The Landmark Series: Neuroendocrine Tumor Liver Metastases.

Abstract:

BACKGROUND:Neuroendocrine tumors are becoming increasingly prevalent, with many patients presenting with or developing metastatic disease to the liver. METHODS:In this landmark series paper, we highlight the critical studies that have defined the surgical management of neuroendocrine tumor liver metastases, as well as several randomized control trials which have investigated strategies for systemic control of metastatic disease. RESULTS:Liver-directed surgical approaches and locally ablative procedures are recommended for patients with limited, resectable, and in some cases, nonresectable tumor burden. Angiographic liver-directed techniques, such as transarterial embolization, chemoembolization, and radioembolization, offer another approach for management in patients with liver-predominant disease. Peptide receptor radionuclide therapy is a promising therapy for patients with hepatic and/or extrahepatic metastases. Various systemic medical therapies are also available as adjunct or definitive therapy for patients with metastatic disease. CONCLUSIONS:This article reviews current data regarding management of neuroendocrine liver metastases and highlights areas for future study.

journal_name

Ann Surg Oncol

authors

Gangi A,Howe JR

doi

10.1245/s10434-020-08787-x

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

3270-3280

issue

9

eissn

1068-9265

issn

1534-4681

pii

10.1245/s10434-020-08787-x

journal_volume

27

pub_type

杂志文章,评审
  • Circulating endothelial cell (CEC) as a diagnostic and prognostic marker in malignant pleural mesothelioma (MPM).

    abstract:BACKGROUND:The purpose of this study was to investigate the diagnostic and prognostic value of circulating endothelial cell (CEC), a potential surrogate of tumor angiogenesis, in malignant pleural mesothelioma (MPM). METHODS:We prospectively evaluated CEC count in 4.0 mL of peripheral blood sampled from patients with ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2506-0

    authors: Yoneda K,Tanaka F,Kondo N,Orui H,Hashimoto M,Takuwa T,Matsumoto S,Okumura Y,Tsubota N,Sato A,Tsujimura T,Kuribayashi K,Fukuoka K,Nakano T,Hasegawa S

    更新日期:2012-12-01 00:00:00

  • Reappraisal of conventional risk stratification for local recurrence based on clinical outcomes in 285 resected phyllodes tumors of the breast.

    abstract:PURPOSE:To ensure a surgical margin of ≥1 cm for the effective treatment of phyllodes tumors of the breast (PTB) a second resection has been recommended, but the outcomes of an extensive series of cases employing the aforementioned criterion cast doubt on this clinical approach. The aim of this study was to identify th...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4395-5

    authors: Yom CK,Han W,Kim SW,Park SY,Park IA,Noh DY

    更新日期:2015-09-01 00:00:00

  • Management of Neuroendocrine Tumor Liver Metastases: Long-Term Outcomes and Prognostic Factors from a Large Prospective Database.

    abstract:BACKGROUND:Liver-directed therapies have been used to treat neuroendocrine liver metastases (NELM) for both symptomatic improvement and tumor growth control. We reviewed our experience with NELM to investigate the outcomes of available treatment modalities and to identify prognostic factors for survival. METHODS:We id...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5839-x

    authors: Fairweather M,Swanson R,Wang J,Brais LK,Dutton T,Kulke MH,Clancy TE

    更新日期:2017-08-01 00:00:00

  • Salvage treatment for isolated regional failure of nasopharyngeal carcinoma after primary radiotherapy.

    abstract:BACKGROUND:Isolated regional failure of nasopharyngeal carcinoma (NPC) after primary treatment is traditionally treated with radical neck dissection (RND). The roles of modified radical neck dissection (MRND) and postoperative radiotherapy after salvage surgery currently remain unclear. METHODS:Medical records from ou...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-2018-3

    authors: Lo WC,Wang CP,Ko JY,Lou PJ,Yang TL,Wang CW,Hu YL,Chen TC

    更新日期:2012-03-01 00:00:00

  • Impact of surgical experience on in-hospital complication rates in patients undergoing minimally invasive prostatectomy: a population-based study.

