Intraoperative Margin Management in Breast-Conserving Surgery: A Systematic Review of the Literature.

Abstract:

BACKGROUND:Breast surgeons have a wide variety of intraoperative techniques available to help achieve low rates for positive margins of excision, with variable levels of evidence. METHODS:A systematic review of the medical literature from 1995 to July 2016 was conducted, with 434 abstracts identified and evaluated. The analysis included 106 papers focused on intraoperative management of breast cancer margins and contained actionable data. RESULTS:Ultrasound-guided lumpectomy for palpable tumors, as an alternative to palpation guidance, can lower positive margin rates, but the effect when used as an alternative to wire localization (WL) for nonpalpable tumors is less certain. Localization techniques such as radioactive seed localization and radioguided occult lesion localization were found potentially to lower positive margin rates as alternatives to WL depending on baseline positive margin rates. Intraoperative pathologic methods including gross histology, frozen section analysis, and imprint cytology all have the potential to lower the rates of positive margins. Cavity-shave margins and the Marginprobe device both lower rates of positive margins, with some potential for negative cosmetic effects. Specimen radiography and multiple miscellaneous techniques did not affect positive margin rates or provided too little evidence for formation of a conclusion. CONCLUSIONS:A systematic review of the literature showed evidence that several intraoperative techniques and actions can lower the rates of positive margins. These results are presented together with graded recommendations.

journal_name

Ann Surg Oncol

authors

Gray RJ,Pockaj BA,Garvey E,Blair S

doi

10.1245/s10434-016-5756-4

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

18-27

issue

1

eissn

1068-9265

issn

1534-4681

pii

10.1245/s10434-016-5756-4

journal_volume

25

pub_type

杂志文章,meta分析
  • Blue dye injection in the arm in order to conserve the lymphatic drainage of the arm in breast cancer patients requiring an axillary dissection.

    abstract:BACKGROUND:Despite the widespread use of the sentinel lymph node biopsy technique, many patients with invasive breast cancer still undergo an axillary lymph node dissection and are at risk of arm lymphedema. With the new awareness of lymphatic spread in the axillary nodes, it should be possible to define a new surgical...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9450-4

    authors: Nos C,Lesieur B,Clough KB,Lecuru F

    更新日期:2007-09-01 00:00:00

  • Exosomal PD-L1 Retains Immunosuppressive Activity and is Associated with Gastric Cancer Prognosis.

    abstract:BACKGROUND:A recent study showed that circulating exosomal PD-L1 is an effective predictor for anti-PD-1 therapy in melanomas. Exosomal PD-L1 induced immunosuppression microenvironments in cancer patients. However, its prognostic value and immunosuppressive effect in gastric cancer (GC) were poorly understood. METHODS...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07431-7

    authors: Fan Y,Che X,Qu J,Hou K,Wen T,Li Z,Li C,Wang S,Xu L,Liu Y,Qu X

    更新日期:2019-10-01 00:00:00

  • Surrogate End Points for Overall Survival in Metastatic, Locally Advanced, or Unresectable Pancreatic Cancer: A Systematic Review and Meta-Analysis of 24 Randomized Controlled Trials.

    abstract:BACKGROUND:Overall survival (OS) has traditionally been the primary end point in studies evaluating the clinical benefit of first-line chemotherapy in metastatic, locally advanced, or unresectable pancreatic cancer (MLAUPC). Given the prolonged follow-up assessment required to obtain OS and its potential to be confound...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1245/s10434-017-5826-2

    authors: Makris EA,MacBarb R,Harvey DJ,Poultsides GA

    更新日期:2017-08-01 00:00:00

  • Radiation Therapy is Independently Associated with Worse Survival After R0-Resection for Stage I-II Non-small Cell Lung Cancer: An Analysis of the National Cancer Data Base.

    abstract:BACKGROUND:The 1998 post-operative radiotherapy meta-analysis for lung cancer showed a survival detriment associated with radiation for stage I-II resected non-small cell lung cancer (NSCLC), but has been criticized for including antiquated radiation techniques. We analyzed the National Cancer Database (NCDB) to determ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5786-6

    authors: Pezzi TA,Mohamed AS,Fuller CD,Blanchard P,Pezzi C,Sepesi B,Hahn SM,Gomez DR,Chun SG

