The Significance of CD44 Variant 9 in Resected Lung Adenocarcinoma: Correlation with Pathological Early-Stage and EGFR Mutation.

abstract：BACKGROUND:HER-2/neu (c-erbB-2, HER2) gene amplification and protein overexpression have been associated with poor prognosis in several solid tumors, including breast and gastric cancer. Its incidence and significance in esophageal adenocarcinoma is unknown. MATERIALS AND METHODS:Tissue microarrays were successfully c...

journal_title：Annals of surgical oncology

authors： Thompson SK,Sullivan TR,Davies R,Ruszkiewicz AR

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Thirty-day mortality after surgery for colorectal cancer may vastly underestimate 1-year mortality. This study aimed to quantify the excess mortality in the first postoperative year of stage I-III colorectal cancer patients and to identify risk factors for excess mortality. METHODS:All 2,131 patients who we...

journal_title：Annals of surgical oncology

authors： Gooiker GA,Dekker JW,Bastiaannet E,van der Geest LG,Merkus JW,van de Velde CJ,Tollenaar RA,Liefers GJ

更新日期：2012-08-01 00:00:00

abstract：:Selected patients with hepatocellular carcinoma are candidates to receive potentially curative treatments, such as hepatic resection or liver transplantation, but nevertheless there is a high risk of tumor recurrence. Microvascular invasion is a histological feature of hepatocellular carcinoma related to aggressive bi...

journal_title：Annals of surgical oncology

authors： Rodríguez-Perálvarez M,Luong TV,Andreana L,Meyer T,Dhillon AP,Burroughs AK

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:We performed a multicenter phase II study on the efficacy and safety of intraoperative radiotherapy (IORT) as partial breast irradiation using multiple devices. METHODS:The primary endpoint was ipsilateral breast tumor recurrence (IBTR). Key inclusion criteria were T < 2.5 cm, age > 50 years, surgical margi...

journal_title：Annals of surgical oncology

authors： Sawaki M,Miyamoto T,Fujisawa T,Itoh Y,Ebara T,Tachibana H,Kodaira T,Kikumori T,Yanagita Y,Iwata H

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:The goal of this study is to report the safety and efficacy of pancreatic resection for isolated metastatic cancers from nonpancreatic primary disease. METHODS:We retrospectively identified patients from a single institution's prospectively gathered pancreaticobiliary database from 1970 to 2007 who underwen...

journal_title：Annals of surgical oncology

authors： Reddy S,Edil BH,Cameron JL,Pawlik TM,Herman JM,Gilson MM,Campbell KA,Schulick RD,Ahuja N,Wolfgang CL

更新日期：2008-11-01 00:00:00

abstract：INTRODUCTION:The moderate-penetrance germline mutations ATM, CHEK2, and PALB2 are implicated in an increased risk of the development of breast cancer. Whether these mutations provide clinical utility to guide treatment strategies and prognosis remains unknown. METHODS:A retrospective case-control study from a tertiary...

journal_title：Annals of surgical oncology

authors： Bergstrom C,Pence C,Berg J,Partain N,Sadeghi N,Mauer C,Pirzadeh-Miller S,Gao A,Li H,Unni N,Syed S

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:Isolated limb perfusion (ILP) results in complete response (CR) rates of 60% to 90% in patients with regionally advanced melanoma. Survival after a CR may be influenced by various factors, particularly out-of-field disease in iliac lymph nodes (ILN) identified during lower-extremity ILP. We examined clinical...

journal_title：Annals of surgical oncology

authors： Zogakis TG,Bartlett DL,Libutti SK,Liewehr DJ,Steinberg SM,Fraker DL,Alexander HR

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:The increasing use of mammography has led to a significant increase in the detection of clinically occult lesions, the majority of which prove to be benign. SFNB has been suggested as a means of expediting a diagnosis for lesions that are malignant while limiting surgical biopsies for those that are benign. ...

journal_title：Annals of surgical oncology

authors： Mitnick JS,Vazquez MF,Pressman PI,Harris MN,Roses DF

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:The presence of tumor cells at the margins of breast lumpectomy specimens is associated with an increased risk of ipsilateral tumor recurrence. Twenty to 30 % of patients undergoing breast-conserving surgery require second procedures to achieve negative margins. This study evaluated the adjunctive use of the...

journal_title：Annals of surgical oncology

authors： Schnabel F,Boolbol SK,Gittleman M,Karni T,Tafra L,Feldman S,Police A,Friedman NB,Karlan S,Holmes D,Willey SC,Carmon M,Fernandez K,Akbari S,Harness J,Guerra L,Frazier T,Lane K,Simmons RM,Estabrook A,Allweis T

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Fine-needle aspiration biopsy (FNAB) of the thyroid categorized as atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is a newly defined category according to the recent Bethesda guidelines. We sought to assess the characteristics and treatment of patients with an A...

