Abstract:
INTRODUCTION:Lymphatic drainage patterns from the breast have been described in the past. Drainage may change after treatment of a breast or axilla, and this may have implications for lymphatic mapping. The aim of this study was to determine the lymphatic drainage patterns in breast cancer patients with a previously treated ipsilateral breast. METHODS:Between January 1999 and November 2008, 115 sentinel node procedures were performed in breast cancer patients who had undergone treatment of the ipsilateral breast in the past. Lymphatic drainage patterns were analyzed based on preoperative lymphoscintigraphy and sentinel lymph node biopsy. Patients were divided into subgroups according to their previous treatment. RESULTS:Sentinel nodes were found in 84% of the patients: in 81 patients (70%) in the axilla, 43 patients (37%) had drainage to more than one site, and in 18 patients (16%) no drainage was detected. The percentage of drainage outside the axilla was higher than in a series of untreated breast cancer patients from our institution (51% versus 33%, P = 0.01). The 16% nonidentification rate was also higher than the 3.1% in patients without previous treatment (P = 0.003). Four patients (3.5%) had lymphatic drainage to the contralateral axilla. Twelve patients (10%) had involved sentinel nodes; these were harvested from the contralateral axilla in two of them. No lymph node recurrences were observed during a median follow-up time of 39 months. CONCLUSION:Lymphatic mapping yields a lymph node in 84% of breast cancer patients who have undergone previous treatment of the breast. Nonidentification and extra-axillary nodes are more frequently encountered than in patients without treatment of the breast in the past. The finding of involved nodes suggests that sentinel node biopsy improves staging. Long-term follow-up will determine the sensitivity of the procedure in this specific situation.
journal_name
Ann Surg Oncoljournal_title
Annals of surgical oncologyauthors
van der Ploeg IM,Oldenburg HS,Rutgers EJ,Baas-Vrancken Peeters MJ,Kroon BB,Valdés Olmos RA,Nieweg OEdoi
10.1245/s10434-009-0841-6subject
Has Abstractpub_date
2010-04-01 00:00:00pages
1069-75issue
4eissn
1068-9265issn
1534-4681journal_volume
17pub_type
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journal_title:Annals of surgical oncology
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究
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更新日期:2013-04-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
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更新日期:2002-04-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00
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更新日期:2017-03-01 00:00:00
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pub_type: 杂志文章
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