    更新日期:2017-05-01 00:00:00

  • Anaplastic thyroid carcinoma: biology, pathogenesis, prognostic factors, and treatment approaches.

    abstract:BACKGROUND:Anaplastic thyroid carcinoma (ATC) is one of the most aggressive solid tumors known to affect humans and carries a dismal prognosis. Our primary aim was to review its epidemiology, biology, risk factors, and prognostic indicators. We also reviewed the individual and combined roles of surgery, radiotherapy, c...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/ASO.2006.05.042

    authors: Are C,Shaha AR

    更新日期:2006-04-01 00:00:00

  • Staging laparoscopy for potentially resectable noncolorectal, nonneuroendocrine liver metastases.

    abstract:BACKGROUND:Carefully selected patients with noncolorectal, nonneuroendocrine (NCNN) liver metastases may benefit from hepatic resection. The incidence of occult unresectable disease and the possible benefits of staging laparoscopy in these patients are not known. METHODS:From December 1997 to July 2000, staging laparo...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02557375

    authors: D'Angelica M,Jarnagin W,Dematteo R,Conlon K,Blumgart LH,Fong Y

    更新日期:2002-03-01 00:00:00

  • Preoperative needle biopsy as a potential quality measure in breast cancer surgery.

    abstract::Preoperative needle diagnosis (PND) is being considered as a quality measure in breast cancer surgery. This criterion has not been thoroughly evaluated in the literature. The purpose of this study is to assess ease of access to these data and rate of compliance in a tertiary care center. We retrospectively reviewed al...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0188-4

    authors: Pocock B,Taback B,Klein L,Joseph KA,El-Tamer M

    更新日期:2009-05-01 00:00:00

  • Cure model survival analysis after hepatic resection for colorectal liver metastases.

    abstract:BACKGROUND:Statistical cure is achieved when a patient population has the same mortality as cancer-free individuals; however, data regarding the probability of cure after hepatectomy of colorectal liver metastases (CLM) have never been provided. We aimed to assess the probability of being statistically cured from CLM b...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4234-0

    authors: Cucchetti A,Ferrero A,Cescon M,Donadon M,Russolillo N,Ercolani G,Stacchini G,Mazzotti F,Torzilli G,Pinna AD

    更新日期:2015-01-01 00:00:00

  • Cumulative imaging radiation exposure following breast-conservation therapy.

    abstract:INTRODUCTION:Radiation from medical imaging may induce cellular damage and increase the risk of cancer. While health care workers are restricted to an annual dose of 50 milliSieverts (mSv), the exposure to patients is not typically recorded. After breast-conservation therapy (BCT), patients are subjected to screening m...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1279-6

    authors: Marti JL,Dauer LT,Stempel M,Patil S,Kaplan JB,Montgomery LL

    更新日期:2011-01-01 00:00:00

  • Clinical usefulness of AJCC response criteria for neoadjuvant chemotherapy in breast cancer.

    abstract:PURPOSE:Recently, the American Joint Committee on Cancer (AJCC) 7th edition proposed new response criteria for neoadjuvant chemotherapy (NAC) in breast cancer. The purpose of this study was to evaluate the clinical usefulness of AJCC response criteria. METHODS:A total of 398 consecutive stage II or III breast cancer p...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2756-x

    authors: Keam B,Im SA,Lim Y,Han SW,Moon HG,Oh DY,Cho N,Lee SH,Han W,Moon WK,Kim DW,Kim TY,Park IA,Noh DY

    更新日期:2013-07-01 00:00:00

  • Surgical Oncologists and the COVID-19 Pandemic: Guiding Cancer Patients Effectively through Turbulence and Change.

    abstract:BACKGROUND:The COVID-19 pandemic has posed extraordinary demands from patients, providers, and health care systems. Despite this, surgical oncologists must maintain focus on providing high-quality, empathetic care for the almost 2 million patients nationally who will be diagnosed with operable cancer this year. The foc...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08673-6

    authors: Hwang ES,Balch CM,Balch GC,Feldman SM,Golshan M,Grobmyer SR,Libutti SK,Margenthaler JA,Sasidhar M,Turaga KK,Wong SL,McMasters KM,Tanabe KK

