Lymph node ratio: role in the staging of node-positive colon cancer.

Abstract:

BACKGROUND:Recent literature has shown that lymph node ratio (LNR) is superior to the number of positive lymph nodes (pLNs) in predicting the prognosis in several malignances other than colon cancer. We hypothesize that LNR may play a similar role in stage III colon cancer. METHODS:We included 24,477 stage III colon cancer cases from the Surveillance, Epidemiology, and End Results cancer registry. Patients were categorized into four groups, LNR1 to 4, according to cutoff points 1/14, 0.25, and 0.50. Kaplan-Meier and Cox proportional hazard model were used to evaluate the prognostic effect and estimate the relative risk (RR) and 95% confidence interval (CI) of LNR. RESULTS:The 5-year survival for patients with stage IIIA, IIIB, and IIIC was 71.3%, 51.7%, and 34.0%, respectively (P < .0001). There was no survival difference among LNR1 to LNR4 for stage IIIA patients. In stage IIIB patients, the 5-year survival for those with LNR1 to LNR4 was 63.5%, 54.7%, 44.4%, and 34.2%, respectively (P < .0001). In stage IIIC patients, the 5-year survival for those with LNR2 to LNR4 was 49.6%, 41.7%, and 25.2%, respectively (P < .0001). LNR is an independent predictor of survival after adjusting patient's age, tumor size, tumor grade, race, number of pLNs, and total number of LNs harvested. (RR 2.30, 95% CI 2.08-2.55). CONCLUSION:Patients with stage IIIB and IIIC colon cancer represent a heterogeneous group of patients with the majority either overstaged or understaged. LNR is a more accurate prognostic method for stage III colon cancer patients. We propose an algorithm to incorporate LNR into current AJCC staging system.

journal_name

Ann Surg Oncol

authors

Wang J,Hassett JM,Dayton MT,Kulaylat MN

doi

10.1245/s10434-007-9716-x

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

1600-8

issue

6

eissn

1068-9265

issn

1534-4681

journal_volume

15

pub_type

杂志文章
  • Implementing the Prospective Surveillance Model (PSM) of Rehabilitation for Breast Cancer Patients with 1-Year Postoperative Follow-up, a Prospective, Observational Study.

    abstract:BACKGROUND:The Prospective Surveillance Model (PSM) of rehabilitation for patients with breast cancer aims for early identification, treatment, and support of physical impairments postoperatively. The purpose of this study was to describe the incidence of impairments during the first postoperative year and the differen...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5315-z

    authors: Lai L,Binkley J,Jones V,Kirkpatrick S,Furbish C,Stratford P,Thompson W,Sidhu A,Farley C,Okoli J,Beech D,Gabram S

    更新日期:2016-10-01 00:00:00

  • Can We Reliably Identify the Pathological Outcomes of Neoadjuvant Chemotherapy in Patients with Breast Cancer? Development and Validation of a Logistic Regression Nomogram Based on Preoperative Factors.

    abstract:BACKGROUND:Pathological responses of neoadjuvant chemotherapy (NCT) are associated with survival outcomes in patients with breast cancer. Previous studies constructed models using out-of-date variables to predict pathological outcomes, and lacked external validation, making them unsuitable to guide current clinical pra...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09214-x

    authors: Zhang J,Xiao L,Pu S,Liu Y,He J,Wang K

    更新日期:2020-10-23 00:00:00

  • Incremental risk associated with contralateral prophylactic mastectomy and the effect on adjuvant therapy.

    abstract:BACKGROUND:Contralateral prophylactic mastectomy (CPM) is expected to add surgical morbidity but this incremental risk has not yet been defined. We sought to quantify the additional risks associated with CPM and determine how these risks influence the time to adjuvant therapy. METHODS:We identified women undergoing ma...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3903-3

    authors: Eck DL,Perdikis G,Rawal B,Bagaria S,McLaughlin SA

    更新日期:2014-10-01 00:00:00

  • Predictors for locoregional recurrence for clinical stage III-N2 non-small cell lung cancer with nodal downstaging after induction chemotherapy and surgery.

