:00

abstract：METHODS:This study evaluated the effectiveness and morbidity associated with 116 peritoneovenous shunts inserted into 89 patients for symptomatic malignant ascites between 1981 and 1991. All patients had previously failed standard medical therapy of salt and fluid restriction, diuretics, and intermittent peritoneal asp...

journal_title：Annals of surgical oncology

authors： Schumacher DL,Saclarides TJ,Staren ED

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:The risk of colorectal cancer (CRC) in chronic kidney disease (CKD) patients relative to the general population is unknown. The aim of this population-based study was to investigate the risk of CRC in patients with CKD. METHODS:The study cohort included patients aged ≥18 years diagnosed with CKD between 200...

journal_title：Annals of surgical oncology

authors： Wu MY,Chang TC,Chao TY,Huang MT,Lin HW

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Despite decreasing rates of subsequent contralateral breast cancer after diagnosis of unilateral primary breast cancer, the proportion of patients electing contralateral prophylactic mastectomy (CPM) is increasing. Our aim was to identify risk factors associated with the identification of occult malignancy (...

journal_title：Annals of surgical oncology

authors： Erdahl LM,Boughey JC,Hoskin TL,Degnim AC,Hieken TJ

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:As tumor burden increases in colorectal cancer, treatment complexity progresses from colectomy to hepatectomy and lastly to cytoreductive surgery with heated intraperitoneal chemotherapy (CRS-HIPEC). The aim of this study was to evaluate whether disparities exist in the access to progressively more complex s...

journal_title：Annals of surgical oncology

authors： Tabrizian P,Overbey J,Carrasco-Avino G,Bagiella E,Labow DM,Sarpel U

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Sentinel node biopsy (SNB) may represent an alternative to elective neck dissection for the staging of patients with early head and neck squamous cell carcinoma (HNSCC). To date, the technique has been successfully described in a number of small single-institution studies. This report describes the long-term...

journal_title：Annals of surgical oncology

authors： Alkureishi LW,Ross GL,Shoaib T,Soutar DS,Robertson AG,Thompson R,Hunter KD,Sorensen JA,Thomsen J,Krogdahl A,Alvarez J,Barbier L,Santamaria J,Poli T,Sesenna E,Kovács AF,Grünwald F,Barzan L,Sulfaro S,Alberti F

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Laparoscopic versus open hepatocellular carcinoma (HCC) resection reduces morbidity without a compromise in oncologic safety.1-4 Moreover, in the subgroup of cirrhotic patients, a decreased risk of prolonged postoperative ascites and liver decompensation has been reported.5-7 METHODS: A 54-year-old homeless,...

journal_title：Annals of surgical oncology

authors： Vega EA,Nicolaescu DC,Salehi O,Kozyreva O,Vellayappan U,Ricklan D,McCarty J,Fontan F,Pomposelli F,Conrad C

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Newer multigene molecular profiling assays for breast carcinoma rely heavily on the quantification of genes of proliferation, whereas traditional histological grading reports the mitotic count. The mitotic activity of invasive breast carcinomas may be undervalued; therefore, an evaluation of the prognostic s...

journal_title：Annals of surgical oncology

authors： Chang JM,McCullough AE,Dueck AC,Kosiorek HE,Ocal IT,Lidner TK,Gray RJ,Wasif N,Northfelt DW,Anderson KS,Pockaj BA

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Seed localization uses a radioactive source to identify nonpalpable breast lesions for excision; it is an emerging alternative to wire localization (WL). Previous single health system studies report decreased rates of re-excision and improved patient convenience with this technique. This study is the first t...

journal_title：Annals of surgical oncology

authors： Rao R,Moldrem A,Sarode V,White J,Amen M,Rao M,Andrews V,Euhus D,Radford L,Ulissey M

更新日期：2010-12-01 00:00:00

abstract：:Over a decade since the discovery of EGFR mutation, and 6 years since prospective clinical trial data proved that routine molecular pathology tests improve survival in stage IV lung cancer, there is still debate whether to test patients with earlier stages of disease (stage I-III). As discoveries of targeted drugs for...

journal_title：Annals of surgical oncology

authors： Azzoli CG

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:Inguinal lymphadenectomy for metastatic melanoma is reported to have a complication rate as high as 50%. Wound dehiscence has been reported to occur in more than half of these patients, and as a result many surgeons routinely use sartorius muscle transposition to protect against the potential for exposed v...

