Abstract:
PURPOSE:Neuropathic pain (NPP) following breast surgery extends morbidity in the postoperative period. The incidence and etiology of postoperative NPP remains unclear and under-reported in literature. This study aims to define the incidence of neuropathic pain following breast surgery and to identify patient characteristics that are predictors for developing postoperative NPP. METHODS:Consecutive female patients undergoing breast resection surgery over a 5-year period (2008-2012) with 1-year minimum follow-up were included in this single-center study. Retrospective chart review was performed to identify patient specific characteristics including the development of post-operative NPP. Data was analyzed using univariate and multivariate logistic regression. RESULTS:A total of 470 patients were identified for study inclusion. The incidence of postoperative NPP was 14.7 % (69 of 470). Significant predictors for the development of postoperative NPP in the univariate analyses included history of diabetes mellitus, diabetic neuropathy, or fibromyalgia, concomitant axillary surgery, axillary node dissection, and taxane-based chemotherapy regimen. Multivariate analysis identified African American race [odds ratio (OR) = 1.78; 95 % CI = 1.01-3.17; p = 0.05), history of diabetes mellitus (OR = 1.98; 95 % CI = 1.0-3.74; p = 0.01) or fibromyalgia (OR = 2.75; 95 % CI = 1.13-6.69; p = 0.03), and taxane-based chemotherapy regimen (OR = 2.85; 95 % CI = 1.23-6.58; p = 0.01) as being independently associated with the development of postoperative NPP. CONCLUSIONS:NPP is a significant risk following breast surgery. African American race, history of either diabetes mellitus or fibromyalgia, and treatment with taxane-based chemotherapy regimens are all associated with an increased risk of NPP.
journal_name
Ann Surg Oncoljournal_title
Annals of surgical oncologyauthors
Wilson GC,Quillin RC 3rd,Hanseman DJ,Lewis JD,Edwards MJ,Shaughnessy EAdoi
10.1245/s10434-013-3156-6subject
Has Abstractpub_date
2013-10-01 00:00:00pages
3330-4issue
10eissn
1068-9265issn
1534-4681journal_volume
20pub_type
杂志文章abstract:: ...
journal_title:Annals of surgical oncology
pub_type: 评论,杂志文章
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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journal_title:Annals of surgical oncology
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journal_title:Annals of surgical oncology
pub_type: 杂志文章,多中心研究
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journal_title:Annals of surgical oncology
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更新日期:2008-06-01 00:00:00
abstract:INTRODUCTION:The change in TNM classification of malignant pleural mesothelioma (MPM) between the seventh and eighth edition classifications has resulted in the downstaging of many advanced-stage patients into pathological stage IB. Many mesotheliomas without lymph node metastasis have been classified as stage IB in th...
journal_title:Annals of surgical oncology
pub_type: 杂志文章
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journal_title:Annals of surgical oncology
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abstract:PURPOSE:We aim to report our results in terms of chronic toxicities and cosmetic outcomes after intraoperative radiotherapy (IORT) using kV X-rays in women treated for early breast cancer at our institution. METHODS:Patients with early breast carcinoma were recruited between April 2011 and November 2014. After breast-...
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
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