    abstract:PURPOSE:Pathologic downstaging following chemotherapy for stage III-N2 NSCLC is a well-known positive prognostic indicator. However, the predictive factors for locoregional recurrence (LRR) in these patients are largely unknown. METHODS:Between 1998 and 2008, 153 patients with clinically or pathologically staged III-N...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2800-x

    authors: Amini A,Lou F,Correa AM,Baldassarre R,Rimner A,Huang J,Roth JA,Swisher SG,Vaporciyan AA,Lin SH

    更新日期:2013-06-01 00:00:00

  • Heat shock protein 27 overexpression in breast cancer lymph node metastasis.

    abstract:BACKGROUND:Heat shock protein 27 (hsp-27) is overexpressed in approximately 67% pure ductal carcinoma in situ (DCIS), in approximately 50% DCIS associated with invasive ductal carcinoma (IDC), and in approximately 25% IDC alone. If this decrease in hsp-27 expression has a role in the progression of malignancy in IDC, w...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02306091

    authors: Storm FK,Mahvi DM,Gilchrist KW

    更新日期:1996-11-01 00:00:00

  • Long-term survival of peritoneal carcinomatosis of colorectal origin.

    abstract:BACKGROUND:Peritoneal carcinomatosis of colorectal cancer is probably best treated by cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC). In The Netherlands Cancer Institute, this treatment has been performed since 1995. The long tradition of this treatment enabled us to study long-term survival in det...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10434-004-1167-z

    authors: Verwaal VJ,van Ruth S,Witkamp A,Boot H,van Slooten G,Zoetmulder FA

    更新日期:2005-01-01 00:00:00

  • Clinical Relevance of microRNA Expressions in Breast Cancer Validated Using the Cancer Genome Atlas (TCGA).

    abstract:BACKGROUND:MicroRNAs (miRNAs) play a critical role in the carcinogenesis and progression of breast cancer. MiRNA-205 has tumor suppressive properties, whereas miRNA-18a has both oncogenic and tumor suppressive roles. MiRNA-744's role in breast cancer is unknown but is tumor-suppressive in vitro. We hypothesize that hig...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5984-2

    authors: Kim SY,Kawaguchi T,Yan L,Young J,Qi Q,Takabe K

    更新日期:2017-10-01 00:00:00

  • Retraction Note to: The American Society of Breast Surgeons 2017 Annual Meeting Official Proceedings, Volume XVIII.

    abstract::The Editors of Annals of Surgical Oncology have retracted the following poster session abstract following an investigation by the authors' institution, which found that the study was not submitted to the IRB for approval. ...

    journal_title:Annals of surgical oncology

    pub_type: 已发布勘误,撤回出版物

    doi:10.1245/s10434-018-6474-x

    authors: Hayes M,Bloomquist E,Wright H

    更新日期:2018-04-20 00:00:00

  • Should adjuvant therapy remain the standard of care for patients with resected adenocarcinoma of the pancreas?

    abstract::Adenocarcinoma of the pancreas continues to be a formidable disease. In the United States, patients who have had resected disease are generally offered adjuvant chemoradiation. The current National Comprehensive Cancer Network practice guidelines uniformly support this practice. We reviewed seven selected series to ev...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/aso.2003.06.015

    authors: Chu QD,Khushalani N,Javle MM,Douglass HO Jr,Gibbs JF

    更新日期:2003-06-01 00:00:00

  • ASO Author Reflections: Solitary Pulmonary Lesion in Patients with Cancer History.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6878-7

    authors: Xie X

    更新日期:2018-12-01 00:00:00

  • Identification of the NEDD4L gene as a prognostic marker by integrated microarray analysis of copy number and gene expression profiling in non-small cell lung cancer.