journal_title：Annals of surgical oncology

authors： Delman KA,Kooby DA,Ogan K,Hsiao W,Master V

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:In primary esophageal cancer, studies have frequently focused on surgical patients in an effort to link outcome to hospital- or surgeon-related experience, with operative mortality used as the main outcome measure. Many studies have found an inverse relationship between operative mortality and hospital volum...

journal_title：Annals of surgical oncology

authors： Verhoef C,van de Weyer R,Schaapveld M,Bastiaannet E,Plukker JT

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Various patient, treatment, and pathologic factors have been associated with an increased risk of local recurrence (LR) following breast-conserving therapy (BCT) for ductal carcinoma in situ (DCIS). However, the strength and importance of individual factors has varied; whether combining factors improves pred...

journal_title：Annals of surgical oncology

authors： Collins LC,Achacoso N,Haque R,Nekhlyudov L,Quesenberry CP Jr,Schnitt SJ,Habel LA,Fletcher SW

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Neuroendocrine tumors are becoming increasingly prevalent, with many patients presenting with or developing metastatic disease to the liver. METHODS:In this landmark series paper, we highlight the critical studies that have defined the surgical management of neuroendocrine tumor liver metastases, as well as...

journal_title：Annals of surgical oncology

authors： Gangi A,Howe JR

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate outcomes after breast-conserving surgery (BCS) and intraoperative radiotherapy (IORT), and to identify risk factors associated with complications. MATERIALS/METHODS:We evaluated patients with early-stage breast cancer treated from January 1, 2011 to January 31, 2014 with...

journal_title：Annals of surgical oncology

authors： Rakhra S,Bethke K,Strauss J,Hayes JP,Hansen N,Khan SA,Helenowski I,Donnelly ED

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The heterogeneous nuclear ribonucleoprotein (hnRNP) K is an essential RNA and DNA binding protein involved in gene expression and signal transduction. The role of hnRNP K in cancer is relatively understudied. However, several cellular functions strongly indicate that hnRNP K is involved in tumorigenesis. Onc...

journal_title：Annals of surgical oncology

authors： Wen F,Shen A,Shanas R,Bhattacharyya A,Lian F,Hostetter G,Shi J

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:In breast cancer treatment, intraoperative sentinel lymph node (SLN) evaluation is used to identify patients who may potentially benefit from immediate completion of axillary lymph node dissection. METHODS:Prospectively collected breast cancer registry data identified 516 SLN biopsies between January 2003 a...

journal_title：Annals of surgical oncology

authors： Pugliese MS,Tickman R,Wang NP,Atwood M,Beatty JD

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:The impact of primary tumor location on overall survival (OS), recurrence-free survival (RFS), and long-term outcomes has not been well established in patients undergoing potentially curative resection of colorectal liver metastases (CRLM). METHODS:A single-institution database was queried for initial resec...

journal_title：Annals of surgical oncology

authors： Creasy JM,Sadot E,Koerkamp BG,Chou JF,Gonen M,Kemeny NE,Saltz LB,Balachandran VP,Peter Kingham T,DeMatteo RP,Allen PJ,Jarnagin WR,D'Angelica MI

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Thoracoscopic lobectomy is well established for the treatment of early non-small cell lung cancer (NSCLC). Its safety and efficacy for advanced-stage disease remain uncertain. METHODS:Between January 1, 2002, and July 31, 2007, a total of 125 patients were evaluated for thoracoscopic lobectomy for advanced ...

journal_title：Annals of surgical oncology

authors： Hennon M,Sahai RK,Yendamuri S,Tan W,Demmy TL,Nwogu C

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Several studies have reported an increased rate of contralateral prophylactic mastectomy (CPM) in patients with unilateral breast cancer. This study reports on CPM trends from the American College of Surgeon's National Cancer Data Base (NCDB) diagnosed over a 10-year period. METHODS:Data about women diagnos...

journal_title：Annals of surgical oncology

authors： Yao K,Stewart AK,Winchester DJ,Winchester DP

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Surgical resection with curative intent for giant cell tumor of bone (GCTB) may be associated with severe morbidity. This interim analysis evaluated reduction in surgical invasiveness after denosumab treatment in patients with resectable GCTB. METHODS:Patients with primary or recurrent GCTB, for whom the in...