journal_title：Annals of surgical oncology

authors： Nagarkatti SS,Faquin WC,Lubitz CC,Garcia DM,Barbesino G,Ross DS,Hodin RA,Daniels GH,Parangi S

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Our study aims to determine whether patients with lobular-type breast cancer have significantly improved rates of breast conservation (BCT) after neoadjuvant chemotherapy (nCT). METHODS:Patients who received nCT and surgery within three prospective trials between 1995 and 2007 at the Medical University of...

journal_title：Annals of surgical oncology

authors： Fitzal F,Mittlboeck M,Steger G,Bartsch R,Rudas M,Dubsky P,Riedl O,Jakesz R,Gnant M

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Clinical practice guidelines have been developed to improve melanoma patient care. However, it is unclear whether failure to comply with these standards (either excessive or inadequate treatment) increases morbidity or relapse rates. Therefore, we undertook this study to evaluate the effect of variance from ...

journal_title：Annals of surgical oncology

authors： Erickson Foster J,Velasco JM,Hieken TJ

更新日期：2008-09-01 00:00:00

abstract：:Until the late 1990s, the application of the sentinel node (SN) concept to gastrointestinal (GI) malignancies was not recognized because of the multidirectional and complicated lymphatic flow from the GI tract. However, several studies supporting the validity of the SN concept for GI cancers have been reported in the ...

journal_title：Annals of surgical oncology

authors： Kitagawa Y,Fujii H,Mukai M,Kubo A,Kitajima M

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Few studies have been undertaken to evaluate the prognostic value of age at diagnosis for determining breast cancer survival in a large population. METHODS:Using the U.S. National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database consisting of 18 population-based cancer registri...

journal_title：Annals of surgical oncology

authors： Liu YR,Jiang YZ,Yu KD,Shao ZM

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:The LAP07 randomized trial calls into question the role of radiation therapy (RT) in the modern treatment of locally advanced pancreatic cancer (LAPC). However, advances in chemotherapy and RT limit application of the LAP07 results to current clinical practice. Here we utilize the National Cancer Database (N...

journal_title：Annals of surgical oncology

authors： Zhong J,Switchenko J,Behera M,Kooby D,Maithel SK,McDonald MW,Lin JY,Cassidy RJ,El-Rayes B,Landry J,Patel PR

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:The management of breast cancer (BC) skin metastases represents a therapeutic challenge. Electrochemotherapy (ECT) combines the administration of bleomycin with temporary permeabilization induced by locally administered electric pulses. Preliminary experience with ECT in BC patients is encouraging. METHODS:...

journal_title：Annals of surgical oncology

authors： Cabula C,Campana LG,Grilz G,Galuppo S,Bussone R,De Meo L,Bonadies A,Curatolo P,De Laurentiis M,Renne M,Valpione S,Fabrizio T,Solari N,Guida M,Santoriello A,D'Aiuto M,Agresti R

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:There is considerable interest in a neoadjuvant approach for resectable pancreatic ductal adenocarcinoma (PDAC). This study evaluated perioperative gemcitabine + erlotinib (G+E) for resectable PDAC. METHODS:A multicenter, cooperative group, single-arm, phase II trial was conducted between April 2009 and Nov...

journal_title：Annals of surgical oncology

authors： Wei AC,Ou FS,Shi Q,Carrero X,O'Reilly EM,Meyerhardt J,Wolff RA,Kindler HL,Evans DB,Deshpande V,Misdraji J,Tamm E,Sahani D,Moore M,Newman E,Merchant N,Berlin J,Goff LW,Pisters P,Posner MC

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:To determine whether the benefits of sentinel-node-based management (SNBM) over routine axillary clearance (RAC) persisted to 5 years. METHODS:A total of 1088 women with breast cancer less than 3 cm in diameter and clinically negative axillary nodes were randomized to SNBM with axillary clearance if the sentin...

journal_title：Annals of surgical oncology

authors： Wetzig N,Gill PG,Espinoza D,Mister R,Stockler MR,Gebski VJ,Ung OA,Campbell I,Simes J

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Effective therapeutic combinations targeting the oncogenic pathway still are unknown in human hepatocellular carcinoma (HCC). The authors previously identified aberrant expression of aurora B kinase as the independent predictor for the lethal recurrence of HCC, showing that AZD1152 induced in vitro and in vi...

journal_title：Annals of surgical oncology

authors： Matsunaga H,Tanaka S,Aihara A,Ogawa K,Matsumura S,Ban D,Ochiai T,Irie T,Kudo A,Nakamura N,Arii S,Tanabe M

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Examination of 15 or more lymph nodes is necessary for accurate staging of gastric adenocarcinoma. This study examined whether prognostic discrimination is improved by distinguishing between pT2 tumors limited to the muscularis propria (MP) and those extending to subserosa (SS). METHODS:A single-institution...