    abstract:BACKGROUND:The relationship between provider volume and complication and transfusion rates in patients undergoing minimally invasive prostatectomy (MIRP) for prostate cancer has not been assessed. Temporal trends in MIRP annual surgical caseload (AC), impact of MIRP surgical experience (SE), and in-hospital complicatio...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1300-0

    authors: Budäus L,Sun M,Abdollah F,Zorn KC,Morgan M,Johal R,Liberman D,Thuret R,Isbarn H,Salomon G,Haese A,Montorsi F,Shariat SF,Perrotte P,Graefen M,Karakiewicz PI

    更新日期:2011-03-01 00:00:00

  • Predictive Potential of Preoperative Nutritional Status in Long-Term Outcome Projections for Patients with Gastric Cancer.

    abstract:BACKGROUND:Preoperative nutritional status not only correlates with the incidence of postoperative complications but also may be indicative of long-term outcomes for patients with cancer. The impact of preoperative nutritional status on outcomes for patients undergoing gastrectomy for gastric cancer (GC) was investigat...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4814-7

    authors: Sakurai K,Ohira M,Tamura T,Toyokawa T,Amano R,Kubo N,Tanaka H,Muguruma K,Yashiro M,Maeda K,Hirakawa K

    更新日期:2016-02-01 00:00:00

  • Is head and neck melanoma different from trunk and extremity melanomas with respect to sentinel lymph node status and clinical outcome?

    abstract:BACKGROUND:Previous studies showed conflicting and inconsistent results regarding the effect of anatomic location of the melanoma on sentinel lymph node (SLN) positivity and/or survival. This study was conducted to evaluate and compare the effect of the anatomic locations of primary melanoma on long-term clinical outco...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-2977-7

    authors: Fadaki N,Li R,Parrett B,Sanders G,Thummala S,Martineau L,Cardona-Huerta S,Miranda S,Cheng ST,Miller JR 3rd,Singer M,Cleaver JE,Kashani-Sabet M,Leong SP

    更新日期:2013-09-01 00:00:00

  • Complete hepatic venous isolation and extracorporeal chemofiltration as treatment for human hepatocellular carcinoma: a phase I study.

    abstract:BACKGROUND:We performed a phase I study of a novel system of complete hepatic venous isolation and extracorporeal chemofiltration in patients with unresectable hepatocellular carcinoma (HCC) to determine (a) whether systemic exposure to doxorubicin could be limited after high-dose hepatic arterial infusion (HAI), and (...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02303811

    authors: Curley SA,Newman RA,Dougherty TB,Fuhrman GM,Stone DL,Mikolajek JA,Guercio S,Guercio A,Carrasco CH,Kuo MT

    更新日期:1994-09-01 00:00:00

  • Knockdown of thrombomodulin enhances HCC cell migration through increase of ZEB1 and decrease of E-cadherin gene expression.

    abstract:BACKGROUND:Thrombomodulin (TM) is a key molecule mediating circulation homeostasis through its binding to thrombin. The TM-thrombin complex can activate protein C and thrombin-activatable fibrinolysis inhibitor to form a tight clot. In many cancer tissues, decrease of TM expression may correlate with cancer metastasis....

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1163-4

    authors: Huang MT,Wei PL,Liu JJ,Liu DZ,Huey-Chun H,An J,Wu CC,Wu CH,Ho YS,Yang YY,Chang YJ

    更新日期:2010-12-01 00:00:00

  • A novel assay to assess the effectiveness of antiangiogenic drugs in human breast cancer.

    abstract:BACKGROUND:Many cytotoxic drugs maintain antiangiogenic properties, but there are no human, tumor-based assays to evaluate their antiangiogenic potential. We used a fibrin-thrombin clot-based angiogenesis model to evaluate the angiogenic response of human breast cancer to various cytotoxic agents commonly used in its t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0145-2

    authors: Lyons JM 3rd,Anthony CT,Thomson JL,Woltering EA

    更新日期:2008-12-01 00:00:00

  • Intraoperative Margin Management in Breast-Conserving Surgery: A Systematic Review of the Literature.