    abstract:PURPOSE:The purpose of this study was to identify prognostic genes by integrated microarray analysis between comparative genomic hybridization and gene expression with laser microdissection in non-small cell lung cancer (NSCLC). METHODS:Integrated microarray analysis in 11 lung adenocarcinomas was performed, and sever...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3059-6

    authors: Sakashita H,Inoue H,Akamine S,Ishida T,Inase N,Shirao K,Mori M,Mimori K

    更新日期:2013-12-01 00:00:00

  • Complete hepatic venous isolation and extracorporeal chemofiltration as treatment for human hepatocellular carcinoma: a phase I study.

    abstract:BACKGROUND:We performed a phase I study of a novel system of complete hepatic venous isolation and extracorporeal chemofiltration in patients with unresectable hepatocellular carcinoma (HCC) to determine (a) whether systemic exposure to doxorubicin could be limited after high-dose hepatic arterial infusion (HAI), and (...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02303811

    authors: Curley SA,Newman RA,Dougherty TB,Fuhrman GM,Stone DL,Mikolajek JA,Guercio S,Guercio A,Carrasco CH,Kuo MT

    更新日期:1994-09-01 00:00:00

  • Intraoperative Margin Management in Breast-Conserving Surgery: A Systematic Review of the Literature.

    abstract:BACKGROUND:Breast surgeons have a wide variety of intraoperative techniques available to help achieve low rates for positive margins of excision, with variable levels of evidence. METHODS:A systematic review of the medical literature from 1995 to July 2016 was conducted, with 434 abstracts identified and evaluated. Th...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析

    doi:10.1245/s10434-016-5756-4

    authors: Gray RJ,Pockaj BA,Garvey E,Blair S

    更新日期:2018-01-01 00:00:00

  • Short-term outcomes of ablation therapy for hepatic tumors: evidence from the 2006-2009 nationwide inpatient sample.

    abstract:BACKGROUND:Radiofrequency ablation (RFA) for the treatment of hepatic tumors has been increasingly used across the United States. Whether treatment-related morbidity has remained low with broader adoption is unclear. We conducted this study to describe in-hospital morbidity associated with RFA for hepatic tumors and to...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2397-0

    authors: Fox JP,Gustafson J,Desai MM,Hellan M,Thambi-Pillai T,Ouellette J

    更新日期:2012-11-01 00:00:00

  • Disseminated peritoneal adenomucinosis: a critical review.

    abstract:BACKGROUND:The term pseudomyxoma peritonei has been used in reference to any condition, benign or malignant, in which the peritoneal cavity becomes filled with a gelatinous substance. The term is nonspecific and does not denote therapeutic or prognostic significance. Controversy centers around which patients benefit fr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10434-999-0797-6

    authors: Wirtzfeld DA,Rodriguez-Bigas M,Weber T,Petrelli NJ

    更新日期:1999-12-01 00:00:00

  • Extracapsular lymph node involvement differs between squamous cell and adenocarcinoma of the esophagus.

    abstract::There is increasing evidence regarding extracapsular lymph node involvement (LNI) as a prognostic factor for recurrence and poor prognosis in gastrointestinal malignancies. The aim of this study was to assess the prevalence and prognostic impact of LNI in patients with resected esophageal cancer, comparing adenocarcin...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0248-9

    authors: Metzger R,Drebber U,Baldus SE,Mönig SP,Hölscher AH,Bollschweiler E

    更新日期:2009-02-01 00:00:00

  • Population-Based Study on Risk Factors for Tumor-Positive Resection Margins in Patients with Gastric Cancer.

    abstract:BACKGROUND:Radical gastrectomy is the cornerstone of the treatment of locally advanced gastric cancer. This study was designed to evaluate factors associated with a tumor-positive resection margin after gastrectomy and to evaluate the influence of hospital volume. METHODS:In this Dutch cohort study, patients with junc...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07381-0

    authors: van der Werf LR,Cords C,Arntz I,Belt EJT,Cherepanin IM,Coene PLO,van der Harst E,Heisterkamp J,Langenhoff BS,Lamme B,van Berge Henegouwen MI,Lagarde SM,Wijnhoven BPL

    更新日期:2019-07-01 00:00:00

  • Resection of residual disease after isolated limb infusion (ILI) is equivalent to a complete response after ILI-alone in advanced extremity melanoma.