    更新日期:2020-08-01 00:00:00

  • Minimesohepatectomy for colorectal liver metastasis invading the middle hepatic vein at the hepatocaval confluence.

    abstract:BACKGROUND:In case of liver tumors invading the middle hepatic vein (MHV) at the hepatocaval confluence (HC) major resection is recommended. We describe a new ultrasound-guided conservative operation for patients with colorectal liver metastasis (CLM) invading the MHV at the HC. METHODS:The case of a 65-year-old woman...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0728-6

    authors: Torzilli G,Botea F,Donadon M,Cimino M,Del Fabbro D,Palmisano A

    更新日期:2010-02-01 00:00:00

  • Suitability of sentinel node mapping as an index of metastasis in early gastric cancer following endoscopic resection.

    abstract:BACKGROUND:When pathological diagnosis following endoscopic resection (ER) for early gastric cancer (EGC) suggests probable lymph node metastasis, additional surgery with lymphadenectomy should be performed. The sentinel node (SN) concept has yet to be applied to tumors following ER. The aim of this study was to evalua...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3662-1

    authors: Mayanagi S,Takeuchi H,Kamiya S,Niihara M,Nakamura R,Takahashi T,Wada N,Kawakubo H,Saikawa Y,Omori T,Nakahara T,Mukai M,Kitagawa Y

    更新日期:2014-09-01 00:00:00

  • Endoscopic Retrograde Biliary Drainage Causes Intra-Abdominal Abscess in Pancreaticoduodenectomy Patients: An Important But Neglected Risk Factor.

    abstract:BACKGROUND:Patients with periampullary cancer frequently suffer obstructive jaundice and commonly require preoperative biliary drainage (PBD) for relief and to avoid related complications. Although research has established a correlation between PBD and surgical wound infection, the impact of PBD on major infectious com...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07189-y

    authors: Wu JM,Ho TW,Yen HH,Wu CH,Kuo TC,Yang CY,Tien YW

    更新日期:2019-04-01 00:00:00

  • Rapid genetic diagnosis with the transcription-reverse transcription concerted reaction system for cancer micrometastasis.

    abstract:BACKGROUND:Detection of cancer micrometastases is required for improvement of cancer therapy. The aim of this study was to establish a rapid and practical genetic assay to detect micrometastasis in gastric cancer and to assess its clinical significance with respect to prognosis. METHODS:A novel RNA amplification syste...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2004.12.043

    authors: Ishii T,Fujiwara Y,Ohnaka S,Hayashi T,Taniguchi H,Takiguchi S,Yasuda T,Yano M,Monden M

    更新日期:2004-08-01 00:00:00

  • Prognostic Significance of Tumor-Positive Internal Mammary Sentinel Lymph Nodes in Breast Cancer: A Multicenter Cohort Study.

    abstract:INTRODUCTION:The introduction of the sentinel lymph node biopsy (SLNB) in breast cancer has renewed interest in lymphatic drainage to the internal mammary (IM) nodes. The clinical impact of tumor positive IM nodes is not completely clear. This study evaluated the incidence and impact on overall survival of metastatic I...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-015-4535-y

    authors: Madsen EV,Aalders KC,van der Heiden-van der Loo M,Gobardhan PD,van Oort PM,van der Ent FW,Rutgers EJ,Valdés Olmes RA,Elias SG,van Dalen T

    更新日期:2015-12-01 00:00:00

  • Morbidity of sentinel node biopsy: relationship between number of excised lymph nodes and patient perceptions of lymphedema.