    abstract:BACKGROUND:Breast surgeons have a wide variety of intraoperative techniques available to help achieve low rates for positive margins of excision, with variable levels of evidence. METHODS:A systematic review of the medical literature from 1995 to July 2016 was conducted, with 434 abstracts identified and evaluated. Th...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析

    doi:10.1245/s10434-016-5756-4

    authors: Gray RJ,Pockaj BA,Garvey E,Blair S

    更新日期:2018-01-01 00:00:00

  • The Impact of the Affordable Care Act on North Carolinian Breast Cancer Patients Seeking Financial Support for Treatment.

    abstract:BACKGROUND:The Affordable Care Act (ACA) was instated on 23 March 2010 to improve healthcare quality, reduce costs, and increase access. The Pretty in Pink Foundation (PIPF), a non-profit 501(C)(3) organization in North Carolina, provides financial assistance and in-kind support to individuals seeking help with breast ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5311-3

    authors: Obeng-Gyasi S,Tolnitch L,Greenup RA,Shelley Hwang E

    更新日期:2016-10-01 00:00:00

  • ASO Author Reflections: Radiation Therapy in Soft Tissue Sarcoma: Who Benefits and How?

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6970-z

    authors: Albertsmeier M,Roeder F,Angele MK

    更新日期:2018-12-01 00:00:00

  • Racial disparities in esophageal cancer outcomes.

    abstract:BACKGROUND:Racial disparities in outcomes have been documented among patients with esophageal cancer. The purpose of this study is to identify mechanisms for ethnicity/race-related differences in the use of cancer-directed surgery and mortality. METHODS:Data from the Surveillance, Epidemiology and End Results (SEER) p...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2807-3

    authors: Revels SL,Morris AM,Reddy RM,Akateh C,Wong SL

    更新日期:2013-04-01 00:00:00

  • Can breast surgeons provide breast cancer genetic testing? An American Society of Breast Surgeons survey.

    abstract:BACKGROUND:Whether breast cancer surgeons are adequately trained, skilled, and experienced to provide breast cancer genetic assessment, testing, and counseling came under debate in September 2013 when a major third-party payer excluded nongenetics specialists from ordering such testing. A literature search having faile...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3711-9

    authors: Beitsch PD,Whitworth PW

    更新日期:2014-12-01 00:00:00

  • Outcomes in Peritoneal Dissemination from Signet Ring Cell Carcinoma of the Appendix Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.

    abstract:BACKGROUND:Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is standard treatment for peritoneal dissemination from appendiceal cancer (AC); however, its role in high-grade histopathologic subtypes (high-grade mucinous carcinoma peritonei [HGMCP] and HGMCP with signet ring cells [HGMCP-S]...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-7007-3

    authors: Munoz-Zuluaga C,Sardi A,King MC,Nieroda C,Sittig M,MacDonald R,Gushchin V

    更新日期:2019-02-01 00:00:00

  • Fibrosis-4 Index, a Noninvasive Fibrosis Marker, Predicts Survival Outcomes After Hepatectomy for Colorectal Cancer Liver Metastases.

    abstract:BACKGROUND:Liver fibrosis influences liver regeneration and surgical outcomes, and several noninvasive models based on laboratory data have been developed to predict liver fibrosis. This study was performed to determine whether the Fibrosis-4 (FIB-4) index, a noninvasive fibrosis marker, can predict the prognosis in pa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08828-5

    authors: Akiyama T,Miyamoto Y,Imai K,Yamashita Y,Nomoto D,Daitoku N,Sakamoto Y,Kiyozumi Y,Tokunaga R,Eto K,Harada K,Hiyoshi Y,Iwatsuki M,Nagai Y,Iwagami S,Baba Y,Yoshida N,Baba H