    abstract:BACKGROUND:Isolated limb infusion (ILI) is a limb-preserving treatment for in-transit extremity melanoma. The benefit of resecting residual disease after ILI is unclear. METHODS:A multi-institutional experience was analyzed comparing patients who underwent ILI plus resection of residual disease (ILI + RES) versus ILI-...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-013-3336-4

    authors: Wong J,Chen YA,Fisher KJ,Beasley GM,Tyler DS,Zager JS

    更新日期:2014-02-01 00:00:00

  • Dickkopf-1 expression as a marker for predicting clinical outcome in esophageal squamous cell carcinoma.

    abstract:BACKGROUND AND OBJECTIVES:Dickkopf-1 (DKK1) is the inhibitor of the canonical Wnt signaling pathway, however it is highly transactivated in various cancers, suggesting the presence of unknown mechanism. Its implication in human esophageal squamous cell carcinoma (ESCC) has not been sufficiently investigated. PATIENTS ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0476-7

    authors: Makino T,Yamasaki M,Takemasa I,Takeno A,Nakamura Y,Miyata H,Takiguchi S,Fujiwara Y,Matsuura N,Mori M,Doki Y

    更新日期:2009-07-01 00:00:00

  • Accuracy of 18-fluoro-2-deoxy-D-glucose positron emission tomography in the pretherapeutic detection of occult para-aortic node involvement in patients with a locally advanced cervical carcinoma.

    abstract:PURPOSE:Patients with locally advanced cervical cancer (LACC) are usually treated with concurrent chemoradiotherapy. Extended-field chemoradiotherapy is indicated in case of para-aortic node involvement at initial assessment. 18-Fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18-FDG PET/CT) i...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-011-1583-9

    authors: Leblanc E,Gauthier H,Querleu D,Ferron G,Zerdoud S,Morice P,Uzan C,Lumbroso S,Lecuru F,Bats AS,Ghazzar N,Bannier M,Houvenaeghel G,Brenot-Rossi I,Narducci F

    更新日期:2011-08-01 00:00:00

  • Patterns of Referral for Adjuvant Chemotherapy for Stage II and III Colon Cancer: A Population-Based Study.

    abstract:PURPOSE:Reasons for variable utilization of adjuvant chemotherapy (ACT) for colon cancer have not been well described. We report medical oncology (MO) referral patterns and subsequent use of ACT. METHODS:Treatment records were linked to the population-based Ontario Cancer Registry to describe MO referral and ACT use a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5181-8

    authors: Chandhoke G,Wei X,Nanji S,Biagi J,Peng Y,Krzyzanowska M,Mackillop WJ,Booth CM

    更新日期:2016-08-01 00:00:00

  • Analysis and comparison of the 7th edition American Joint Committee on Cancer (AJCC) nodal staging system for metastatic cutaneous squamous cell carcinoma of the head and neck.

    abstract:BACKGROUND:The American Joint Committee on Cancer (AJCC) substantially changed the staging of cutaneous squamous cell carcinoma (cSCC) in the 7th edition of its staging manual. We aim to compare the 7th edition AJCC staging of nodal metastases from cSCC with the N1S3 staging system. METHODS:Analysis of 603 patients fr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-012-2504-2

    authors: Clark JR,Rumcheva P,Veness MJ

    更新日期:2012-12-01 00:00:00

  • Factors associated with local-regional failure after definitive chemoradiation for locally advanced esophageal cancer.

    abstract:BACKGROUND:Locally advanced esophageal cancer is often treated with a trimodality approach. While a substantial proportion of such patients initially achieve a clinical complete response (cCR) after chemoradiation, only a small proportion achieve durable control. We analyzed patients who reached cCR after definitive ch...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3303-0

    authors: Amini A,Ajani J,Komaki R,Allen PK,Minsky BD,Blum M,Xiao L,Suzuki A,Hofstetter W,Swisher S,Gomez D,Liao Z,Lee JH,Bhutani MS,Welsh JW