    abstract:BACKGROUND:Sentinel lymph node biopsy (SLNB) is associated with reduced morbidity, although lymphedema remains a significant complication. Previously, we found no association between number of excised lymph nodes (LNs) and measured lymphedema in SLNB patients. In this analysis, we examined the relationship between numb...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1688-1

    authors: Goldberg JI,Riedel ER,Morrow M,Van Zee KJ

    更新日期:2011-10-01 00:00:00

  • Value of Omentoplasty in Abdominoperineal Resection with Primary Perineal Closure for Rectal Cancer.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,信件

    doi:10.1245/s10434-018-6489-3

    authors: Sandhu L,Chang GJ

    更新日期:2018-12-01 00:00:00

  • Lymphatic drainage patterns from the treated breast.

    abstract:INTRODUCTION:Lymphatic drainage patterns from the breast have been described in the past. Drainage may change after treatment of a breast or axilla, and this may have implications for lymphatic mapping. The aim of this study was to determine the lymphatic drainage patterns in breast cancer patients with a previously tr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0841-6

    authors: van der Ploeg IM,Oldenburg HS,Rutgers EJ,Baas-Vrancken Peeters MJ,Kroon BB,Valdés Olmos RA,Nieweg OE

    更新日期:2010-04-01 00:00:00

  • RAS Mutation is Associated with Unsalvageable Recurrence Following Hepatectomy for Colorectal Cancer Liver Metastases.

    abstract:BACKGROUND:RAS mutation status predicts survival after hepatectomy for colorectal liver metastases (CRLM) and survival after repeat hepatectomy for intrahepatic recurrence. This study was aimed at determining the impact of RAS mutation on amenability of recurrence to local therapy and on post-recurrence survival follow...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-6517-3

    authors: Okuno M,Goumard C,Kopetz S,Vega EA,Joechle K,Mizuno T,Omichi K,Tzeng CD,Chun YS,Vauthey JN,Conrad C

    更新日期:2018-08-01 00:00:00

  • Adverse outcomes associated with noncompliance with melanoma treatment guidelines.

    abstract:BACKGROUND:Clinical practice guidelines have been developed to improve melanoma patient care. However, it is unclear whether failure to comply with these standards (either excessive or inadequate treatment) increases morbidity or relapse rates. Therefore, we undertook this study to evaluate the effect of variance from ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0021-0

    authors: Erickson Foster J,Velasco JM,Hieken TJ

    更新日期:2008-09-01 00:00:00

  • Mesenteric lymph node involvement in advanced ovarian cancer patients undergoing rectosigmoid resection: prognostic role and clinical considerations.

    abstract:BACKGROUND:The aim of this retrospective study was to investigate the incidence of mesenteric lymph node (MLN) involvement, and its prognostic role in advanced ovarian cancer (OC). METHODS:OC patients undergoing rectosigmoid resection during primary debulking surgery or interval debulking surgery were recorded. Progre...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3558-0

    authors: Gallotta V,Fanfani F,Fagotti A,Chiantera V,Legge F,Gueli Alletti S,Nero C,Margariti AP,Papa V,Alfieri S,Ciccarone F,Scambia G,Ferrandina G

    更新日期:2014-07-01 00:00:00

  • Quilting prevents seroma formation following breast cancer surgery: closing the dead space by quilting prevents seroma following axillary lymph node dissection and mastectomy.

    abstract:BACKGROUND:Seroma is a frequent problem after mastectomy (ME) and axillary lymph node dissection (ALND). Seroma is associated with pain, discomfort, impaired mobilisation and repeated aspirations, often resulting in a surgical site infection (SSI). It has already been demonstrated that minimizing dead space through fix...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3359-x

    authors: ten Wolde B,van den Wildenberg FJ,Keemers-Gels ME,Polat F,Strobbe LJ

    更新日期:2014-03-01 00:00:00

  • Short-Course Radiotherapy Followed by Neoadjuvant Bevacizumab, Capecitabine, and Oxaliplatin and Subsequent Radical Treatment in Primary Stage IV Rectal Cancer: Long-Term Results of a Phase II Study.

    abstract:BACKGROUND:In a Dutch phase II trial conducted between 2006 and 2010, short-course radiotherapy followed by systemic therapy with capecitabine, oxaliplatin, and bevacizumab as neoadjuvant treatment and subsequent radical surgical treatment of primary tumor and metastatic sites was evaluated. In this study, we report th...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5897-0

    authors: Bisschop C,van Dijk TH,Beukema JC,Jansen RLH,Gelderblom H,de Jong KP,Rutten HJT,van de Velde CJH,Wiggers T,Havenga K,Hospers GAP