    更新日期:2020-09-01 00:00:00

  • Molecular profiling of micrometastatic cancer cells.

    abstract::Malignant tumors of epithelial tissue are the most common form of cancer and are responsible for the majority of cancer-related deaths in Western industrialized countries. As a result of progress in surgical treatment of these tumors, lethality is linked increasingly to early metastasis, which is generally occult at t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Pantel K,Hosch SB

    更新日期:2001-10-01 00:00:00

  • Postoperative Infectious Complications are Associated with Adverse Oncologic Outcomes in Esophageal Cancer Patients Undergoing Preoperative Chemotherapy.

    abstract:BACKGROUND:For some types of cancer, postoperative complications can negatively influence survival, but the association between these complications and oncological outcomes is unclear for patients with esophageal cancer who receive preoperative treatments. METHODS:Data were retrospectively analyzed for patients who un...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-5045-7

    authors: Yamashita K,Makino T,Miyata H,Miyazaki Y,Takahashi T,Kurokawa Y,Yamasaki M,Nakajima K,Takiguchi S,Mori M,Doki Y

    更新日期:2016-06-01 00:00:00

  • Clinical significance of GAB2, a scaffolding/docking protein acting downstream of EGFR in human colorectal cancer.

    abstract:PURPOSE:Recent studies indicated that the scaffolding adaptor protein GAB2 (GRB2-associated binding protein 2) plays a critical role in the proliferation and migration of various cancers. This study aimed to determine the role of aberrant GAB2 expression in human colorectal cancer (CRC). METHODS:Quantitative real-time...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3889-x

    authors: Matsumura T,Sugimachi K,Takahashi Y,Uchi R,Sawada G,Ueda M,Hirata H,Sakimura S,Ueo H,Takano Y,Kurashige J,Shinden Y,Eguchi H,Sudo T,Yamamoto H,Doki Y,Mori M,Mimori K

    更新日期:2014-12-01 00:00:00

  • Correlation between gp96 expression and the surgical outcome in patients with esophageal squamous cell carcinoma.

    abstract:BACKGROUND:Heat-shock protein gp96 plays an important role in antitumor immunoreactions. Gp96 has a close relationship with antitumor immunity. This study evaluated the correlation between gp96 expression and the prognosis in esophageal squamous cell carcinoma. METHODS:Seventy-eight patients with primarily resected es...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1128-7

    authors: Akutsu Y,Matsubara H,Kano M,Usui A,Yoneyama Y,Ikeda N,Komatsu A,Yusup G

    更新日期:2011-03-01 00:00:00

  • Prevention of anastomotic leakage after total gastrectomy with perioperative supplemental oxygen administration: a prospective randomized, double-blind, controlled, single-center trial.

    abstract:BACKGROUND:The role of supplemental oxygen therapy in the healing of esophagojejunal anastomosis is still very much in an experimental stage. The aim of the present prospective, randomized study was to assess the effect of administration of perioperative supplemental oxygen therapy on esophagojejunal anastomosis, where...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1245/s10434-012-2714-7

    authors: Schietroma M,Cecilia EM,Carlei F,Sista F,De Santis G,Piccione F,Amicucci G

    更新日期:2013-05-01 00:00:00

  • Tumor-Infiltrating Lymphocytes in a Contemporary Cohort of Women with Ductal Carcinoma In Situ (DCIS).

    abstract:BACKGROUND:Growing evidence suggests that the tumor immune microenvironment influences breast cancer development and prognosis. Density of tumor-infiltrating lymphocytes (TILs) within invasive breast cancer is correlated with response to therapy, especially in triple-negative disease. The clinical relevance and outcome...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07562-x

    authors: Darvishian F,Ozerdem U,Adams S,Chun J,Pirraglia E,Kaplowitz E,Guth A,Axelrod D,Shapiro R,Price A,Troxel A,Schnabel F,Roses D

    更新日期:2019-10-01 00:00:00

  • Comprehensive needs assessment of clinical breast evaluation skills of primary care residents.