    更新日期:2014-01-01 00:00:00

  • Radiation Therapy is Independently Associated with Worse Survival After R0-Resection for Stage I-II Non-small Cell Lung Cancer: An Analysis of the National Cancer Data Base.

    abstract:BACKGROUND:The 1998 post-operative radiotherapy meta-analysis for lung cancer showed a survival detriment associated with radiation for stage I-II resected non-small cell lung cancer (NSCLC), but has been criticized for including antiquated radiation techniques. We analyzed the National Cancer Database (NCDB) to determ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5786-6

    authors: Pezzi TA,Mohamed AS,Fuller CD,Blanchard P,Pezzi C,Sepesi B,Hahn SM,Gomez DR,Chun SG

    更新日期:2017-05-01 00:00:00

  • The Landmark Series: Randomized Trials Examining Surgical Margins for Cutaneous Melanoma.

    abstract::Between 1980 and 2004, six randomized, controlled trials (RCTs) have been performed to evaluate the width of surgical margin excision for primary cutaneous melanoma and its influence on recurrence and survival. These trials have led to the current recommendation of not more than a 2-cm margin excision and have allowed...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-019-07866-y

    authors: Angeles CV,Wong SL,Karakousis G

    更新日期:2020-01-01 00:00:00

  • Natural History of Gastric Cancer: Observational Study of Gastric Cancer Patients Not Treated During Follow-Up.

    abstract:BACKGROUND:Understanding the natural progression of untreated gastric cancer is critical for determining the disease prognosis as well as treatment options and timing. The aim of this study is to analyze the natural history of gastric cancer. PATIENTS AND METHODS:We included patients with gastric cancer who had not re...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07455-z

    authors: Oh SY,Lee JH,Lee HJ,Kim TH,Huh YJ,Ahn HS,Suh YS,Kong SH,Kim GH,Ahn SJ,Kim SH,Choi Y,Yang HK

    更新日期:2019-09-01 00:00:00

  • Hypomethylation of long interspersed nuclear element-1 (LINE-1) is associated with poor prognosis via activation of c-MET in hepatocellular carcinoma.

    abstract:BACKGROUND:Long interspersed nuclear element-1 (LINE-1) methylation status, representing global DNA methylation levels, is associated with patient prognosis in several types of cancer. This study was designed to examine the prognostic significance of LINE-1 methylation in patients with hepatocellular carcinoma (HCC) an...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3874-4

    authors: Zhu C,Utsunomiya T,Ikemoto T,Yamada S,Morine Y,Imura S,Arakawa Y,Takasu C,Ishikawa D,Imoto I,Shimada M

    更新日期:2014-12-01 00:00:00

  • The effect of hospital volume on the outcome of breast cancer surgery.

    abstract:BACKGROUND:This study was conducted to investigate whether annual surgical unit caseload affects extent of breast cancer surgery, breast cancer recurrence or breast cancer-specific survival. METHODS:In a population-based cohort study, 12,604 women diagnosed with breast cancer in Finland during the years 1998-2001 were...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1514-1

    authors: Peltoniemi P,Peltola M,Hakulinen T,Häkkinen U,Pylkkänen L,Holli K

    更新日期:2011-06-01 00:00:00

  • ASO Author Reflections: Health Disparities in Pancreatic Cancer.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6961-0

    authors: Lutfi W,Hogg ME

    更新日期:2018-12-01 00:00:00

  • Clinicopathological Features and Outcomes in Individuals with Breast Cancer and ATM, CHEK2, or PALB2 Mutations.

    abstract:INTRODUCTION:The moderate-penetrance germline mutations ATM, CHEK2, and PALB2 are implicated in an increased risk of the development of breast cancer. Whether these mutations provide clinical utility to guide treatment strategies and prognosis remains unknown. METHODS:A retrospective case-control study from a tertiary...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09158-2

    authors: Bergstrom C,Pence C,Berg J,Partain N,Sadeghi N,Mauer C,Pirzadeh-Miller S,Gao A,Li H,Unni N,Syed S

    更新日期:2020-09-29 00:00:00