    更新日期:2017-09-01 00:00:00

  • Salvage treatment for isolated regional failure of nasopharyngeal carcinoma after primary radiotherapy.

    abstract:BACKGROUND:Isolated regional failure of nasopharyngeal carcinoma (NPC) after primary treatment is traditionally treated with radical neck dissection (RND). The roles of modified radical neck dissection (MRND) and postoperative radiotherapy after salvage surgery currently remain unclear. METHODS:Medical records from ou...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-2018-3

    authors: Lo WC,Wang CP,Ko JY,Lou PJ,Yang TL,Wang CW,Hu YL,Chen TC

    更新日期:2012-03-01 00:00:00

  • Long-Term Outcomes of Local Excision Following Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer.

    abstract:BACKGROUND:Local excision might represent an alternative to total mesorectal excision for patients with locally advanced rectal cancer who achieve a major or complete clinical response after neoadjuvant chemoradiotherapy. METHODS:Between August 2005 and July 2011, 63 patients with mid-low rectal adenocarcinoma who had...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09243-6

    authors: D'Alimonte L,Bao QR,Spolverato G,Capelli G,Del Bianco P,Albertoni L,De Paoli A,Guerrieri M,Mantello G,Gambacorta MA,Canzonieri V,Valentini V,Coco C,Pucciarelli S

    更新日期:2020-10-30 00:00:00

  • Workload Differentiates Breast Surgical Procedures: NSM Associated with Higher Workload Demand than SSM.

    abstract:BACKGROUND:Breast surgery has evolved with more focus on improving cosmetic outcomes, which requires increased operative time and technical complexity. Implications of these technical advances in surgery for the surgeon are unclear, but they may increase intraoperative demands, both mentally and physically. We prospect...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-08159-0

    authors: Hallbeck MS,Law KE,Lowndes BR,Linden AR,Morrow M,Blocker RC,Cain SM,Degnim AC,Hieken TJ,Jakub JW,Racz JM,Farley DR,Nelson H,Boughey JC

    更新日期:2020-05-01 00:00:00

  • Correlation between prognostic factors and increasing age in melanoma.

    abstract:BACKGROUND:Age of patients with melanoma varies directly with mortality and inversely with the presence of sentinel lymph node (SLN) metastasis. To gain further insight into this apparent paradox, we analyzed the relationship between age and other major prognostic factors. METHODS:The Sunbelt Melanoma Trial is a prosp...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1245/aso.2004.04.015

    authors: Chao C,Martin RC 2nd,Ross MI,Reintgen DS,Edwards MJ,Noyes RD,Hagendoorn LJ,Stromberg AJ,McMasters KM

    更新日期:2004-03-01 00:00:00

  • Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study.

    abstract:BACKGROUND:Cytotoxic T lymphocyte-associated antigen (CTLA)-4 can inhibit T-cell responses and is involved in tolerance against self antigens. We previously reported autoimmune manifestations and objective cancer regressions in patients with metastatic melanoma treated with CTLA-4 blockade. The possibility of activatin...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2005.03.536

    authors: Maker AV,Phan GQ,Attia P,Yang JC,Sherry RM,Topalian SL,Kammula US,Royal RE,Haworth LR,Levy C,Kleiner D,Mavroukakis SA,Yellin M,Rosenberg SA

    更新日期:2005-12-01 00:00:00

  • The effect of hospital volume on the outcome of breast cancer surgery.

    abstract:BACKGROUND:This study was conducted to investigate whether annual surgical unit caseload affects extent of breast cancer surgery, breast cancer recurrence or breast cancer-specific survival. METHODS:In a population-based cohort study, 12,604 women diagnosed with breast cancer in Finland during the years 1998-2001 were...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1514-1

    authors: Peltoniemi P,Peltola M,Hakulinen T,Häkkinen U,Pylkkänen L,Holli K

    更新日期:2011-06-01 00:00:00