    abstract:BACKGROUND:Health care reform places primary care (PC) physicians in an increasingly significant role for breast cancer screening and diagnosis. This study assessed the adequacy of traditional PC resident training to prepare physicians for this front-line role. METHODS:Sixty-eight primary care residents, representing ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02303850

    authors: Chalabian J,Formenti S,Russell C,Pearce J,Dunnington G

    更新日期:1998-03-01 00:00:00

  • Prognostic Utility of Pre- and Postoperative Circulating Tumor DNA Liquid Biopsies in Patients with Peritoneal Metastases.

    abstract:BACKGROUND:Circulating tumor DNA (ctDNA) is a promising technology for treatment selection, prognostication, and surveillance after definitive therapy. Its use in the perioperative setting for patients with metastatic disease has not been well studied. We characterize perioperative plasma ctDNA and its association with...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08331-x

    authors: Baumgartner JM,Riviere P,Lanman RB,Kelly KJ,Veerapong J,Lowy AM,Kurzrock R

    更新日期:2020-09-01 00:00:00

  • Clinicopathological Features and Outcome of Lung Cancer Patients with Hematological Malignancy.

    abstract:PURPOSE:The aim of this study was to report the incidence of lung cancer in patients with hematological malignancy (HM), as well as patient characteristics and outcome. METHODS:We investigated 1503 consecutive patients treated for HM and 1208 patients who underwent surgical resection for lung cancer. RESULTS:Lung can...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4885-5

    authors: Shoji F,Yamazaki K,Kouso H,Mori R,Takase K,Okamura S,Takeo S

    更新日期:2016-02-01 00:00:00

  • Changes in breast cancer therapy because of pathology second opinions.

    abstract:BACKGROUND:Examination of pathology slides is a routine part of a breast cancer second opinion. The purpose of this study was to determine how often the pathologic second opinion (1) altered the diagnosis and (2) resulted in a change in the surgical procedure. METHODS:Patients presenting between 1997 and 2001 for a se...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02574516

    authors: Staradub VL,Messenger KA,Hao N,Wiley EL,Morrow M

    更新日期:2002-12-01 00:00:00

  • Optical See-Through Cancer Vision Goggles Enable Direct Patient Visualization and Real-Time Fluorescence-Guided Oncologic Surgery.

    abstract:BACKGROUND:The inability to visualize the patient and surgical site directly, limits the use of current near infrared fluorescence-guided surgery systems for real-time sentinel lymph node biopsy and tumor margin assessment. METHODS:We evaluated an optical see-through goggle augmented imaging and navigation system (GAI...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5804-8

    authors: Mondal SB,Gao S,Zhu N,Habimana-Griffin L,Akers WJ,Liang R,Gruev V,Margenthaler J,Achilefu S

    更新日期:2017-07-01 00:00:00

  • Surgical safety and oncologic effectiveness in robotic versus conventional open thyroidectomy in thyroid cancer: a systematic review and meta-analysis.

    abstract:BACKGROUND:Although many experiences using the da Vinci Robot System have been reported by several groups, there is substantial controversy over the role of the robot in thyroidectomy. We performed a systematic review and meta-analyses in order to evaluate the safety and effectiveness of robotic thyroidectomy (RT) comp...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1245/s10434-015-4375-9

    authors: Son SK,Kim JH,Bae JS,Lee SH

    更新日期:2015-09-01 00:00:00

  • Positive bone marrow biopsy is associated with a decreased disease-free survival in patients with operable breast cancer.

    abstract:BACKGROUND:Bone marrow (BM) biopsy has been suggested as an independent prognostic factor in patients with breast cancer. METHODS:Patients operated for breast cancer from June 2000 to April 2008 were enrolled in this protocol after signing an informed consent. After primary surgery, BM aspirate from the iliac crest wa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0619-x

    authors: Fortunato L,Mascaro A,Baldi A,Farina M,Cortese G,Ventrone MA,Amini M,Vitelli C

    更新日期:2009-11-01 00:00:00