journal_title：Annals of surgical oncology

authors： Rutkowski P,Ferrari S,Grimer RJ,Stalley PD,Dijkstra SP,Pienkowski A,Vaz G,Wunder JS,Seeger LL,Feng A,Roberts ZJ,Bach BA

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:Our aim was to evaluate the utility of in vitro drug sensitivity testing in patients with peritoneal surface malignancies undergoing cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS:We found data for 27 patients who underwent CRS plus HIPEC from September 2009 to May ...

journal_title：Annals of surgical oncology

authors： Bhagwandin S,Naffouje S,Salti G

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:We sought to identify genes associated with the progression and metastasis of esophageal squamous-cell cancer by comparing the expression profiles of normal, primary cancer, and metastatic cancer cells isolated with laser microdissection. METHODS:Oligo microarray analysis identified several lymph node-speci...

journal_title：Annals of surgical oncology

authors： Kita Y,Mimori K,Iwatsuki M,Yokobori T,Ieta K,Tanaka F,Ishii H,Okumura H,Natsugoe S,Mori M

更新日期：2011-01-01 00:00:00

abstract：:Breast cancer is a progressive, phenotypic, genetic and epigenetic alteration, induced by various stimulants of which the principal steroid hormone, estrogen, initiates and promotes neoplastic transformation of normal ductal mammary epithelium to acquire distinct biochemical and molecular characteristics. The molecula...

journal_title：Annals of surgical oncology

authors： Bland KI

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Arginine plays a pivotal role in regulating ureagenesis, polyamine biosynthesis, and nitric oxide production, metabolic pathways that may be stimulated in the liver of the tumor-bearing host. Normally, plasma arginine is excluded from the hepatocyte intracellular space by the low basal activity of its membra...

journal_title：Annals of surgical oncology

authors： Espat NJ,Copeland EM,Souba WW

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:The accurate preoperative diagnosis of depth of tumor invasion and nodal status in distal rectal cancer is important because neoadjuvant chemotherapy or lateral pelvic lymph node dissection is indicated for patients with T3-T4 tumor or nodal involvement. This study aimed to determine the optimal cutoff value...

journal_title：Annals of surgical oncology

authors： Kobayashi H,Kikuchi A,Okazaki S,Ishiguro M,Ishikawa T,Iida S,Uetake H,Sugihara K

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is associated with significantly longer survival in patients with peritoneal carcinomatosis (PC). So far, no morphological imaging method has proven to accurately assess the intra-abdominal tumor spread. This study was design...

journal_title：Annals of surgical oncology

authors： Pfannenberg C,Königsrainer I,Aschoff P,Oksüz MO,Zieker D,Beckert S,Symons S,Nieselt K,Glatzle J,Weyhern CV,Brücher BL,Claussen CD,Königsrainer A

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:In approximately 40% of the breast cancer patients with sentinel lymph node (SLN) metastases, additional nodal metastases are detected in the completion axillary lymph node dissection (cALND). The MSKCC nomogram can help to quantify a patient's individual risk for non-SLN metastases with fairly accurate pred...

journal_title：Annals of surgical oncology

authors： Smidt ML,Strobbe LJ,Groenewoud HM,der Wilt GJ,Van Zee KJ,Wobbes T

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:The effectiveness of perioperative adjuvant chemotherapy for colorectal cancer liver metastasis (CRLM) remains a matter of debate. Despite the lack of clear evidence supporting its effectiveness after curative hepatectomy, adjuvant chemotherapy has been widely used clinically. The purpose of this study was t...

journal_title：Annals of surgical oncology

authors： Hirokawa F,Hayashi M,Miyamoto Y,Asakuma M,Shimizu T,Komeda K,Inoue Y,Uchiyama K

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:With the exception of papillary and follicular thyroid cancer, malignant cancers of the thyroid, parathyroid, adrenal, and endocrine pancreas are uncommon. These rare malignancies present a challenge to both the clinician and patient, because few data exist on their incidence or survival. We analyzed the incide...

journal_title：Annals of surgical oncology

authors： James BC,Aschebrook-Kilfoy B,Cipriani N,Kaplan EL,Angelos P,Grogan RH

更新日期：2016-02-01 00:00:00