journal_title：Annals of surgical oncology

authors： Sarela AI,Turnbull AD,Coit DG,Klimstra D,Brennan MF,Karpeh MS

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Neoadjuvant chemoradiation followed by surgery and adjuvant chemotherapy is typically recommended for patients with locally advanced rectal cancer. Patients with pathologically node-negative tumors have an improved prognosis, but recurrence patterns and independent prognostic factors in these patients have b...

journal_title：Annals of surgical oncology

authors： Govindarajan A,Reidy D,Weiser MR,Paty PB,Temple LK,Guillem JG,Saltz LB,Wong WD,Nash GM

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:We postulated that the worse prognosis of melanoma with advancing age reflected more aggressive tumor biology and that in younger patients the prognosis would be more favorable. MATERIALS AND METHODS:The expanded AJCC melanoma staging database contained 11,088 patients with complete data for analysis, inclu...

journal_title：Annals of surgical oncology

authors： Balch CM,Soong SJ,Gershenwald JE,Thompson JF,Coit DG,Atkins MB,Ding S,Cochran AJ,Eggermont AM,Flaherty KT,Gimotty PA,Johnson TM,Kirkwood JM,Leong SP,McMasters KM,Mihm MC Jr,Morton DL,Ross MI,Sondak VK

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:This study was designed to investigate the correlation between postoperative recurrence of hepatocellular carcinoma (HCC) and perioperative expression and dynamic changes in cancer stem cell (CSC) markers in tumors and peripheral blood. METHODS:In HCC patients who underwent curative resection (n = 64) or li...

journal_title：Annals of surgical oncology

authors： Choi GH,Kim GI,Yoo JE,Na DC,Han DH,Roh YH,Park YN,Choi JS

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Surgery for locally advanced rectal cancers beyond the plane of total mesorectal excision (TME) or extramesorectal nodal involvement should include complete resection. This study evaluated the oncologic feasibility and safety of robot-assisted surgery for rectal cancer beyond the TME plane. METHODS:The stud...

journal_title：Annals of surgical oncology

authors： Shin US,Nancy You Y,Nguyen AT,Bednarski BK,Messick C,Maru DM,Dean EM,Nguyen ST,Hu CY,Chang GJ

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Thick (>or=4-mm) primary melanomas are believed to be associated with a high incidence of occult distant metastases. The use of sentinel lymph node (SLN) mapping and biopsy in the treatment lesions has been questioned. METHODS:A retrospective review of a computerized database identified 114 patients who und...

journal_title：Annals of surgical oncology

authors： Carlson GW,Murray DR,Hestley A,Staley CA,Lyles RH,Cohen C

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:Our aim was to investigate the detrusor muscle sampling rate after monopolar versus bipolar transurethral resection of bladder tumor (TURBT). METHODS:This was a single-center, prospective, randomized, phase III trial on monopolar versus bipolar TURBT. Baseline patient characteristics, disease characteristics a...

journal_title：Annals of surgical oncology

authors： Teoh JY,Chan ES,Yip SY,Tam HM,Chiu PK,Yee CH,Wong HM,Chan CK,Hou SS,Ng CF

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:A patient's likelihood of dying from breast cancer or another cause can be assessed with competing risks analyses. METHODS:Data for a cohort of 678 patients with primary invasive breast cancer accrued from 1971 to 1990, updated to 1995, included cause of death (e.g., breast cancer vs. other cause). We inves...

journal_title：Annals of surgical oncology

authors： Fish EB,Chapman JA,Link MA

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:The modifiable variable best proven to improve survival after resection of pancreatic adenocarcinoma is the addition of adjuvant chemotherapy. A theoretical advantage of minimally invasive pancreaticoduodenectomy (MI-PD) is the potential for greater use and earlier initiation of adjuvant therapy, but this be...

journal_title：Annals of surgical oncology

authors： Nussbaum DP,Adam MA,Youngwirth LM,Ganapathi AM,Roman SA,Tyler DS,Sosa JA,Blazer DG 3rd

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Appendiceal goblet cell adenocarcinoma (GCA) is often misclassified and mistreated due to mixed histologic features. In general, cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is standard of care for peritoneal carcinomatosis (PC) from mucinous appendiceal tumors; however, i...

journal_title：Annals of surgical oncology

authors： Zambrano-Vera K,Sardi A,Munoz-Zuluaga C,Studeman K,Nieroda C,Sittig M,King MC,Sipok A,Gushchin V

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Transarterial chemoembolization (TACE) is often utilized for patients with inoperable neuroendocrine carcinoma liver metastases. Often, metastatic disease is not limited to the liver. The impact of extrahepatic disease (EHD) on outcomes and response after TACE has not been described. METHODS:We reviewed 192...

journal_title：Annals of surgical oncology

authors： Arrese D,McNally ME,Chokshi R,Feria-Arias E,Schmidt C,Klemanski D,Gregory G,Khabiri H,Shah M,Bloomston M

更新日期：2013-04-01 00:00:00